Interventions for cough in cancer.


BACKGROUND:Cough is a common symptom in patients with malignancies, especially in patients with lung cancer. Cough is not well controlled in clinical practice and clinicians have few management options to treat it. OBJECTIVES:The primary objective of this review was to determine the effectiveness of interventions, both pharmacological and non-pharmacological, (other than chemotherapy and external beam radiotherapy) in the management of cough in malignant disease (especially in lung cancer). SEARCH STRATEGY:Databases searched included: The Cochrane Central Register of Controlled Trials (CENTRAL) and the Database of Abstracts of Reviews of Effectiveness (DARE) (The Cochrane Library issue 4, 2009); MEDLINE (1966 to May 2010); EMBASE (1980 to May 2010); CINAHL (1980 to May 2010); PSYCHINFO (1980 to May 2010); AMED (1985 to May 2010); SIGLE (1980 to May 2010); British Nursing Index (1985 to May 2010); CancerLit (1975 to May 2010). We searched for cough suppressants, antitussives and other drugs with antitussive activity as well as non-pharmacological interventions (see Appendices 1-4 for search terms). SELECTION CRITERIA:We selected randomised controlled trials (RCTs) and clinical trials (quasi-experimental trials, and trials where there is a comparison group but no mention of randomisation) in participants with primary or metastatic lung cancer or other cancers. DATA COLLECTION AND ANALYSIS:Two review authors independently assessed titles and abstracts of all studies, and extracted data from all selected studies before reaching consensus. A third review author arbitrated with any disagreement. Meta-analysis was not attempted due to the heterogeneity of studies. MAIN RESULTS:Seventeen studies met inclusion criteria and examined either brachytherapy, laser or photodynamic therapy (eight studies) or a variety of pharmacological therapies (nine studies). Overall, there was absence of credible evidence and the majority of studies were of low methodological quality and high risk of bias. Brachytherapy seemed to improve cough in a variety of doses in selected participants, suggesting that possibly the lowest effective dose should be used to minimise side effects. Photodynamic therapy was examined in one study, and while improvements in cough were observed, its role over other therapies for cough is unclear. Some indication of effect was observed with morphine, codeine, dihydrocodeine, levodropropizine, sodium cromoglycate and butamirate citrate linctus (cough syrup), although all studies had significant risk of bias. AUTHORS' CONCLUSIONS:No practice recommendations could be drawn from this review. There is an urgent need to increase the number and quality of studies evaluating the effects of interventions in the management of cough in cancer.


Molassiotis A,Bailey C,Caress A,Brunton L,Smith J




Has Abstract


2010-09-08 00:00:00








  • Vitamin E supplementation in people with cystic fibrosis.

    abstract:BACKGROUND:People with cystic fibrosis are at an increased risk of fat-soluble vitamin deficiency, including vitamin E. Vitamin E deficiency can cause a host of conditions such as haemolytic anaemia, cerebellar ataxia and cognitive difficulties. Vitamin E supplementation is widely recommended for people with cystic fib...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析


    authors: Okebukola PO,Kansra S,Barrett J

    更新日期:2020-09-06 00:00:00

  • Physical activity programs for promoting bone mineralization and growth in preterm infants.

    abstract:BACKGROUND:Lack of physical stimulation may contribute to metabolic bone disease of preterm infants, resulting in poor bone mineralization and growth. Physical activity programs combined with adequate nutrition might help to promote bone mineralization and growth. OBJECTIVES:The primary objective was to assess whether...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Schulzke SM,Kaempfen S,Trachsel D,Patole SK

    更新日期:2014-04-22 00:00:00

  • Combined spinal-epidural versus spinal anaesthesia for caesarean section.

    abstract:BACKGROUND:Single-shot spinal anaesthesia (SSS) and combined spinal-epidural (CSE) anaesthesia are both commonly used for caesarean section anaesthesia. Spinals offer technical simplicity and rapid onset of nerve blockade which can be associated with hypotension. CSE anaesthesia allows for more gradual onset and also p...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Simmons SW,Dennis AT,Cyna AM,Richardson MG,Bright MR

    更新日期:2019-10-11 00:00:00

  • Bypass surgery for chronic lower limb ischaemia.

