当前位置： SCI文献检索 > Journal of Neuroinflammation期刊下所有文献 > Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke.

Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke.

Abstract：

BACKGROUND:Oxidative stress plays an important and causal role in the mechanisms by which ischemia/reperfusion (I/R) injury increases brain damage after stroke. Accordingly, reducing oxidative stress has been proposed as a therapeutic strategy for limiting damage in the brain after stroke. Myeloperoxidase (MPO) is a highly potent oxidative enzyme that is capable of inducing both oxidative and nitrosative stress in vivo. METHODS:To determine if and the extent to which MPO-generated oxidants contribute to brain I/R injury, we treated mice subjected to middle cerebral artery occlusion (MCAO) with N-acetyl lysyltyrosylcysteine amide (KYC), a novel, specific and non-toxic inhibitor of MPO. Behavioral testing, ischemic damage, blood-brain-barrier disruption, apoptosis, neutrophils infiltration, microglia/macrophage activation, and MPO oxidation were analyzed within a 7-day period after MCAO. RESULTS:Our studies show that KYC treatment significantly reduces neurological severity scores, infarct size, IgG extravasation, neutrophil infiltration, loss of neurons, apoptosis, and microglia/macrophage activation in the brains of MCAO mice. Immunofluorescence studies show that KYC treatment reduces the formation of chlorotyrosine (ClTyr), a fingerprint biomarker of MPO oxidation, nitrotyrosine (NO2Tyr), and 4-hydroxynonenal (4HNE) in MCAO mice. All oxidative products colocalized with MPO in the infarcted brains, suggesting that MPO-generated oxidants are involved in forming the oxidative products. CONCLUSIONS:MPO-generated oxidants play detrimental roles in causing brain damage after stroke which is effectively reduced by KYC.

journal_name

J Neuroinflammation

journal_title

Journal of neuroinflammation

authors

Yu G,Liang Y,Huang Z,Jones DW,Pritchard KA Jr,Zhang H

doi

10.1186/s12974-016-0583-x

subject

Has Abstract

pub_date

2016-05-24 00:00:00

pages

119

issue

1

issn

1742-2094

pii

10.1186/s12974-016-0583-x

journal_volume

13

pub_type

杂志文章

相关文献

Journal of Neuroinflammation文献大全
  • Infiltrating T lymphocytes reduce myeloid phagocytosis activity in synucleinopathy model.

    abstract：BACKGROUND:Synucleinopathies comprise a group of neurodegenerative diseases associated with abnormal accumulation of α-synuclein. One of the key factors that contribute to the progression of synucleinopathies is neuroinflammation. However, the role of lymphocytes in synucleinopathies like Parkinson's disease (PD) remai...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-016-0632-5

    authors： Sommer A,Fadler T,Dorfmeister E,Hoffmann AC,Xiang W,Winner B,Prots I

    更新日期：2016-06-30 00:00:00

  • Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder.

    abstract：OBJECTIVE:Converging lines of evidence point to the existence of immune dysfunction in autism spectrum disorder (ASD), which could directly affect several key neurodevelopmental processes. Previous studies have shown higher cytokine levels in patients with autism compared with matched controls or subjects with other de...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-10-38

    authors： Napolioni V,Ober-Reynolds B,Szelinger S,Corneveaux JJ,Pawlowski T,Ober-Reynolds S,Kirwan J,Persico AM,Melmed RD,Craig DW,Smith CJ,Huentelman MJ

    更新日期：2013-03-14 00:00:00

  • Antibodies to myelin oligodendrocyte glycoprotein in HIV-1 associated neurocognitive disorder: a cross-sectional cohort study.

    abstract：BACKGROUND:Neuroinflammation and demyelination have been suggested as mechanisms causing HIV-1 associated neurocognitive disorder (HAND). This cross-sectional cohort study explores the potential role of antibodies to myelin oligodendrocyte glycoprotein (MOG), a putative autoantigen in multiple sclerosis, in the pathoge...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-7-79

    authors： Lackner P,Kuenz B,Reindl M,Morandell M,Berger T,Schmutzhard E,Eggers C

    更新日期：2010-11-17 00:00:00

  • Complement is activated in progressive multiple sclerosis cortical grey matter lesions.

