Anti-cholinergic drugs for wheeze in children under the age of two years.

Abstract:

BACKGROUND:Wheeze in infancy and early childhood is common and appears to be increasing though the magnitude of any increase is unclear. Most wheezing episodes in infancy are precipitated by respiratory viral infections. Treatment of very young children with wheeze remains controversial. Anti-cholinergics are often prescribed but practice varies widely and the efficacy of this form of therapy remains the subject for debate. OBJECTIVES:Wheeze in infancy and early childhood is common and appears to be increasing. Most wheezing episodes in infancy are a result of viral infection. Bronchodilator medications such as beta2-agonists and anti-cholinergic agents are often used to relieve symptoms, but patterns of use vary. The objective of this review was to assess the effects of anti-cholinergic therapy in the treatment of wheezing infants. SEARCH STRATEGY:We searched the Cochrane Airways Group trials register and the reference lists of articles. We contacted researchers in the field and industry sources. SELECTION CRITERIA:Randomised trials that compared anti-cholinergic therapy with placebo or beta2-agonists in wheezing children under two years of age. Children with acute bronchiolitis and chronic lung disease were excluded. DATA COLLECTION AND ANALYSIS:Eligibility for inclusion and quality of trials were assessed independently by two reviewers. MAIN RESULTS:Six trials involving 321 infants in three different settings were included. Compared with beta2-agonist alone, the combination of ipratropium bromide and beta2-agonist was associated with a reduced need for additional treatment, but no difference was seen in treatment response, respiratory rate or oxygen saturation improvement in the emergency department. There was no significant difference in length of hospital stay between ipratropium bromide and placebo; or between ipratropium bromide and beta2-agonist combined compared with beta2-agonist alone. However, combined ipratropium bromide and beta2-agonist compared to placebo showed significantly improved clinical scores at 24 hours. Parents preferred ipratropium bromide over nebulised water or placebo for relief of their children's symptoms at home. REVIEWER'S CONCLUSIONS:There is not enough evidence to support the uncritical use of anti-cholinergic therapy for wheezing infants, although parents using it at home were able to identify benefits.

authors

Everard ML,Bara A,Kurian M

doi

10.1002/14651858.CD001279

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

CD001279

issue

2

issn

1469-493X

pii

CD001279

pub_type

杂志文章,评审
  • Medical interventions for primary open angle glaucoma and ocular hypertension.

    abstract:BACKGROUND:Primary open angle glaucoma (POAG) is a progressive optic neuropathy with an elevated intraocular pressure (IOP), where the optic nerve head becomes pathologically excavated and the visual field (VF) is characteristically altered. Ocular hypertension (OHT) is a condition with elevated IOP but without discern...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003167.pub3

    authors: Vass C,Hirn C,Sycha T,Findl O,Bauer P,Schmetterer L

    更新日期:2007-10-17 00:00:00

  • Orotracheal intubation in infants performed with a stylet versus without a stylet.

    abstract:BACKGROUND:Neonatal endotracheal intubation is a common and potentially life-saving intervention. It is a mandatory skill for neonatal trainees, but one that is difficult to master and maintain. Intubation opportunities for trainees are decreasing and success rates are subsequently falling. Use of a stylet may aid intu...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD011791.pub2

    authors: O'Shea JE,O'Gorman J,Gupta A,Sinhal S,Foster JP,O'Connell LA,Kamlin COF,Davis PG

    更新日期:2017-06-22 00:00:00

  • Prophylactic versus therapeutic amnioinfusion for oligohydramnios in labour.

    abstract:BACKGROUND:Amnioinfusion aims to relieve umbilical cord compression during labour by infusing a liquid into the uterine cavity. OBJECTIVES:The objective of this review was to assess the effects of prophylactic amnioinfusion for women in labour with oligohydramnios, but not fetal heart deceleration, compared with thera...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000176.pub2

    authors: Novikova N,Hofmeyr GJ,Essilfie-Appiah G

    更新日期:2012-09-12 00:00:00

  • Acupuncture for neuropathic pain in adults.

    abstract:BACKGROUND:Neuropathic pain may be caused by nerve damage, and is often followed by changes to the central nervous system. Uncertainty remains regarding the effectiveness and safety of acupuncture treatments for neuropathic pain, despite a number of clinical trials being undertaken. OBJECTIVES:To assess the analgesic ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD012057.pub2

    authors: Ju ZY,Wang K,Cui HS,Yao Y,Liu SM,Zhou J,Chen TY,Xia J

    更新日期:2017-12-02 00:00:00

  • Antibiotics for preventing lower respiratory tract infections in high-risk children aged 12 years and under.