    abstract:BACKGROUND:Bypass surgery is one of the mainstay treatments for patients with critical lower limb ischaemia (CLI). This is the second update of the review first published in 2000. OBJECTIVES:To assess the effects of bypass surgery in patients with chronic lower limb ischaemia. SEARCH METHODS:For this update, the Coch...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Antoniou GA,Georgiadis GS,Antoniou SA,Makar RR,Smout JD,Torella F

    更新日期:2017-04-03 00:00:00

  • Day centres for severe mental illness.

    abstract:BACKGROUND:The number of people with severe mental illness who receive treatment whilst living at home has increased greatly over the last 30 years. Day centres and day hospitals frequently supplement this treatment. OBJECTIVES:To determine the effects of non-medical day centre care for people with severe mental illne...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Catty J,Burns T,Comas A

    更新日期:2001-01-01 00:00:00

  • Support surfaces for treating pressure ulcers.

    abstract:BACKGROUND:Pressure ulcers are treated by reducing pressure on the areas of damaged skin. Special support surfaces (including beds, mattresses and cushions) designed to redistribute pressure, are widely used as treatments. The relative effects of different support surfaces are unclear. OBJECTIVES:To assess the effects...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: McInnes E,Dumville JC,Jammali-Blasi A,Bell-Syer SE

    更新日期:2011-12-07 00:00:00

  • Hypertonic salt solution for peri-operative fluid management.

    abstract:BACKGROUND:Fluid excess may place people undergoing surgery at risk for various complications. Hypertonic salt solution (HS) maintains intravascular volume with less intravenous fluid than isotonic salt (IS) solutions, but may increase serum sodium. This review was published in 2010 and updated in 2016. OBJECTIVES:To ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Shrum B,Church B,McArthur E,Burns KE,Znajda T,McAlister V

    更新日期:2016-06-06 00:00:00

  • Risk scoring for the primary prevention of cardiovascular disease.

    abstract:BACKGROUND:The current paradigm for cardiovascular disease (CVD) emphasises absolute risk assessment to guide treatment decisions in primary prevention. Although the derivation and validation of multivariable risk assessment tools, or CVD risk scores, have attracted considerable attention, their effect on clinical outc...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Karmali KN,Persell SD,Perel P,Lloyd-Jones DM,Berendsen MA,Huffman MD

    更新日期:2017-03-14 00:00:00

  • Interventions for improving modifiable risk factor control in the secondary prevention of stroke.

    abstract:BACKGROUND:People with stroke or transient ischaemic attack (TIA) are at increased risk of future stroke and other cardiovascular events. Stroke services need to be configured to maximise the adoption of evidence-based strategies for secondary stroke prevention. Smoking-related interventions were examined in a separate...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Bridgwood B,Lager KE,Mistri AK,Khunti K,Wilson AD,Modi P

    更新日期:2018-05-07 00:00:00

  • Stabilisation splint therapy for temporomandibular pain dysfunction syndrome.

    abstract:BACKGROUND:Pain dysfunction syndrome (PDS) is the most common temporomandibular disorder (TMD). There are many synonyms for this condition including facial arthromylagia, TMJ dysfunction syndrome, myofacial pain dysfunction syndrome, craniomandibular dysfunction and myofacial pain dysfunction. The aetiology of PDS is m...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Al-Ani MZ,Davies SJ,Gray RJ,Sloan P,Glenny AM

    更新日期:2004-01-01 00:00:00

  • Fewer-than-four ports versus four ports for laparoscopic cholecystectomy.

    abstract:BACKGROUND:Traditionally, laparoscopic cholecystectomy is performed using two 10-mm ports and two 5-mm ports. Recently, a reduction in the number of ports has been suggested as a modification of the standard technique with a view to decreasing pain and improving cosmesis. The safety and effectiveness of using fewer-tha...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Gurusamy KS,Vaughan J,Rossi M,Davidson BR

    更新日期:2014-02-20 00:00:00

  • Food supplementation for improving the physical and psychosocial health of socio-economically disadvantaged children aged three months to five years.

    abstract:BACKGROUND:Undernutrition contributes to five million deaths of children under five each year. Furthermore, throughout the life cycle, undernutrition contributes to increased risk of infection, poor cognitive functioning, chronic disease, and mortality. It is thus important for decision-makers to have evidence about th...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Kristjansson E,Francis DK,Liberato S,Benkhalti Jandu M,Welch V,Batal M,Greenhalgh T,Rader T,Noonan E,Shea B,Janzen L,Wells GA,Petticrew M

    更新日期:2015-03-05 00:00:00

  • Vitamin K supplementation for cystic fibrosis.

