Abstract：
:Since the introduction of imatinib mesylate for the treatment of chronic myeloid leukaemia, impressive clinical responses were observed in the majority of patients in chronic phase. However, not all patients experience an optimal response to imatinib mesylate or even to the more potent, second generation tyrosine kinase inhibitors. Furthermore, responses are not sustained in a number of patients, and it is yet unclear whether the inhibitors can be safely discontinued in patients who achieve long-term remission. The emergence of resistance to second generation tyrosine kinase inhibitors has become a significant problem that led to extensive studies on the causal mechanisms. This review will describe our current state of knowledge on why and how chronic myeloid leukaemia cells can develop resistance to second generation tyrosine kinase inhibitors. :Os doentes com leucemia mielóide crónica em fase crónica, tratados com imatinib mesilato obtêm na maioria dos casos uma respostaclínica. Contudo, nem todos atingem uma resposta óptima ao imatinib mesilato, ou sequer aos mais potentes inibidores da tirosina cinase de segunda geração. Além disso, algumas respostas não são duradouras e ainda não é claro se os inibidores podem ser interrompidos em doentes em remissão prolongada. Os mecanismos de resistência aos inibidores da tirosina cinase de segunda geraçãotornaram-se objecto de numerosos estudos. Esta revisão descreve o conhecimento actual sobre como e porquê as células de leucemiamielóide crónica podem desenvolver resistência aos inibidores da tirosina cinase de segunda geração.
journal_name
Acta Med Portjournal_title
Acta medica portuguesaauthors
Diamond J,da Silva MGsubject
Has Abstractpub_date
2013-07-01 00:00:00pages
402-8issue
4eissn
0870-399Xissn
1646-0758journal_volume
26pub_type
杂志文章,评审abstract：:The case of a 31 man with acute disautonomia envolving the parasympathetic and sympathetic systems but sparing sympathetic cholinergic division is presented. A Hodgkin lymphoma was diagnosed allowing the diagnosis of a paraneoplastic syndrome. ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:Labour is very important in breech presentation and it is associated to significant morbidity and mortality enhancement in recent years. The authors made a retrospective study of breech presentation and labour with this kind of fetal presentation, in Santa Maria Hospital in 1993 and analysed the following data: matern...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1999-04-01 00:00:00
abstract：INTRODUCTION:The Portuguese version of the Children's Sleep Habits Questionnaire showed adequate psychometric properties in a community sample but the American cut-off seemed inadequate. This study aimed to validate this questionnaire in clinical populations of children with sleep disorders and with attention deficit/ ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.10906
更新日期：2019-03-29 00:00:00
abstract：:Multiple sclerosis (MS) is a chronic neuroinflammatory autoimmune disease believed to arise from complex interactions of both environmental and genetic factors. As in other complex diseases with autoimmune features, a genetic association with the human leukocyte antigen (HLA) complex is well documented. Association...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2012-07-01 00:00:00
abstract：:Nowadays, prostate cancer is very frequent in men. The evolution of the possibilities of early diagnosis and the results obtained with radical therapeutics have brought this pathology to our attention. The physicians involved, either general practitioners or specialists in internal medicine or urology, must pay maximu...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:The contribution of carotid and vertebral angiography for surgical planning, particularly for the infratemporal approach, in 24 jugulotympanic paragangliomas with otoneurological symptoms is discussed. These symptoms included peripheral facial palsy, sensorineural hypoacusis, labyrinthine and nervous syndrome of the j...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:The effect of different concentrations of aluminum sulphate on the nonenzymatic oxidation of dopamine was studied in order to evaluate the action of this metal on neuromelanin synthesis. Data shows that under the studied conditions, aluminum partially inhibits dopamine self-oxidation, decreasing the formation of some ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：UNLABELLED:Tobacco smoking is the cause of more than half million deaths/year in the European Union (EU). Monitoring smoking prevalence is an important tool to evaluate the epidemic and its evolution and to assess the effectiveness of preventive measures. The comparison between countries may help us identify good contr...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
abstract：:Spinal arachnoiditis, an inflammatory process involving all three meningeal layers as well as the nerve roots, is a cause of persistent symptoms in 6% to 16% of postoperative patients. Although spinal surgery is the most common antecedent associated with arachnoiditis, multiple causes have been reported, including inf...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1998-01-01 00:00:00
abstract：:The use of the transoesophageal echocardiography (TEE) in the critically ill patient admitted to the general intensive care unit begins to turn out to be very important but it is still little spread. The full implementation of the echocardiography in the general intensive cares is compromised by the acoustic window. H...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2011-12-01 00:00:00
abstract：:Wernicke Encephalopathy (WE) is a severe neurological disease caused by vitamin B1 (thiamine) deficiency, which is potentially treatable if early diagnosed. This is the clinical case of a young female patient, with renal insufficiency on haemodialysis, who has been submitted to an abdominal surgery. After the interven...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2006-11-01 00:00:00
abstract：INTRODUCTION:Acute appendicitis (AA) is the leading cause of emergency abdominal surgery in children. The diagnosis is essentially clinical, but some methodologies, such as Alvarado score (AS), have been developed in order to avoid non-therapeutic laparotomy (15-30%). AS ≥ 5 or 6 is compatible with AA and is an indicat...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：:A correlation between urinary tract infection, vesicoureteral reflux and voiding disorders has increasingly been reported. Voiding dysfunction increases the incidence of recurrent urinary tract infection, induces and perpetuates vesicoureteral reflux, even after surgical antireflux treatment, and may result in permane...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：:Congenital absence of the inferior vena cava is a rare vascular anomaly, and most cases are asymptomatic. Nevertheless, patients with inferior vena cava malformations may have increased risk of deep venous thrombosis. Particularly, cases of bilateral deep venous thrombosis may arise owing to an insufficient collateral...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.7744
更新日期：2017-04-28 00:00:00
abstract：:We report 3 years of experience with operative ultrasonography on 200 patients who underwent cholecystectomy for biliary lithiasis. Intraoperative ultrasonography and intraoperative cholangiography were performed on all of these patients and compared with the operative findings. The diagnostic accuracy of sonography w...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:From January 1980 until October 1991 we operated 112 patients with Gastric cancer in which Surgery was considered palliative by intra-operative criteria or by pathological analysis of the resected specimen. Locally irresectable tumour was found in 24.1% of the cases, peritoneal metastases (mets.) in 21.4%, liver mets....