    abstract：BACKGROUND:The symptoms of multiple sclerosis (MS) are caused by damage to myelin and nerve cells in the brain and spinal cord. Inflammation is tightly linked with neurodegeneration, and it is the accumulation of neurodegeneration that underlies increasing neurological disability in progressive MS. Determining patholog...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-016-0611-x

    authors： Watkins LM,Neal JW,Loveless S,Michailidou I,Ramaglia V,Rees MI,Reynolds R,Robertson NP,Morgan BP,Howell OW

    更新日期：2016-06-22 00:00:00

  • Neuronal apoptosis by HIV-1 Vpr: contribution of proinflammatory molecular networks from infected target cells.

    abstract：BACKGROUND:Human immunodeficiency virus type 1 (HIV-1) induces neuronal dysfunction through host cellular factors and viral proteins including viral protein R (Vpr) released from infected macrophages/microglia. Vpr is important for infection of terminally differentiated cells such as macrophages. The objective of this ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-9-138

    authors： Guha D,Nagilla P,Redinger C,Srinivasan A,Schatten GP,Ayyavoo V

    更新日期：2012-06-22 00:00:00

  • Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice.

    abstract：BACKGROUND:The FDA-approved small-molecule drug ibrutinib is an effective targeted therapy for patients with chronic lymphocytic leukemia (CLL). Ibrutinib inhibits Bruton's tyrosine kinase (BTK), a kinase involved in B cell receptor signaling. However, the potential regulation of neuroinflammatory responses in the brai...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-018-1308-0

    authors： Nam HY,Nam JH,Yoon G,Lee JY,Nam Y,Kang HJ,Cho HJ,Kim J,Hoe HS

    更新日期：2018-09-19 00:00:00

  • Melittin restores proteasome function in an animal model of ALS.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a paralyzing disorder characterized by the progressive degeneration and death of motor neurons and occurs both as a sporadic and familial disease. Mutant SOD1 (mtSOD1) in motor neurons induces vulnerability to the disease through protein misfolding, mitochondrial dysfunction, oxi...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-8-69

    authors： Yang EJ,Kim SH,Yang SC,Lee SM,Choi SM

    更新日期：2011-06-20 00:00:00

  • CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke.

    abstract：BACKGROUND:Chemokine (C-X3-C motif) ligand 1 (CX3CL1)/ CX3C chemokine receptor 1 (CX3CR1) signaling is important in modulating the communication between neurons and resident microglia/migrated macrophages in the central nervous system (CNS). Although CX3CR1 deficiency is associated with an improved outcome following is...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-11-26

    authors： Tang Z,Gan Y,Liu Q,Yin JX,Liu Q,Shi J,Shi FD

    更新日期：2014-02-03 00:00:00

  • Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.

    abstract：BACKGROUND:Endoplasmic reticulum (ER) stress is a hallmark of neurodegenerative diseases such as multiple sclerosis (MS). However, this physiological mechanism has multiple manifestations that range from impaired clearance of unfolded proteins to altered mitochondrial dynamics and apoptosis. While connections between t...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-016-0788-z

    authors： Haile Y,Deng X,Ortiz-Sandoval C,Tahbaz N,Janowicz A,Lu JQ,Kerr BJ,Gutowski NJ,Holley JE,Eggleton P,Giuliani F,Simmen T

    更新日期：2017-01-23 00:00:00

  • Astroglial TLR9 antagonism promotes chemotaxis and alternative activation of macrophages via modulation of astrocyte-derived signals: implications for spinal cord injury.

