Spreading Effect of tDCS in Individuals with Attention-Deficit/Hyperactivity Disorder as Shown by Functional Cortical Networks: A Randomized, Double-Blind, Sham-Controlled Trial.

Abstract:

BACKGROUND:Transcranial direct current stimulation (tDCS) is known to modulate spontaneous neural network excitability. The cognitive improvement observed in previous trials raises the potential of this technique as a possible therapeutic tool for use in attention-deficit/hyperactivity disorder (ADHD) population. However, to explore the potential of this technique as a treatment approach, the functional parameters of brain connectivity and the extent of its effects need to be more fully investigated. OBJECTIVE:The aim of this study was to investigate a functional cortical network (FCN) model based on electroencephalographic activity for studying the dynamic patterns of brain connectivity modulated by tDCS and the distribution of its effects in individuals with ADHD. METHODS:Sixty ADHD patients participated in a parallel, randomized, double-blind, sham-controlled trial. Individuals underwent a single session of sham or anodal tDCS at 1 mA of current intensity over the left dorsolateral prefrontal cortex for 20 min. The acute effects of stimulation on brain connectivity were assessed using the FCN model based on electroencephalography activity. RESULTS:Comparing the weighted node degree within groups prior to and following the intervention, a statistically significant difference was found in the electrodes located on the target and correlated areas in the active group (p < 0.05), while no statistically significant results were found in the sham group (p ≥ 0.05; paired-sample Wilcoxon signed-rank test). CONCLUSION:Anodal tDCS increased functional brain connectivity in individuals with ADHD compared to data recorded in the baseline resting state. In addition, although some studies have suggested that the effects of tDCS are selective, the present findings show that its modulatory activity spreads. Further studies need to be performed to investigate the dynamic patterns and physiological mechanisms underlying the modulatory effects of tDCS. TRIAL REGISTRATION:ClinicalTrials.gov NCT01968512.

journal_name

Front Psychiatry

journal_title

Frontiers in psychiatry

authors

Cosmo C,Ferreira C,Miranda JG,do Rosário RS,Baptista AF,Montoya P,de Sena EP

doi

10.3389/fpsyt.2015.00111

subject

Has Abstract

pub_date

2015-08-04 00:00:00

pages

111

issn

1664-0640

journal_volume

6

pub_type

杂志文章
  • Very-Brief, Web-Based Interventions for Reducing Alcohol Use and Related Problems among College Students: A Review.

    abstract::Very-brief, web-based alcohol interventions have great potential due to their convenience, ease of dissemination, and college students' stated preference for this intervention modality. To address the efficacy of these interventions, we conducted a review of the literature to identify randomized controlled trials (RCT...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2015.00129

    authors: Leeman RF,Perez E,Nogueira C,DeMartini KS

    更新日期:2015-09-28 00:00:00

  • Neurological Soft Signs and Psychopathology in Chronic Schizophrenia: A Cross-Sectional Study in Three Age Groups.

    abstract::As established in a wealth of studies subtle motor and sensory neurological abnormalities or neurological soft signs (NSS) are frequently found in patients with schizophrenia at any stage of their illness. However, the potential impact of chronicity and age on NSS was scarcely investigated. Therefore, we assessed NSS ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00098

    authors: Herold CJ,Lässer MM,Seidl UW,Hirjak D,Thomann PA,Schröder J

    更新日期:2018-03-26 00:00:00

  • Vocational Profile and Correlates of Employment in People With Schizophrenia: The Role of Avolition.

    abstract:Objective:Employment was associated with recovery in individuals with schizophrenia. Our study aimed to delineate the vocational profile and investigate factors associated with likelihood of employment in individuals with schizophrenia. Materials and Methods:276 community dwelling outpatients with schizophrenia were r...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00856

    authors: Ang MS,Rekhi G,Lee J

    更新日期:2020-08-27 00:00:00

  • Freedom Restrictive Coercive Measures in Forensic Psychiatry.

    abstract::Background: In Germany, people suffering from severe mental illness who have committed serious offenses and have considerably reduced or suspended criminal responsibility can be detained and treated in forensic psychiatric hospitals. In the German federal state of Baden-Wuerttemberg, all psychiatric hospitals includin...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00146

    authors: Flammer E,Frank U,Steinert T

    更新日期:2020-03-05 00:00:00

  • Pathways from cannabis to psychosis: a review of the evidence.

    abstract::The nature of the relationship between cannabis use (CU) and psychosis is complex and remains unclear. Researchers and clinicians remain divided regarding key issues such as whether or not cannabis is an independent cause of psychosis and schizophrenia. This paper reviews the field in detail, examining questions of ca...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2013.00128

    authors: Burns JK

    更新日期:2013-10-14 00:00:00

  • Identifying phronotypes in psychiatry.

