Mediastinal small cell carcinoma with liver and bone marrow metastasis, mimicking lymphoma.

Abstract:

:Primary mediastinal neuroendocrine tumors are a rare malignancy that accounts for < 10% of all mediastinal tumors. The case presented here involves a 52-year-old man who had been suffering for 3 mo from chronic cough, anorexia and substantial weight loss, as well as 2 wk of jaundice prior to his admission. A computed tomography scan showed a 4.3 cm × 6.6 cm mediastinal mass with multiple liver nodules scattered along both hepatic lobes. Endoscopic ultrasound showed a large heterogeneous hypoechoic mass at the mediastinum with multiple target-like nodules in the liver. Fine-needle aspiration specimens revealed numerous, small, round cells with hyperchromatic nuclei, scarce cytoplasm, and frequent mitotic features. Immunohistochemical study revealed positive results for AE1/AE3, CD56 and chromogranin A, with negative findings for synaptophysin, CK20, vimentin, CK8/18 and CD45. The patient was subsequently diagnosed with a poorly differentiated neuroendocrine carcinoma, small cell type. A bone marrow biopsy also revealed extensive involvement by the carcinoma.

journal_name

World J Clin Cases

authors

Nawarawong N,Pongpruttipan T,Aswakul P,Prachayakul V

doi

10.12998/wjcc.v3.i10.915

subject

Has Abstract

pub_date

2015-10-16 00:00:00

pages

915-9

issue

10

issn

2307-8960

journal_volume

3

pub_type

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