Multivitamin mineral supplementation in patients with chronic fatigue syndrome.

Abstract:

BACKGROUND:Chronic fatigue syndrome (CFS) is characterized by medically unexplained persistent or reoccurring fatigue lasting at least 6 months. CFS has a multifactorial pathogenesis in which oxidative stress (OS) plays a prominent role. Treatment is with a vitamin and mineral supplement, but this therapeutic option so far has not been properly researched. MATERIAL AND METHODS:This prospective study included 38 women of reproductive age consecutively diagnosed by CDC definition of CFS and treated with a multivitamin mineral supplement. Before and after the 2-month supplementation, SOD activity was determined and patients self-assessed their improvement in 2 questionnaires: the Fibro Fatigue Scale (FFS) and the Quality of Life Scale (SF36). Results There was a significant improvement in SOD activity levels; and significant decreases in fatigue (p=0.0009), sleep disorders (p=0.008), autonomic nervous system symptoms (p=0.018), frequency and intensity of headaches (p=0.0001), and subjective feeling of infection (p=0.0002). No positive effect on quality of life was found. CONCLUSIONS:Treatment with a vitamin and mineral supplement could be a safe and easy way to improve symptoms and quality of life in patients with CFS.

journal_name

Med Sci Monit

authors

Maric D,Brkic S,Tomic S,Novakov Mikic A,Cebovic T,Turkulov V

doi

10.12659/MSM.889333

subject

Has Abstract

pub_date

2014-01-14 00:00:00

pages

47-53

eissn

1234-1010

issn

1643-3750

pii

889333

journal_volume

20

pub_type

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