Ivermectin for onchocercal eye disease (river blindness).

Abstract:

BACKGROUND:It is believed that ivermectin (a microfilaricide) could prevent blindness due to onchocerciasis. However, when given to everyone in communities where onchocerciasis is common, the effects of ivermectin on lesions affecting the eye are uncertain and data on whether the drug prevents visual loss is unclear. OBJECTIVES:The aim of this review is to assess the effectiveness of ivermectin in preventing visual acuity and visual field loss in onchocercal eye disease. The secondary aim is to assess the effects of ivermectin on lesions affecting the eye in onchocerciasis. SEARCH STRATEGY:We searched the Cochrane Eyes and Vision Group specialised register, the Cochrane Controlled Trials Register - CENTRAL, MEDLINE, EMBASE, the reference lists of identified trials, the Science Citation Index and we contacted investigators, experts and pharmaceutical companies to identify additional trials. SELECTION CRITERIA:We included randomised controlled trials with at least one year follow up, comparing ivermectin at a dose of 150 micrograms per kilogram of body weight with either placebo or no treatment. Participants were people normally resident in endemic onchocercal communities with or without one or more characteristic signs of ocular onchocerciasis. DATA COLLECTION AND ANALYSIS:Two reviewers independently extracted data and assessed trial quality. Study authors were contacted for additional information. Trials varied in design and setting, so no meta-analysis was done. MAIN RESULTS:This review includes five trials with data from 3810 participants. All the trials compared ivermectin with placebo and were judged to be of moderate risk of bias in terms of methodological quality. No statistically significant difference was observed in any trial (reporting visual acuity outcome) between ivermectin and placebo groups for visual acuity loss. REVIEWER'S CONCLUSIONS:Questions about the effectiveness of ivermectin in preventing visual acuity loss have not been answered by best available evidence.

authors

Ejere H,Schwartz E,Wormald R

doi

10.1002/14651858.CD002219

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

CD002219

issue

1

issn

1469-493X

pii

CD002219

pub_type

杂志文章,评审
  • WITHDRAWN: Immunoglobulin treatment for respiratory syncytial virus infection.

    abstract:BACKGROUND:Respiratory syncytial virus (RSV) bronchiolitis and pneumonia hospitalise hundreds of thousands of infants every year. Treatment is largely supportive therapy, (for example, oxygen, fluids and occasionally mechanical ventilation). Ribavirin, an antiviral agent, is licensed for severe RSV infection, although ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD004883.pub3

    authors: Fuller HL,Del Mar CB

    更新日期:2010-09-08 00:00:00

  • Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Pulmonary rehabilitation has become a cornerstone in the management of patients with stable Chronic Obstructive Pulmonary Disease (COPD). Systematic reviews have shown large and important clinical effects of pulmonary rehabilitation in these patients. In unstable COPD patients who have suffered from an exace...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005305.pub2

    authors: Puhan M,Scharplatz M,Troosters T,Walters EH,Steurer J

    更新日期:2009-01-21 00:00:00

  • Push versus gravity for intermittent bolus gavage tube feeding of premature and low birth weight infants.

    abstract:BACKGROUND:Many small, sick and premature infants are unable to coordinate sucking, swallowing and breathing, and therefore, require gavage feeding. In gavage feeding, milk feeds are delivered through a tube passed via the nose or mouth into the stomach. Intermittent bolus milk feeds may be administered using a syringe...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD005249.pub2

    authors: Dawson JA,Summan R,Badawi N,Foster JP

    更新日期:2012-11-14 00:00:00

  • Intravesical electromotive drug administration for non-muscle invasive bladder cancer.

    abstract:BACKGROUND:Electromotive drug administration (EMDA) is the use of electrical current to improve the delivery of intravesical agents to reduce the risk of recurrence in people with non-muscle invasive bladder cancer (NMIBC). It is unclear how effective this is in comparison to other forms of intravesical therapy. OBJEC...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD011864.pub2

    authors: Jung JH,Gudeloglu A,Kiziloz H,Kuntz GM,Miller A,Konety BR,Dahm P

    更新日期:2017-09-12 00:00:00

  • Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants.