    abstract:BACKGROUND:Malabsorption and deficiency of fat-soluble vitamins K may occur in cystic fibrosis, a genetic disorder affecting multiple organs. Vitamin K is known to play an important role in both blood coagulation and bone formation, hence the role of supplementation of vitamin K in this category needs to be reviewed. T...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章


    authors: Jagannath VA,Thaker V,Chang AB,Price AI

    更新日期:2020-06-04 00:00:00

  • Interventions to facilitate return to work in adults with adjustment disorders.

    abstract:BACKGROUND:Adjustment disorders are a frequent cause of sick leave and various interventions have been developed to expedite the return to work (RTW) of individuals on sick leave due to adjustment disorders. OBJECTIVES:To assess the effects of interventions facilitating RTW for workers with acute or chronic adjustment...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Arends I,Bruinvels DJ,Rebergen DS,Nieuwenhuijsen K,Madan I,Neumeyer-Gromen A,Bültmann U,Verbeek JH

    更新日期:2012-12-12 00:00:00

  • Normal saline versus lower-chloride solutions for kidney transplantation.

    abstract:BACKGROUND:The ideal intravenous fluid for kidney transplantation has not been defined, despite the common use of normal saline during the peri-operative period. The high chloride content of normal saline is associated with an increased risk of hyperchloraemic metabolic acidosis, which may in turn increase the risk of ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Wan S,Roberts MA,Mount P

    更新日期:2016-08-09 00:00:00

  • Pharmacotherapy for trichotillomania.

    abstract:BACKGROUND:Trichotillomania (TTM) (hair-pulling disorder) is a prevalent and disabling disorder characterised by recurrent hair-pulling. The effect of medication on trichotillomania has not been systematically evaluated. OBJECTIVES:To assess the effects of medication for trichotillomania in adults compared with placeb...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Rothbart R,Amos T,Siegfried N,Ipser JC,Fineberg N,Chamberlain SR,Stein DJ

    更新日期:2013-11-08 00:00:00

  • Antenatal lower genital tract infection screening and treatment programs for preventing preterm delivery.

    abstract:BACKGROUND:Preterm birth is birth before 37 weeks' gestation. Genital tract infection is one of the causes of preterm birth. Infection screening during pregnancy has been used to reduce preterm birth. However, infection screening may have some adverse effects, e.g. increased antibiotic drug resistance, increased costs ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Swadpanich U,Lumbiganon P,Prasertcharoensook W,Laopaiboon M

    更新日期:2008-04-16 00:00:00

  • Miniport versus standard ports for laparoscopic cholecystectomy.

    abstract:BACKGROUND:In conventional (standard) laparoscopic cholecystectomy, four abdominal ports (two of 10 mm diameter and two of 5 mm diameter) are used. Recently, use of smaller ports have been reported. OBJECTIVES:To assess the benefits and harms of miniport (defined as ports smaller than conventional ports) laparoscopic ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Gurusamy KS,Samraj K,Ramamoorthy R,Farouk M,Fusai G,Davidson BR

    更新日期:2010-03-17 00:00:00

  • WITHDRAWN: Heparin for the prevention of venous thromboembolism in general medical patients (excluding stroke and myocardial infarction).

    abstract:BACKGROUND:Venous thromboembolic disease has been extensively studied in surgical patients. The benefit of thromboprophylaxis is now generally accepted, but it is medical patients who make up the greater proportion of the hospital population. Medical patients differ from surgical patients with regard to their health an...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Alikhan R,Cohen AT

    更新日期:2010-02-17 00:00:00

  • Intermittent inhaled corticosteroid therapy versus placebo for persistent asthma in children and adults.

    abstract:BACKGROUND:International guidelines advocate using daily inhaled corticosteroids (ICS) in the management of children and adults with persistent asthma. However, in real world clinical settings, these medicines are often used at irregular intervals by patients. Recent evidence suggests that the use of intermittent ICS, ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Chong J,Haran C,Chauhan BF,Asher I

    更新日期:2015-07-22 00:00:00

  • Developmental care for promoting development and preventing morbidity in preterm infants.

    abstract:BACKGROUND:Preterm infants experience a range of morbidity related to the immaturity of their organ systems and to concurrent disease states. An unfavourable environment in the neonatal intensive care unit (NICU) may compound this morbidity. Modification of the environment could minimize the iatrogenic effects. Develop...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Symington A,Pinelli J

