Abstract：
OBJECTIVE:In jawbones, ameloblastomas and odontogenic keratocysts share many clinical features in common such as aggressiveness, high recurrence rates and radical management options. Understanding the pathogenesis and biological aspects of these tumors would improve the success of diagnose and treatment procedures. The aim of this study was to exhibit the reasons of high recurrence rates and growth potentials of ameloblastomas and keratocystic odontogenic tumours by investigating the expression of IL-1α and IL-6 and IL-1α -889 gene polymorphism. IL-1α and IL-6 are shown as very effective tissue degrading factors in bone remodelling. STUDY DESIGN:This study included 25 cases of ameloblastomas, 41 cases of keratocystic odontogenic tumors (parakeratinized odontogenic keratocysts) and 8 cases of orthokeratinized odontogenic keratocysts. All histological slides were stained immunohistochemically to show the expression of IL-1α and IL-6. Restriction fragment length analysis was used to investigate the cytokine gene polymorphism. RESULTS AND CONCLUSIONS:The higher expression rates of IL-1α and IL-6 were associated with tumor size in ameloblastomas and with cyst wall thickness in keratocystic odontogenic tumors. This finding suggested us that the cytokines IL-1α and IL-6 play a role on aggressive behaviour of ameloblastomas and keratocystic odontogenic tumors by making easy bone resorption. In addition, IL-1α (-889) T polymorphism was found consistent with increased IL-1α expression but not seem as a risk factor on the development of these tumors.
journal_name
Med Oral Patol Oral Cir Bucaljournal_title
Medicina oral, patologia oral y cirugia bucalauthors
Sengüven B,Oygür Tsubject
Has Abstractpub_date
2011-07-01 00:00:00pages
e467-72issue
4eissn
1698-4447issn
1698-6946pii
16837journal_volume
16pub_type
杂志文章abstract：OBJECTIVES:To explore the correlation between the severity of radiotherapy-induced glossitis (RTG) and endothelial cell injury in local tissues in a rat model. STUDY DESIGN:The RTG animal model was designed and used by our team. The Oral mucositis index(OMI) was documented daily. Immunohistochemistry (IHC) Staining of...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.17057
更新日期：2011-09-01 00:00:00
abstract：:There are few studies on bucco-maxillary lesions in children and adolescents, and reports on odontogenic tumors (OT) are scanty. Comparison among the available data is difficult due to differences in the criteria used in each study. The aim of the present work was to perform a retrospective study of OT in patients age...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
abstract：UNLABELLED:Diagnosis of Sjögren's syndrome (SS) is complex and the usefulness of labial minor salivary glands biopsy in this process remains controversial. OBJECTIVE:to evaluate the clinical and laboratorial profile and histological features on labial minor salivary glands from patients under investigation of SS. STU...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.19486
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVES:The Head and Neck Squamous Cell Carcinoma (HNSCC) ranks sixth worldwide. The mechanisms of growth, invasion and metastasis of this pathology are extensively studied and generally related to specific variations in signaling pathways like the PI3K-Akt; however most of these competent studies have been performe...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.17538
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Third molar extraction is a very common procedure in Dentistry. The aim of this study was to evaluate the quality of life (QoL) and satisfaction of patients undergoing extraction of an upper third molar under local anesthesia. A second objective was to describe the evolution of self-reported pain measured in...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.21781
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:To investigate the occupational profile, educational level, marital status and deleterious habits to the health of patients with maxillofacial fractures of a population of northeastern Brazil. MATERIAL AND METHODS:A retrospective study of patients records admitted to the Division of Oral and Maxillofacial S...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.21969
更新日期：2018-01-01 00:00:00
abstract：UNLABELLED:The current indicators used to gather information on oral health in children are basically clinical indexes that register mainly dental caries, periodontal disease, and malocclusion. These indexes should be complemented with emotional and social aspects related to the individual experience and perception of ...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.16.e430
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVES:Patients with chronic graft-versus-host disease (cGVHD) often suffer from dry mouth and oral mucosal lesions. The primary objective of this study was to investigate the safety of an intra-oral electrostimulator (GenNarino) in symptomatic cGVHD patients. The secondary objective was to study the impact on the ...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,随机对照试验
doi：10.4317/medoral.19429
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:It is now well established that IL-4 has a central role in the development of monocytes to multinucleated giant cells (MGCs) by inducing the expression of integrins on the surface of monocytes. The aim of this study was to investigate the potential role of IL-4 in induction of β5 integrin expression in the p...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.20935
更新日期：2017-01-01 00:00:00
abstract：:Recently there have been reports of osteonecrosis of the jaw (ONJ) in patients with chronic therapy with bisphosphonates (Bps). So far three drugs have been linked: Pamidronate of disodium, Zoledronic acid and Alendronate of sodium. It is due to a non detected side effect in clinical trials before commercialization, a...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND:Oral rehabilitation of atrophic maxillae features high complexity, for which there are several therapeutic modalities reported on scientific literature. Zygomatic implant placement is a viable option that features low morbidity and allows immediate prosthetic loading. The purpose of the present study was to ...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：10.4317/medoral.23569
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Alzheimer's disease (AD), the main cause of dementia in the adult population, is characterized by a progressive loss of cognitive function. It is considered that neuroinflammation plays a fundamental role in its onset and progression. The bacteria present in the disbiotic microbiome generated during the cour...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：10.4317/medoral.23940
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVES:The principle of the intraosseous anesthesia (IOA) relies on the perforation of the cortical plate of the bone for direct application of the local anesthetic solution into the underlying cancellous structures. During this procedure, IOA needles might accidentally come in contact with the tooth roots. The aim...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.18386
