Bioinformatic Profiling of Prognosis-Related Genes in Malignant Glioma Microenvironment.

Abstract:

:BACKGROUND Gliomas are the most common primary tumors of the brain and spinal cord. The tumor microenvironment (TME) is the cellular environment in which tumors exist. This study aimed to identify the role of the TME and the effects of genes involved in the TME of malignant glioma. MATERIAL AND METHODS The ESTIMATE algorithms in the R package were used to calculate the immune and stromal scores of samples in the TCGA and GSE4290 datasets. The associations of stromal and immune scores with clinicopathological characteristics and overall survival of malignant glioma patients were assessed by analysis of variance and Kaplan-Meier analysis. Differentially expressed genes (DEGs) were obtained through the median immune and stromal score using the R package "limma". Functional enrichment analysis and the PPI network MCODE were used to analyze DEGs. RESULTS Increased immune and stromal scores were closely related with advanced glioma grade and poor prognosis (all P<0.01). In total, 558 DEGs were found and most were related to tumor prognosis. Functional enrichment analysis showed that DEGs were associated with cell-matrix regulation and immune response. Four hub modules related to tumor angiogenesis, collagen formation, and immune response were found and analyzed. Previously overlooked microenvironment-related genes such as LAMB1, FN1, ACTN1, TRIM, SERPINH1, CYBA, LAIR1, and LILRB2 showed prognostic values in malignant glioma patients. CONCLUSIONS The glioma stromal/immune scores are closely related to glioma grade, histology, and survival time. Some glioma microenvironment-related genes including LAMB1, FN1, ACTN1, TRIM6, SERPINH1, CYBA, LAIR1, and LILRB2 show prognostic values in malignant gliomas and serve as potential biomarkers.

journal_name

Med Sci Monit

authors

Li Y,Deng G,Qi Y,Zhang H,Gao L,Jiang H,Ye Z,Liu B,Chen Q

doi

10.12659/MSM.924054

subject

Has Abstract

pub_date

2020-08-26 00:00:00

pages

e924054

eissn

1234-1010

issn

1643-3750

pii

924054

journal_volume

26

pub_type

杂志文章
  • Prognostic value of duration of untreated psychosis in long-term outcome of schizophrenia.

    abstract:BACKGROUND:The goal of this prognostic study was to investigate whether the duration of untreated psychosis (DUP) may have a prognostic value with regard to the further course of the illness. MATERIAL/METHODS:Fifty-eight patients (77% of the original study group) diagnosed with DSM III schizophrenia and later re-diagn...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.881768

    authors: Cechnicki A,Hanuszkiewicz I,Polczyk R,Bielańska A

    更新日期:2011-05-01 00:00:00

  • Hypoxia-Induced Activation of JAK/STAT3 Signaling Pathway Promotes Trophoblast Cell Viability and Angiogenesis in Preeclampsia.

    abstract::BACKGROUND To explore the effect of hypoxic preconditioning on the JAK/STAT3 signaling pathway and its effect on trophoblast cell viability and angiogenesis in preeclampsia (PE). MATERIAL AND METHODS Placental tissues from normal pregnant women and PE patients were collected to detect the expression levels of JAK and ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.905418

    authors: Xu C,Li X,Guo P,Wang J

    更新日期:2017-10-14 00:00:00

  • Impact of repetitive transcranial magnetic stimulation on post-stroke dysmnesia and the role of BDNF Val66Met SNP.

    abstract:BACKGROUND:Little is known about the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) on dysmnesia and the impact of brain nucleotide neurotrophic factor (BDNF) Val66Met single-nucleotide polymorphism (SNP). This study investigated the impact of low-frequency rTMS on post-stroke dysmnesia an...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,随机对照试验

    doi:10.12659/MSM.892337

    authors: Lu H,Zhang T,Wen M,Sun L

    更新日期:2015-03-14 00:00:00

  • Association Between IL-10 Gene Polymorphism and Diabetic Retinopathy.

