当前位置： SCI文献检索 > DISEASES OF THE ESOPHAGUS期刊下所有文献 > Prognostic significance of gamma-glutamyltransferase in patients with resectable esophageal squamous cell carcinoma.

Prognostic significance of gamma-glutamyltransferase in patients with resectable esophageal squamous cell carcinoma.

Abstract：

:Gamma-glutamyltransferase (GGT) is a membrane-bound enzyme involved in the glutathione metabolism. Studies suggested that GGT was a marker of apoptotic balance and modulated tumor progression, invasion and drug resistance. Recently, GGT was shown to be associated with the progression of high-grade esophageal epithelial dysplasia to invasive carcinoma. This study was conducted to investigate the value of pre-therapeutic serum GGT levels as prognostic parameter in esophageal squamous cell carcinoma. Six hundred thirty-nine resectable esophageal squamous cell carcinoma patients were recruited in this study and were stratified into two GGT risk groups. The association of pre-therapeutic serum GGT levels and clinical-pathological parameters was examined. Univariate and multivariate survival analyses were performed. GGT serum levels were associated with gender, smoking status, TNM stage and lymph node involvement. Higher pre-therapeutic serum GGT was found in males, smoker, advanced TNM stage and lymph node positive patients. Patients assigned to the low-risk group had higher 5-year overall survival rate (53.1% vs. 33.0%, P < 0.01) and disease-free survival rate (45.2% vs. 23.4%, P < 0.01) than the high-risk group. Patients with high-risk group of GGT had 1.568 (95% confidence interval [CI], 1.259 ∼ 1.952) times the risk of death and 1.582 (95% CI, 1.286 ∼ 1.946) times the risk of disease recurrence contrast with those with low-risk group of GGT. The pre-therapeutic serum GGT is a novel independent prognostic parameter for disease-free survival and overall survival in resectable esophageal squamous cell carcinoma.

journal_name

Dis Esophagus

journal_title

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

authors

Yang F,Zhang S,Yang H,Luo K,Wen J,Hu Y,Hu R,Huang Q,Chen J,Fu J

doi

10.1111/dote.12227

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

496-504

issue

5

eissn

1120-8694

issn

1442-2050

journal_volume

28

pub_type

杂志文章

相关文献

DISEASES OF THE ESOPHAGUS文献大全
  • Esophageal schistosomiasis in a patient with megaesophagus.

    abstract：:The authors report a case of schistosomiasis of uncommon location. A patient submitted to esophagectomy for Chagas' megaesophagus was found to have eggs of Schistosoma mansoni upon pathologic examination of the surgical specimen. The authors discuss the anatomopathological aspects of schistosomiasis, as well as its oc...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/10.1.71

    authors： Gagliardi D,Corsi PR,Eckley CA,Marigo C,Fava J

    更新日期：1997-01-01 00:00:00

  • Practice patterns and adherence to clinical guidelines for diagnosis and management of eosinophilic esophagitis among gastroenterologists.

    abstract：:Real-world practice patterns of eosinophilic esophagitis (EoE) among gastroenterologists are not well-described. The aim is to describe practice patterns of EoE diagnosis and management and assess concordance with consensus guidelines. We conducted a cross-sectional online survey of gastroenterologists in the USA usin...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doaa025

    authors： Eluri S,Iglesia EGA,Massaro M,Peery AF,Shaheen NJ,Dellon ES

    更新日期：2020-05-07 00:00:00

  • Efficacy of leukotriene receptor antagonist for erosive esophagitis: a preliminary retrospective comparative study.

    abstract：:While diagnostic overlap exists between gastroesophageal reflux disease and eosinophilic esophagitis especially on histological findings, therapeutic approaches for the two disease entities are very different. Recently, anti-inflammatory treatment, in addition to acid suppressants, has been investigated for gastroesop...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2011.01299.x

    authors： Lee H,Park JC,Shin SK,Lee SK,Lee YC

    更新日期：2012-09-01 00:00:00

  • High-resolution manometry findings in patients with achalasia and massive dilated megaesophagus.

