Lung transplantation in patients with connective tissue disorders and esophageal dysmotility.

Abstract:

:Lung and esophageal dysfunction are common in patients with connective tissue disease (CTD). Recent reports have suggested a link between pathologic gastroesophageal reflux and bronchiolitis obliterans syndrome (BOS) after lung transplant. Because patients with CTD have a high incidence of esophageal dysmotility and reflux, this group may be at increased risk of allograft dysfunction after lung transplantation. Little is known about antireflux surgery in these patients. Our aims were to describe: (i) the esophageal motility and reflux profile of patients with CTD referred for lung transplantation; and (ii) the safety and outcomes of laparoscopic fundoplication in this group. A retrospective review of 26 patients with CTD referred for lung transplantation between July 2003 and June 2007 at a single center. Esophageal studies included manometry and ambulatory 24-h pH monitoring. Twenty-three patients had esophageal manometry and ambulatory 24-h pH monitoring. Nineteen patients (83%) had pathologic distal reflux and 7 (30%) also had pathologic proximal reflux. Eighteen patients (78%) had impaired or absent peristalsis. Eleven of 26 patients underwent lung transplantation. Ten patients are alive at a median follow-up of 26 months (range 3-45) and one has bronchiolitis obliterans syndrome-1. Six patients had a laparoscopic fundoplication, 1 before transplantation and 5 after. All fundoplication patients are alive at median follow-up of 25 months (range 19-45). In conclusion, esophageal dysmotility and reflux are common in CTD patients referred for lung transplant. For this group, laparoscopic fundoplication is safe in experienced hands.

journal_name

Dis Esophagus

authors

Gasper WJ,Sweet MP,Golden JA,Hoopes C,Leard LE,Kleinhenz ME,Hays SR,Patti MG

doi

10.1111/j.1442-2050.2008.00828.x

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

650-5

issue

7

eissn

1120-8694

issn

1442-2050

pii

DES828

journal_volume

21

pub_type

杂志文章
  • Impedance characteristics of esophageal motor function in achalasia.

    abstract::Detailed data on patterns of esophageal bolus transport in patients with achalasia are still lacking. To study these we applied the novel technique of multichannel intraluminal impedance measurements. Ten patients with achalasia were studied using a 16 channel system. Liquid and semisolid boluses of 10 mL were applied...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/j.1442-2050.2004.00372.x

    authors: Nguyen HN,Domingues GR,Winograd R,Lammert F,Silny J,Matern S

    更新日期:2004-01-01 00:00:00

  • When are reflux episodes symptomatic?

    abstract::Careful scrutiny of pH recordings and symptom diaries in patients having 24-hour pH-metry reveals that most reflux episodes are asymptomatic. Although this observation is well known and long recognized, the explanation for why one reflux episode leads to symptoms and others do not is incompletely understood. Forty-fou...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/j.1442-2050.2007.00650.x

    authors: Portale G,Peters J,Hsieh CC,Tamhankar A,Arain M,Hagen J,DeMeester S,DeMeester T

    更新日期:2007-01-01 00:00:00

  • How many lymph nodes should be dissected in esophagectomy with or without neoadjuvant therapy to get accurate staging?

    abstract::It is essential to dissect an adequate number of lymph nodes (LNs) to ensure staging accuracy during esophagectomy with or without neoadjuvant therapy. We developed a statistical model to quantify the probability of precise nodal staging based on previous studies. Esophageal cancer patients who underwent esophagectomy...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/doz009

    authors: Zhan C,Shi Y,Jiang W,Sun F,Li M,Lu T,Yin J,Ma K,Yang X,Wang Q

    更新日期:2020-01-16 00:00:00

  • A structured training pathway to implement robot-assisted minimally invasive esophagectomy: the learning curve results from a high-volume center.

    abstract::To ensure safe implementation of robot-assisted minimally invasive esophagectomy (RAMIE), the learning process should be optimized. This study aimed to report the results of a surgeon who implemented RAMIE in a German high-volume center by following a tailored and structured training pathway that involved proctoring. ...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/doaa047

    authors: Kingma BF,Hadzijusufovic E,Van der Sluis PC,Bano E,Lang H,Ruurda JP,Hillegersberg van R,Grimminger PP

    更新日期:2020-11-26 00:00:00

  • Clinical benefits of a swallowing intervention for esophageal cancer patients after esophagectomy.