    abstract:BACKGROUND:Genetic and environmental factors both play important roles in the occurrence and progression of diabetic retinopathy (DR). IL-10 592 gene polymorphism is associated with diabetes pathogenesis. This study analyzed the relationship between IL-10 gene promoter-592 loci polymorphism (SNP) in a diabetic model ra...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.894371

    authors: Dong H,Li Q,Wang M,Wan G

    更新日期:2015-10-22 00:00:00

  • Role of MicroRNA-93 I in Pathogenesis of Left Ventricular Remodeling via Targeting Cyclin-D1.

    abstract::BACKGROUND The objective of this study was to identify the pathway responsible for ventricular remodeling. MATERIAL AND METHODS We collected remodeling myocardium tissue (n=18) and control myocardium tissue (n=22), and detected the expression of 4 miRNAs in these 2 groups using real-time PCR. We then searched the miRN...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.897542

    authors: Zhang J,Qin L,Han L,Zhao Y,Jing H,Song W,Shi H

    更新日期:2017-08-17 00:00:00

  • Proton Magnetic Resonance Spectroscopy (¹H-MRS) Study of Early Traumatic Brain Injury in Rabbits.

    abstract::BACKGROUND The aim of this study was to investigate the relationship between dynamic changes of cerebral metabolism and degree of trauma in rabbit models of traumatic brain injury (TBI) by using proton magnetic resonance spectroscopy (¹H-MRS). MATERIAL AND METHODS Thirty-five Chinese rabbits were randomly divided into...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.904788

    authors: Xiao Y,Fu Y,Zhou Y,Xia J,Wang L,Hu C

    更新日期:2017-05-19 00:00:00

  • Effect of carbogen on tumour oxygenation and 32P-colloid interstitial irradiation response.

    abstract:BACKGROUND:Interstitial irradiation therapy using radionuclides is a slow and continual process in which the effect is exerted gradually, thus improvement of the hypoxic status of the tumor will also take a long time. It has been known that carbogen delivery of 5-15 min increases tumor oxygenation. However, the long-te...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Zhan HW,Liu HB,Bao CK,Ye XJ,Zhang H,He GQ

    更新日期:2010-01-01 00:00:00

  • Frequency of elevated biomarkers in patients with cryptogenic hepatocellular carcinoma.

    abstract:BACKGROUND:The incidence of hepatocellular carcinoma (HCC) continues to increase in Japan, but the clinical characteristics of Japanese patients with HCC have not been well described. The aim of this study was to determine the frequencies and utilities of elevated a-fetoprotein (AFP) and des-gamma-carboxy prothrombin (...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.889361

    authors: Taura N,Ichikawa T,Miyaaki H,Ozawa E,Tsutsumi T,Tsuruta S,Kato Y,Goto T,Kinoshita N,Fukushima M,Kato H,Ohata K,Ohba K,Masuda J,Hamasaki K,Yatsuhashi H,Nakao K

    更新日期:2013-09-06 00:00:00

  • Insulin Resistance Is Associated with Interleukin 1β (IL-1β) in Non-Diabetic Hemodialysis Patients.

    abstract::BACKGROUND Insulin resistance (IR) and inflammation are associated with increased risk of complications in chronic kidney disease (CKD) patients. However, the relationship between IR and the important proinflammatory interleukin-1β (IL-1β) is unclear in CKD patients. MATERIAL AND METHODS We conducted a cross-sectional...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.906269

    authors: Bi X,Ai H,Wu Q,Fan Q,Ding F,Hu C,Ding W

    更新日期:2018-02-13 00:00:00

  • Prolonged unintended brain cooling may inhibit recovery from brain injuries: case study and literature review.

    abstract:BACKGROUND:Tracheal intubation of comatose patients is common, but contrary to most standards for respiratory care, heated nebulizers are not always used. This deviation from recommendations appears to be widespread. CASE REPORT:In the case examined, a tracheotomized patient suffering from severe anoxic brain injury w...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,评审

    doi:

    authors: Ford GP,Reardon DC

    更新日期:2006-08-01 00:00:00

  • Diagnosis of Lyme borreliosis using enzyme immunoanalysis.

