Regulation of Connexins Expression Levels by MicroRNAs, an Update.

abstract：:The RR-interval time series or tachograms obtained from electrocardiograms have been widely studied since they reflect the cardiac variability, and this is an indicative of the health status of a person. The tachogram can be seen as a highly non-linear and complex time series, and therefore, should be analyzed with no...

journal_title：Frontiers in physiology

authors： Solís-Montufar EE,Gálvez-Coyt G,Muñoz-Diosdado A

更新日期：2020-08-12 00:00:00

abstract：:Cortical spreading depolarisation (CSD) is a transient disruption of ion balance that propagates along the cortex. It has been identified as an important factor in the progression of cerebral damage associated with stroke or traumatic brain injury. We analysed local field potential signals during CSD in old and young ...

journal_title：Frontiers in physiology

authors： Makra P,Menyhárt Á,Bari F,Farkas E

更新日期：2018-11-08 00:00:00

abstract：:Atherosclerosis is considered as a chronic disease of arterial wall, with a strong contribution of inflammation. Dendritic cells (DCs) play a crucial role in the initiation of proatherogenic inflammatory response. Mature DCs present self-antigens thereby supporting differentiation of naïve T cells to effector cells th...

journal_title：Frontiers in physiology

authors： Chistiakov DA,Sobenin IA,Orekhov AN,Bobryshev YV

更新日期：2014-05-27 00:00:00

abstract：:The generation of neural network dynamics relies on the interactions between the intrinsic and synaptic properties of their neural components. Moreover, neuromodulators allow networks to change these properties and adjust their activity to specific challenges. Endogenous continuous ("tonic") neuromodulation can regula...

journal_title：Frontiers in physiology

authors： Peña-Ortega F

更新日期：2012-07-20 00:00:00

abstract：:Genetically modified mice provide a number of models for studying cardiac channelopathies related to cardiac Na(+) channel (SCN5A) abnormalities. We review key pathophysiological features in these murine models that may underlie clinical features observed in sinus node dysfunction and progressive cardiac conduction di...

journal_title：Frontiers in physiology

authors： Huang CL,Lei L,Matthews GD,Zhang Y,Lei M

更新日期：2012-07-06 00:00:00

abstract：:The epithelial Na+ channel (ENaC) provides for Na+ absorption in various types of epithelia including the kidney, lung, and colon where ENaC is localized to the apical membrane to enable Na+ entry into the cell. The degree of Na+ entry via ENaC largely depends on the number of active channels localized to the cell mem...

journal_title：Frontiers in physiology

authors： Cheung TT,Ismail NAS,Moir R,Arora N,McDonald FJ,Condliffe SB

更新日期：2019-02-08 00:00:00

abstract：:Data-driven computational neural network models have been used to study mechanisms for generating the motor patterns for breathing and breathing related behaviors such as coughing. These models have commonly been evaluated in open loop conditions or with feedback of lung volume simply represented as a filtered version...

journal_title：Frontiers in physiology

authors： O'Connor R,Segers LS,Morris KF,Nuding SC,Pitts T,Bolser DC,Davenport PW,Lindsey BG

更新日期：2012-07-23 00:00:00

abstract：:In aged subjects, late-onset Alzheimer's disease (LOAD) starts in the lateral entorhinal allocortex where a failure of clearance mechanisms triggers an accumulation of neurotoxic amyloid-β42 oligomers (Aβ42-os). In neurons and astrocytes, Aβ42-os enhance the transcription of Aβ precursor protein (APP) and β-secretase/...

journal_title：Frontiers in physiology

authors： Chiarini A,Armato U,Liu D,Dal Prà I

更新日期：2016-04-26 00:00:00

abstract：:Ecdysteroids play an essential role in controlling insect development and reproduction. Their pathway is regulated by a group of enzymes called Halloween gene proteins. The relationship between the Halloween genes and ecdysteroid synthesis has yet to be clearly understood in diamondback moth, Plutella xylostella (L.),...

journal_title：Frontiers in physiology

authors： Peng L,Wang L,Zou MM,Vasseur L,Chu LN,Qin YD,Zhai YL,You MS

更新日期：2019-08-28 00:00:00

abstract：:The Proline, Glutamate, Valine and Lysine-rich (PEVK) region of titin constitutes an entropic spring that provides passive tension to striated muscle. To study the functional and structural repercussions of a small reduction in the size of the PEVK region, we investigated skeletal muscles of a mouse with the constitut...

journal_title：Frontiers in physiology

authors： van der Pijl RJ,Hudson B,Granzier-Nakajima T,Li F,Knottnerus AM,Smith J,Chung CS,Gotthardt M,Granzier HL,Ottenheijm CAC

