Abstract:
INTRODUCTION:Effects of pulmonary rehabilitation (PR) in chronic obstructive pulmonary disease (COPD) patients with severely impaired health status are poorly documented since these patients are usually excluded from clinical trials. This retrospective, observational study aims to study the impact of disease on health status and the effects of PR on COPD patients referred to a tertiary center for PR in The Netherlands. METHODS:Between June 2006 and June 2010, 437 patients with COPD were allocated to our intensive, comprehensive PR program. Patients participated in this interdisciplinary program for 12 weeks for a weekly average of 20-25 hours. Before and directly after, several measures of physical performance and health-related quality of life were determined. RESULTS:At baseline, most patients (75%) had a Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage of III-IV. Peak exercise performance on a cycle ergometer was on average reduced to 43 ± 29 Watt, and health-related quality of life was significantly impaired, with a total score on the St George's Respiratory Questionnaire (SGRQ) of 66. Health-care utilization in the year preceding PR was very high. After rehabilitation, all outcome measures improved statistically significantly (P < 0.001). Exercise performance measured with the 6 minute walking distance test improved clinically significantly in 68% of the patients, whereas 75% of the patients showed a clinically meaningful improvement in quality of life as measured with the SGRQ. Multiple regression analysis revealed that 19% of the variation in responses on the 6 minute walking distance test and the SGRQ could be explained on the basis of baseline characteristics. CONCLUSION:The present study provides data to indicate that COPD patients may substantially benefit from rehabilitation in a tertiary pulmonary rehabilitation center, despite a severely impaired health status and high level of health-care utilization, in which prior treatment in primary and secondary care have failed to improve health status. Individual rehabilitation responses can only partially be predicted on the basis of baseline characteristics. Consequently, no firm conclusions can be drawn from this study with respect to the selection of candidates that could be deemed eligible for this rehabilitation program when entering the program.
journal_name
Int J Chron Obstruct Pulmon Disauthors
van Ranst D,Otten H,Meijer JW,van 't Hul AJdoi
10.2147/COPD.S24579subject
Has Abstractpub_date
2011-01-01 00:00:00pages
647-57eissn
1176-9106issn
1178-2005pii
copd-6-647journal_volume
6pub_type
杂志文章abstract::Regenerative or stem cell therapy is an emerging field of treatment based on stimulation of endogenous resident stem cells or administration of exogenous stem cells to treat diseases or injury and to replace malfunctioning or damaged tissues. Current evidence suggests that in the lung, these cells may participate in t...
journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章,评审
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journal_title:International journal of chronic obstructive pulmonary disease
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journal_title:International journal of chronic obstructive pulmonary disease
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章,随机对照试验
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更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
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journal_title:International journal of chronic obstructive pulmonary disease
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
doi:10.2147/COPD.S96809
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.2147/COPD.S16975
更新日期:2011-01-01 00:00:00
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
doi:10.2147/COPD.S111724
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
doi:10.2147/COPD.S168049
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
doi:10.2147/COPD.S87714
更新日期:2015-09-08 00:00:00
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章,随机对照试验
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-09-29 00:00:00
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pub_type: 杂志文章,评审
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