    abstract：:Achalasia may present in a non-advanced or an advanced (end stage) stage based on the degree of esophageal dilatation. Manometric parameters and esophageal caliber may be prognostic for the outcome of treatment. The correlation between manometry and disease stage has not been yet fully studied. This study aims to desc...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/dow008

    authors： Menezes MA,Andolfi C,Herbella FA,Patti MG

    更新日期：2017-05-01 00:00:00

  • Morbidity following salvage esophagectomy for squamous cell carcinoma: the MD Anderson experience.

    abstract：:The survival advantage associated with the addition of surgical therapy in esophageal squamous cell carcinoma (ESCC) patients who demonstrate a complete clinical response to chemoradiotherapy is unclear, and many institutions have adopted an organ-preserving strategy of selective surgery in this population. We sought ...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doz067

    authors： Mitchell KG,Nelson DB,Corsini EM,Vaporciyan AA,Antonoff MB,Mehran RJ,Rice DC,Roth JA,Sepesi B,Walsh GL,Bhutani MS,Maru DM,Wu CC,Nguyen QN,Ajani JA,Swisher SG,Hofstetter WL

    更新日期：2020-03-16 00:00:00

  • Delivering esophago-gastric cancer care during the COVID-19 pandemic in the United Kingdom: a surgical perspective.

    abstract：BACKGROUND:The COVID-19 pandemic continues to have a significant impact on the provision of medical care. Planning to ensure there is capability to treat those that become ill with the virus has led to an almost complete moratorium on elective work. This study evaluates the impact of COVID-19 on cancer, in particular s...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doaa091

    authors： Wahed S,Chmelo J,Navidi M,Hayes N,Phillips AW,Immanuel A

    更新日期：2020-09-04 00:00:00

  • The utility of endoscopic screening for patients with esophageal or head and neck cancer.

    abstract：:In a series of 378 patients with esophageal carcinoma, 43 patients with head and neck carcinoma were divided into two groups: 30 patients without symptoms whose esophageal or head and neck second primary carcinomas were incidentally detected by an endoscopic examination for the second carcinoma (group 1) and 13 patien...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1046/j.1442-2050.1999.00045.x

    authors： Murakami S,Hashimoto T,Noguchi T,Hazamada S,Uchida Y,Suzuki M,Yanagisawa S

    更新日期：1999-01-01 00:00:00

  • Programmed death-1 ligands and tumor infiltrating T lymphocytes in primary and lymph node metastasis of esophageal cancer patients.

    abstract：:Neoadjuvant chemotherapy (NAC) is administered to many patients with esophageal squamous cell carcinoma (ESCC) prior to surgery, but it is also true that some of these patients demonstrated no response to the therapy following surgery. In addition, the prognosis of advanced case such as ESCC patients with lymph node m...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doy063

    authors： Konno-Kumagai T,Fujishima F,Nakamura Y,Nakano T,Nagai T,Kamei T,Sasano H

    更新日期：2019-03-01 00:00:00

  • Comparison of the effect of a cornstarch thickened formula and strengthened regular formula on regurgitation, gastric emptying and weight gain in infantile regurgitation.

    abstract：:The purpose of this study was to evaluate the efficacy of a specially selected cornstarch-supplemented formula on clinical symptoms, gastric emptying and weight gain in infants with regurgitation. We performed a prospective randomised trial evaluating the therapeutic efficacy of two different formula feedings (cornsta...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1442-2050.2007.00662.x

    authors： Chao HC,Vandenplas Y

    更新日期：2007-01-01 00:00:00

  • Lower esophageal sphincter pressure in patients with gastroesophageal reflux diseases and posture and time patterns.

    abstract：:Gastroesophageal reflux disease is caused predominantly by lower esophageal sphincter insufficiency. Reports suggest that it is possible to distinguish between two main mechanisms causing reflux: low basal sphincter pressure leading to free reflux, mostly occurring at night in the supine position, and increased transi...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2004.00394.x

    authors： Meining A,Fackler A,Tzavella K,Storr M,Allescher HD,Klauser A,Heldwein W

    更新日期：2004-01-01 00:00:00

  • Health-related quality of life in long-term survivors after high-dose chemoradiotherapy followed by surgery in esophageal cancer.

