Recent developments in Alzheimer's disease therapeutics.

abstract：BACKGROUND:Vaccination has reduced the global incidence of measles to the lowest rates in history. However, local interruption of measles virus transmission requires sustained high levels of population immunity that can be challenging to achieve and maintain. The herd immunity threshold for measles is typically stipula...

journal_title：BMC medicine

authors： Funk S,Knapp JK,Lebo E,Reef SE,Dabbagh AJ,Kretsinger K,Jit M,Edmunds WJ,Strebel PM

更新日期：2019-09-25 00:00:00

abstract：:In the past decade, numerous studies have made connections between sequence variants in human genomes and predisposition to complex diseases. However, most of these variants lie outside of the charted regions of the human genome whose function we understand; that is, the sequences that encode proteins. Consequently, t...

journal_title：BMC medicine

authors： St Laurent G,Vyatkin Y,Kapranov P

更新日期：2014-06-12 00:00:00

abstract：BACKGROUND:Medical apps are widely available, increasingly used by patients and clinicians, and are being actively promoted for use in routine care. However, there is little systematic evidence exploring possible risks associated with apps intended for patient use. Because self-medication errors are a recognized source...

journal_title：BMC medicine

authors： Huckvale K,Adomaviciute S,Prieto JT,Leow MK,Car J

更新日期：2015-05-06 00:00:00

abstract：BACKGROUND:Functional somatic symptoms and disorders are common and complex phenomena involving both bodily and brain processes. They pose major challenges across medical specialties. These disorders are common and have significant impacts on patients' quality of life and healthcare costs. MAIN BODY:We outline five pr...

journal_title：BMC medicine

authors： Burton C,Fink P,Henningsen P,Löwe B,Rief W,EURONET-SOMA Group.

更新日期：2020-03-03 00:00:00

abstract：BACKGROUND:Pendred syndrome, an autosomal-recessive disorder characterized by deafness and goiter, is caused by a mutation of SLC26A4, which codes for the anion exchanger pendrin. We investigated the relationship between pendrin expression and deafness using mice that have (Slc26a4+/+ or Slc26a4+/-) or lack (Slc26a4-/-...

journal_title：BMC medicine

authors： Jabba SV,Oelke A,Singh R,Maganti RJ,Fleming S,Wall SM,Everett LA,Green ED,Wangemann P

更新日期：2006-12-22 00:00:00

abstract：BACKGROUND:Pneumonia in people with dementia has been associated with severe discomfort. We sought to assess the effectiveness of a practice guideline for optimal symptom relief for nursing home residents with dementia and pneumonia. METHODS:A single-blind, multicenter, cluster randomized controlled trial was conducte...

journal_title：BMC medicine

authors： van der Maaden T,de Vet HC,Achterberg WP,Boersma F,Schols JM,Mehr DR,Galindo-Garre F,Hertogh CM,Koopmans RT,van der Steen JT

更新日期：2016-08-11 00:00:00

abstract：:Although prostate-specific antigen (PSA) screening has improved the detection of prostate cancer, allowing for stage migration to less advanced disease, the precise mortality benefit of early detection is unclear. This is in part due to a discrepancy between the two large randomized controlled trials comparing PSA scr...

journal_title：BMC medicine

authors： Kim EH,Andriole GL

更新日期：2015-03-24 00:00:00

abstract：:Although global efforts in the past decade have halved the number of deaths due to malaria, there are still an estimated 219 million cases of malaria a year, causing more than half a million deaths. In this forum article, we asked experts working in malaria research and control to discuss the ways in which malaria mig...

journal_title：BMC medicine

authors： Tanner M,Greenwood B,Whitty CJ,Ansah EK,Price RN,Dondorp AM,von Seidlein L,Baird JK,Beeson JG,Fowkes FJ,Hemingway J,Marsh K,Osier F

更新日期：2015-07-25 00:00:00

abstract：:Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Ischemia is the leading cause of AKI, and short of supportive measures, no currently available therapy can effectively treat or prevent ischemic AKI. This paper discusses recent developments in the understanding of ischemic A...

journal_title：BMC medicine

authors： Munshi R,Hsu C,Himmelfarb J

更新日期：2011-02-02 00:00:00

abstract：:The approval of sorafenib and active development of many other molecularly targeted agents in hepatocellular carcinoma (HCC) have presented a challenge to understand the mechanism of action of sorafenib and identify predictive biomarkers to select patients more likely to benefit from sorafenib. The preclinical study b...

journal_title：BMC medicine

authors： Zhu AX

更新日期：2009-08-24 00:00:00

abstract：BACKGROUND:When an outbreak of a novel pathogen occurs, some of the most pressing questions from a public-health point of view relate to its transmissibility, and the probabilities of different clinical outcomes following infection, to allow an informed response. Estimates of these quantities are often based on househo...