    abstract：BACKGROUND:The recruitment of immune system cells into the central nervous system (CNS) has a profound effect on the outcomes of injury and disease. Glia-derived chemoattractants, including chemokines, play a pivotal role in this process. In addition, cytokines and chemokines influence the phenotype of infiltrating imm...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-020-01748-x

    authors： Li L,Ni L,Heary RF,Elkabes S

    更新日期：2020-02-25 00:00:00

  • Exosomes derived from atorvastatin-modified bone marrow dendritic cells ameliorate experimental autoimmune myasthenia gravis by up-regulated levels of IDO/Treg and partly dependent on FasL/Fas pathway.

    abstract：BACKGROUND:Previously, we have demonstrated that spleen-derived dendritic cells (DCs) modified with atorvastatin suppressed immune responses of experimental autoimmune myasthenia gravis (EAMG). However, the effects of exosomes derived from atorvastatin-modified bone marrow DCs (BMDCs) (statin-Dex) on EAMG are still unk...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-016-0475-0

    authors： Li XL,Li H,Zhang M,Xu H,Yue LT,Zhang XX,Wang S,Wang CC,Li YB,Dou YC,Duan RS

    更新日期：2016-01-12 00:00:00

  • Lack of neuroinflammation in the HIV-1 transgenic rat: an [(18)F]-DPA714 PET imaging study.

    abstract：BACKGROUND:HIV-associated neuroinflammation is believed to be a major contributing factor in the development of HIV-associated neurocognitive disorders (HAND). In this study, we used micropositron emission tomography (PET) imaging to quantify neuroinflammation in HIV-1 transgenic rat (Tg), a small animal model of HIV, ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-015-0390-9

    authors： Lee DE,Yue X,Ibrahim WG,Lentz MR,Peterson KL,Jagoda EM,Kassiou M,Maric D,Reid WC,Hammoud DA

    更新日期：2015-09-17 00:00:00

  • Influence of type I IFN signaling on anti-MOG antibody-mediated demyelination.

    abstract：BACKGROUND:Antibodies with specificity for myelin oligodendrocyte glycoprotein (MOG) are implicated in multiple sclerosis and related diseases. The pathogenic importance of anti-MOG antibody in primary demyelinating pathology remains poorly characterized. OBJECTIVE:The objective of this study is to investigate whether...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-017-0899-1

    authors： Berg CT,Khorooshi R,Asgari N,Owens T

    更新日期：2017-06-24 00:00:00

  • Selective suppression of the JNK-MMP2/9 signal pathway by tetramethylpyrazine attenuates neuropathic pain in rats.

    abstract：BACKGROUND:Activated astrocytes release matrix metalloproteinase-2/9 (MMP-2/9) to induce central sensitization and maintain neuropathic pain. However, the mechanisms involved in the activation of MMP-2/9 on astrocytes during pain remain poorly understood. Meanwhile, there is a lack of effective treatment to inhibit the...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-017-0947-x

    authors： Jiang L,Pan CL,Wang CY,Liu BQ,Han Y,Hu L,Liu L,Yang Y,Qu JW,Liu WT

    更新日期：2017-08-31 00:00:00

  • LncGBP9/miR-34a axis drives macrophages toward a phenotype conducive for spinal cord injury repair via STAT1/STAT6 and SOCS3.

    abstract：BACKGROUND:Acute spinal cord injury (SCI) could cause mainly two types of pathological sequelae, the primary mechanical injury, and the secondary injury. The macrophage in SCI are skewed toward the M1 phenotype that might cause the failure to post-SCI repair. METHODS:SCI model was established in Balb/c mice, and the c...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-020-01805-5

    authors： Zhou J,Li Z,Wu T,Zhao Q,Zhao Q,Cao Y

    更新日期：2020-04-28 00:00:00

  • Evidence for the involvement of gamma delta T cells in the immune response in Rasmussen encephalitis.

    abstract：BACKGROUND:Rasmussen encephalitis (RE) is a rare neuroinflammatory disease characterized by intractable seizures and progressive atrophy on one side of the cerebrum. Perivascular cuffing and clusters of T cells in the affected cortical hemisphere are indicative of an active cellular immune response. METHODS:Peripheral...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-015-0352-2

    authors： Owens GC,Erickson KL,Malone CC,Pan C,Huynh MN,Chang JW,Chirwa T,Vinters HV,Mathern GW,Kruse CA

