The dynamics of the epileptic brain reveal long-memory processes.


:The pattern of epileptic seizures is often considered unpredictable and the interval between events without correlation. A number of studies have examined the possibility that seizure activity respects a power-law relationship, both in terms of event magnitude and inter-event intervals. Such relationships are found in a variety of natural and man-made systems, such as earthquakes or Internet traffic, and describe the relationship between the magnitude of an event and the number of events. We postulated that human inter-seizure intervals would follow a power-law relationship, and furthermore that evidence for the existence of a long-memory process could be established in this relationship. We performed a post hoc analysis, studying eight patients who had long-term (up to 2 years) ambulatory intracranial EEG data recorded as part of the assessment of a novel seizure prediction device. We demonstrated that a power-law relationship could be established in these patients (β = - 1.5). In five out of the six subjects whose data were sufficiently stationary for analysis, we found evidence of long memory between epileptic events. This memory spans time scales from 30 min to 40 days. The estimated Hurst exponents range from 0.51 to 0.77 ± 0.01. This finding may provide evidence of phase-transitions underlying the dynamics of epilepsy.


Front Neurol


Frontiers in neurology


Cook MJ,Varsavsky A,Himes D,Leyde K,Berkovic SF,O'Brien T,Mareels I




Has Abstract


2014-10-24 00:00:00








  • Sleep Duration and Stroke: A Mendelian Randomization Study.

    abstract::Study Objectives: To clarify the effects of sleep duration on stroke and stroke subtypes, we adopted a Mendelian randomization (MR) approach to evaluate their causal relationship. Methods: A genome-wide association study including 446,118 participants from UK biobank was used to identify instruments for short sleep, l...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Lu H,Wu PF,Li RZ,Zhang W,Huang GX

    更新日期:2020-10-07 00:00:00

  • Substance P Saliva Reduction Predicts Pharyngeal Dysphagia in Parkinson's Disease.

    abstract::Introduction: Although patients with Parkinson's disease (PD) often suffer from oropharyngeal dysphagia, knowledge about the underlying pathophysiological mechanisms is limited. Substance P (SP) is a localization-independent neurotransmitter of the entire nervous system. Reduced levels of SP were found in saliva of pa...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Schröder JB,Marian T,Claus I,Muhle P,Pawlowski M,Wiendl H,Suntrup-Krueger S,Meuth SG,Dziewas R,Ruck T,Warnecke T

    更新日期:2019-04-16 00:00:00

  • Functional Network-Based Statistics Reveal Abnormal Resting-State Functional Connectivity in Minimal Hepatic Encephalopathy.

    abstract::Purpose: Whole-brain functional network analysis is an emerging methodology for exploring the mechanisms underlying hepatic encephalopathy (HE). This study aimed to identify the brain subnetwork that is significantly altered within the functional connectome in minimal HE (MHE), the earliest stage of HE. Materials and ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Zhan C,Chen HJ,Gao YQ,Zou TX

    更新日期:2019-01-29 00:00:00

  • The vestibular implant: quo vadis?

    abstract:OBJECTIVE:To assess the progress of the development of the vestibular implant (VI) and its feasibility short-term. DATA SOURCES:A search was performed in Pubmed, Medline, and Embase. Key words used were "vestibular prosth*" and "VI." The only search limit was language: English or Dutch. Additional sources were medical...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: van de Berg R,Guinand N,Stokroos RJ,Guyot JP,Kingma H

    更新日期:2011-08-11 00:00:00

  • Clinical Features and Correlates of Excessive Daytime Sleepiness in Parkinson's Disease.

    abstract::Objective: To explore the clinical features and correlates of excessive daytime sleepiness (EDS) in a Chinese population of Parkinson's disease (PD) patients. Methods: Patients with clinically established or clinically probable PD were recruited. Clinical and demographic data were collected, and participants were eval...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Xiang YQ,Xu Q,Sun QY,Wang ZQ,Tian Y,Fang LJ,Yang Y,Tan JQ,Yan XX,Tang BS,Guo JF

    更新日期:2019-02-19 00:00:00

  • Peri-Hemorrhagic Edema and Secondary Hematoma Expansion after Intracerebral Hemorrhage: From Benchwork to Practical Aspects.

    abstract::Spontaneous intracerebral hemorrhage (SICH) is the most lethal type of stroke. Half of these deaths occur within the acute phase. Frequently observed deterioration during the acute phase is often due to rebleeding or peri-hematomal expansion. The exact pathogenesis that leads to rebleeding or peri-hemorrhagic edema re...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Babi MA,James ML