更新日期：2020-05-29 00:00:00

abstract：:Voltage-gated potassium (Kv) channels shape the action potentials of excitable cells and regulate membrane potential and ion homeostasis in excitable and non-excitable cells. With 40 known members in the human genome and a variety of homomeric and heteromeric pore-forming α subunit interactions, post-translational mod...

journal_title：Frontiers in physiology

authors： Kanda VA,Abbott GW

更新日期：2012-06-28 00:00:00

abstract：:The ketogenic diet (KD) has been utilized as a dietary therapeutic for nearly a century. One experimental model particularly responsive to the KD is the BTBRT+tf/j (BTBR) mouse, which displays phenotypic characteristics of autism spectrum disorder (ASD) and insulin resistance. Recently, the study of impaired mitochond...

journal_title：Frontiers in physiology

authors： Newell C,Shutt TE,Ahn Y,Hittel DS,Khan A,Rho JM,Shearer J

更新日期：2016-12-27 00:00:00

abstract：UNLABELLED:Limitations of current methods: Normalization of resting energy expenditure (REE) for body composition using the 2-compartment model fat mass (FM), and fat-free mass (FFM) has inherent limitations for the interpretation of REE and may lead to erroneous conclusions when comparing people with a wide range of a...

journal_title：Frontiers in physiology

authors： Bosy-Westphal A,Braun W,Schautz B,Müller MJ

更新日期：2013-03-25 00:00:00

abstract：:Pesticide resistance is a serious problem that poses a major challenge to pest control. One of the most potent resistance mechanisms is the overexpression of genes coding for detoxification enzymes. The expression of detoxification genes is regulated by a series of transcription factors. Previous studies have revealed...

journal_title：Frontiers in physiology

authors： Tang GH,Xiong Y,Liu Y,Song ZH,Yang Y,Shen GM,Wang JJ,Jiang HB

更新日期：2019-08-20 00:00:00

abstract：:Inflammation-induced impaired function of vascular endothelium may cause leakage of plasma proteins that can lead to edema. Proteins may leave the vascular lumen through two main paracellular and transcellular pathways. As the first involves endothelial cell (EC) junction proteins and the second caveolae formation, th...

journal_title：Frontiers in physiology

authors： Muradashvili N,Tyagi R,Lominadze D

更新日期：2012-05-31 00:00:00

abstract：:Excessive alcohol consumption is associated with hepatic steatosis and dysregulation of the gut microbiota in patients with alcohol use disorder (AUD). However, how gut microbiota responds when patients stop drinking has not been well studied. In this study, we use shotgun metagenomic sequencing to elucidate the alter...

journal_title：Frontiers in physiology

authors： Gao B,Emami A,Zhou R,Lang S,Duan Y,Wang Y,Jiang L,Loomba R,Brenner DA,Stärkel P,Schnabl B

更新日期：2020-04-24 00:00:00

abstract：:High-intensity interval training (HIT) is an effective approach for improving a range of physiological markers associated with physical fitness. A considerable body of work has demonstrated substantial improvements in cardiorespiratory fitness following short-term training programmes, while emerging evidence suggests ...

journal_title：Frontiers in physiology

authors： Hurst C,Scott JPR,Weston KL,Weston M

更新日期：2019-05-22 00:00:00

abstract：:Long-duration spaceflight has been shown to negatively affect the lumbopelvic muscles of crewmembers. Through analysis of computed tomography scans of crewmembers on 4- to 6-month missions equipped with the interim resistive exercise device, the structural deterioration of the psoas, quadratus lumborum, and paraspinal...

journal_title：Frontiers in physiology

authors： McNamara KP,Greene KA,Moore AM,Lenchik L,Weaver AA

更新日期：2019-05-21 00:00:00

abstract：:The Paramisgurnus dabryanus was exposed to air to assess the changes in plasma, liver and muscle free amino acid (FAA) contents. The FAA concentrations in plasma, liver and muscle of P. dabryanus were significantly affected by aerial exposure (P < 0.05). After 12 h of aerial exposure, the plasma glutamate contents inc...

journal_title：Frontiers in physiology

authors： Zhang YL,Wang GY,Zhang ZH,Xie YY,Jin H,Dong ZR

更新日期：2019-01-29 00:00:00

abstract：:In insects, locomotion is the result of rhythm generating thoracic circuits and their modulation by sensory reflexes and by inputs from the two head ganglia, the cerebral and the gnathal ganglia (GNG), which act as higher order neuronal centers playing different functions in the initiation, goal-direction, and mainten...

journal_title：Frontiers in physiology

authors： Emanuel S,Kaiser M,Pflueger HJ,Libersat F

更新日期：2020-02-21 00:00:00

abstract：:Sulfur is both crucial to life and a potential threat to health. While colonic sulfur metabolism mediated by eukaryotic cells is relatively well studied, much less is known about sulfur metabolism within gastrointestinal microbes. Sulfated compounds in the colon are either of inorganic (e.g., sulfates, sulfites) or or...