    abstract::Refinements in the methods of diagnosis for psychiatric disorders are critically needed. These new methods should be based on objectively measured brain characteristics that provide clinically useful information. Studying the brain with respect to psychiatric disorders, however, faces numerous challenges. Utilizing te...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2010.00141

    authors: Kozel FA

    更新日期:2010-10-20 00:00:00

  • Methylphenidate Dose-Dependently Affects Aggression and Improves Fear Extinction and Anxiety in BALB/cJ Mice.

    abstract::Overt aggression, increased anxiety, and dysfunctional fear processing are often observed in individuals with conduct disorder (CD) and attention-deficit hyperactivity disorder (ADHD). Methylphenidate (MPH), a psychostimulant increasing dopamine and noradrenaline tone, is effective in reducing aggression in both CD an...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00768

    authors: Jager A,Kanters D,Geers F,Buitelaar JK,Kozicz T,Glennon JC

    更新日期:2019-10-25 00:00:00

  • Comparison of Psychological Stress Levels and Associated Factors Among Healthcare Workers, Frontline Workers, and the General Public During the Novel Coronavirus Pandemic.

    abstract::Objective: We aimed to conduct a comparative analysis of the psychological stress experienced by healthcare workers, frontline workers, and the general public and to assess the factors associated with psychological stress in each of these groups. Methods: We conducted an online survey targeting healthcare workers, fro...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.583971

    authors: Luan R,Pu W,Dai L,Yang R,Wang P

    更新日期:2020-12-01 00:00:00

  • Brief interventions for hazardous and harmful alcohol consumption in accident and emergency departments.

    abstract::The prevalence of alcohol abuse among patients treated in accident and emergency departments (A&E) is considered as substantial. This paper is a narrative review of studies investigating the effectiveness of brief interventions (BI) for hazardous and harmful alcohol consumption in A&E. A&E departments in hospitals (an...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2014.00152

    authors: Wojnar M,Jakubczyk A

    更新日期:2014-11-03 00:00:00

  • Psychometric Properties of the Bermond-Vorst Alexithymia Questionnaire (BVAQ) in the General Population and a Clinical Population.

    abstract:Introduction:The Bermond-Vorst Alexithymia Questionnaire (BVAQ) has been validated in student samples and small clinical samples, but not in the general population; thus, representative general-population norms are lacking. Aim:We examined the factor structure of the BVAQ in Longitudinal Internet Studies for the Socia...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00111

    authors: de Vroege L,Emons WHM,Sijtsma K,van der Feltz-Cornelis CM

    更新日期:2018-04-23 00:00:00

  • A Randomized Controlled Trial on the Efficacy of a Psychosocial Behavioral Intervention to Improve the Lifestyle of Patients With Severe Mental Disorders: Study Protocol.

    abstract::Patients with severe mental disorders die on average 20 years prior to the general population. This mortality gap is mainly due to the higher prevalence of physical diseases and the adoption of unhealthy lifestyle behaviors.The LIFESTYLE trial aims to evaluate the efficacy of a new psychosocial group intervention (inc...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2018.00235

    authors: Sampogna G,Fiorillo A,Luciano M,Del Vecchio V,Steardo L Jr,Pocai B,Barone M,Amore M,Pacitti F,Dell'Osso L,Di Lorenzo G,Maj M,LIFESTYLE Working Group.

    更新日期:2018-06-07 00:00:00

  • Decision-Making Dysfunctions of Counterfactuals in Depression: Who Might I have Been?

    abstract::Cognitive neuroscience enables us now to decompose major depressive disorder into dysfunctional component processes and relate these processes to specific neural substrates. This approach can be used to illuminate the biological basis of altered psychological processes in depression, including abnormal decision-making...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2013.00143

    authors: Howlett JR,Paulus MP

    更新日期:2013-11-08 00:00:00

  • A Transnosographic Self-Assessment of Social Cognitive Impairments (ACSO): First Data.

    abstract::Social cognition refers to the mental operations underlying social interactions. Given the major role of social cognitive deficits in the disability associated with severe psychiatric disorders, they therefore constitute a crucial therapeutic target. However, no easily understandable and transnosographic self-assessme...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00847

    authors: Graux J,Thillay A,Morlec V,Sarron PY,Roux S,Gaudelus B,Prost Z,Brénugat-Herné L,Amado I,Morel-Kohlmeyer S,Houy-Durand E,Franck N,Carteau-Martin I,Danset-Alexandre C,Peyroux E