    abstract:BACKGROUND:Lower respiratory tract infections (LRTIs) in young children account for 1.4 million deaths annually worldwide. Antibiotics could be beneficial in preventing LRTIs in high-risk children, and may also help prevent school absenteeism and work days missed by children and/or carers. While it is well documented t...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD011530.pub2

    authors: Onakpoya IJ,Hayward G,Heneghan CJ

    更新日期:2015-09-26 00:00:00

  • Proton pump inhibitors for chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a common and progressive disease characterised by chronic cough, airflow limitation and recurrent exacerbations. Since COPD exacerbations are linked to rising mortality and reduced quality of life, the condition poses a substantial burden on individuals, societ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD013113.pub2

    authors: Kikuchi S,Imai H,Tani Y,Tajiri T,Watanabe N

    更新日期:2020-08-25 00:00:00

  • Serenoa repens for benign prostatic hyperplasia.

    abstract:OBJECTIVES:This systematic review aimed to assess the effects of Serenoa repens in the treatment of Benign Prostatic Hyperplasia (BPH). SEARCH STRATEGY:Trials were searched in computerized general and specialized databases (MEDLINE, EMBASE, Cochrane Library, Phytodok), by checking bibliographies, and by contacting man...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001423

    authors: Wilt T,Ishani A,Stark G,MacDonald R,Mulrow C,Lau J

    更新日期:2000-01-01 00:00:00

  • Oral anticoagulants versus antiplatelet therapy for preventing further vascular events after transient ischaemic attack or minor stroke of presumed arterial origin.

    abstract:BACKGROUND:Patients who are entered in clinical trials after a transient ischaemic attack (TIA) or non disabling ischaemic stroke have an annual risk of important vascular events (death from all vascular causes, non-fatal stroke, or non-fatal myocardial infarction) of between 4 and 11 percent. Aspirin, in a daily dose ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001342

    authors: Algra A,de Schryver EL,van Gijn J,Kappelle LJ,Koudstaal PJ

    更新日期:2001-01-01 00:00:00

  • Exercise for depression.

    abstract:BACKGROUND:Depression is a common and important cause of morbidity and mortality worldwide. Depression is commonly treated with antidepressants and/or psychological therapy, but some people may prefer alternative approaches such as exercise. There are a number of theoretical reasons why exercise may improve depression....

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004366.pub6

    authors: Cooney GM,Dwan K,Greig CA,Lawlor DA,Rimer J,Waugh FR,McMurdo M,Mead GE

    更新日期:2013-09-12 00:00:00

  • Relaxation techniques for pain management in labour.

    abstract:BACKGROUND:Many women would like to avoid pharmacological or invasive methods of pain management in labour and this may contribute to the popularity of complementary methods of pain management. This review examined currently available evidence on the use of relaxation therapies for pain management in labour. This is an...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD009514.pub2

    authors: Smith CA,Levett KM,Collins CT,Armour M,Dahlen HG,Suganuma M

    更新日期:2018-03-28 00:00:00

  • Interventions for growth failure in childhood Crohn's disease.

    abstract:BACKGROUND:Crohn's disease in childhood is a chronic relapsing condition. Fifteen to forty per cent of children with Crohn's disease have growth retardation (Griffiths 1993a). Some treatment modalities including corticosteroids have been implicated in growth failure but it is thought mainly to be secondary to uncontrol...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003873.pub2

    authors: Newby EA,Sawczenko A,Thomas AG,Wilson D

    更新日期:2005-07-20 00:00:00

  • Posture and fluids for preventing post-dural puncture headache.

    abstract:BACKGROUND:Potentially disabling postural headache occurs after dural puncture in 1-70% of patients. It has been suggested that such headaches may be less common if patients routinely have a period of bed rest or receive supplementary fluids after the procedure. OBJECTIVES:To assess the effects on post dural puncture ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001790

    authors: Sudlow C,Warlow C

    更新日期:2002-01-01 00:00:00

  • Hepatitis B immunisation in persons not previously exposed to hepatitis B or with unknown exposure status.