    abstract:BACKGROUND:Respiratory failure due to lung immaturity is a major cause of mortality in preterm infants. Although intermittent positive pressure ventilation (IPPV) saves lives, lung distortion during its use is associated with lung injury and chronic lung disease (CLD). Conventional IPPV is provided at 30-80 breaths per...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000104

    authors: Henderson-Smart DJ,Bhuta T,Cools F,Offringa M

    更新日期:2001-01-01 00:00:00

  • Ibuprofen with or without an antiemetic for acute migraine headaches in adults.

    abstract:BACKGROUND:Migraine is a common, disabling condition and a burden for the individual, health services and society. Many sufferers do not seek professional help, relying instead on over-the-counter analgesics. Co-therapy with an antiemetic should help to reduce symptoms commonly associated with migraine headaches. OBJE...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD008039.pub2

    authors: Rabbie R,Derry S,Moore RA,McQuay HJ

    更新日期:2010-10-06 00:00:00

  • Timing of hypertonic saline inhalation for cystic fibrosis.

    abstract:BACKGROUND:Inhalation of hypertonic saline improves sputum rheology, accelerates mucociliary clearance and improves clinical outcomes of people with cystic fibrosis. This is an update of a previously published Cochrane Review. OBJECTIVES:To determine whether the timing of hypertonic saline inhalation (in relation to a...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD008816.pub4

    authors: Elkins M,Dentice R

    更新日期:2020-02-28 00:00:00

  • Electric fans for reducing adverse health impacts in heatwaves.

    abstract:BACKGROUND:Heatwaves are hot weather events, which breach regional or national thresholds, that last for several days. They are likely to occur with increasing frequency in some parts of the world. The potential consequences were illustrated in Europe in August 2003 when there were an estimated 30,000 excess deaths due...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD009888.pub2

    authors: Gupta S,Carmichael C,Simpson C,Clarke MJ,Allen C,Gao Y,Chan EY,Murray V

    更新日期:2012-07-11 00:00:00

  • Prophylactic antibiotics for preventing early central venous catheter Gram positive infections in oncology patients.

    abstract:BACKGROUND:Long-term tunnelled central venous catheters (TCVC) are increasingly used in oncology patients. Despite guidelines on insertion, maintenance and use, infections remain an important complication. Most infections are caused by Gram-positive bacteria. Therefore antimicrobial prevention strategies aimed at these...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003295

    authors: van de Wetering MD,van Woensel JB

    更新日期:2003-01-01 00:00:00

  • Combination inhaled steroid and long-acting beta2-agonist versus tiotropium for chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Combination therapy (inhaled corticosteroids and long-acting beta2-agonists) and tiotropium are both used in the treatment of chronic obstructive pulmonary disease (COPD). There is uncertainty about the relative benefits and harms of these treatments. OBJECTIVES:To compare the relative effects of inhaled co...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007891.pub3

    authors: Welsh EJ,Cates CJ,Poole P

    更新日期:2013-05-31 00:00:00

  • Opioid antagonists with minimal sedation for opioid withdrawal.

    abstract:BACKGROUND:Managed withdrawal is a necessary step prior to drug-free treatment or as the end point of long-term substitution treatment. OBJECTIVES:To assess the effectiveness of opioid antagonists in combination with minimal sedation to manage opioid withdrawal. SEARCH STRATEGY:We searched the Cochrane Central Regist...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD002021.pub3

    authors: Gowing L,Ali R,White JM

    更新日期:2009-10-07 00:00:00

  • Re-feeding versus discarding gastric residuals to improve growth in preterm infants.

    abstract:BACKGROUND:Routine monitoring of gastric residuals in preterm infants on gavage feeds is a common practice in many neonatal intensive care units and is used to guide the initiation and advancement of feeds. No guidelines or consensus is available on whether to re-feed or discard the aspirated gastric residuals. Althoug...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD012940.pub2

    authors: Abiramalatha T,Thanigainathan S,Balakrishnan U

    更新日期:2019-07-08 00:00:00

  • Pharmacotherapy augmentation strategies in treatment-resistant anxiety disorders.

    abstract:BACKGROUND:A large proportion of patients with anxiety disorders fail to respond to first-line medication interventions, despite evidence of the effectiveness of these agents. OBJECTIVES:To assess the effects of medication versus placebo augmentation in the treatment of patients with anxiety disorders who have failed ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005473.pub2

    authors: Ipser JC,Carey P,Dhansay Y,Fakier N,Seedat S,Stein DJ

    更新日期:2006-10-18 00:00:00

  • Decongestants, antihistamines and nasal irrigation for acute sinusitis in children.