    abstract:BACKGROUND:Antiborrelia antibodies in Lyme borreliosis (LB) are mostly detected by enzyme immunoassay (EIA), confirmed by immunoblot (the "two-step system"). In indicated cases, direct evidence of Borrelia burgdorferi is obtained with the PCR method, electron microscopy and cultivation. The "one-step system" of testing...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Cermakova Z,Ryskova O,Honegr K,Cermakova E,Hanovcova I

    更新日期:2005-04-01 00:00:00

  • Fluid Shear Stress Increases Osteocyte and Inhibits Osteoclasts via Downregulating Receptor-Activator of Nuclear Factor κB (RANK)/Osteoprotegerin Expression in Myeloma Microenvironment.

    abstract::BACKGROUND The aim of this study was to determine the effects of myeloma cells exposed to fluid shear stress on osteocytes and osteoclasts, and clarify the potential underlying mechanisms. MATERIAL AND METHODS A flow and a non-flow model were established using a flow fluid chamber. The myeloma cell line U266 and murin...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.915986

    authors: Wang X,He Y,Tian S,Zhu F,Huang B,Zhang J,Chen Z,Wang H

    更新日期:2019-08-10 00:00:00

  • Chemosensitizing Effect of Astragalus Polysaccharides on Nasopharyngeal Carcinoma Cells by Inducing Apoptosis and Modulating Expression of Bax/Bcl-2 Ratio and Caspases.

    abstract::BACKGROUND Platinum-based chemotherapy is the most effective regimen for nasopharyngeal carcinoma, which presents highly invasive and metastatic activity. However, the dose-related toxicity of chemotherapy agents limits the dose administration. Astragalus polysaccharide (APS) is the major active ingredient extracted f...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.903170

    authors: Zhou Z,Meng M,Ni H

    更新日期:2017-01-26 00:00:00

  • Ripasudil Attenuates Lipopolysaccharide (LPS)-Mediated Apoptosis and Inflammation in Pulmonary Microvascular Endothelial Cells via ROCK2/eNOS Signaling.

    abstract::BACKGROUND Microvascular endothelial inflammation and apoptosis are responsible for septic acute lung injury (ALI). Ripasudil is a novel Rho/Rho kinase (ROCK) inhibitor which shows therapeutic effects on several vascular diseases. The aim of this study was to investigate the protective effects and correlated molecular...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.910184

    authors: Yang J,Ruan F,Zheng Z

    更新日期:2018-05-16 00:00:00

  • YM155 Down-Regulates Survivin and Induces P53 Up-Regulated Modulator of Apoptosis (PUMA)-Dependent in Oral Squamous Cell Carcinoma Cells.

    abstract::BACKGROUND YM155, which inhibits the anti-apoptotic protein survivin, is known to exert anti-tumor effects in various cancers. However, there were few reports describing the inhibitory effect of YM155 on human oral squamous cell carcinoma (OSCC) cells that highly express survivin. In this study, we investigated the an...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.901643

    authors: Yan X,Su H

    更新日期:2017-04-24 00:00:00

  • Clinical Features of 167 Inpatients with Autosomal Dominant Polycystic Kidney Disease at a Single Center in China.

    abstract::BACKGROUND The aim of this study was to describe the clinical characteristics of Chinese ADPKD inpatients and to identify the factors associated with disease severity. MATERIAL AND METHODS We included 167 hospitalized patients (inpatients) with ADPKD in this study. Multiple regression analyses were conducted to determ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.910127

    authors: Meng J,Xu Y,Li A,Fan S,Shen X,Ma D,Zhang L,Hao Z,Zhang X,Liang C

    更新日期:2018-09-16 00:00:00

  • Resveratrol Induces Endothelial Progenitor Cells Angiogenesis via MiR-542-3p by Targeting Angiopoietin-2 and Involves in Recanalization of Venous Thrombosis.