    abstract:BACKGROUND:The benefits and harms of hepatitis B vaccination in persons not previously exposed to hepatitis B infection or with unknown exposure status have not been established. OBJECTIVES:To assess the benefits and harms of hepatitis B vaccination in people not previously exposed to hepatitis B infection or with unk...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006481.pub2

    authors: Mathew JL,El Dib R,Mathew PJ,Boxall EH,Brok J

    更新日期:2008-07-16 00:00:00

  • Macrolide antibiotics for cystic fibrosis.

    abstract:BACKGROUND:Chronic severe infection with Pseudomonas aeruginosa, affects many people with cystic fibrosis (CF). There is evidence from the laboratory and from other disease processes that macrolide antibiotics, whilst not directly active against Pseudomonas aeruginosa, may have indirect actions against this organism. ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD002203.pub2

    authors: Southern KW,Barker PM,Solis A

    更新日期:2004-01-01 00:00:00

  • Antibiotic prophylaxis for surgery for proximal femoral and other closed long bone fractures.

    abstract:BACKGROUND:Surgical site infection and other hospital-acquired infections cause significant morbidity after internal fixation of fractures. The administration of antibiotics may reduce the frequency of infections. OBJECTIVES:To determine whether the prophylactic administration of antibiotics in people undergoing surgi...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000244.pub2

    authors: Gillespie WJ,Walenkamp GH

    更新日期:2010-03-17 00:00:00

  • Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants.

    abstract:BACKGROUND:Indomethacin is used as standard therapy to close a patent ductus arteriosus (PDA) but is associated with reduced blood flow to several organs. Ibuprofen, another cyclo-oxygenase inhibitor, may be as effective as indomethacin with fewer side effects. OBJECTIVES:To determine the efficacy and safety of ibupro...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003481.pub5

    authors: Ohlsson A,Walia R,Shah SS

    更新日期:2013-04-30 00:00:00

  • Preoperative bathing or showering with skin antiseptics to prevent surgical site infection.

    abstract:BACKGROUND:Surgical site infections (SSIs) are wound infections that occur after invasive (surgical) procedures. Preoperative bathing or showering with an antiseptic skin wash product is a well-accepted procedure for reducing skin bacteria (microflora). It is less clear whether reducing skin microflora leads to a lower...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004985.pub4

    authors: Webster J,Osborne S

    更新日期:2012-09-12 00:00:00

  • Surgery for cervical radiculopathy or myelopathy.

    abstract:BACKGROUND:Cervical spondylosis causes pain and disability by compressing the spinal cord or roots. Surgery to relieve the compression may reduce the pain and disability, but is associated with a small but definite risk. . OBJECTIVES:To determine whether: 1) surgical treatment of cervical radiculopathy or myelopathy i...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD001466.pub3

    authors: Nikolaidis I,Fouyas IP,Sandercock PA,Statham PF

    更新日期:2010-01-20 00:00:00

  • Delayed antibiotics for respiratory infections.

    abstract:BACKGROUND:Concerns exist regarding antibiotic prescribing for acute respiratory tract infections (ARTIs) owing to adverse reactions, cost and antibacterial resistance. One strategy to reduce antibiotic prescribing is to provide prescriptions but to advise delay in the hope symptoms will resolve first. This is an updat...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004417.pub4

    authors: Spurling GK,Del Mar CB,Dooley L,Foxlee R,Farley R

    更新日期:2013-04-30 00:00:00

  • Antifibrinolytic drugs for acute traumatic injury.

    abstract:BACKGROUND:Uncontrolled bleeding is an important cause of death in trauma victims. Antifibrinolytic treatment has been shown to reduce blood loss following surgery and may also be effective in reducing blood loss following trauma. OBJECTIVES:To assess the effect of antifibrinolytic drugs in patients with acute traumat...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004896.pub4

    authors: Ker K,Roberts I,Shakur H,Coats TJ

    更新日期:2015-05-09 00:00:00

  • Prophylactic antibiotic therapy for chronic bronchitis.

    abstract:BACKGROUND:The use of prophylactic antibiotics to reduce the frequency and severity of acute exacerbations of chronic bronchitis is controversial. OBJECTIVES:To determine if prophylactic antibiotics reduce the frequency of exacerbations and/or days of disability in subjects with chronic bronchitis. SEARCH STRATEGY:We...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004105

    authors: Staykova T,Black PN,Chacko EE,Poole P

    更新日期:2003-01-01 00:00:00

  • Psychosocial interventions for preventing and treating depression in dialysis patients.

