Abstract：
:Stevens-Johnson syndrome and toxic epidermal necrolysis are potentially life-threatening adverse cutaneous drug reactions. Clinically, it manifests as a rash, often morbilliform, or atypical target lesions that evolve to epidermal detachment. There is mucosal involvement in almost all patients. The loss of skin's barrier function has important implications in the maintaining of homeostasis in these patients, often determining its internment in Burn Units or Intensive Care Units. The drugs most often involved are allopurinol, antibiotics, including ß-lactams and sulfonamides, anti-inflammatory drugs (NSAIDs) and aromatic anticonvulsants. The clinical manifestations appear on average 7 to 21 days after the onset of the involved drug. The diagnosis is clinical and supported by histopathology, whose main finding is keratinocytes' necrosis and cleavage of the dermo-epidermal junction. The differential diagnosis is carried out with erythema multiforme, acute generalized exanthematous pustulosis, staphylococcal scalded skin syndrome, paraneoplastic pemphigus and graft versus host disease. A timely recognition of these situations is of utmost importance in order to intervene as early as possible. The suspension of the drug believed to be involved is paramount.
journal_name
Acta Med Portjournal_title
Acta medica portuguesaauthors
Oliveira A,Sanches M,Selores Msubject
Has Abstractpub_date
2011-12-01 00:00:00pages
995-1002eissn
0870-399Xissn
1646-0758journal_volume
24 Suppl 4pub_type
杂志文章,评审abstract：:Brain radiotherapy aims at controlling the pathological lesion(s) as well as avoiding damaging critical structures. However, side effects may occur. Neurocognitive function is often involved impairing quality of life. This dysfunction is among the most frequent complications of brain irradiation. Sparing as much as fe...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：INTRODUCTION:In this study, we reviewed a clinical series composed by all malignant lung lesions submitted to computed tomography-guided percutaneous thermal radiofrequency ablation, in our hospital, a rather recent technique that has been gaining scientific recognition. MATERIAL AND METHODS:For data purposes, all rad...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.5620
更新日期：2015-01-01 00:00:00
abstract：INTRODUCTION:Postpartum haemorrhage is still the main cause of maternal morbidity and mortality. Many treatments are available, but they may threaten fertility potential. As a uterine sparing procedure, we aimed to review uterine compression sutures in order to better understand when they should represent an appropriat...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.11987
更新日期：2019-10-07 00:00:00
abstract：:Osteoporosis in men, despite being a less important public health problem than osteoporosis in women, should not be neglected as it has many deleterious effects as well as social and economic costs. Finding the cause of osteoporosis is more complex in men than in women, and prevention should be based on an early evalu...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1995-05-01 00:00:00
abstract：INTRODUCTION:PFAPA syndrome (Periodic Fever, Aphthous stomatitis, Pharyngitis, Adenitis) is a benign sporadic syndrome of unknown cause and an important diagnosis to consider in the child with recurrent fever and tonsillitis. OBJECTIVES:To describe the presentation, age of onset, time until diagnosed, episode duration...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：INTRODUCTION:The use of adequate assessment tools in health care is crucial for the management of care. The lack of specific tools in Portugal for assessing the performance of children who use cochlear implants motivated the translation and adaptation of the EARS (Evaluation of Auditory Responses to Speech) test batter...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:Essencial Thrombocytemia is a rare chronic myeloproliferative disease of unknown etiology, characterized by markedly elevated platelet production (> 600,000/ml). It is more frequent among women above 50 years of age and may be associated with hemorrhagic or thrombotic tendencies. The authors report a case of Essencial...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：:Ankle injuries are the most frequently encountered injuries in clinical practice. They are often managed by general practicians, and not only by orthopaedic or physiatric physicians. This injury is usually non-complicated, but some care should be taken to assure an adequate management and to exclude severe lesions. Th...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2008-05-01 00:00:00
abstract：:Escherichia coli endocarditis is a rare condition, even though bacteriemia by such agent is common. The infection, normally from a urinary origin, may, in fact, progress without major hemodynamic disturbance and minimal symptoms, regardless its ability of destruction of heart's valvular apparatus. We present a case re...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
abstract：:The circumstances preceding the future revision of the medical curriculum are analysed, main internal and external stimuli are described, and sources of resistance to changes in medical training require new educational philosophy, privileging oriented training during undergraduation, as a preliminary phase of medical ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:Secondary malignancy of the penis is a rare clinical condition, often associated with disseminated genitourinary malignancies. The prognosis is poor and the treatment options include penectomy, local surgical excision, radiation therapy, chemotherapy and supportive therapy. Neither of these therapeutic options lead to...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.5775
更新日期：2015-07-01 00:00:00
abstract：:Fever of unknown origin is a diagnostic challenge. When the diagnosis remains elusive despite extensive non-invasive diagnostic studies, it can be necessary to conduct more invasive procedures, such as liver biopsy. We report a male with fever of unknown origin who had tender enlarged liver and raised liver enzymes wh...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：:In adults, endogenous hyperinsulinemic hypoglycaemia is almost invariably due to insulinoma. The authors describe a 29 year old patient with repeated postprandial symptomatic hypoglycaemias and negative prolonged fast test. Distal pancreatectomy was performed, directed by positive arteriographic testing. Histological ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2003-11-01 00:00:00
abstract：:The aim of this study was to evaluate the accuracy of ultrasound biometric and hemodynamic fetal parameters for the prenatal diagnosis of intrauterine retardation in a sample of 438 pregnant women who had their first visit before the 16th week of gestation at the outpatient clinic of the Department of Obstetrics and G...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：:Modern medicine has many roots on greco-roman practice of the medical art. The authors analyse the work De Medicina by Aulus Cornelius Celsus. They look upon the nature of the medical knowledge, the principles of ethics, causality and describe the mental disorders (phrenitis, depression, third insanity, seizure disord...