    abstract::BACKGROUND Endothelial progenitor cells (EPCs) play an important role in therapeutic angiogenesis. Besides, resveratrol (RSV) exerts many pharmacological functions in regulation of cell function. Furthermore, microRNAs (miRNAs) have been considered to be of great significance in biological process. In this study, we a...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.917013

    authors: Lu Z,Wang S,Zhu X,Yuan X,Zhan Y,Li Y,Wang W

    更新日期:2019-10-13 00:00:00

  • Evaluation of CBASS sequence in degenerative disease of the lumbar spine based on analysis of consecutive 78 cases.

    abstract:BACKGROUND:Despite high efficiency of magnetic resonance (MR) imaging in degenerative disease of lumbar spine (DDLS), in many cases its appearance is ambiguous or not compatible with clinical findings. Therefore, different new techniques have been proposed to improve the quality of MR images. One of them is CBASS (Comp...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Maksymowicz H,Sasiadek M,Dusza B,Filarski J

    更新日期:2004-06-01 00:00:00

  • An initial assessment of correlations between host- and virus-related factors affecting analogues antiviral therapy in HBV chronically infected patients.

    abstract:BACKGROUND:Success in treating hepatitis B virus (HBV) infection with nucleoside analogues drugs is limited by the emergence of drug-resistant viral strains upon prolonged therapy. In addition to mutation patterns in the viral polymerase gene, host factors are assumed to contribute to failure of treatment in chronic HB...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.889788

    authors: Stalke P,Rybicka M,Wróblewska A,Dreczewski M,Stracewska E,Smiatacz T,Bielawski KP

    更新日期:2014-02-26 00:00:00

  • Usefulness of mean platelet volume and neutrophil-to-lymphocyte ratio for evaluation of children with Familial Mediterranean fever.

    abstract:BACKGROUND:Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by recurrent attacks of serositis, fever, and rash. Clinical and subclinical inflammatory processes may contribute to atherosclerosis in FMF patients, with mean platelet volume (MPV) as a potential indicator for atherosclerosis r...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.892139

    authors: Uluca Ü,Ece A,Şen V,Karabel D,Yel S,Güneş A,Tan I,Sabas M

    更新日期:2014-09-05 00:00:00

  • Mean Platelet Volume, C-Reactive Protein, and Prognosis in Patients with Acute Ischemic Stroke Following Intravenous Thrombolytic Treatment.

    abstract::BACKGROUND The aim of this study was to investigate the association between mean platelet volume (MPV), C-reactive protein (CRP), and prognosis in patients with acute ischemic stroke (AIS) following intravenous (IV) thrombolytic treatment. MATERIAL AND METHODS A retrospective clinical study included 129 patients withi...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.906813

    authors: İnanç Y,Giray S,İnanç Y

    更新日期:2018-06-05 00:00:00

  • Stool vs. Serum Hepatitis B Virus DNA in Patients with Chronic Hepatitis B.

    abstract::BACKGROUND Serum hepatitis B virus (HBV) DNA and hepatitis B e antigen (HBeAg) liver function in patients with chronic hepatitis B (CHB) are significantly associated. A comparison of clinical significance of fecal HBV DNA and serum HBV DNA has not yet been reported. MATERIAL AND METHODS Stool and serum samples were co...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.896243

    authors: Zheng JS,Chen MM,Yang HF,Zhou XT,Liu YY,Li JB

    更新日期:2015-12-09 00:00:00

  • Biomechanics of Hybrid Anterior Cervical Fusion and Artificial Disc Replacement in 3-Level Constructs: An In Vitro Investigation.

    abstract:BACKGROUND:The ideal surgical approach for cervical disk disease remains controversial, especially for multilevel cervical disease. The purpose of this study was to investigate the biomechanics of the cervical spine after 3-level hybrid surgery compared with 3-level anterior cervical discectomy and fusion (ACDF). MATE...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.896085

    authors: Liao Z,Fogel GR,Pu T,Gu H,Liu W

    更新日期:2015-11-03 00:00:00

  • Meta-analysis of Ubiquilin1 gene polymorphism and Alzheimer's disease risk.