    更新日期：2015-07-19 00:00:00

  • Ultrastructural evidence of microglial heterogeneity in Alzheimer's disease amyloid pathology.

    abstract：BACKGROUND:Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by the deposition of extracellular fibrillar amyloid β (fΑβ) and the intracellular accumulation of neurofibrillary tangles. As AD progresses, Aβ drives a robust and prolonged inflammatory response via its recognition by micr...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-019-1473-9

    authors： El Hajj H,Savage JC,Bisht K,Parent M,Vallières L,Rivest S,Tremblay MÈ

    更新日期：2019-04-16 00:00:00

  • Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system.

    abstract：BACKGROUND:Increasing evidence supports a key role for inflammation in the neurodegenerative process of familial amyloidotic polyneuropathy (FAP). While there seems to be an overactivation of the neuronal interleukin-1 signaling pathway, the immune response is apparently compromised in FAP. Accordingly, little immune c...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-017-0891-9

    authors： Gonçalves NP,Moreira J,Martins D,Vieira P,Obici L,Merlini G,Saraiva M,Saraiva MJ

    更新日期：2017-06-06 00:00:00

  • Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis.

    abstract：BACKGROUND:Multiple Sclerosis (MS) is an acquired inflammatory demyelinating disorder of the central nervous system (CNS) and is the leading cause of nontraumatic disability among young adults. Activated microglial cells are important effectors of demyelination and neurodegeneration, by secreting cytokines and others n...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-8-149

    authors： Virgili N,Espinosa-Parrilla JF,Mancera P,Pastén-Zamorano A,Gimeno-Bayon J,Rodríguez MJ,Mahy N,Pugliese M

    更新日期：2011-11-02 00:00:00

  • Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles.

    abstract：BACKGROUND:The mechanism of leukocyte transendothelial migration (TEM) across the highly restrictive blood-brain barrier (BBB) remains enigmatic, with paracellular TEM thought to require leukocytes to somehow navigate the obstructive endothelial tight junctions (TJs). Transient interactions between TJ proteins on the r...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-016-0755-8

    authors： Paul D,Baena V,Ge S,Jiang X,Jellison ER,Kiprono T,Agalliu D,Pachter JS

    更新日期：2016-11-16 00:00:00

  • CCAAT/enhancer-binding protein δ (C/EBPδ) aggravates inflammation and bacterial dissemination during pneumococcal meningitis.

    abstract：BACKGROUND:The prognosis of bacterial meningitis largely depends on the severity of the inflammatory response. The transcription factor CAAT/enhancer-binding protein δ (C/EBPδ) plays a key role in the regulation of the inflammatory response during bacterial infections. Consequently, we assessed the role of C/EBPδ durin...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-015-0309-5

    authors： Valls Serón M,Duitman J,Geldhoff M,Engelen-Lee J,Havik SR,Brouwer MC,van de Beek D,Spek CA

    更新日期：2015-05-10 00:00:00

  • Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid.

    abstract：BACKGROUND:Immunoglobulin G (IgG) effector functions are regulated by the composition of glycans attached to a conserved N-glycosylation site in the Fc part. Intrathecal production of IgG, especially IgG1, is a hallmark of multiple sclerosis (MS), but nothing is known about IgG Fc glycosylation in MS and in cerebrospin...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-015-0450-1

    authors： Wuhrer M,Selman MH,McDonnell LA,Kümpfel T,Derfuss T,Khademi M,Olsson T,Hohlfeld R,Meinl E,Krumbholz M

    更新日期：2015-12-18 00:00:00

  • Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis.

    abstract：BACKGROUND:Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are substantial, and long-term sequelae develop in about half of survivors. Disease outcome has been related to the severity of the pro-inflammatory response in the subarachnoid space. The complement system, wh...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-016-0770-9

    authors： Kasanmoentalib ES,Valls Seron M,Ferwerda B,Tanck MW,Zwinderman AH,Baas F,van der Ende A,Schwaeble WJ,Brouwer MC,van de Beek D