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION:Bone defects are rather common after oral surgery and may prove difficult to repair. OBJECTIVE:We provide a histomorphological analysis of the bone regenerative capacity of platelet-rich plasma at different concentrations and the extraction of platelet-rich bone marrow, compared with beta-tricalcium phosp...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.14.e620
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVES:To asses whether dental eruption order can play a role in the early diagnosis of crossed laterality. STUDY DESIGN:Dental eruption pattern along with eye, ear, hand and foot lateralism were examined on 131 children between 6 to 8 years old from public schools from a multietnic population area of Barcelona ci...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.19567
更新日期：2014-09-01 00:00:00
abstract：:Cowden's disease, or multiple hamartoma syndrome, is an autosomal dominant genodermatosis, characterized by the presence of multiple cutaneous hamartomas, oral fibromas and benign acral keratosis. It affects multiple organs (breast, thyroids, stomach, colon), with the strong possibility of malignant neoplasia developi...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2006-08-01 00:00:00
abstract：:Bisphosphonates is a group of inorganic pyrophosphates analogues that suppress bone resorption by inducing osteoclast inactivation, being frequently used for management of diseases affecting bone metabolism, bone metastases and bone tumors. However, since 2003 many cases describing the presence of necrotic bone exposu...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：10.4317/medoral.19094
更新日期：2014-03-01 00:00:00
abstract：:Worldwide, the use of cocaine has an increased over the years, various secondary effects have been described. Here we present a 48 years old female with a 2-month evolution bucconasal ulcer in the hard palate induced by cocaine usage accompanied by swallow and phonation dysfunctions. Ethiopathogenesis, differential di...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND:Evaluation of the efficacy and safety of a mandibular advancement device (MAD) (KlearwayTM) in the treatment of mild-to-moderate obstructive sleep apnea and chronic roncopathy. MATERIAL AND METHODS:A randomized, placebo-controlled, double blinded, and crossover clinical trial was conducted. Placebo device (...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,随机对照试验
doi：10.4317/medoral.20649
更新日期：2015-09-01 00:00:00
abstract：:In this review, we examined a 45-year-old Asian man who had been diagnosed with florid osseous dysplasia (FOD) of the mandible and acute perimandibular cellulitis. This presentation occurred after a history of off-and-on swellings of the jaw and multiple treatments received at another hospital. An aggressive resection...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2009-09-01 00:00:00
abstract：:Osteochondroma is the most common benign neoplasia of the skeleton. In the head it was been described in cranial base, posterior maxillary surface, maxillary sinus, and different mandibular areas like condyle, ramus, body and symphysis. Osteochondroma of the coronoid process are rare. We present a review of the litera...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：
更新日期：2006-05-01 00:00:00
abstract：:Regional odontodysplasia (RO) is an unusual, non-hereditary anomaly of the dental hard tissues with characteristic clinical, radiographic and histological findings. Clinically, RO affects the primary and permanent dentition in the maxilla and mandible or both jaws. Radiographically, there is a lack of contrast between...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:A description is made of transcrestal sinus lift using the sinus balloon technique, evaluating the bone height achieved and implant success one year after prosthetic loading. MATERIAL AND METHOD:Between January and July 2007, transcrestal sinus lift using the sinus balloon technique for dental implant placem...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.17268
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVES:We attempt to investigate a possible association between periodontal disease (PD) and mental disorders (MD) in a population of Brazilian Police. STUDY METHOD:From a total study population consisting of 803 policemen, 345 police officers were obtained by a sample calculation using the finite population corre...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:Lichen sclerosus is a mucocutaneous autoimmune disease which might be initiated by infectious pathogens as Borrelia Bugrdorferi and HPV. This disease shows destructive potential and is rarely diagnosed in oral mucosa. The purpose of this paper is to evaluate the characteristics of cases described in literatu...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：10.4317/medoral.21606
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Retrospective studies to assess the distribution of oral diseases (ODs) are helpful in estimating the prevalence of oral diagnoses in the population, and thus help in preventive and curative services. Prevalence and frequency data for ODs are available from many countries, but information from Chile is scarc...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：10.4317/medoral.21665
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Diabetes and periodontal disease share common features in terms of inflammatory responses. Current scientific evidence suggests that treatment of periodontal disease might contribute to glycemic control. The objective of the study is a review of the last three years. MATERIAL AND METHODS:A literature search...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：10.4317/medoral.21048
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to determine the prevalence of level IIb metastasis in patients with oral squamous cell carcinomas (OSCCs). MATERIAL AND METHODS:A prospective analysis of 56 patients with OSCC who underwent surgical treatment of the primary lesion with simultaneous neck dissection was performe...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.20491
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the effectiveness in the formation of resin tags, adhesive lateral branches and hybrid layers of five adhesive systems, when bonding to dentine. MATERIAL AND METHODS:Flat dentin surfaces from 25 molars were bonded with several adhesive systems according to the manufacturers' instructions. Composi...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.15.e112
更新日期：2010-01-01 00:00:00
abstract：INTRODUCTION:As important effector cells of the innate immune system, neutrophils are involved in rejection of solid organ and/or tissue transplants. But their role in rejection of oral mucosa transplantation (OMT) remains unclear. The aim of this study is to observe the spatial-temporal change of neutrophils during ac...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.16.e341
更新日期：2011-05-01 00:00:00
