Abstract：
:This review summarises the fundamental immunologic principles regarding the cellular and molecular relations involved with immune function in a normal gestation. During the past decades, more information has been gathered to explain these complex immunological mechanisms. These mechanisms include both fetal factors such as trophoblast cell properties and altered MHC Class I expression and local maternal factors such as specialized uterine natural killer cells and a shifting of the T-helper cell cytokine profile from a type 1 to a type II array. Other novel immunomodulators are found to be expressed in the local uterine environment to aid in fetal survival. Increased knowledge about the immune relationship between the mother and the fetus permits not only a better understanding about pathological outcomes of pregnancy and gestational complications of autoimmune diseases but also the development of therapeutic approaches for solid organ transplantation.
journal_name
Acta Med Portjournal_title
Acta medica portuguesaauthors
Sarafana S,Coelho R,Neves A,Costa Trindade Jsubject
Has Abstractpub_date
2007-07-01 00:00:00pages
355-8issue
4eissn
0870-399Xissn
1646-0758journal_volume
20pub_type
杂志文章,评审abstract：:The authors join the celebrations of the Centenary of the establishment of the Faculdade de Medicina da Universidade de Lisboa, on the 22(nd) April 2011, through the historical account of one of its main pilasters, the Institute of Anatomy. It is discussed the scope of its creation at the time, the important work done...
journal_title：Acta medica portuguesa
pub_type： 历史文章,杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：:We describe a case report of a 69 year old woman with atrial myxoma, presented as a cerebellar syndrome caused by ischemic infarctions of the posterior circulation. The transthoracic 2D echocardiogram provided the diagnosis of a left atrial myxoma. Seven months after surgical removal of the cardiac tumor, the cerebell...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:Endometriosis was first described by Russel more than one-hundred years ago and still remains a clinical entity of difficult comprehension, with totally aberrant symptomatology, particularly in extra-genital situations. The present article describes a clinical case of recurring right-sided catamenial pneumothorax in a...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to determine the safety and efficacy in the first sixteen patients operated by endoscopic third ventriculostomy for triventricular obstructive hydrocephalus in the Hospital of S. João-Porto. METHODS:Operated from December 1998 to December 1999, there were one adult, one teenager...
journal_title：Acta medica portuguesa
pub_type： 临床试验,杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:Testicular microlithiasis is a rare entity, usually asymptomatic and bilateral. There are however reports that until 40% of the cases may be related with testicular tumours. We report an 11-year-old boy, with a four-month history of left testicular mass. Sonography showed increased volume of left testis and bilateral ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
abstract：INTRODUCTION:Biological and biosimilar medicinal products have specific characteristics that call for a closer monitoring of their safety profile. Since the current legal framework stems from both European and national regulations, some gaps in the operational field may be expected. The goal of this paper is to identif...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.8079
更新日期：2017-03-31 00:00:00
abstract：:A new case of nephrotoxic effect of Maneb is related. The patient used this product as fungicide and developed a progressive illness with acute renal failure. The study by light and electron microscopy revealed severe tubular lesions that disappeared some months later with tubular cell regeneration. However, in spite ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1989-08-01 00:00:00
abstract：:Congenital muscular dystrophy (CMD) is one of the most frequent dystrophies of childhood, which is commonly characterized by neonatal muscle impairment with or without clinical evidence of central nervous system involvement. CMDs were classified into five clinically distinct forms: the two classical CMDs with and with...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：:Our study included 42 patients with obstructive sleep apnea (OSAS) confirmed by polysomnography. In these patients we investigated the clinical manifestations, the results of the laboratory examinations, including polysomnography, ORL observations and tests of pulmonary function, as well as the therapeutic results. Ou...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:In the present article, regarding a clinical case of Thrombasthenia of Glanzmann with severe anaemia by menometrorrhagia, the authors propose the vaginal hysterectomy and the administration of the recombinant factor VIIa on the immediate pre and postoperative as effective therapeutical alternatives. ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2004-03-01 00:00:00
abstract：:The authors report a case of 32-week-old newborn, admitted to the Intensive Care Unit for Newborns. Mechanical ventilation was needed from the first day of life. The patient was treated with indomethacin on the second day of life due to patent ductus arteriosus. On the seventh day pneumoperitoneum was diagnosed, emerg...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1998-12-01 00:00:00
abstract：:Fever of unknown origin is a diagnostic challenge. When the diagnosis remains elusive despite extensive non-invasive diagnostic studies, it can be necessary to conduct more invasive procedures, such as liver biopsy. We report a male with fever of unknown origin who had tender enlarged liver and raised liver enzymes wh...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：:Fever and rash are a common combination of symptoms in the young adult patient. The etiologic investigation is usually oriented towards the most common diseases, but atypical presentations of less frequent conditions should also be recalled. We describe the case of a 44 year-old Portuguese woman who presented with fev...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.9776
更新日期：2018-06-29 00:00:00