    abstract:BACKGROUND:The efficacy of decongestants, antihistamines and nasal irrigation in children with clinically diagnosed acute sinusitis has not been systematically evaluated. OBJECTIVES:To determine the efficacy of decongestants, antihistamines or nasal irrigation in improving symptoms of acute sinusitis in children. SEA...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007909.pub4

    authors: Shaikh N,Wald ER

    更新日期:2014-10-27 00:00:00

  • WITHDRAWN: Reduction versus abrupt cessation in smokers who want to quit.

    abstract:BACKGROUND:The standard way to stop smoking is to quit abruptly on a designated quit day. A number of smokers have tried unsuccessfully to quit this way. Reducing smoking before quitting could be an alternative approach to cessation. Before this method is adopted it is important to determine whether it is at least as s...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD008033.pub4

    authors: Lindson N,Aveyard P,Hughes JR

    更新日期:2019-10-01 00:00:00

  • Written and verbal information versus verbal information only for patients being discharged from acute hospital settings to home.

    abstract:BACKGROUND:It is becoming commonplace for patients to be discharged earlier from acute hospital settings to their own homes and be required to manage various aspects of their own care. This has increased the need for detailed information to be given to patients and/or significant others to enable them to effectively ma...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003716

    authors: Johnson A,Sandford J,Tyndall J

    更新日期:2003-01-01 00:00:00

  • WITHDRAWN: Day care for pre-school children.

    abstract:BACKGROUND:The debate about how, where and by whom young children should be looked after is one which has occupied much social policy and media attention in recent years. Mothers undertake most of the care of young children. Internationally, out-of-home day-care provision ranges widely. These different levels of provis...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000564.pub2

    authors: Zoritch B,Roberts I,Oakley A

    更新日期:2016-10-11 00:00:00

  • Vaccines for women to prevent neonatal tetanus.

    abstract:BACKGROUND:Tetanus is an acute, often fatal, disease caused by an exotoxin produced by Clostridium tetani. It occurs in newborn infants born to mothers who do not have sufficient circulating antibodies to protect the infant passively, by transplacental transfer. Prevention may be possible by the vaccination of pregnant...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD002959.pub3

    authors: Demicheli V,Barale A,Rivetti A

    更新日期:2013-05-31 00:00:00

  • Household interventions for preventing domestic lead exposure in children.

    abstract:BACKGROUND:Lead poisoning is associated with physical, cognitive and neurobehavioural impairment in children and trials have tested many household interventions to prevent lead exposure. This is an update of the original review by the same authors first published in 2008. OBJECTIVES:To determine the effectiveness of h...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006047.pub4

    authors: Yeoh B,Woolfenden S,Lanphear B,Ridley GF,Livingstone N,Jorgensen E

    更新日期:2014-12-15 00:00:00

  • Spinal cord stimulation for cancer-related pain in adults.

    abstract:BACKGROUND:This is an update of a review first published in The Cochrane Library in Issue 3, 2013. Cancer-related pain places a heavy burden on public health with related high expenditure. Severe pain is associated with a decreased quality of life in patients with cancer. A significant proportion of patients with cance...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD009389.pub3

    authors: Peng L,Min S,Zejun Z,Wei K,Bennett MI

    更新日期:2015-06-29 00:00:00

  • Substitution treatment of injecting opioid users for prevention of HIV infection.

    abstract:BACKGROUND:Injecting drug users are vulnerable to infection with HIV and other blood borne viruses as a result of collective use of injecting equipment as well as sexual behaviour. OBJECTIVES:To assess the effect of oral substitution treatment for opioid dependent injecting drug users on rates of HIV infections, and h...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004145.pub2

    authors: Gowing L,Farrell M,Bornemann R,Ali R

    更新日期:2004-10-18 00:00:00

  • Alternative positions for the baby at birth before clamping the umbilical cord.

