Abstract:
:Bisphosphonates is a group of inorganic pyrophosphates analogues that suppress bone resorption by inducing osteoclast inactivation, being frequently used for management of diseases affecting bone metabolism, bone metastases and bone tumors. However, since 2003 many cases describing the presence of necrotic bone exposures in the jaws have been described in patients receiving these drugs, what represent a significant complication of bisphosphonates treatment. The overall incidence of bisphosphonate-related osteonecrosis of the jaws is low, ranging from 0.7% to 12%, mainly observed in those patients receiving intravenously treatment. Osteonecrosis of the jaws associated to oral bisphosphonate, particularly alendronate, has also been reported by a number of authors. Considering that alendronate is one of the most used drug worldwide, specially for treatment of osteoporosis, a better understanding of osteonecrosis of the jaws related to its use and how to manage these patients is extremely important. Therefore, in the current manuscript the authors aim to review the most important topics related to this pathological presentation.
journal_name
Med Oral Patol Oral Cir Bucaljournal_title
Medicina oral, patologia oral y cirugia bucalauthors
Paiva-Fonseca F,Santos-Silva AR,Della-Coletta R,Vargas PA,Lopes MAdoi
10.4317/medoral.19094subject
Has Abstractpub_date
2014-03-01 00:00:00pages
e106-11issue
2eissn
1698-4447issn
1698-6946pii
19094journal_volume
19pub_type
杂志文章,评审abstract::The evaluation of bone regeneration and peri-implantary bone apposition requires laboratory techniques that allow the evaluation of hard tissues without needing to decalcify them. In this study, we describe the cutting-grinding procedure (EXAKT system) for obtaining samples of undecalcified bone and aim to establish t...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,评审
doi:
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVES:The principle of the intraosseous anesthesia (IOA) relies on the perforation of the cortical plate of the bone for direct application of the local anesthetic solution into the underlying cancellous structures. During this procedure, IOA needles might accidentally come in contact with the tooth roots. The aim...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.18386
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness in the formation of resin tags, adhesive lateral branches and hybrid layers of five adhesive systems, when bonding to dentine. MATERIAL AND METHODS:Flat dentin surfaces from 25 molars were bonded with several adhesive systems according to the manufacturers' instructions. Composi...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.15.e112
更新日期:2010-01-01 00:00:00
abstract::Based on a few case reports of oral mucosal diseases a number of questions is raised about the role of dentists-general practitioners in the diagnostic procedure and management of patients with such diseases. For instance, are dentists prepared to prescribe topical corticosteroids and should dentists be taught how and...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.24465
更新日期:2021-01-04 00:00:00
abstract:BACKGROUND:In a variable proportion of maxillary sinuses alveolar antral artery is located close to the residual ridge, increasing the chances for haemorrhagic complications during sinus floor elevation procedures. MATERIAL AND METHODS:Retrospective observational study of CBCT explorations performed for implant-treatm...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.21475
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Osteonecrosis of the jaw (ONJ) is a destructive bone process in patients undergoing bisphosphonate therapy and it is modulated by local and systemic factors. The purpose of this article is to determine the prevalence of ONJ in patients who have undergone intravenous bisphosphonate therapy, and relate the ris...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.20092
更新日期:2015-05-01 00:00:00
abstract::Osteochondroma is the most common benign neoplasia of the skeleton. In the head it was been described in cranial base, posterior maxillary surface, maxillary sinus, and different mandibular areas like condyle, ramus, body and symphysis. Osteochondroma of the coronoid process are rare. We present a review of the litera...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,评审
doi:
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:To elucidate the significance of absorbable surgical sutures in the occurrence of stitch abscess after surgery in patients with oral squamous cell carcinoma (SCC). MATERIAL AND METHODS:The subjects were 251 patients who underwent excision and/or reconstruction and/or neck dissection for oral SCC using absor...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.21445
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Dabigatran is a newly commercialized drug that is replacing other anticoagulants in the prevention of venous thromboembolism, stroke and systemic arterial valve embolism. It acts directly on thrombin presenting in a dynamic and predictable way, which does not require monitoring these patients. Therefore, we ...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,评审
doi:10.4317/medoral.21202
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:To assess the knowledge and preventive attitudes that Spanish dentists have towards oral cancer, before and after an educational intervention. METHODS:A quasi-experimental study based on a nationwide intervention. All Spanish dentists were offered an on-site course on oral cancer. An individual questionnaire...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.15.e422
更新日期:2010-05-01 00:00:00
abstract:PURPOSE:The purpose of the article is to present 8 new cases of metastatic tumors occurring in the jawbones, their clinical features , diagnostic workup and management. PATIENTS AND METHODS:The records of 8 patients with metastatic jaw lesions were reviewed. Demographic data, presenting symptoms, primary tumor site, r...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2006-03-01 00:00:00
abstract::We grouped as oral lichenoid disease (OLD) a series of chronic inflammatory processes with autoimmune base that affect the epithelium of the oral mucosa. This disease presents in 2% of the population with a marked predilection for the female gender, especially perimenopausal women. Clinically, it is characterized by t...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,评审
doi:
更新日期:2009-03-01 00:00:00
abstract:INTRODUCTION:Odontomas are benign odontogenic tumors composed of enamel, dentine, cement and pulp tissue. They are usually clinically asymptomatic, but often associated with tooth eruption disturbances. In exceptional cases the odontoma erupts into the mouth . The present study reports three cases of odontomas erupted ...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,评审