    abstract:BACKGROUND:Some studies have evaluated the association between the Ubiquilin 1 (UBQLN1) gene UBQ-8i polymorphism and Alzheimer's disease (AD). However, the results remain uncertain. We carried out a meta-analysis to derive a more comprehensive estimation of this association. MATERIAL/METHODS:Case-control studies were ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,meta分析

    doi:10.12659/MSM.891030

    authors: Zhang T,Jia Y

    更新日期:2014-11-12 00:00:00

  • Analysis of Pre- and Postoperative Pain Variation in Osteoporotic Vertebral Compression Fracture Patients Undergoing Kyphoplasty.

    abstract::BACKGROUND Balloon kyphoplasty (KP) has been widely applied in the treatment of elderly patients with osteoporosis vertebral compression fracture (OVCF), but there has been little research on the pain relief effect. Therefore, we performed this study of patients who received KP. The study included a set of fluoroscopy...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.906456

    authors: Mei X,Sun ZY,Zhou F,Luo ZP,Yang HL

    更新日期:2017-12-18 00:00:00

  • Detection of Atherosclerotic Plaques in the Rabbit Aorta Using Ultrasound Microbubbles Conjugated to Interleukin-18 Antibodies.

    abstract::BACKGROUND The purpose of the study was to investigate the ability of microbubbles (MBs) targeting interleukin-18 (IL-18) to detect plaques in a rabbit atherosclerotic plaque model. MATERIAL AND METHODS A rabbit atherosclerotic plaque model was established. The locations of the atherosclerotic plaques were verified by...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.907572

    authors: Jiang ZZ,Liu XT,Ma CY,He C,Li XY,Hou CL,Cheng ZS,Xia GY

    更新日期:2017-11-16 00:00:00

  • Prognostic factors for the time of occurrence and dynamics of distant metastases and local recurrences after radical treatment in patients with rectal cancer.

    abstract:BACKGROUND:A remarkable increase has been noted in the rate of incidence of rectal cancer. Post- or preoperative adjuvant treatment has significantly decreased the risk of local recurrence, but still only about 50% of all patients with rectal cancer treated radically can achieve a permanent cure. The majority of failur...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Chmielarz A,Kryj M,Wloch J,Półtorak S,Sacher A,Lasek-Kryj M

    更新日期:2001-11-01 00:00:00

  • Types and incidence of disease among soldiers IX and X of the Polish Military Contingent in Afghanistan.

    abstract:BACKGROUND:The conditions encountered during military service in Afghanistan create number of different medical problems, resulting in interruptions in the performance of soldiers and even evacuation to the home country. A search of the literature yielded no comprehensive studies of medical problems of any single natio...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.883194

    authors: Ziemba R

    更新日期:2012-07-01 00:00:00

  • The Effects of Hesperidin on Neuronal Apoptosis and Cognitive Impairment in the Sevoflurane Anesthetized Rat are Mediated Through the PI3/Akt/PTEN and Nuclear Factor-κB (NF-κB) Signaling Pathways.

    abstract::BACKGROUND Hesperidin (HPD) is a bioflavonoid found in citrus fruits. This study aimed to investigate the effects of HPD on cerebral morphology and cognitive behavior in sevoflurane anesthetized neonatal rats and the molecular mechanisms involved. MATERIAL AND METHODS Sixty neonatal Sprague-Dawley rats were divided in...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.920522

    authors: Huang H,Hu C,Xu L,Zhu X,Zhao L,Min J

    更新日期:2020-04-16 00:00:00

  • Screening of Critical Genes and MicroRNAs in Blood Samples of Patients with Ruptured Intracranial Aneurysms by Bioinformatic Analysis of Gene Expression Data.

    abstract::BACKGROUND This study aimed to identify more potential genes and miRNAs associated with the pathogenesis of intracranial aneurysms (IAs). MATERIAL AND METHODS The dataset of GSE36791 (accession number) was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were screened for in ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.902953

    authors: Bo L,Wei B,Wang Z,Kong D,Gao Z,Miao Z

    更新日期:2017-09-20 00:00:00