    更新日期:2019-11-21 00:00:00

  • Self-Regulation of Breathing as an Adjunctive Treatment of Insomnia.

    abstract::Sleep is a quiescent behavioral state during which complex homeostatic functions essential to health and well-being occur. Insomnia is a very common psychiatric disorder leading to a myriad of detrimental effects including loss of concentration, memory, and performance as well as disease. Current pharmaceutical treatm...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00780

    authors: Jerath R,Beveridge C,Barnes VA

    更新日期:2019-01-29 00:00:00

  • Preliminary Reliability and Validity of the DMRS-SR-30, a Novel Self-Report Measure Based on the Defense Mechanisms Rating Scales.

    abstract::Defense mechanisms are psychological factors that influence emotional distress and quality of life. There are a number of measures assessing the construct of defense mechanisms, but only few available instruments reflect the gold-standard theoretical hierarchical organization of defenses. We report on the development ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00870

    authors: Di Giuseppe M,Perry JC,Lucchesi M,Michelini M,Vitiello S,Piantanida A,Fabiani M,Maffei S,Conversano C

    更新日期:2020-08-26 00:00:00

  • Burnout Syndrome and Logotherapy: Logotherapy as Useful Conceptual Framework for Explanation and Prevention of Burnout.

    abstract::Burnout syndrome is a state of total exhaustion related to work conditions and stress from work. Recent findings suggest that logotherapy and the concepts of existential meaning and life fulfilment could provide a useful framework for explaining and potentially preventing burnout. This review article summarizes and re...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2019.00382

    authors: Riethof N,Bob P

    更新日期:2019-06-14 00:00:00

  • 25 Hz Magnetic Seizure Therapy Is Feasible but Not Optimal for Chinese Patients With Schizophrenia: A Case Series.

    abstract::Magnetic seizure therapy (MST) is a potential alternative to electroconvulsive therapy (ECT), but there is currently a lack of reports about MST in Chinese patients with schizophrenia. Our objective was to investigate the feasibility and acceptability of add-on MST in the treatment of patients with schizophrenia. Eigh...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2018.00224

    authors: Jiang J,Li Q,Sheng J,Yang F,Cao X,Zhang T,Jia Y,Wang J,Li C

    更新日期:2018-05-29 00:00:00

  • A Peptide Link Between Human Cytomegalovirus Infection, Neuronal Migration, and Psychosis.

    abstract::Alongside biological, psychological, and social risk factors, psychotic syndromes may be related to disturbances of neuronal migration. This highly complex process characterizes the developing brain of the fetus, the early postnatal brain, and the adult brain, as reflected by changes within the subventricular zone and...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00349

    authors: Lucchese G,Flöel A,Stahl B

    更新日期:2020-05-08 00:00:00

  • Using structural neuroimaging to make quantitative predictions of symptom progression in individuals at ultra-high risk for psychosis.

    abstract::Neuroimaging holds the promise that it may one day aid the clinical assessment of individual psychiatric patients. However, the vast majority of studies published so far have been based on average differences between groups, which do not permit accurate inferences at the level of the individual. We examined the potent...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2013.00187

    authors: Tognin S,Pettersson-Yeo W,Valli I,Hutton C,Woolley J,Allen P,McGuire P,Mechelli A

    更新日期:2014-01-29 00:00:00

  • Computer-Assisted Cognitive-Behavioral Therapy to Treat Adolescents With Depression in Primary Health Care Centers in Santiago, Chile: A Randomized Controlled Trial.

    abstract::Introduction: Evidence from developed countries shows the efficacy of computer-assisted cognitive-behavioral therapy (cCBT) in addressing adolescent depression in home and/or school settings. This paper presents the results of a randomized controlled trial (RCT) of a brief therapist-guided cCBT intervention for adoles...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00552

    authors: Martínez V,Rojas G,Martínez P,Gaete J,Zitko P,Vöhringer PA,Araya R

    更新日期:2019-07-30 00:00:00

  • Reliving, Replaying Lived Experiences Through Auditory Verbal Hallucinations: Implications on Theories and Management.

    abstract::Objective: This study aims to understand the impact of negative life experience (NLE) in auditory hallucinations (AHs) and explain the heterogeneity in phenomenology of auditory verbal hallucinations (AVHs). Method: In depth interviews were conducted with 21 individuals (7 males and 14 females) experiencing AHs and ac...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00528

    authors: Vallath S,Luhrmann T,Bunders J,Ravikant L,Gopikumar V

    更新日期:2018-10-30 00:00:00

  • Fluctuations in Affective States and Self-Efficacy to Resist Non-Suicidal Self-Injury as Real-Time Predictors of Non-Suicidal Self-Injurious Thoughts and Behaviors.