    更新日期:2000-01-01 00:00:00

  • Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer.

    abstract:BACKGROUND:Epithelial ovarian cancer presents at an advanced stage in the majority of patients. These women require chemotherapy and surgery for optimal treatment. Conventional treatment is to perform surgery first and then give chemotherapy. However, it is important to determine whether there is any advantage to using...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Morrison J,Swanton A,Collins S,Kehoe S

    更新日期:2007-10-17 00:00:00

  • Adverse events in people taking macrolide antibiotics versus placebo for any indication.

    abstract:BACKGROUND:Macrolide antibiotics (macrolides) are among the most commonly prescribed antibiotics worldwide and are used for a wide range of infections. However, macrolides also expose people to the risk of adverse events. The current understanding of adverse events is mostly derived from observational studies, which ar...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析


    authors: Hansen MP,Scott AM,McCullough A,Thorning S,Aronson JK,Beller EM,Glasziou PP,Hoffmann TC,Clark J,Del Mar CB

    更新日期:2019-01-18 00:00:00

  • Baclofen for alcohol withdrawal.

    abstract:BACKGROUND:Baclofen shows potential for rapidly reducing symptoms of severe alcohol withdrawal syndrome (AWS) in people with alcoholism. Treatment with baclofen is easy to manage and rarely produces euphoria or other pleasant effects, or craving for the drug. This is an updated version of the original Cochrane Review p...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Liu J,Wang LN

    更新日期:2017-08-20 00:00:00

  • Electromagnetic field stimulation for treating delayed union or non-union of long bone fractures in adults.

    abstract:BACKGROUND:Delayed union and non-union of fractures are a considerable cause of morbidity to patients. Laboratory studies have shown that electromagnetic fields can stimulate the formation of new bone, indicating a potential role for electromagnetic stimulation in the treatment of fractures that have failed to heal. O...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Griffin XL,Costa ML,Parsons N,Smith N

    更新日期:2011-04-13 00:00:00

  • Bezafibrate for primary biliary cirrhosis.

    abstract:BACKGROUND:Treatment of primary biliary cirrhosis is complicated. There are studies suggesting that bezafibrate, alone or in combination with ursodeoxycholic acid (UDCA), is effective in the treatment of primary biliary cirrhosis, but no systematic review has summarised the evidence yet. OBJECTIVES:To assess the benef...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Rudic JS,Poropat G,Krstic MN,Bjelakovic G,Gluud C

    更新日期:2012-01-18 00:00:00

  • Tailored interventions to overcome identified barriers to change: effects on professional practice and health care outcomes.

    abstract:BACKGROUND:Strategies to implement change in health professional performance have variable impact. A potential explanation is that the barriers to implementation are different in different settings and at different times. Change may be more likely if the strategies were specifically chosen to address the identified bar...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Shaw B,Cheater F,Baker R,Gillies C,Hearnshaw H,Flottorp S,Robertson N

    更新日期:2005-07-20 00:00:00

  • Non-steroidal anti-inflammatory drugs and perioperative bleeding in paediatric tonsillectomy.

    abstract:BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAIDs) are used for pain relief following tonsillectomy in children. However, as they inhibit platelet aggregation and prolong bleeding time, they could cause increased perioperative bleeding. The overall risk remains unclear. OBJECTIVES:The primary objective of this r...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Cardwell M,Siviter G,Smith A

    更新日期:2005-04-18 00:00:00

  • Video calls for reducing social isolation and loneliness in older people: a rapid review.

    abstract:BACKGROUND:The current COVID-19 pandemic has been identified as a possible trigger for increases in loneliness and social isolation among older people due to the restrictions on movement that many countries have put in place. Loneliness and social isolation are consistently identified as risk factors for poor mental an...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析


    authors: Noone C,McSharry J,Smalle M,Burns A,Dwan K,Devane D,Morrissey EC

    更新日期:2020-05-21 00:00:00

  • Strategies for improving the acceptability and acceptance of the copper intrauterine device.

    abstract:BACKGROUND:Intrauterine devices (IUDs) are highly effective and are the most widely used reversible contraceptive method in the world. However, in developed countries IUDs are among the least common methods of contraception used. We evaluated the effect of interventions to increase uptake of the copper IUD, a long-acti...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Arrowsmith ME,Aicken CR,Saxena S,Majeed A

    更新日期:2012-03-14 00:00:00