journal_title：BMC medicine

authors： House T,Inglis N,Ross JV,Wilson F,Suleman S,Edeghere O,Smith G,Olowokure B,Keeling MJ

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:This study was conducted to assess whether patient-reported outcomes (PROs) differ by the underlying diagnosis (rheumatoid arthritis (RA)/inflammatory arthritis, osteoarthritis (OA), avascular necrosis of bone (AVN), other) in patients undergoing primary total hip arthroplasty (THA). METHODS:We used prospec...

journal_title：BMC medicine

authors： Singh JA,Lewallen DG

更新日期：2013-09-24 00:00:00

abstract：BACKGROUND:Polymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism. However, knowledge on antigenic diversity of key antigens, the im...

journal_title：BMC medicine

authors： Terheggen U,Drew DR,Hodder AN,Cross NJ,Mugyenyi CK,Barry AE,Anders RF,Dutta S,Osier FH,Elliott SR,Senn N,Stanisic DI,Marsh K,Siba PM,Mueller I,Richards JS,Beeson JG

更新日期：2014-10-16 00:00:00

abstract：BACKGROUND:Comorbidity between depressive and anxiety disorders is common. A hypothesis of the network perspective on psychopathology is that comorbidity arises due to the interplay of symptoms shared by both disorders, with overlapping symptoms acting as so-called bridges, funneling symptom activation between symptom ...

journal_title：BMC medicine

authors： Groen RN,Ryan O,Wigman JTW,Riese H,Penninx BWJH,Giltay EJ,Wichers M,Hartman CA

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:Castration-resistant prostate cancer (CRPC) is associated with wide variations in survival. Recent studies of whole blood mRNA expression-based biomarkers strongly predicted survival but the genes used in these biomarker models were non-overlapping and their relationship was unknown. We developed a biomarker...

journal_title：BMC medicine

authors： Wang L,Gong Y,Chippada-Venkata U,Heck MM,Retz M,Nawroth R,Galsky M,Tsao CK,Schadt E,de Bono J,Olmos D,Zhu J,Oh WK

更新日期：2015-08-21 00:00:00

abstract：BACKGROUND:Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study was to examine the association of red meat, processed meat, and poultry consumption with the risk of early d...

journal_title：BMC medicine

authors： Rohrmann S,Overvad K,Bueno-de-Mesquita HB,Jakobsen MU,Egeberg R,Tjønneland A,Nailler L,Boutron-Ruault MC,Clavel-Chapelon F,Krogh V,Palli D,Panico S,Tumino R,Ricceri F,Bergmann MM,Boeing H,Li K,Kaaks R,Khaw KT,Wareha

更新日期：2013-03-07 00:00:00

abstract：BACKGROUND:The term 'lower value services' concerns healthcare that is of little or no value to the patient and consequently should not be provided routinely, or not be provided at all. De-adoption of lower value care may occur through explicit recommendations in clinical guidelines. The present study aimed to generate...

journal_title：BMC medicine

authors： Wammes JJ,van den Akker-van Marle ME,Verkerk EW,van Dulmen SA,Westert GP,van Asselt AD,Kool RB

更新日期：2016-11-25 00:00:00

abstract：BACKGROUND:To help design population-based pediatric palliative care services, we sought to describe the hospital care received in the last year of life by children and young adults who died. We also determined the proportion with complex chronic conditions (CCCs) and tested whether the use of hospital services increas...

journal_title：BMC medicine

authors： Feudtner C,DiGiuseppe DL,Neff JM

更新日期：2003-12-23 00:00:00

abstract：BACKGROUND:Network meta-analyses using individual participant data (IPD-NMAs) have been increasingly used to compare the effects of multiple interventions. Although there have been many studies on statistical methods for IPD-NMAs, it is unclear whether there are statistical defects in published IPD-NMAs and whether the...

journal_title：BMC medicine

authors： Gao Y,Shi S,Li M,Luo X,Liu M,Yang K,Zhang J,Song F,Tian J

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Health-related research funders, regulators and journals expect that de-identified individual-level health data be shared widely, with as few restrictions as possible; yet, in reality, the volume of shared data remains low. MAIN BODY:Health researchers and other data producers are reluctant to share their d...

journal_title：BMC medicine

authors： Waithira N,Mutinda B,Cheah PY

更新日期：2019-04-17 00:00:00

abstract：BACKGROUND:The benefit-risk balance of vaccines is regularly debated by the public, but the utility of media monitoring for regulatory bodies is unclear. A media monitoring study was conducted at the European Medicines Agency (EMA) concerning human papillomavirus (HPV) vaccines during a European Union (EU) referral pro...

journal_title：BMC medicine

authors： Bahri P,Fogd J,Morales D,Kurz X,ADVANCE consortium.

