Etiologic role of root canal infection in apical periodontitis and its relationship with clinical symptomatology.

Abstract:

:Evidence shows the polymicrobial etiology of endodontic infections, in which bacteria and their products are the main agents for the development, progression, and dissemination of apical periodontitis. Microbial factors in necrotic root canals (e.g., endotoxin) may spread into apical tissue, evoking and supporting a chronic inflammatory load. Thus, apical periodontitis is the result of the complex interplay between microbial factors and host defense against invasion of periradicular tissues. This review of the literature aims to discuss the complex network between endodontic infectious content and host immune response in apical periodontitis. A better understanding of the relationship of microbial factors with clinical symptomatology is important to establish appropriate therapeutic procedures for a more predictable outcome of endodontic treatment.

journal_name

Braz Oral Res

journal_title

Brazilian oral research

authors

Gomes BPFA,Herrera DR

doi

10.1590/1807-3107bor-2018.vol32.0069

subject

Has Abstract

pub_date

2018-10-18 00:00:00

pages

e69

issue

suppl 1

eissn

1806-8324

issn

1807-3107

pii

S1806-83242018000500604

journal_volume

32

pub_type

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