Abstract：
SUMMARY:Failure to intubate and cross esophageal tumors by endosonography is reported in as many as 30% of cases and is thought to be associated with an especially poor prognosis. The aim of this study was to audit the above in a large consecutive case series of Endoscopic Ultrasound (EUS) examinations for esophageal cancer performed in a regional specialist cancer network with particular reference to outcome. A consecutive series of 411 patients underwent EUS examination by a specialist radiologist over a period of 9 years. Forty (10%) of patients required dilation, and there was total failure to cross the tumor in 12 patients (2.9%). Failure to traverse the primary tumor was associated with a diagnosis of squamous cell cancer (8 of 12 patients, 66%, rho = -0.182, P = 0.011). Limited staging information was obtained in 7 of these patients, which altered the computed tomography stage in 5 patients (71%, 3 upstaged, 2 downstaged). Six patients received definitive chemoradiotherapy, two patients surgery and four patients palliative chemotherapy. The median and 5-year survival in patients whose tumors were not crossed was 10 months and 28%, respectively, compared with 24 months and 24%, respectively in patients whose tumors were fully assessed. Failure to cross esophageal tumors in practice was far less common than the literature suggests, and esophageal tumor luminal stenosis should no longer be considered a limitation of endosonography.
journal_name
Dis Esophagusjournal_title
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagusauthors
Morgan MA,Twine CP,Lewis WG,Lambe R,Oliphant HE,Robinson M,Crosby TD,Roberts SAdoi
10.1111/j.1442-2050.2008.00809.xsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
508-13issue
6eissn
1120-8694issn
1442-2050pii
DES809journal_volume
21pub_type
杂志文章abstract：:The cancer stem cell theory states that cancers contain tumor-forming cells that have the ability to self-renew as well as give rise to cells that differentiate. Cancer stem cells have been identified in several solid tumors, but stem cells in normal human esophagus or in Barrett's esophagus or adenocarcinoma have not...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2010.01061.x
更新日期：2010-09-01 00:00:00
abstract：:Short gastric vessels (SGV) division is a controversial topic in antireflux surgery. Some surgeons do not divide the SGV routinely to perform a fundoplication; however, excessive tension of the gastric fundus (GF) forces this procedure necessary in some cases. This study aims to evaluate in a cadaveric model of Nissen...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2009.00945.x
更新日期：2009-01-01 00:00:00
abstract：:Progressive dysphagia of unknown etiology may still provide a diagnostic challenge despite an increase in the number and quality of investigations available. We describe a 64-year-old man who presented with progressive dysphagia and weight loss. Following a number of investigations, a diagnosis of diffuse esophageal l...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2010.01114.x
更新日期：2011-04-01 00:00:00
abstract：:The prognosis of esophageal squamous cell carcinoma is primarily determined by staging. Although radiological methods have revealed lymph node metastasis preoperatively, these radiological findings cannot be correlated with pathological staging. The aim of this study was to compare the expressions of p53, vascular end...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2007.00634.x
更新日期：2007-01-01 00:00:00
abstract：:Para-aortic lymph node (PALN) recurrence is often seen in patients with lower thoracic esophageal cancer treated by esophagectomy with extended lymph node dissection. However, the clinicopathological characteristics of patients with PALN metastasis and the significance of PALN dissection are unknown. A total of 283 pa...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2011.01222.x
更新日期：2012-02-01 00:00:00
abstract：:Neoadjuvant chemotherapy may improve the outcome of esophageal cancer after esophagectomy, but is accompanied by considerable toxicity by collateral destruction of normal cells. Such side effects may be avoided by developing therapies that specifically target molecular characteristics of tumors. The aim of the present...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2009.00951.x
更新日期：2009-01-01 00:00:00
abstract：:Accurate evaluation of radical radiotherapy requires well designed research with valid and appropriate outcomes. This study reviewed standards of outcome reporting and study design in randomized controlled trials (RCTs) of radiation-based therapy for esophageal cancer and made recommendations for future work. Randomiz...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章,评审
doi：10.1111/dote.12168
更新日期：2015-02-01 00:00:00
