Abstract:
:The Signaling Lymphocyte Activation Molecule Family (SLAMF) genes, which encode cell-surface receptors that modulate innate and adaptive immune responses, lay within a genomic region of human and mouse chromosome 1 that confers a predisposition for the development of systemic lupus erythematosus (SLE). Herein, we demonstrate that the SLAMF member Ly9 arises as a novel receptor contributing to the reinforcement of tolerance. Specifically, Ly9-deficient mice spontaneously developed features of systemic autoimmunity such as the production of anti-nuclear antibodies (ANA), -dsDNA, and -nucleosome autoantibodies, independently of genetic background [(B6.129) or (BALB/c.129)]. In aged (10- to 12-month-old) Ly9 (-/-) mice key cell subsets implicated in autoimmunity were expanded, e.g., T follicular helper (Tfh) as well as germinal center (GC) B cells. More importantly, in vitro functional experiments showed that Ly9 acts as an inhibitory receptor of IFN-γ producing CD4(+) T cells. Taken together, our findings reveal that the Ly9 receptor triggers cell intrinsic safeguarding mechanisms to prevent a breach of tolerance, emerging as a new non-redundant inhibitory cell-surface receptor capable of disabling autoantibody responses.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
de Salort J,Cuenca M,Terhorst C,Engel P,Romero Xdoi
10.3389/fimmu.2013.00225subject
Has Abstractpub_date
2013-07-31 00:00:00pages
225issn
1664-3224journal_volume
4pub_type
杂志文章abstract::γδ T cells represent an evolutionarily primitive T cell subset characterized by distinct T cell receptors (TCRs) and innate and adaptive immune functions. However, the presence of this T cell subset in ancient vertebrates remains unclear. In this study, γδ T cells from a zebrafish (Danio rerio) model were subjected to...
journal_title:Frontiers in immunology
pub_type: 杂志文章
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abstract::Over the last decade, the acceleration in the clinical use of mesenchymal stromal cells (MSCs) has been nothing short of spectacular. Perhaps most surprising is how little we know about the "MSC product." Although MSCs are being delivered to patients at an alarming rate, the regulatory requirements for MSC therapies (...
journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.3389/fimmu.2018.02390
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pub_type: 杂志文章
doi:10.3389/fimmu.2020.00235
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pub_type: 杂志文章,评审
doi:10.3389/fimmu.2019.01068
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2019.01765
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2018.00055
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2014.00086
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2016.00696
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pub_type: 临床试验,杂志文章
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更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章
doi:10.3389/fimmu.2014.00404
更新日期:2014-08-25 00:00:00
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pub_type: 杂志文章
doi:10.3389/fimmu.2017.00965
更新日期:2017-08-11 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2018.02531
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pub_type: 杂志文章,评审
doi:10.3389/fimmu.2019.00972
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2012.00213
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.3389/fimmu.2017.00079
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pub_type: 杂志文章
doi:10.3389/fimmu.2018.01730
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2016.00183
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pub_type: 杂志文章,评审
doi:10.3389/fimmu.2016.00216
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.3389/fimmu.2018.01764
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