    abstract:Introduction:Although research over the past decade has resulted in significantly increased knowledge about distal risk factors for non-suicidal self-injury (NSSI), little is known about short-term (proximal) factors that predict NSSI thoughts and behaviors. Drawing on contemporaneous theories of NSSI, as well as the c...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00214

    authors: Kiekens G,Hasking P,Nock MK,Boyes M,Kirtley O,Bruffaerts R,Myin-Germeys I,Claes L

    更新日期:2020-03-20 00:00:00

  • Resilience as a Mediator Between Interpersonal Risk Factors and Hopelessness in Depression.

    abstract::Several studies investigated the role of resilience as a mediating factor for psychopathological phenotypes. The aim of the current study is to explore the putative role of resilience as a mediator between different vulnerability factors and depressive symptoms. One hundred and fifty patients with a major depressive d...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00010

    authors: Collazzoni A,Stratta P,Pacitti F,Rossi A,Santarelli V,Bustini M,Talevi D,Socci V,Rossi R

    更新日期:2020-02-28 00:00:00

  • Pleasure and addiction.

    abstract::What is the role and value of pleasure in addiction? Foddy and Savulescu (1) have claimed that substance use is just pleasure-oriented behavior. They describe addiction as "strong appetites toward pleasure" and argue that addicts suffer in significant part because of strong social and moral disapproval of lives domina...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2013.00117

    authors: Kennett J,Matthews S,Snoek A

    更新日期:2013-09-25 00:00:00

  • Novel Contribution of Secreted Amyloid-β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder.

    abstract::The most replicated neuroanatomical finding in autism is the tendency toward brain overgrowth, especially in younger children. Research shows that both gray and white matter are enlarged. Proposed mechanisms underlying brain enlargement include abnormal inflammatory and neurotrophic signals that lead to excessive, abe...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2019.00165

    authors: Sokol DK,Maloney B,Westmark CJ,Lahiri DK

    更新日期:2019-04-10 00:00:00

  • Diminished Health Returns of Educational Attainment Among Immigrant Adults in the United States.

    abstract::Objectives: Marginalization-related diminished returns (MDRs) refer to weaker health effects of educational attainment for socially marginalized groups compared to the socially privileged groups. Most of the existing literature on MDRs, however, has focused on marginalization due to race, ethnicity, and sexual orienta...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.535624

    authors: Assari S,Cobb S,Cuevas AG,Bazargan M

    更新日期:2020-11-27 00:00:00

  • Plasticity and Susceptibility of Brain Morphometry Alterations to Insufficient Sleep.

    abstract::Background: Insufficient sleep is common in daily life and can lead to cognitive impairment. Sleep disturbance also exists in neuropsychiatric diseases. However, whether and how acute and chronic sleep loss affect brain morphology remain largely unknown. Methods: We used voxel-based morphology method to study the brai...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00266

    authors: Dai XJ,Jiang J,Zhang Z,Nie X,Liu BX,Pei L,Gong H,Hu J,Lu G,Zhan Y

    更新日期:2018-06-27 00:00:00

  • Modeling Trait Anxiety: From Computational Processes to Personality.

    abstract::Computational methods are increasingly being applied to the study of psychiatric disorders. Often, this involves fitting models to the behavior of individuals with subclinical character traits that are known vulnerability factors for the development of psychiatric conditions. Anxiety disorders can be examined with ref...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2017.00001

    authors: Raymond JG,Steele JD,Seriès P

    更新日期:2017-01-23 00:00:00

  • Emotional vs. Neutral Face Exploration and Habituation: An Eye-Tracking Study of Preschoolers With Autism Spectrum Disorders.

    abstract::Diminished orienting to social stimuli, and particularly to faces, is a core feature of autism spectrum disorders (ASDs). Impaired face processing has been linked to atypical attention processes that trigger a cascade of pathological development contributing to impaired social communication. The aim of the present stu...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.568997

    authors: Bochet A,Franchini M,Kojovic N,Glaser B,Schaer M

    更新日期:2021-01-13 00:00:00

  • Are Individual Learning Experiences More Important Than Heritable Tendencies? A Pilot Twin Study on Placebo Analgesia.

    abstract::Objective: Predicting who will be a placebo responder is a prerequisite to maximize placebo effects in pain treatment and to minimize them in clinical trials. First evidence exists that genetics could affect placebo effects. However, a classical twin study to estimate the relative contribution of genetic influences co...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00679

    authors: Weimer K,Hahn E,Mönnikes N,Herr AK,Stengel A,Enck P

    更新日期:2019-09-18 00:00:00