    更新日期:2017-01-19 00:00:00

  • Age-Related Influences of Prior Sleep on Brain Activation during Verbal Encoding.

    abstract::Disrupted sleep is more common in older adults (OLD) than younger adults (YOUNG), often co-morbid with other conditions. How these sleep disturbances affect cognitive performance is an area of active study. We examined whether brain activation during verbal encoding correlates with sleep quantity and quality the night...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Jonelis MB,Drummond SP,Salamat JS,McKenna BS,Ancoli-Israel S,Bondi MW

    更新日期:2012-04-03 00:00:00

  • The Dominant-Subthalamic Nucleus Phenomenon in Bilateral Deep Brain Stimulation for Parkinson's Disease: Evidence from a Gait Analysis Study.

    abstract:Background:It has been suggested that parkinsonian [Parkinson's disease (PD)] patients might have a "dominant" (DOM) subthalamic nucleus (STN), whose unilateral electrical stimulation [deep brain stimulation (DBS)] could lead to an improvement in PD symptoms similar to bilateral STN-DBS. Objectives:Since disability in...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Rizzone MG,Ferrarin M,Lanotte MM,Lopiano L,Carpinella I

    更新日期:2017-10-30 00:00:00

  • Validation of the Dutch Version of the Boston Carpal Tunnel Questionnaire.

    abstract::The Boston Carpal Tunnel Questionnaire (BCTQ) is a scale that has been developed specifically for carpal tunnel syndrome (CTS). It consists of the Functional Status Scale (FSS) and the Symptom Severity Scale (SSS). It is the most widely used patient reported outcome measure in CTS and has been validated in many langua...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: De Kleermaeker FGCM,Levels M,Verhagen WIM,Meulstee J

    更新日期:2019-11-07 00:00:00

  • Coding of Velocity Storage in the Vestibular Nuclei.

    abstract::Semicircular canal afferents sense angular acceleration and output angular velocity with a short time constant of ≈4.5 s. This output is prolonged by a central integrative network, velocity storage that lengthens the time constants of eye velocity. This mechanism utilizes canal, otolith, and visual (optokinetic) infor...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Yakushin SB,Raphan T,Cohen B

    更新日期:2017-08-16 00:00:00

  • Obstructive sleep apnea and non-alcoholic Fatty liver disease: is the liver another target?

    abstract::Obstructive sleep apnea (OSA) is recurrent obstruction of the upper airway during sleep leading to intermittent hypoxia (IH). OSA has been associated with all components of the metabolic syndrome as well as with non-alcoholic fatty liver disease (NAFLD). NAFLD is a common condition ranging in severity from uncomplicat...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Mirrakhimov AE,Polotsky VY

    更新日期:2012-10-17 00:00:00

  • CD8(+) T Cell-Mediated Neuronal Dysfunction and Degeneration in Limbic Encephalitis.

    abstract::Autoimmune inflammation of the limbic gray matter structures of the human brain has recently been identified as major cause of mesial temporal lobe epilepsy with interictal temporal epileptiform activity and slowing of the electroencephalogram, progressive memory disturbances, as well as a variety of other behavioral,...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Ehling P,Melzer N,Budde T,Meuth SG

    更新日期:2015-07-15 00:00:00

  • Post-cueing deficits with maintained cueing benefits in patients with Parkinson's disease dementia.

    abstract::In Parkinson's disease (PD), internal cueing mechanisms are impaired leading to symptoms like hypokinesia. However, external cues can improve movement execution by using cortical resources. These cortical processes can be affected by cognitive decline in dementia. It is still unclear how dementia in PD influences exte...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Gräber S,Liepelt-Scarfone I,Csoti I,Maetzler W,Sultan F,Berg D

    更新日期:2014-11-17 00:00:00

  • Assessing the Safety of Craniotomy for Resection of Primary Central Nervous System Lymphoma: A Nationwide Inpatient Sample Analysis.

    abstract:BACKGROUND:Unlike many other central nervous system (CNS) tumors, the surgical management of primary central nervous system lymphomas (PCNSL) is traditionally limited by diagnostic biopsy. Studies that predate the use of modern neurosurgical techniques have reported a prohibitive operative morbidity for this surgery. T...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Yun J,Yang J,Cloney M,Mehta A,Singh S,Iwamoto FM,Neugut AI,Sonabend AM

    更新日期:2017-09-12 00:00:00

  • Lateral Fluid Percussion Injury Impairs Hippocampal Synaptic Soluble N-Ethylmaleimide Sensitive Factor Attachment Protein Receptor Complex Formation.