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Pancreatic cancer (PaC) remains extremely lethal worldwide even after resection. PaC resection rates are low, making prognostic studies in resected PaC difficult. This large international population-based study aimed at exploring factors associated with survival in patients with resected TNM stage I-II PaC r...

journal_title：BMC medicine

authors： Huang L,Balavarca Y,van der Geest L,Lemmens V,Van Eycken L,De Schutter H,Johannesen TB,Zadnik V,Primic-Žakelj M,Mägi M,Grützmann R,Besselink MG,Schrotz-King P,Brenner H,Jansen L

更新日期：2019-03-25 00:00:00

abstract：BACKGROUND:Wild type 2 poliovirus was last observed in 1999. The Sabin-strain oral polio vaccine type 2 (OPV2) was critical to eradication, but it is known to revert to a neurovirulent phenotype, causing vaccine-associated paralytic poliomyelitis. OPV2 is also transmissible and can establish circulating lineages, calle...

journal_title：BMC medicine

authors： McCarthy KA,Chabot-Couture G,Famulare M,Lyons HM,Mercer LD

更新日期：2017-10-04 00:00:00

abstract：BACKGROUND:Mucin 4 (MUC4) plays an important role in protecting and lubricating the epithelial surface of reproductive tracts, but its role in the pathogenesis of endometriosis is largely unknown. METHODS:To correlate MUC4 polymorphism with the risk of endometriosis and endometriosis-related infertility, we performed ...

journal_title：BMC medicine

authors： Chang CY,Chang HW,Chen CM,Lin CY,Chen CP,Lai CH,Lin WY,Liu HP,Sheu JJ,Tsai FJ

更新日期：2011-02-24 00:00:00

abstract：BACKGROUND:Alopecia areata (AA) is one of the most common autoimmune diseases and targets the hair follicles, with high impact on the quality of life and self-esteem of patients due to hair loss. Clinical management and outcomes are challenged by current limited immunosuppressive and immunomodulating regimens. METHODS...

journal_title：BMC medicine

authors： Li Y,Yan B,Wang H,Li H,Li Q,Zhao D,Chen Y,Zhang Y,Li W,Zhang J,Wang S,Shen J,Li Y,Guindi E,Zhao Y

更新日期：2015-04-20 00:00:00

abstract：BACKGROUND:Breast cancer patients who have not previously attended mammography screening may be more likely to discontinue adjuvant hormone therapy and therefore have a worse disease prognosis. METHODS:We conducted a population-based cohort study using data from Stockholm Mammography Screening Program, Stockholm-Gotla...

journal_title：BMC medicine

authors： He W,Eriksson L,Törnberg S,Strand F,Hall P,Czene K

更新日期：2019-01-31 00:00:00

abstract：BACKGROUND:The vascular contributions to neurodegeneration and neuroinflammation may be assessed by magnetic resonance imaging (MRI) and ultrasonography (US). This review summarises the methodology for these widely available, safe and relatively low cost tools and analyses recent work highlighting their potential utili...

journal_title：BMC medicine

authors： Malojcic B,Giannakopoulos P,Sorond FA,Azevedo E,Diomedi M,Oblak JP,Carraro N,Boban M,Olah L,Schreiber SJ,Pavlovic A,Garami Z,Bornstein NM,Rosengarten B

更新日期：2017-02-09 00:00:00

abstract：BACKGROUND:The peer review process is a cornerstone of biomedical research. We aimed to evaluate the impact of interventions to improve the quality of peer review for biomedical publications. METHODS:We performed a systematic review and meta-analysis. We searched CENTRAL, MEDLINE (PubMed), Embase, Cochrane Database of...

journal_title：BMC medicine

authors： Bruce R,Chauvin A,Trinquart L,Ravaud P,Boutron I

更新日期：2016-06-10 00:00:00

abstract：:The damage to health caused by intimate partner violence demands effective responses from healthcare providers and healthcare systems worldwide. To date, most evidence for the few existing, effective interventions in use comes from high-income countries. Gupta et al. provide rare evidence of a nurse-delivered intimate...

journal_title：BMC medicine

authors： Taft A,Colombini M

更新日期：2017-07-12 00:00:00

abstract：BACKGROUND:The possible relationship between chronic inflammatory diseases and their co-morbidities has become an increasing focus of research. Both chronic periodontitis and chronic obstructive pulmonary disease are neutrophilic, inflammatory conditions characterized by the loss of local connective tissue. Evidence su...

journal_title：BMC medicine

authors： Usher AK,Stockley RA

更新日期：2013-11-13 00:00:00