Drugs for treating neurocysticercosis (tapeworm infection of the brain).

Abstract:

BACKGROUND:Anthelminthic drugs may shrink brain cysts in neurocysticercosis, but can also cause severe adverse effects. OBJECTIVES:The objective of this review was to assess the effects of drug treatment in human neurocysticercosis in relation to survival, cyst persistence, subsequent seizures and hydrocephalus. SEARCH STRATEGY:We searched the Cochrane Infectious Diseases Group trials register and Medline. We contacted researchers and experts in the field and drug manufacturers. SELECTION CRITERIA:Randomised or quasi-randomised trials comparing a cysticidal drug with a placebo or a control group receiving symptomatic therapy, in patients with neurocystercosis. DATA COLLECTION AND ANALYSIS:Assessment of trial quality and data extraction was done independently by two reviewers. MAIN RESULTS:Four studies involving 305 people met the inclusion criteria. None reported on withdrawal of anticonvulsant therapy, headache relief, disability or death as outcomes. A difference just approaching significance was detected between cysticidal therapy and placebo in relation to cyst persistence up to six months (relative risk 0.83, 95% confidence interval 0.70 to 0.99). Two trials reported on seizures after one to two years follow-up and found no difference (relative risk 0.95, 95% 0.59 to 1.51). There was no difference detected for hydrocephalus (relative risk 2.19, 95% confidence interval 0.29 to 16.55). REVIEWER'S CONCLUSIONS:There is insufficient evidence to assess whether cysticidal therapy in neurocysticerosis is associated with beneficial effects.

authors

Salinas R,Prasad K

doi

10.1002/14651858.CD000215

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

CD000215

issue

2

issn

1469-493X

pii

CD000215

pub_type

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