    abstract:BACKGROUND:The third stage of labour is from birth of the baby until delivery of the placenta. Clamping the umbilical cord is one component of active management of the third stage. Deferring cord clamping allows blood flow between the baby and the placenta to continue; net transfer to the baby is called placental trans...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007555.pub2

    authors: Airey RJ,Farrar D,Duley L

    更新日期:2010-10-06 00:00:00

  • Augmentation of cognitive and behavioural therapies (CBT) with d-cycloserine for anxiety and related disorders.

    abstract:BACKGROUND:A significant number of patients who suffer with anxiety and related disorders (that is post-traumatic stress disorder (PTSD), social anxiety disorder (SAnD), panic disorder with or without agoraphobia (PD), specific phobia (SPh) and obsessive compulsive disorder (OCD)) fail to respond optimally to first-lin...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007803.pub2

    authors: Ori R,Amos T,Bergman H,Soares-Weiser K,Ipser JC,Stein DJ

    更新日期:2015-05-10 00:00:00

  • Prophylactic antibiotics for penetrating abdominal trauma.

    abstract:BACKGROUND:Penetrating abdominal trauma occurs when the peritoneal cavity is breached. Routine laparotomy for penetrating abdominal injuries began in the 1800s, with antibiotics first being used in World War II to combat septic complications associated with these injuries. This practice was marked with a reduction in s...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007370.pub2

    authors: Brand M,Goosen J,Grieve A

    更新日期:2009-10-07 00:00:00

  • Length of hospitalisation for people with severe mental illness.

    abstract:BACKGROUND:In high-income countries, over the last three decades, the length of hospital stays for people with serious mental illness has reduced drastically although considerable variation remains. In lower-income countries this variation may be greater. Some argue that reduction in hospital stay leads to 'revolving d...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000384.pub3

    authors: Babalola O,Gormez V,Alwan NA,Johnstone P,Sampson S

    更新日期:2014-01-30 00:00:00

  • Hepatitis B vaccination during pregnancy for preventing infant infection.

    abstract:BACKGROUND:Infant hepatitis B infection increases the risk of chronic infection, cirrhosis or liver cancer (hepatocellular carcinoma) in the adult. Perinatal transmission is a common route of infection. OBJECTIVES:To assess the effectiveness and adverse effects of hepatitis B vaccine administered to pregnant women for...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007879.pub3

    authors: Sangkomkamhang US,Lumbiganon P,Laopaiboon M

    更新日期:2014-11-11 00:00:00

  • Laryngeal mask airway versus endotracheal tube for percutaneous dilatational tracheostomy in critically ill adults.

    abstract:BACKGROUND:Percutaneous dilatational tracheostomy (PDT) is one of the most common bedside surgical procedures performed in critically ill adults, on intensive care units (ICUs), who require long-term ventilation. PDT is associated with relevant life-threatening complications: Cuff rupture or accidental extubation may l...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD009901.pub3

    authors: Strametz R,Bergold MN,Weberschock T

    更新日期:2018-11-15 00:00:00

  • Interventions for relieving the pain and discomfort of screening mammography.

    abstract:BACKGROUND:The pain of mammography is recognised as a significant deterrent for women considering this examination, and may affect participation in breast screening. OBJECTIVES:To review interventions to reduce or relieve the pain and discomfort of screening mammography. SEARCH STRATEGY:For this update, the Cochrane ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD002942.pub2

    authors: Miller D,Livingstone V,Herbison P

    更新日期:2008-01-23 00:00:00

  • Intranasal steroids for acute sinusitis.

    abstract:BACKGROUND:Acute sinusitis is a common reason for primary care visits. It causes significant symptoms and often results in time off work and school. OBJECTIVES:We examined whether intranasal corticosteroids (INCS) are effective in relieving symptoms of acute sinusitis. SEARCH STRATEGY:We searched the Cochrane Central...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005149.pub3

    authors: Zalmanovici A,Yaphe J

    更新日期:2009-10-07 00:00:00

  • Extra fluids for breastfeeding mothers for increasing milk production.

    abstract:BACKGROUND:Breastfeeding is known to be the biological norm. Despite this, many women wean their babies because of perceived insufficient breast milk production. Mothers are sometimes advised to increase their fluid intake in the hope that this could improve breast milk production. The effect of extra fluid on human br...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD008758.pub2

    authors: Ndikom CM,Fawole B,Ilesanmi RE

    更新日期:2014-06-11 00:00:00