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
abstract：:Several infectious, neoplastic or inflammatory skin diseases, may be early manifestations of HIV infection. We reviewed the clinical data of 226 HIV seropositive male patients with cutaneous disease, from a total of 337 inpatients at the Infectious Diseases Unit--Department of Medicine 1--Curry Cabral Hospital, from 1...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:Kikuchi and Fujimoto's disease, also known as histiocytic necrotizing lymphadenopathy, is a rare and benign disorder of the lymph nodes of young adults. The etiology of this disease is unknown, an autoimmune mechanism has been suggested, although some cases of association with several viruses has been described. We re...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2005-05-01 00:00:00
abstract：:Pleural effusions can be a manifestation of several nosological entities. Etiologic diagnosis involves a good clinical history, followed by thoracocentesis with pleural biopsy and eventually bronchoscopy or thoracoscopy. The differentiation between transudates and exudates, by the biochemical characteristics of the pl...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1995-10-01 00:00:00
abstract：INTRODUCTION:Peritoneal dialysis is the dialytic method of choice in chronic end-stage renal disease in children. This study main purpose was to characterize the long-term survival of a pediatric population who began peritoneal dialysis within the first two years of life. MATERIAL AND METHODS:A descriptive and retrosp...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.6913
更新日期：2016-09-01 00:00:00
abstract：INTRODUCTION:Deep brain stimulation (DBS) is effective in advanced Parkinson's disease (PD), improving motor symptoms, fluctuations and quality of life. However, adverse psychiatric outcomes have been reported, albeit variably and in an unstandardized fashion. We aimed to summarize the published evidence on the outcome...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,meta分析,评审
doi：10.20344/amp.4928
更新日期：2014-05-01 00:00:00
abstract：:The Bartter syndrome is a rare hereditary salt-wasting tubulopathy, characterized by metabolic alkalosis, hypokalemia, hyperreninemia and hyperaldosteronemia of varying severity. Indomethacin and high doses of oral potassium have been until now the therapeutic strategies used, with high risk of gastrointestinal injury...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:Some families fulfilling the Amsterdam Criteria (AC) differ from the Lynch syndrome (LS) in that colorectal cancers (CRC) do not present microsatellite instability (MSI) and DNA mismatch repair gene mutations are not found. These families have been designated as Familial Colorectal Cancer type X (XS) and the...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2009-05-01 00:00:00
abstract：:Endoscopic interventional techniques have created a wide new perspective for non-surgical treatment of chronic pancreatitis (CP). Surgery and endoscopy differ in their techniques, but are comparable with regard to tactics. The aim of methods in CP is to relieve pain and/or local complications. The preliminary results ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1995-06-01 00:00:00
abstract：:Several intra-arterial embolization techniques with polimerization substances, particles, thrombogenic coils and silicone and latex balloons have been used in the endovascular therapy of arteriovenous fistulas in different vascular territories. Using the Seldinger technique by femural route and with a coaxial system i...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：:Before the age of 8 in females and 9 in males, the presence of pubic hair can be the first sign of a gonadal or adrenal disease. In order to identify the late onset type of congenital adrenal hyperplasia in premature pubescence, we did the adrenal short stimulation test with Synacthen, on 30 children. Five girls and o...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:This review summarises the fundamental immunologic principles regarding the cellular and molecular relations involved with immune function in a normal gestation. During the past decades, more information has been gathered to explain these complex immunological mechanisms. These mechanisms include both fetal factors su...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2007-07-01 00:00:00
abstract：:Over the years a number of high quality studies has established the effectiveness of external measures (tape, brace) and neuromuscular training for the prevention of ankle sprains. The general conclusion derived from these studies is that recurrent ankle sprains can be effectively prevented using any of these measures...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：:During pregnancy immunological, metabolic, hormonal and vascular changes occur, and can cause specific skin diseases. The specific dermatoses of pregnancy have undergone numerous changes in nomenclature and classification, partly due to advances in the knowledge of the pathogenesis of these skin diseases. Currently th...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2013-09-01 00:00:00
abstract：:In this article we reviewed some examples of our experience in clinical applications of functional MRI (fMRI) in the motor and verbal fluency tasks evaluation. Seventeen patients with supratentorial cerebral pathology (5 arteriovenous malformations--AVMs, 2 meningiomas, 1 tuberculoma, 1 cortical tuberoma, 1 DNET, 2 ce...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
