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Apolipoproteins A-1 and B and the likelihood of non-fatal stroke and myocardial infarction -- data from The Third National Health and Nutrition Examination Survey.

Abstract：

BACKGROUND:The measurement of plasma apolipoproteins (APO) has been proposed for predicting the risk of cardiovascular diseases. However, the association between APOs and stroke is not well defined. MATERIAL/METHODS:We evaluated the association between plasma concentrations of APO A-1 and APO B with a physician diagnosis of stroke (n=153), and electrocardiogram evidence or physician diagnosis of myocardial infarction (n=379), in a nationally representative sample of 3,696 US adults aged >40 years who participated in the Third National Health and Nutrition Examination Survey. Multivariate logistic regression analyses were used to investigate these relationships. RESULTS:After adjusting for differences in age, gender, race/ethnicity, education, hypertension, cholesterol, body mass index, and cigarette smoking, the upper quartile of APO A-1 (> or = 161 mg/dl) when compared with the lowest quartile (<126 mg/dL) was inversely associated with the likelihood of myocardial infarction (Odds Ratio [OR], 0.6; 95% Confidence Interval [CI] 0.4-0.9) but not stroke. APO B concentrations were not associated with either myocardial infarction or stroke. However, an APO A-1 to B ratio > or = 1.59 when compared with a ratio < or = 1.04 was associated with a decreased likelihood of myocardial infarction (OR, 0.3; 95% CI, 0.2-0.6); and stroke (OR 0.4, 95% CI, 0.2-1.0). CONCLUSIONS:Higher APO A-1 concentrations were associated with a decreased likelihood for myocardial infarction but not for stroke. The APO A-1 to B ratio was inversely associated with both myocardial infarction and stroke and may be an important protective clinical marker for atherosclerosis.

journal_name

Med Sci Monit

journal_title

Medical science monitor : international medical journal of experimental and clinical research

authors

Qureshi AI,Giles WH,Croft JB,Guterman LR,Hopkins LN

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

CR311-6

issue

eissn

1234-1010

issn

1643-3750

pii

2657

journal_volume

pub_type

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Apolipoproteins A-1 and B and the likelihood of non-fatal stroke and myocardial infarction -- data from The Third National Health and Nutrition Examination Survey.