    abstract:BACKGROUND:People with end-stage kidney disease (ESKD) treated with dialysis are frequently affected by major depression. Dialysis patients have prioritised depression as a critically important clinical outcome in nephrology trials. Psychological and social support are potential treatments for depression, although a Co...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD004542.pub3

    authors: Natale P,Palmer SC,Ruospo M,Saglimbene VM,Rabindranath KS,Strippoli GF

    更新日期:2019-12-02 00:00:00

  • Therapeutic ultrasound for carpal tunnel syndrome.

    abstract:BACKGROUND:Therapeutic ultrasound may be offered to people experiencing mild to moderate symptoms of carpal tunnel syndrome (CTS). The effectiveness and duration of benefit of this non-surgical intervention remain unclear. OBJECTIVES:To review the effects of therapeutic ultrasound compared with no treatment, placebo o...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD009601.pub2

    authors: Page MJ,O'Connor D,Pitt V,Massy-Westropp N

    更新日期:2013-03-28 00:00:00

  • Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding.

    abstract:BACKGROUND:There is conflicting evidence regarding the clinical efficacy of proton pump inhibitors (PPI) initiated before endoscopy for upper gastrointestinal bleeding. OBJECTIVES:To systematically review evidence from randomised controlled trials (RCTs) of PPI treatment initiated before endoscopy for upper gastrointe...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005415.pub3

    authors: Sreedharan A,Martin J,Leontiadis GI,Dorward S,Howden CW,Forman D,Moayyedi P

    更新日期:2010-07-07 00:00:00

  • Educational, supportive and behavioural interventions to improve usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea.

    abstract:BACKGROUND:Although highly effective in the treatment of obstructive sleep apnoea (OSA), continuous positive airway pressure (CPAP) is not universally accepted by users. Educational, supportive and behavioural interventions may help people with OSA initiate and maintain regular and continued use of CPAP. OBJECTIVES:To...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD007736.pub3

    authors: Askland K,Wright L,Wozniak DR,Emmanuel T,Caston J,Smith I

    更新日期:2020-04-07 00:00:00

  • Blue-light filtering intraocular lenses (IOLs) for protecting macular health.

    abstract:BACKGROUND:An intraocular lens (IOL) is a synthetic lens that is surgically implanted within the eye following removal of the crystalline lens, during cataract surgery. While all modern IOLs attenuate the transmission of ultra-violet (UV) light, some IOLs, called blue-blocking or blue-light filtering IOLs, also reduce ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD011977.pub2

    authors: Downie LE,Busija L,Keller PR

    更新日期:2018-05-22 00:00:00

  • Benzodiazepines for delirium.

    abstract:BACKGROUND:Delirium occurs in 30% of hospitalised patients and is associated with prolonged hospital stay and increased morbidity and mortality. The results of uncontrolled studies have been unclear, with some suggesting that benzodiazepines may be useful in controlling non-alcohol related delirium. OBJECTIVES:To dete...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD006379.pub2

    authors: Lonergan E,Luxenberg J,Areosa Sastre A,Wyller TB

    更新日期:2009-01-21 00:00:00

  • Media-delivered cognitive behavioural therapy and behavioural therapy (self-help) for anxiety disorders in adults.

    abstract:BACKGROUND:Anxiety disorders are the most common mental health problems. They are chronic and unremitting. Effective treatments are available, but access to services is limited. Media-delivered behavioural and cognitive behavioural interventions (self-help) aim to deliver treatment with less input from professionals co...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005330.pub4

    authors: Mayo-Wilson E,Montgomery P

    更新日期:2013-09-09 00:00:00

  • Surgical treatment options for carpal tunnel syndrome.

    abstract:BACKGROUND:Carpal tunnel syndrome is a common disorder, for which several surgical treatment options are available. OBJECTIVES:To compare the efficacy of the various surgical techniques in relieving symptoms and promoting return to work and/or activities of daily living and to compare the occurrence of side-effects an...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003905.pub2

    authors: Scholten RJ,Gerritsen AA,Uitdehaag BM,van Geldere D,de Vet HC,Bouter LM

    更新日期:2004-10-18 00:00:00

  • EEG for children with complex febrile seizures.

    abstract:BACKGROUND:Febrile seizures can be classified as simple or complex. Complex febrile seizures are associated with fever that lasts longer than 15 minutes, occur more than once within 24 hours and are confined to one side of the child's body. It is common in some countries for doctors to recommend an electroencephalograp...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD009196.pub2

    authors: Shah PB,James S,Elayaraja S

    更新日期:2014-01-24 00:00:00