    abstract::Dysphagia after esophagectomy is the main cause of a prolonged postoperative stay. The present study investigated the effects of a swallowing intervention led by a speech-language-hearing therapist (SLHT) on postoperative dysphagia. We enrolled 276 consecutive esophageal cancer patients who underwent esophagectomy and...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/doaa094

    authors: Takatsu J,Higaki E,Hosoi T,Yoshida M,Yamamoto M,Abe T,Shimizu Y

    更新日期:2020-10-29 00:00:00

  • Does the site of anastomosis for esophagectomy affect long-term quality of life?

    abstract::Long-term survival after esophagectomy is improving, and hence, quality of life (QOL) of these patients has become a priority. There has been extensive debate regarding the optimal site of surgical anastomosis (cervical or intrathoracic). We aimed to evaluate the impact of anastomotic site on long-term QOL postesophag...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/dote.12301

    authors: Wormald JC,Bennett J,van Leuven M,Lewis MP

    更新日期:2016-01-01 00:00:00

  • Inverse correlation between NKG2D expression on CD8+ T cells and the frequency of CD4+CD25+ regulatory T cells in patients with esophageal cancer.

    abstract::Although malignant diseases are known to be associated with immune suppression, detailed mechanisms of this phenomenon are still unknown. NKG2D is an activating cell surface receptor expressed by natural killer (NK) cells and CD8+ T cells, and it has been reported that NKG2D engagement is extremely important for T cel...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/j.1442-2050.2008.00855.x

    authors: Osaki T,Saito H,Fukumoto Y,Yamada Y,Fukuda K,Tatebe S,Tsujitani S,Ikeguchi M

    更新日期:2009-01-01 00:00:00

  • Assessment of the incidence of squamous cell papilloma of the esophagus and the presence of high-risk human papilloma virus.

    abstract:BACKGROUND AND AIMS:There has been a recent increase in the incidence of oropharyngeal cancer (OPC) associated with high-risk human papilloma virus (HPV) infection. We investigated the incidence of esophageal papilloma and the presence of high-risk HPV infection. METHODS:This is a cross-sectional study conducted at a ...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/dote.12475

    authors: Pantham G,Ganesan S,Einstadter D,Jin G,Weinberg A,Fass R

    更新日期:2017-01-01 00:00:00

  • Delivering esophago-gastric cancer care during the COVID-19 pandemic in the United Kingdom: a surgical perspective.

    abstract:BACKGROUND:The COVID-19 pandemic continues to have a significant impact on the provision of medical care. Planning to ensure there is capability to treat those that become ill with the virus has led to an almost complete moratorium on elective work. This study evaluates the impact of COVID-19 on cancer, in particular s...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/doaa091

    authors: Wahed S,Chmelo J,Navidi M,Hayes N,Phillips AW,Immanuel A

    更新日期:2020-09-04 00:00:00

  • Targeted next-generation sequencing of commonly mutated genes in esophageal adenocarcinoma patients with long-term survival.

    abstract::Survival of patients with esophageal adenocarcinoma remains poor and individual differences in prognosis remain unexplained. This study investigated whether gene mutations can explain why patients with high-risk (pT3-4, pN+) esophageal adenocarcinoma survive past 5 years after esophagectomy. Six long-term survivors (L...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/dox058

    authors: Visser E,Franken IA,Brosens LAA,de Leng WWJ,Strengman E,Offerhaus JA,Ruurda JP,van Hillegersberg R

    更新日期:2017-09-01 00:00:00

  • S100A4 regulates motility and invasiveness of human esophageal squamous cell carcinoma through modulating the AKT/Slug signal pathway.

    abstract::The involvement of S100A4 in modulating invasiveness of esophageal squamous cell carcinoma (ESCC) cell lines was explored. It was shown that S100A4 expression is positively correlated with the degree of invasiveness in human ESCC cells. The S100A4-rich EC-1 cells displayed higher migratory and invasive cell behavior w...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/j.1442-2050.2012.01323.x

    authors: Zhang K,Zhang M,Zhao H,Yan B,Zhang D,Liang J

    更新日期:2012-11-01 00:00:00

  • Prospective non-randomized study of preoperative concurrent platinum plus 5-fluorouracil-based chemoradiotherapy with or without paclitaxel in esophageal cancer patients: long-term follow-up.