abstract：:This study assessed the clinical value of CYFRA 21-1 in comparison with squamous cell carcinoma antigen (SCC-Ag), carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) in patients with esophageal squamous cell carcinoma. In 112 primary cancer patients, the diagnostic sensitivity of CYFRA 21-1 (33.9%) ...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:SUMMARY. We present a case of a 20-year-old, previously healthy, male student who presented with dysphagia secondary to mechanical esophageal obstruction that resolved spontaneously. Although our patient did not have 'classic' patient characteristics, we believe that the clinical evidence supports the conclusion that ...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2005.00462.x
更新日期：2005-01-01 00:00:00
abstract：:The purpose of the study was to investigate the difference in overall survival in patients with localized carcinoma of esophagus treated using chemo-radiation (bi-modality, BM) or chemo-radiation followed by surgery (tri-modality, TM). From 1981 to 1999, 65 patients were identified who had localized carcinoma of the e...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1046/j.1442-2050.2001.00185.x
更新日期：2001-01-01 00:00:00
abstract：:Increasing experience with transhiatal esophagectomy (THE) has brought with it a good understanding of the advantages and disadvantages of the technique. As in our case, diaphragmatic hernias after THE may result from excess manipulation and extension of the hiatus during surgery. The varying nature of the clinical pr...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1046/j.1442-2050.2002.00233.x
更新日期：2002-01-01 00:00:00
abstract：:Esophageal perforation is an uncommon and challenging surgical emergency associated with high rates of morbidity and mortality. At present, no consensus exists on optimal management of the condition. The Pittsburgh Severity Score (PSS) is a tool intended to stratify perforation severity and guide treatment. However, t...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1093/dote/doy109
更新日期：2019-02-01 00:00:00
abstract：:Achalasia is a disorder of esophageal motility that has been well documented for over 300 years. Despite this, the initiating factor or factors and the underlying mechanisms leading to the characteristic features of achalasia, the absence of distal esophageal peristalsis and abnormal lower esophageal sphincter relaxat...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章,评审
doi：10.1111/j.1442-2050.2006.00569.x
更新日期：2006-01-01 00:00:00
abstract：:Anastomotic leakage is one of the most severe complications after esophageal resection with gastric tube reconstruction. Impaired perfusion of the gastric fundus is seen as the main contributing factor for this complication. Optical modalities show potential in recognizing compromised perfusion in real time, when isch...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章,评审
doi：10.1093/dote/dox161
更新日期：2018-06-01 00:00:00
abstract：:Lung and esophageal dysfunction are common in patients with connective tissue disease (CTD). Recent reports have suggested a link between pathologic gastroesophageal reflux and bronchiolitis obliterans syndrome (BOS) after lung transplant. Because patients with CTD have a high incidence of esophageal dysmotility and r...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2008.00828.x
更新日期：2008-01-01 00:00:00
abstract：:Gamma-glutamyltransferase (GGT) is a membrane-bound enzyme involved in the glutathione metabolism. Studies suggested that GGT was a marker of apoptotic balance and modulated tumor progression, invasion and drug resistance. Recently, GGT was shown to be associated with the progression of high-grade esophageal epithelia...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/dote.12227
更新日期：2015-07-01 00:00:00
abstract：UNLABELLED:In this study, we investigated the implication of oxygen-derived free radicals in reflux esophagitis of humans. For this purpose we assessed oxidative stress in distal esophageal biopsies of controls, patients with various grades of esophagitis, Barrett's esophagus with and without severe associated esophagi...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1093/dote/10.1.29
更新日期：1997-01-01 00:00:00
abstract：:Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is standard of care for locally advanced esophageal cancer in many countries. After nCRT up to one third of all patients have a pathologically complete response in the resection specimen, posing an ethical imperative to reconsider the necessity of standard surge...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章,评审
doi：10.1093/dote/dox100
更新日期：2017-12-01 00:00:00
abstract：:Esophageal squamous cell carcinoma (ESCC) is the predominant histological subtype of esophageal cancer in Asia, characterized by high incidence and mortality rate. Although significant progress has been made in surgery and adjuvant chemoradiotherapy, the prognosis of the patients with this cancer still remains poor. I...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章,评审