doi:
更新日期:2009-06-01 00:00:00
abstract::Bite injuries to the head and neck region can result in facial disfigurement with distressing physical and psychological consequences. This article reviewed the causes and management of facial bite wounds due to dog bites. A PUBMED search of the National Library of Medicine from 1995 to December 2005 was conducted. Ke...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,评审
doi:
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Despite efforts to prevent postoperative discomfort, there are still many immediate side effects associated with the surgical extraction of impacted lower third molars. Cicatrization is a physiological process through which the loss of integrity of oral mucosa is recovered and damaged tissues are repaired. B...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,随机对照试验
doi:10.4317/medoral.21281
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Cheilitis granulomatosa (CG) is a disturbing and persistent idiopathic lip swelling. The cause and treatment has not been wholly elucidated. Some reports infer that CG is mainly associated with dental infection but no firm or reliable microbiological evidence has been provided for a causative organism. This ...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.23041
更新日期:2019-11-01 00:00:00
abstract:INTRODUCTION:Bracket debonding from the tooth surface is a common problem in fixed orthodontics. The aims of the present study were to assess the bond strength and failure sites in two ways of bonding technique, with metallic and ceramic brackets. MATERIALS AND METHODS:One hundred premolars were assigned to 4 groups o...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.17024
更新日期:2012-01-01 00:00:00
abstract::Mineral trioxide aggregate (MTA) has shown potential as a repair material for perforations. This clinical case demonstrates that when MTA was used as a repair material for root perforation due to invasive cervical resorption, the tooth was well in function for 27 months. Both clinical and radiographic follow-up showed...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2008-10-01 00:00:00
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journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.21146
更新日期:2016-09-01 00:00:00
abstract::In this review, we examined a 45-year-old Asian man who had been diagnosed with florid osseous dysplasia (FOD) of the mandible and acute perimandibular cellulitis. This presentation occurred after a history of off-and-on swellings of the jaw and multiple treatments received at another hospital. An aggressive resection...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:The aim of this study is to describe the presence, to reveal the frequency and characteristics of accessory canals (ACs) of the canalis sinuosus (CS) by cone beam computed tomography (CBCT). MATERIAL AND METHODS:A total of 326 CBCT examinations were scanned retrospectively. The anatomical views were evaluat...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.23235
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the effect of two different concentrations (4 and 8 mg) of dexamethasone to decrease the swelling and trismus after the surgical extraction of mandibular impacted third molars. METHODS:This randomized clinical trial comprised thirty (30) adult patients of both genders with...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2008-02-01 00:00:00
abstract::Sarcoidosis is a multisystemic granulomatous disease of unknown aetiology that usually presents with bilateral hiliar adenopathies, pulmonary infiltrations, and ocular and cutaneous lesions. The specific cutaneous lesions, or granulomatous, are produced in from 9% to 37% of patients with systemic sarcoidosis. Neverthe...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Evaluation of the efficacy and safety of a mandibular advancement device (MAD) (KlearwayTM) in the treatment of mild-to-moderate obstructive sleep apnea and chronic roncopathy. MATERIAL AND METHODS:A randomized, placebo-controlled, double blinded, and crossover clinical trial was conducted. Placebo device (...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,随机对照试验
doi:10.4317/medoral.20649
更新日期:2015-09-01 00:00:00
abstract::Liposarcomas represent between 15 and 18% of all sarcomas with the most common site being the extremities and retroperitoneum. Liposarcomas of the head and neck are rare, with an estimated incidence representing 3 to 5.6% of all liposarcomas. Liposarcomas most commonly present in the soft tissues of the neck. Primary ...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:The aim of this prospective controlled study is the comparison between long-term children survived leukaemia and a control group in terms of the decayed, missing or filled permanent teeth (DMFT) and dental anomalies. STUDY DESIGN:Fifty-two long term children survived leukaemia, aged from 8 to 15 years (27 fe...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.17955
更新日期:2012-11-01 00:00:00
abstract::Traumatic neuromas are rare entities which characteristically arise subsequently to surgery and are usually accompanied by pain, typically neuralgic. We present an unusual case of an intraosseous traumatic neuroma of the inferior alveolar nerve following tooth extraction. A 56-year-old man consulted for paresthesias a...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVES:Visfatin, also known as nicotiamide phosphoribosyltransferase or pre-B cell colony enhancing factor, is a pro-inflammatory cytokine whose serum level is increased in various cancers. In this study, we investigated whether plasma visfatin levels were altered in patients with oral squamous cell carcinoma (OSCC...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.18574
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Nuclear localization of cyclin B1 is an indicator for cells undergoing mitotic division, and the overexpression has shown promising results as a good prognostic predictor for patients of squamous cell carcinoma (SCC). Cyclin B1 overexpression among histological grades of conventional oral squamous cell carci...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.18220
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:The Franciscan Hospital for Children Oral Health-Related Quality of Life questionnaire (FHC-OHRQOL-Q) is an instrument designed specifically for parents and caregivers of patients with special needs that has not yet been applied in Spain. The aim of this study was to adapt it to Spanish and evaluate its reli...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.22553
更新日期:2018-09-01 00:00:00