Abstract:
:Evidence shows the polymicrobial etiology of endodontic infections, in which bacteria and their products are the main agents for the development, progression, and dissemination of apical periodontitis. Microbial factors in necrotic root canals (e.g., endotoxin) may spread into apical tissue, evoking and supporting a chronic inflammatory load. Thus, apical periodontitis is the result of the complex interplay between microbial factors and host defense against invasion of periradicular tissues. This review of the literature aims to discuss the complex network between endodontic infectious content and host immune response in apical periodontitis. A better understanding of the relationship of microbial factors with clinical symptomatology is important to establish appropriate therapeutic procedures for a more predictable outcome of endodontic treatment.
journal_name
Braz Oral Resjournal_title
Brazilian oral researchauthors
Gomes BPFA,Herrera DRdoi
10.1590/1807-3107bor-2018.vol32.0069subject
Has Abstractpub_date
2018-10-18 00:00:00pages
e69issue
suppl 1eissn
1806-8324issn
1807-3107pii
S1806-83242018000500604journal_volume
32pub_type
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