    abstract：:Curative treatment of esophageal cancer with definitive or preoperative high-dose chemoradiotherapy inflicts a major strain on the patients with potentially severe physical, emotional, and social consequences. The aim of this study was to assess various aspects of quality of life and fatigue in long-term survivors fol...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2010.01104.x

    authors： Hurmuzlu M,Aarstad HJ,Aarstad AK,Hjermstad MJ,Viste A

    更新日期：2011-01-01 00:00:00

  • Successfully treated case of cervical abscess and mediastinitis due to esophageal perforation after gastrointestinal endoscopy.

    abstract：:Perforations of the esophagus are uncommon complications of flexible gastrointestinal endoscopy. Perforations after endoscopy are likely to occur in the cervical esophagus, where fiber insertion is difficult anatomically. The diagnosis should be made as soon as possible, because mediastinitis and sepsis frequently dev...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1046/j.1442-2050.2002.00253.x

    authors： Sato S,Kajiyama Y,Kuniyasu T,Machida M,Ouchi K,Sakai N,Sakamoto S,Iwanuma Y,Kamano T,Okamura S,Nagahama A,Tsurumaru M

    更新日期：2002-01-01 00:00:00

  • Risk of malignant progression in Barrett's esophagus indefinite for dysplasia.

    abstract：:Barrett's esophagus is a well-recognized risk factor for esophageal adenocarcinoma. The natural history of Barrett's esophagus classified as ‘indefinite for dysplasia’ (IND) is poorly characterized. The aim of this study is to characterize the natural history of IND by determining the rate of neoplastic progression an...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/dow025

    authors： Ma M,Shroff S,Feldman M,DeMarshall M,Price C,Tierney A,Falk GW

    更新日期：2017-03-01 00:00:00

  • Fas ligand and Fas receptor are coexpressed in normal human esophageal epithelium: a potential mechanism of apoptotic epithelial turnover.

    abstract：:Fas (CD95/Apo-1) receptor (FasR) is a cell-surface receptor that mediates apoptotic cell death upon triggering by Fas ligand (FasL). We sought to determine whether normal human esophageal epithelial cells express FasL and/or FasR and whether their localization is consistent with a role in the turnover of normal esopha...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1046/j.1442-2050.1999.00032.x

    authors： Bennett MW,O'Connell J,O'Sullivan GC,Roche D,Brady C,Collins JK,Shanahan F

    更新日期：1999-01-01 00:00:00

  • Diabetes mellitus is an independent risk for gastroesophageal reflux disease among urban African Americans.

    abstract：:An association between gastroesophageal reflux disease (GERD) and diabetes mellitus (DM) has been reported. Studies have not been population-based and have failed to include a representative sample of African American subjects. The aim of the study was to determine if DM is independently associated with GERD among urb...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/dote.12213

    authors： Natalini J,Palit A,Sankineni A,Friedenberg FK

    更新日期：2015-07-01 00:00:00

  • Neoadjuvant chemoradiotherapy followed by esophagectomy for initially resectable squamous cell carcinoma of the esophagus with multiple lymph node metastasis.

    abstract：:Neoadjuvant chemoradiotherapy (CRT) was expected to improve surgical curability and prognosis for advanced esophageal cancer. However, the clinical efficacy of neoadjuvant CRT followed by esophagectomy with three-field lymphadenectomy (3FL) for initially resectable esophageal squamous cell carcinoma (SCC) remains uncl...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2005.00521.x

    authors： Nabeya Y,Ochiai T,Matsubara H,Okazumi S,Shiratori T,Shuto K,Aoki T,Miyazaki S,Gunji Y,Uno T,Ito H,Shimada H

    更新日期：2005-01-01 00:00:00

  • S100A4 regulates motility and invasiveness of human esophageal squamous cell carcinoma through modulating the AKT/Slug signal pathway.

