Abstract:
:Sickle cell anemia (SCA) is the most prevalent genetic disease worldwide. Recurrent vaso-occlusive infarcts predispose SCA patients to infections, which are the primary causes of morbidly and mortality. This study aimed to evaluate the relationship between SCA and endodontic diseases. Personal information, medical data (hematological indices, virologic testing, blood transfusions, medications received, splenectomy) and information on the need for endodontic treatment were obtained from SCA patients who were registered and followed up by the Fundação Hemominas, Minas Gerais, Brazil.These data were compared with the need for root canal treatment in SCA patients. One hundred eight patients comprised the studied population, and the rate of the need for endodontic therapy was 10.2%. Among the medical data, a significant difference was observed for eosinophil (p = 0.045) counts and atypical lymphocyte counts (p = 0.036) when the groups (with and without the need for endodontic treatment) were compared. Statistical relevance was observed when comparing the patients with and without the need for root canal therapy concerned eosinophil counts and atypical lymphocyte counts. The differences in statistical medical data, observed between the groups suggest that both parameters are naturally connected to the stimulation of the immune system that can occur in the presence of root canal infections and that can be harmful to SCA individuals.
journal_name
Braz Oral Resjournal_title
Brazilian oral researchauthors
Ferreira SB,Tavares WL,Rosa MA,Brito LC,Vieira LQ,Martelli H Júnior,Ribeiro AP Sobrinhodoi
10.1590/1807-3107BOR-2016.vol30.0060subject
Has Abstractpub_date
2016-05-20 00:00:00issue
1eissn
1806-8324issn
1807-3107pii
S1806-83242016000100255journal_volume
30pub_type
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