journal_title：Acta medica portuguesa
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：INTRODUCTION:Adolescents are a target group for reproductive health intervention. Family physicians, gynecologists and pediatricians are the main providers of contraceptive counseling. MATERIAL AND METHODS:Correlational, cross-sectional study, approved by the ethics committee of Leiria Hospital, Portugal. Data was col...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.11088
更新日期：2019-08-01 00:00:00
abstract：:A new case of nephrotoxic effect of Maneb is related. The patient used this product as fungicide and developed a progressive illness with acute renal failure. The study by light and electron microscopy revealed severe tubular lesions that disappeared some months later with tubular cell regeneration. However, in spite ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1989-08-01 00:00:00
abstract：:Lithopedions are extremely rare conditions. Less than 300 cases were described worldwide. We report a case occurring in a woman of 77 years of age, admitted with dehydration, urinary tract infection and infected limb pressure ulcers. She had been recently admitted in a Surgery ward for incarcerated umbilical hernia. A...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：:Atrial septum aneurysms are an uncommon condition, underestimated before the routine use of echocardiography. Their clinical importance has increased after being associated with thromboembolic events. The authors made a review of clinical, diagnostic and therapeutic features of this entity after reporting six clinical...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1998-04-01 00:00:00
abstract：:A growing number of thyroid nodules are detected incidentally during imaging tests performed for unrelated reasons and constitute both a clinical and public health problem. Due to scarce information and lack of long term follow-up studies of individuals with subclinical nodules, there are no consensual guidelines for ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2006-07-01 00:00:00
abstract：:Appropriate nutritional support is crucial in the therapeutic approach of multiple conditions, which justifies the frequent and increasing use of specific access routes for enteral and parenteral nutrition. This article reviews the relevant literature concerning indications, procedures, effectiveness and complications...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2014-09-01 00:00:00
abstract：INTRODUCTION:Visceral leishmaniasis is an endemic disseminated infection, considered to be the third most frequent opportunistic parasitic infection in Europe. It is especially prevalent in patients co-infected with human immunodeficiency virus, in whom it poses a great therapeutic challenge due to increased risk of re...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.8291
更新日期：2017-06-30 00:00:00
abstract：:The aim of the study was to assess, in patients with non insulin dependent diabetes mellitus (NIDDM), either with previous failure to sulphonylureas or insulin treated since the disease started, if the combination of gliclazide to insulin therapy might induce a reduction of daily insulin requirement. 30 caucasian type...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1991-03-01 00:00:00
abstract：:This is a case report of a 29-year-old white female patient with Kikuchi's disease, presenting fever, polyarthritis, lymph gland enlargement, anemia, leucopenia with a relative lymphocytosis, altered liver function tests and circulating immune complexes. A literature review is made with emphasis on the etiology, clini...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：INTRODUCTION:MEN2A is an autossomal dominant cancer syndrome characterised by the presence of medullary thyroid cancer, pheochromocytoma and primary hyperparathyroidism. Germline mutations of the RET protooncogene constitute the molecular defect and can be identified in affected individuals. Genetic screening of family...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2003-07-01 00:00:00
abstract：:Labour is very important in breech presentation and it is associated to significant morbidity and mortality enhancement in recent years. The authors made a retrospective study of breech presentation and labour with this kind of fetal presentation, in Santa Maria Hospital in 1993 and analysed the following data: matern...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1999-04-01 00:00:00
abstract：:Manic and hypomanic states associated with antidepressant treatments are relatively common; however, when specifically considering mirtazapine, those side effects are infrequent. The authors report a clinical case regarding a manic episode with dysphoric features in a patient with no personal or family previous psychi...
journal_title：Acta medica portuguesa
pub_type：
doi：10.20344/amp.9916
更新日期：2019-10-01 00:00:00
abstract：:In recent years, the time for motherhood has been postponed, which is related to social aspects and can lead to health problems for the pregnant women and the child. An appropriate follow-up of the pregnancy is essential for identification and early treatment of possible complications. The purpose of this study was to...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2011-11-01 00:00:00
abstract：INTRODUCTION:The objective of the study was to evaluate the experience of our service in the treatment of esophageal perforations. MATERIALS AND METHODS:Retrospective chart review of the nine cases occurred between January 1, 1996 and December 31, 2011. Seven occurred after accidental ingestion of foreign bodies and i...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：:The Bartter syndrome is a rare hereditary salt-wasting tubulopathy, characterized by metabolic alkalosis, hypokalemia, hyperreninemia and hyperaldosteronemia of varying severity. Indomethacin and high doses of oral potassium have been until now the therapeutic strategies used, with high risk of gastrointestinal injury...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