    abstract：:The involvement of S100A4 in modulating invasiveness of esophageal squamous cell carcinoma (ESCC) cell lines was explored. It was shown that S100A4 expression is positively correlated with the degree of invasiveness in human ESCC cells. The S100A4-rich EC-1 cells displayed higher migratory and invasive cell behavior w...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2012.01323.x

    authors： Zhang K,Zhang M,Zhao H,Yan B,Zhang D,Liang J

    更新日期：2012-11-01 00:00:00

  • Gastric tube cancer after esophagectomy for cancer: a systematic review.

    abstract：:Gastric conduit used for reconstruction after esophagectomy for cancer has the potential to develop a metachronous neoplasm known as gastric tube cancer (GTC). The aim of this study was to review literature and evaluate outcomes and possible treatment strategies for GTC. A comprehensive systematic literature search wa...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doz049

    authors： Gentile D,Riva P,Da Roit A,Basato S,Marano S,Castoro C

    更新日期：2019-08-01 00:00:00

  • A novel variant of esophageal atresia with tracheo-esophageal fistula with a crossed-over proximal esophageal pouch: a diagnostic dilemma.

    abstract：:Diagnosis of esophageal atresia (EA) with tracheo-esophageal fistula (TEF) can be easily done in newborns with symptoms of excessive salivation and failure to pass infant-feeding tube (IFT) into the stomach. There are many reports in the literature which describe the diagnostic pitfall of this IFT test. We describe a ...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2010.01175.x

    authors： Rathod K,Khanna S,Kanojia RP,Rao KL

    更新日期：2012-07-01 00:00:00

  • Recommendations for neoadjuvant pathologic staging (ypTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals.

    abstract：:We report analytic and consensus processes that produced recommendations for neoadjuvant pathologic stage groups (ypTNM) of esophageal and esophagogastric junction cancer for the AJCC/UICC cancer staging manuals, 8th edition. The Worldwide Esophageal Cancer Collaboration provided data for 22,654 patients with epitheli...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 共识发展会议,杂志文章,实务指引

    doi：10.1111/dote.12538

    authors： Rice TW,Ishwaran H,Kelsen DP,Hofstetter WL,Apperson-Hansen C,Blackstone EH,Worldwide Esophageal Cancer Collaboration Investigators.

    更新日期：2016-11-01 00:00:00

  • Novel association of achalasia with hereditary sensory and motor neuropathy with sensorineural deafness.

    abstract：:Achalasia is a primary esophageal motility disorder. Unlike diffuse esophageal spasm, it has not previously been described in association with hereditary sensory and motor neuropathy (HSMN). An 18-year-old-male with HSMN with sensorineural deafness presented with a 2-day history of dysphagia to solids and liquids. Ach...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type：

    doi：10.1111/dote.12111

    authors： Asthana AK,Lubel JS,Kohn GP

    更新日期：2016-08-01 00:00:00

  • Long esophagomyotomy for diffuse esophageal spasm and related disorders: an historical overview.

    abstract：:In summary, the role of long esophagomyotomy for patients with DES and related motor disorders remains controversial. The results are poorer than those following esophagomyotomy for achalasia, and long-term postoperative follow-up of these patients is essential because early good results may be misleading. Two methods...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 历史文章,杂志文章

    doi：10.1093/dote/11.4.210

    authors： Ellis FH Jr

    更新日期：1998-10-01 00:00:00

  • Evolution of the surgical technique of minimally invasive Ivor-Lewis esophagectomy: description according to the IDEAL framework.

    abstract：:Totally minimally invasive Ivor-Lewis esophagectomy (Ivor Lewis TMIE) is a technically challenging procedure and is associated with a learning curve. Refinement of surgical technique is an important part of this learning curve. However, detailed descriptions of these refinements according to the idea, development, exp...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doy079

    authors： Stenstra MHBC,van Workum F,van den Wildenberg FJH,Polat F,Rosman C

    更新日期：2019-03-01 00:00:00

  • Use of multiple channel pH monitoring for evaluation of ultra-distal reflux in patients after fundoplication for treatment of Barrett's esophagus.