    abstract::Combined modality treatment for esophageal carcinoma seems to improve survival over surgery alone. Different combinations of cytotoxic drugs have been studied to improve antitumor efficacy and limit the toxicity of chemoradiotherapy (CRT) with inconsistent results. We present a prospective study of neoadjuvant CRT wit...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1442-2050.2009.00984.x

    authors: Zemanova M,Petruzelka L,Pazdro A,Kralova D,Smejkal M,Pazdrova G,Honova H

    更新日期:2010-02-01 00:00:00

  • Significant decline in the prevalence of Barrett's esophagus among patients with gastroesophageal reflux disease.

    abstract::Barrett's esophagus (BE), a premalignant condition for the development of esophageal adenocarcinoma (EAC), is a consequence of chronic gastroesophageal reflux disease (GERD). Although the incidence of EAC is increasing, a similar trend for BE is not clear. We aimed to evaluate the prevalence of newly diagnosed BE over...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/doaa131

    authors: Hamade N,Weng G,Desai M,Chandrasekar VT,Dasari C,Kennedy K,Sharma P

    更新日期:2021-01-16 00:00:00

  • Outcome of floppy Nissen fundoplication with intraoperative manometry to treat sliding hiatal hernia.

    abstract::The aim of this study was to evaluate the effectiveness of floppy Nissen fundoplication with intraoperative esophageal manometry. Between February 1992 and July 2004, there were 102 patients with sliding hiatal hernia undergoing transabdominal Nissen fundoplication. They were divided into three groups: 27 patients wer...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/j.1442-2050.2007.00777.x

    authors: Lei Y,Li JY,Jiang J,Wang J,Zhang QY,Wang TY,Krasna MJ

    更新日期:2008-01-01 00:00:00

  • Infant acid suppression use is associated with the development of eosinophilic esophagitis.

    abstract::Eosinophilic esophagitis (EoE) is an esophageal allergic inflammatory disorder often presenting with infant/toddler gastroesophageal reflux symptoms refractory to treatment, including acid suppression trials with histamine H2 antagonists and proton pump inhibitors. We propose to evaluate the impact of infant acid supp...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/doaa073

    authors: Kuhn BR,Young AJ,Justice AE,Chittoor G,Walton NA

    更新日期:2020-10-12 00:00:00

  • The impact of the speed of food intake on gastroesophageal reflux events in obese female patients.

    abstract::Obesity increases the risk of gastroesophageal reflux disease (GERD). The majority of the reflux attacks occur postprandially. The influence of the speed of food intake on gastroesophageal reflux events is unclear in obese patients. To determine the influence of the speed of food intake on intraesophageal reflux event...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/dote.12499

    authors: Bor S,Erdogan A,Bayrakci B,Yildirim E,Vardar R

    更新日期:2017-01-01 00:00:00

  • Laparoscopic Heller myotomy with Dor fundoplication for achalasia: long-term outcomes and effect on chest pain.

    abstract::The aim of the present study was to evaluate the long-term outcomes of laparoscopic Heller myotomy with Dor fundoplication (LHD) and its effect on chest pain. Between June 1995 and August 2009, a total of 35 patients with achalasia underwent an LHD. The symptom scores were calculated by combining the frequency and the...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/j.1442-2050.2009.01032.x

    authors: Sasaki A,Obuchi T,Nakajima J,Kimura Y,Koeda K,Wakabayashi G

    更新日期:2010-05-01 00:00:00

  • Do dysplastic proximal resection margins predict the risk of anastomotic recurrence and overall survival in patients with esophageal squamous cell carcinoma?

    abstract::Positive proximal resection margins are strongly associated with anastomotic recurrence in esophageal cancer. However, the prognostic significance of dysplastic proximal resection margins remains unclear. The aim of this study is to investigate whether the dysplastic proximal resection margin can predict anastomotic r...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/doy090

    authors: Chen YH,Yeh CJ,Wen YW,Chuang WY,Chao YK

    更新日期:2019-05-01 00:00:00

  • In vivo molecular imaging of HER2 expression in a rat model of Barrett's esophagus adenocarcinoma.