doi：10.1111/j.1442-2050.2008.00845.x
更新日期：2009-01-01 00:00:00
abstract：:Spontaneous or iatrogenic esophageal perforations are despite advances of modern surgery and intensive care medicine still potentially life-threatening events with a considerable mortality rate. Recently, encouraging results on the sealing of esophageal perforations by placement of endoluminal prostheses were reported...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2007.00652.x
更新日期：2007-01-01 00:00:00
abstract：:Esophageal perforation is uncommon and traditionally has a high rate of morbidity and mortality. Our aim was to perform a 13-year retrospective review of the cases managed in our district general hospital. Thirty-four cases of esophageal perforation diagnosed between 1995 and 2008 were retrospectively analyzed. There ...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2009.00959.x
更新日期：2009-01-01 00:00:00
abstract：:Prevalence data for heartburn in the urban Black American community is lacking. In order to estimate prevalence for this community, we analyzed data from an ongoing cohort study in progress at our hospital. Comprehensive interviews allowed for exploration of factors associated with heartburn. Complex, stratified sampl...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/dote.12007
更新日期：2013-08-01 00:00:00
abstract：:Totally minimally invasive Ivor-Lewis esophagectomy (Ivor Lewis TMIE) is a technically challenging procedure and is associated with a learning curve. Refinement of surgical technique is an important part of this learning curve. However, detailed descriptions of these refinements according to the idea, development, exp...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1093/dote/doy079
更新日期：2019-03-01 00:00:00
abstract：:Heller's esophagomyotomy relieves dysphagia but does not restore esophageal peristalsis. The myotomy may induce reflux and the addition of a 360 degrees fundoplication may be hazardous with regard to the remaining aperistaltic esophagus. The aim of this prospectively randomized clinical trial was to compare the outcom...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1442-2050.2003.00348.x
更新日期：2003-01-01 00:00:00
abstract：:We reviewed our experience with 262 consecutive two-layer, hand-sewn cervical esophageal anastomoses in patients undergoing surgery for esophageal carcinoma. Anastomotic leak rates were determined for the entire group and the frequency of post-operative esophageal dilatations was obtained for the first 101 patients. I...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1046/j.1442-2050.1999.00051.x
更新日期：1999-01-01 00:00:00
abstract：:In a prior study, baseline mutational load (ML) predicted progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) in Barrett's esophagus (BE) with an area under the curve (AUC) of 0.95. We aimed to validate the test characteristics of this predictive biomarker panel using crude DNA lysates in a la...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1093/dote/doy026
更新日期：2018-11-01 00:00:00
abstract：:Human epidermal growth factor receptor 2 (HER2) is involved in the malignant progression of several human cancers, including esophageal adenocarcinoma (EAC). The purpose of this study was to evaluate HER2 overexpression and to explore the feasibility of confocal laser endomicroscopy for in vivo molecular imaging of HE...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/dote.12210
更新日期：2015-05-01 00:00:00
abstract：:One of the most common causes of a failed Nissen fundoplication is disruption of the crural repair. We investigated the thickness of the subdiaphragmatic fascia overlying the right and left limb of the right crus in cadavers to determine any difference. Sub-diaphragmatic fascia specimens were obtained from three sites...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2006.00554.x
更新日期：2006-01-01 00:00:00
abstract：:Apolipoprotein E (ApoE) is the most well-described genetic risk factor for Alzheimer's disease and nonpathological cognitive decline. While possession of the E2 allele may have protective properties, substantial research evidence suggests the E4 allele increases the risk of cognitive degeneration. As neurodegenerative...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/dote.12162
更新日期：2015-01-01 00:00:00
abstract：:To find new genes involved in esophageal squamous cell carcinogenesis, we constructed custom cDNA arrays and used the arrays to compare gene expression profiles of 12 matched normal and malignant esophageal samples including seven superficial cancer tissues. The arrays represented nearly 4000 genes, including 1728 tha...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2005.00432.x
更新日期：2005-01-01 00:00:00