    abstract：:Dysplasia and esophageal adenocarcinoma may arise in patients with Barrett's esophagus after fundoplication esophageal pH monitoring showing no acid in esophagus. This suggests the need to develop methodology to evaluate the occurrence of ultra-distal reflux (1cm above the LES). The objective of the study was to compa...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2010.01160.x

    authors： Seguro FC,Santo MA,Szachnowicz S,Maluf Filho F,Kishi HS,Falcão AM,Nasi A,Sallum RA,Cecconello I

    更新日期：2011-08-01 00:00:00

  • Relevant issues in tumor regression grading of histopathological response to neoadjuvant treatment in adenocarcinomas of the esophagus and gastroesophageal junction.

    abstract：:Multimodality treatment combining surgery and oncologic treatment has become widely applied in curative treatment of esophageal and gastroesophageal junction adenocarcinoma. There is a need for a standardized tumor regression grade scoring system for clinically relevant effects of neoadjuvant treatment effects. There ...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doaa005

    authors： Klevebro F,Tsekrekos A,Low D,Lundell L,Vieth M,Detlefsen S

    更新日期：2020-06-15 00:00:00

  • Adjuvant chemotherapy of cisplatin, 5-fluorouracil and leucovorin for complete resectable esophageal cancer: a case-matched cohort study in east China.

    abstract：:It is still controversial whether adjuvant chemotherapy of cisplatin, 5-fluorouracil and leucovorin can increase the overall survival of esophageal cancer patients, and which subgroup of patients get most benefits from it. Between 1998 and 2004, 66 esophageal cancer patients with adjuvant chemotherapy and 160 well-mat...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2007.00748.x

    authors： Zhang J,Zhang YW,Chen ZW,Zhou XY,Lu S,Luo QQ,Hu H,Miao LS,Ma LF,Xiang JQ

    更新日期：2008-01-01 00:00:00

  • How many lymph nodes should be dissected in esophagectomy with or without neoadjuvant therapy to get accurate staging?

    abstract：:It is essential to dissect an adequate number of lymph nodes (LNs) to ensure staging accuracy during esophagectomy with or without neoadjuvant therapy. We developed a statistical model to quantify the probability of precise nodal staging based on previous studies. Esophageal cancer patients who underwent esophagectomy...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doz009

    authors： Zhan C,Shi Y,Jiang W,Sun F,Li M,Lu T,Yin J,Ma K,Yang X,Wang Q

    更新日期：2020-01-16 00:00:00

  • Prognostic significance of failure to cross esophageal tumors by endoluminal ultrasound.

    abstract：SUMMARY:Failure to intubate and cross esophageal tumors by endosonography is reported in as many as 30% of cases and is thought to be associated with an especially poor prognosis. The aim of this study was to audit the above in a large consecutive case series of Endoscopic Ultrasound (EUS) examinations for esophageal c...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2008.00809.x

    authors： Morgan MA,Twine CP,Lewis WG,Lambe R,Oliphant HE,Robinson M,Crosby TD,Roberts SA

    更新日期：2008-01-01 00:00:00

  • Heller's esophagomyotomy with or without a 360 degrees floppy Nissen fundoplication for achalasia. Long-term results from a prospective randomized study.

    abstract：:Heller's esophagomyotomy relieves dysphagia but does not restore esophageal peristalsis. The myotomy may induce reflux and the addition of a 360 degrees fundoplication may be hazardous with regard to the remaining aperistaltic esophagus. The aim of this prospectively randomized clinical trial was to compare the outcom...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1442-2050.2003.00348.x

    authors： Falkenback D,Johansson J,Oberg S,Kjellin A,Wenner J,Zilling T,Johnsson F,Von Holstein CS,Walther B

    更新日期：2003-01-01 00:00:00

  • Benign esophagorespiratory fistula: a case series and a novel technique of definitive management.

    abstract：:Benign esophagorespiratory fistula is a relatively rare condition in adults that poses a technical challenge to manage. This case series describes our experience in the treatment of benign esophagorespiratory fistula in 12 adults. A retrospective review of case records of 12 patients with benign esophagorespiratory fi...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2012.01347.x

    authors： Deshpande G,Samarasam I,Banerjee S,Gnanamuthu RB,Chandran S,Mathew G

    更新日期：2013-02-01 00:00:00