journal_title：Frontiers in physiology

authors： Carbonero F,Benefiel AC,Alizadeh-Ghamsari AH,Gaskins HR

更新日期：2012-11-28 00:00:00

abstract：:Heart Failure (HF) is associated with significantly high morbidity and mortality. We performed a meta-analysis and updated new evidences from randomized controlled trials (RCTs) to determine the effects of Tai Chi (TC) in patients with HF. Electronic literature search of Medline, PubMed, EMBASE, the Cochrane Library, ...

journal_title：Frontiers in physiology

authors： Ren X,Li Y,Yang X,Li J,Li H,Yuan Z,Sun Y,Shang H,Xing Y,Gao Y

更新日期：2017-12-07 00:00:00

abstract：:Human diseases have been investigated in the context of single genes as well as complex networks of genes. Though single gene approaches have been extremely successful in the past, most human diseases are complex and better characterized by multiple interacting genes commonly known as networks or pathways. With the ad...

journal_title：Frontiers in physiology

authors： Sahoo D

更新日期：2012-07-23 00:00:00

abstract：:The bacterium Rickettsia rickettsii is the etiological agent of Brazilian spotted fever (BSF), which is transmitted in Brazil mainly by the tick Amblyomma sculptum. Herein, larvae and nymphs of six populations of A. sculptum were exposed to R. rickettsii by feeding on needle-inoculated guinea pigs, and thereafter rear...

journal_title：Frontiers in physiology

authors： Gerardi M,Ramírez-Hernández A,Binder LC,Krawczak FS,Gregori F,Labruna MB

更新日期：2019-05-28 00:00:00

abstract：:Tyrophagus putrescentiae (Schrank, 1781) is an emerging source of allergens in stored products and homes. Feces proteases are the major allergens of astigmatid mites (Acari: Acaridida). In addition, the mites are carriers of microorganisms and microbial adjuvant compounds that stimulate innate signaling pathways. We s...

journal_title：Frontiers in physiology

authors： Erban T,Rybanska D,Harant K,Hortova B,Hubert J

更新日期：2016-02-24 00:00:00

abstract：:People over 65 years of age constitute over 80% of patients with heart failure (HF) and the incidence of HF is 10 per 1,000 in people aged above 65 years. Approximately 25% of older patients with HF exhibit evidence of frailty. Frail patients with cardiovascular disease (CVD) have a worse prognosis than non-frail pati...

journal_title：Frontiers in physiology

authors： Uchmanowicz I,Nessler J,Gobbens R,Gackowski A,Kurpas D,Straburzynska-Migaj E,Kałuzna-Oleksy M,Jankowska EA

更新日期：2019-07-03 00:00:00

abstract：BACKGROUND:The potential for cross acclimation between environmental stressors is not well understood. Thus, the aim of this investigation was to determine the effect of fixed-workload heat or hypoxic acclimation on cellular, physiological, and performance responses during post acclimation hypoxic exercise in humans. ...

journal_title：Frontiers in physiology

authors： Lee BJ,Miller A,James RS,Thake CD

更新日期：2016-03-08 00:00:00

abstract：:Heat acclimation by post-exercise hot water immersion (HWI) on six consecutive days reduces thermal strain and improves exercise performance during heat stress. However, the retention of adaptations by this method remains unknown. Typically, adaptations to short-term, exercise-heat-acclimation (<7 heat exposures) deca...

journal_title：Frontiers in physiology

authors： Zurawlew MJ,Mee JA,Walsh NP

更新日期：2019-08-28 00:00:00

abstract：:Purpose: Few large-scale population-based studies have adequately examined the relationships between steroid hormones, health status and physical fitness. The purpose of the study was to describe the relationship of serum basal endogenous steroid hormones (testosterone, TES; empirical free testosterone, EFT; cortisol,...

journal_title：Frontiers in physiology

authors： Gagnon SS,Nindl BC,Vaara JP,Santtila M,Häkkinen K,Kyröläinen H

更新日期：2018-07-27 00:00:00

abstract：Background:There is an increasing interest in the use of eccentric muscle exercise to improve physical condition, especially with regards to its health-related benefits. However, it is known that unaccustomed eccentric exercise causes muscle damage and delayed pain, commonly defined as "delayed onset muscle soreness" (...

journal_title：Frontiers in physiology

authors： Dominguez-Balmaseda D,Diez-Vega I,Larrosa M,San Juan AF,Issaly N,Moreno-Pérez D,Burgos S,Sillero-Quintana M,Gonzalez C,Bas A,Roller M,Pérez-Ruiz M

更新日期：2020-07-21 00:00:00