    abstract::Traumatic brain injury (TBI) and the activation of secondary injury mechanisms have been linked to impaired cognitive function, which, as observed in TBI patients and animal models, can persist for months and years following the initial injury. Impairments in neurotransmission have been well documented in experimental...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Carlson SW,Henchir J,Dixon CE

    更新日期:2017-10-10 00:00:00

  • A Comparison of FES and SCS for Neuroplastic Recovery After SCI: Historical Perspectives and Future Directions.

    abstract::There is increasing evidence that neuroplastic changes can occur even years after spinal cord injury, leading to reduced disability and better health which should reduce the cost of healthcare. In motor-incomplete spinal cord injury, recovery of leg function may occur if repetitive training causes afferent input to th...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Duffell LD,Donaldson NN

    更新日期:2020-06-30 00:00:00

  • Acute Injection of Omega-3 Triglyceride Emulsion Provides Very Similar Protection as Hypothermia in a Neonatal Mouse Model of Hypoxic-Ischemic Brain Injury.

    abstract::Therapeutic hypothermia (HT) is a currently accepted treatment for neonatal asphyxia and is a promising strategy in adult stroke therapy. We previously reported that acute administration of docosahexaenoic acid (DHA) triglyceride emulsion (tri-DHA) protects against hypoxic-ischemic (HI) injury in neonatal mice. We que...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Manual Kollareth DJ,Zirpoli H,Ten VS,Deckelbaum RJ

    更新日期:2021-01-15 00:00:00

  • Extracranial Trigger Site Surgery for Migraine: A Systematic Review With Meta-Analysis on Elimination of Headache Symptoms.

    abstract::Introduction: The headache phase of migraine could in selected cases potentially be treated by surgical decompression of one or more "trigger sites," located at frontal, temporal, nasal, and occipital sites. This systematic review with subsequent meta-analysis aims at critically evaluating the currently available evid...

    journal_title:Frontiers in neurology



    authors: Vincent AJPE,van Hoogstraten WS,Maassen Van Den Brink A,van Rosmalen J,Bouwen BLJ

    更新日期:2019-02-14 00:00:00

  • Parkinson's Disease Dementia and Dementia with Lewy Bodies Have Similar Neuropsychological Profiles.

    abstract::Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are common causes of dementia worldwide. Although considered separate entities based on the relative temporal onset of motor symptoms vs. diagnosis of dementia, it is unknown if these diseases truly have distinct cognitive profiles. We hypothesized...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Aldridge GM,Birnschein A,Denburg NL,Narayanan NS

    更新日期:2018-03-12 00:00:00

  • The Broad Concept of "Spasticity-Plus Syndrome" in Multiple Sclerosis: A Possible New Concept in the Management of Multiple Sclerosis Symptoms.

    abstract::Multiple sclerosis (MS) pathology progressively affects multiple central nervous system (CNS) areas. Due to this fact, MS produces a wide array of symptoms. Symptomatic therapy of one MS symptom can cause or worsen other unwanted symptoms (anticholinergics used for bladder dysfunction produce impairment of cognition, ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Fernández Ó,Costa-Frossard L,Martínez-Ginés M,Montero P,Prieto JM,Ramió L

    更新日期:2020-03-17 00:00:00

  • Age- and Sex-Associated Impacts of Body Mass Index on Stroke Type Risk: A 27-Year Prospective Cohort Study in a Low-Income Population in China.

    abstract::The relationship between body mass index (BMI) and stroke type has remained controversial despite studies demonstrating that BMI is related to stroke risk, especially in specific groups. We assessed the age- and sex-associated impacts of BMI on stroke type in a low-income, poorly educated population in China. The asso...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Gu H,Shao S,Liu J,Fan Z,Chen Y,Ni J,Wang C,Tu J,Ning X,Lou Y,Li B,Wang J

    更新日期:2019-05-01 00:00:00

  • Conveniently-Grasped Field Assessment Stroke Triage (CG-FAST): A Modified Scale to Detect Large Vessel Occlusion Stroke.

    abstract::Background and Purpose: Patients with large vessel occlusion stroke (LVOS) need to be rapidly identified and transferred to comprehensive stroke centers (CSC). However, previous pre-hospital strategy remains challenging. We aimed to develop a modified scale to better predict LVOS. Methods: We retrospectively reviewed ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Gong X,Chen Z,Shi F,Zhang M,Xu C,Zhang R,Lou M

    更新日期:2019-04-17 00:00:00

  • Agreement Between High-Resolution Ultrasound and Electro-Physiological Examinations for Diagnosis of Carpal Tunnel Syndrome in the Indonesian Population.