    更新日期：2017-01-03 00:00:00

  • T-cell reconstitution during murine acquired immunodeficiency syndrome (MAIDS) produces neuroinflammation and mortality in animals harboring opportunistic viral brain infection.

    abstract：BACKGROUND:Highly active antiretroviral therapy (HAART) restores inflammatory immune responses in AIDS patients which may unmask previous subclinical infections or paradoxically exacerbate symptoms of opportunistic infections. In resource-poor settings, 25% of patients receiving HAART may develop CNS-related immune rec...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-10-98

    authors： Mutnal MB,Schachtele SJ,Hu S,Lokensgard JR

    更新日期：2013-07-31 00:00:00

  • Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation.

    abstract：BACKGROUND:Mice with pilocarpine-induced temporal lobe epilepsy (TLE) are characterized by intense hippocampal neuroinflammation, a prominent pathological hallmark of TLE that is known to contribute to neuronal hyperexcitability. Recent studies indicate that Adam10, a member of a disintegrin and metalloproteinase domai...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-018-1260-z

    authors： Zhu X,Li X,Zhu M,Xu K,Yang L,Han B,Huang R,Zhang A,Yao H

    更新日期：2018-08-04 00:00:00

  • Molecular and cellular neuroinflammatory status of mouse brain after systemic lipopolysaccharide challenge: importance of CCR2/CCL2 signaling.

    abstract：BACKGROUND:Genetic and environmental factors are critical elements influencing the etiology of major depression. It is now accepted that neuroinflammatory processes play a major role in neuropsychological disorders. Neuroinflammation results from the dysregulation of the synthesis and/or release of pro- and anti-inflam...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-11-132

    authors： Cazareth J,Guyon A,Heurteaux C,Chabry J,Petit-Paitel A

    更新日期：2014-07-28 00:00:00

  • Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt.

    abstract：BACKGROUND:Previous studies have suggested that peroxisome proliferator activated receptor-gamma (PPAR-gamma)-mediated neuroprotection involves inhibition of microglial activation and decreased expression and activity of inducible nitric oxide synthase (iNOS); however, the underlying molecular mechanisms have not yet b...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-5-4

    authors： Xing B,Xin T,Hunter RL,Bing G

    更新日期：2008-01-18 00:00:00

  • Strain-dependent variation in the early transcriptional response to CNS injury using a cortical explant system.

    abstract：BACKGROUND:While it is clear that inbred strains of mice have variations in immunological responsiveness, the influence of genetic background following tissue damage in the central nervous system is not fully understood. A cortical explant system was employed as a model for injury to determine whether the immediate tra...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-8-122

    authors： Graber DJ,Harris BT,Hickey WF

    更新日期：2011-09-26 00:00:00

  • Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance.

    abstract：BACKGROUND:Abundant reports indicated that depression was often comorbid with type 2 diabetes and even metabolic syndrome. Considering they might share common biological origins, it was tentatively attributed to the chronic cytokine-mediated inflammatory response which was induced by dysregulation of HPA axis and overa...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-017-0985-4

    authors： Su WJ,Peng W,Gong H,Liu YZ,Zhang Y,Lian YJ,Cao ZY,Wu R,Liu LL,Wang B,Wang YX,Jiang CL

    更新日期：2017-10-30 00:00:00

  • Alterations of peripheral nerve excitability in an experimental autoimmune encephalomyelitis mouse model for multiple sclerosis.

    abstract：BACKGROUND:Experimental autoimmune encephalomyelitis (EAE) is the most commonly used and clinically relevant murine model for human multiple sclerosis (MS), a demyelinating autoimmune disease characterized by mononuclear cell infiltration into the central nervous system (CNS). The aim of the present study was to apprai...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-020-01936-9

    authors： Teixeira NB,Picolo G,Giardini AC,Boumezbeur F,Pottier G,Kuhnast B,Servent D,Benoit E

    更新日期：2020-09-07 00:00:00