abstract：:The correct practice of specialized Clinical Pathology is dependent on the acquired aptitude and capacity gained by residents during their specialization. So, the adopted program for residents must be practical and detailed, obviously exceeding the simple and routine execution of laboratory methods and techniques. In ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：INTRODUCTION:Diabetes is a major public health problem and it is related to socioeconomic factors. The aim of this study is to describe socioeconomic inequalities in the distribution of diabetes in the population with 25 years or more, resident in Portugal in 2014. MATERIAL AND METHODS:Data from the Health National Su...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.8235
更新日期：2017-08-31 00:00:00
abstract：:A retrospective epidemiological study was made based on 1,768 burn patients admitted either to the Burns Unit or the general wards of the Plastic Surgery Department of Prelada Hospital in Oporto, from October 1988 until November 1997, corresponding to almost 8.5% of the overall patients admitted. The average age of th...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：:Atrial septum aneurysms are an uncommon condition, underestimated before the routine use of echocardiography. Their clinical importance has increased after being associated with thromboembolic events. The authors made a review of clinical, diagnostic and therapeutic features of this entity after reporting six clinical...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1998-04-01 00:00:00
abstract：INTRODUCTION:Creatine deficiency syndromes are a recently described group of diseases characterized by inborn errors of creatine metabolism. Clinical features include a spectrum of neurodevelopment disorders of diverse severity. They are characterized by low levels of cerebral creatine caused by different pathogenic mu...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2012-11-01 00:00:00
abstract：INTRODUCTION:Clinically isolated syndrome may be the first manifestation of multiple sclerosis, a chronic demyelinating disease of the central nervous system, and it is defined by a single clinical episode suggestive of demyelination. However, patients with this syndrome, even with long term follow up, may not develop ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：10.20344/amp.7650
更新日期：2016-11-01 00:00:00
abstract：INTRODUCTION:Acute appendicitis (AA) is the leading cause of emergency abdominal surgery in children. The diagnosis is essentially clinical, but some methodologies, such as Alvarado score (AS), have been developed in order to avoid non-therapeutic laparotomy (15-30%). AS ≥ 5 or 6 is compatible with AA and is an indicat...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：INTRODUCTION:Outpatient antimicrobial therapy programs have been in place for more than four decades. They provide safe and effective treatment for a selected group of patients while reducing costs. In Europe in general, and in Portugal in particular, these programs are still a relatively new phenomenon. The aim of thi...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.11730
更新日期：2019-09-02 00:00:00
abstract：:Sepsis is a common pathology during the neonatal period. Low-birth weight is the most important isolated risk factor. With the purpose of determining the prevalence of nosocomial infection in newborns of very low birth weight (VLBW), finding the microbial flora and the mortality of these patients, the authors retrospe...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:Rhabdomyolysis is a common entity that often has a multifactorial etiology. It usually affects healthy individuals, following trauma, excessive physical activity, convulsive crisis, alcohol and other drugs consumption or infections. Accumulation of intracellular calcium, activation of proteases and lipases, production...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2005-07-01 00:00:00
abstract：:Nowadays, prostate cancer is very frequent in men. The evolution of the possibilities of early diagnosis and the results obtained with radical therapeutics have brought this pathology to our attention. The physicians involved, either general practitioners or specialists in internal medicine or urology, must pay maximu...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：INTRODUCTION:Periarticular corticosteroid injection utilization by General Practitioners treating musculoskeletal disease in primary health care system is internationally acknowledged. This article aims at analyzing this evidence and contributing to the discussion of a potential development of the technique in Portugal...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2015-09-01 00:00:00
abstract：:Cutaneous cytomegalovirus (CMV) infection has been observed in a variety of nonspecific skin lesions. Because of this fact, its diagnosis is rare and frequently accidental. The presence of the virus has also been observed in apparently normal skin, from both a clinical and histological point of view. In this context, ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1997-06-01 00:00:00
abstract：:Diaphragmatic Pacing was used to treat ventilatory failure in a young boy with bilateral diaphragmatic palsy secondary to cervical cord injury, on chronic mechanical ventilation for 6 months. The indications for diaphragmatic pacing in ventilatory failure were discussed, as well as the assessment of phrenic nerve inte...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1995-11-01 00:00:00
abstract：:The recent improvement in surgical of therapy of carriers of hepatocellular carcinoma is due to both an early diagnosis of the illness and in the evaluation of set of prognostic and resectability factors. On describing a clinical case of a hepatocellular carcinoma localized on the left lobe of a healthy liver, the imp...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：:Fabry disease (FD) is a rare disorder resulting from mutations of the alpha-Galactosidase A lysosomal enzyme gene. Accumulation of enzyme substrates leads to multisystemic clinical manifestations and multiorgan progressive damage with high morbidity and mortality. Recombinant enzyme replacement therapy (RERT) now avai...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
abstract：:The authors, using the Cancer Registry data of S. Antonio General Hospital in Oporto, selected the cancer cases from 1981 to 1993. Distribution according to age, sex, topography and morphology is presented. Seven point nine percent of the 12,124 cases mentioned in the Registry were skin cancers (n = 883). They were mo...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