    abstract::Carpal tunnel syndrome (CTS) is a disorder of the wrist due to narrowing of the carpal tunnel. It can be caused by trauma or tumors in the tunnel resulting in compression of the median nerve. This disorder is often diagnosed with early symptoms such as tingling, numbness, and weakness that subsequently lead to hand mu...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Emril DR,Zakaria I,Amrya M

    更新日期:2019-08-26 00:00:00

  • Quinidine Therapy for Lennox-Gastaut Syndrome With KCNT1 Mutation. A Case Report and Literature Review.

    abstract::Mutations in the Potassium channel subfamily T member 1 (KCNT1) gene have been reported in a range of epileptic encephalopathies. Here we report the case of a 12-year-old male suffering from multiple types of epileptic seizures and cognitive decline from the age of 10. The patient had four types of epileptic seizures,...

    journal_title:Frontiers in neurology



    authors: Jia Y,Lin Y,Li J,Li M,Zhang Y,Hou Y,Liu A,Zhang L,Li L,Xiang P,Ye J,Huang Z,Wang Y

    更新日期:2019-02-05 00:00:00

  • A Case of Acoustic Shock with Post-trauma Trigeminal-Autonomic Activation.

    abstract::This study reports the case of an acoustic shock injury (ASI), which did not result in a significant hearing loss, but was followed by manifold chronic symptoms both within (tinnitus, otalgia, tingling in the ear, tension in the ear, and red tympanum) and outside the ears (blocked nose, pain in the neck/temporal regio...

    journal_title:Frontiers in neurology



    authors: Londero A,Charpentier N,Ponsot D,Fournier P,Pezard L,Noreña AJ

    更新日期:2017-08-16 00:00:00

  • Shining a Light on Awareness: A Review of Functional Near-Infrared Spectroscopy for Prolonged Disorders of Consciousness.

    abstract::Qualitative clinical assessments of the recovery of awareness after severe brain injury require an assessor to differentiate purposeful behavior from spontaneous behavior. As many such behaviors are minimal and inconsistent, behavioral assessments are susceptible to diagnostic errors. Advanced neuroimaging tools can b...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Rupawala M,Dehghani H,Lucas SJE,Tino P,Cruse D

    更新日期:2018-05-22 00:00:00

  • Severe Blood-Brain Barrier Disruption in Cardioembolic Stroke.

    abstract:Background:Previous studies demonstrated that cardioembolism (CE) was prone to develop hemorrhagic transformation (HT), whereas hyper-permeability of blood-brain barrier (BBB) might be one reason for the development of HT. We, thus, aimed to investigate whether the BBB permeability (BBBP) was higher in CE stroke than o...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Liu C,Shi F,Chen Z,Yan S,Ding X,Lou M

    更新日期:2018-02-08 00:00:00

  • Rhythms of Core Clock Genes and Spontaneous Locomotor Activity in Post-Status Epilepticus Model of Mesial Temporal Lobe Epilepsy.

    abstract::The interaction of Mesial Temporal Lobe Epilepsy (mTLE) with the circadian system control is apparent from an oscillatory pattern of limbic seizures, daytime's effect on seizure onset and the efficacy of antiepileptic drugs. Moreover, seizures per se can interfere with the biological rhythm output, including circadian...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Matos HC,Koike BDV,Pereira WDS,de Andrade TG,Castro OW,Duzzioni M,Kodali M,Leite JP,Shetty AK,Gitaí DLG

    更新日期:2018-08-02 00:00:00

  • Impaired Self-Other Distinction and Subcortical Gray-Matter Alterations Characterize Socio-Cognitive Disturbances in Multiple Sclerosis.

    abstract::Introduction: Recent studies of patients with multiple sclerosis (MS) have revealed disturbances in distinct components of social cognition, such as impaired mentalizing and empathy. The present study investigated this socio-cognitive profile in MS patients in more detail, by examining their performance on tasks measu...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Czekóová K,Shaw DJ,Saxunová K,Dufek M,Mareček R,Vaníček J,Brázdil M

    更新日期:2019-05-21 00:00:00

  • Atherosclerosis Might Be Responsible for Branch Artery Disease: Evidence From White Matter Hyperintensity Burden in Acute Isolated Pontine Infarction.

    abstract::Objective: To investigate an MRI-based etiological classification for acute isolated pontine infarcts and to assess differences in vascular risk factors, clinical characteristics and WMH burden among the etiological subtypes. Methods: All participants from SMART cohort with DWI-proven acute isolated pontine infarcts (...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Zhou L,Yao M,Peng B,Zhu Y,Ni J,Cui L

    更新日期:2018-10-09 00:00:00