    abstract::Human epidermal growth factor receptor 2 (HER2) is involved in the malignant progression of several human cancers, including esophageal adenocarcinoma (EAC). The purpose of this study was to evaluate HER2 overexpression and to explore the feasibility of confocal laser endomicroscopy for in vivo molecular imaging of HE...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/dote.12210

    authors: Realdon S,Dassie E,Fassan M,Dall'Olmo L,Hatem G,Buda A,Arcidiacono D,Diamantis G,Zhang H,Greene MI,Sturniolo GC,Rugge M,Alberti A,Battaglia G

    更新日期:2015-05-01 00:00:00

  • Angiolipoma of the esophagus: a rare clinical dilemma.

    abstract::Benign tumors of the esophagus are a rare but diverse group of lesions. Although non-malignant in biology, their presence can cause significant morbidity, including dysphagia, bleeding, gastrointestinal obstruction, and even asphyxiation. Diagnosis is frequently made using radiographic and endoscopic means, even in th...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/j.1442-2050.2006.00567.x

    authors: Jensen EH,Klapman JB,Kelley ST

    更新日期:2006-01-01 00:00:00

  • Viruses and esophageal cancer.

    abstract::Esophageal adenocarcinoma (EAC) has had the fastest increasing incidence of any solid tumor in the United States in the last 30 years. Long standing gastroesophageal reflux disease is a well-established risk factor with strong associations with obesity, alcohol and tobacco. However, there are likely additional contrib...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/doaa036

    authors: Chang C,Worrell SG

    更新日期:2020-12-07 00:00:00

  • Reporting outcomes of definitive radiation-based treatment for esophageal cancer: a review of the literature.

    abstract::Accurate evaluation of radical radiotherapy requires well designed research with valid and appropriate outcomes. This study reviewed standards of outcome reporting and study design in randomized controlled trials (RCTs) of radiation-based therapy for esophageal cancer and made recommendations for future work. Randomiz...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章,评审

    doi:10.1111/dote.12168

    authors: Main BG,Strong S,McNair AG,Falk SJ,Crosby T,Blazeby JM

    更新日期:2015-02-01 00:00:00

  • Liver metastases from esophageal carcinoma: is there a role for surgical resection?

    abstract::Esophageal cancer recurrence rates after esophagectomy are high, and locally recurrent or distant metastatic disease has poor prognosis. Management is limited to palliative chemotherapy and symptomatic interventions. We report our experience of four patients who have undergone successful liver resection for metastases...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/dote.12233

    authors: Huddy JR,Thomas RL,Worthington TR,Karanjia ND

    更新日期:2015-07-01 00:00:00

  • Decision analysis supports the use of drain amylase-based enhanced recovery method after esophagectomy.

    abstract::Postesophagectomy anastomotic leak is a common postsurgical complication. The current standard method of detecting leak is esophagram usually late in the postoperative period. Perianastomotic drain amylase level had shown promising results in early detection anastomosis leak. Previous studies have shown that postopera...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/doy041

    authors: Jiang B,Ho VP,Ginsberg J,Fu SJ,Perry Y,Argote-Greene L,Linden PA,Towe CW

    更新日期:2018-10-01 00:00:00

  • Telomerase activity and survival of late-stage South African esophageal carcinoma patients.

    abstract::Squamous cell carcinoma of the esophagus is a cancer with a high incidence in South Africa. We have investigated the prognostic value of telomerase activity in tumors as well as nearby normal tissue. Biopsies from 98 patients (71 men and 27 women) were analyzed using an adaptation of the TRAP assay. We found all tumor...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/j.1442-2050.2004.00417.x

    authors: van den Heever WM,Pretorius GH,Smit SJ

    更新日期:2004-01-01 00:00:00

  • Influence of the esophageal hiatus size on the lower esophageal sphincter, on reflux activity and on symptomatology.

    abstract::Hiatal hernia is an underlying factor contributing to gastroesophageal reflux disease (GERD). However, it remains elusive whether the size of the esophageal hiatus has a de facto influence on the lower esophageal sphincter (LES), on the intensity of patient reflux, on GERD symptoms and on the quality of life (QoL). On...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/j.1442-2050.2011.01238.x

    authors: Koch OO,Kaindlstorfer A,Antoniou SA,Asche KU,Granderath FA,Pointner R

    更新日期:2012-04-01 00:00:00

  • Treatment choices and outcomes of patients with manometrically diagnosed achalasia.

    abstract::This prospective population-based study was designed to evaluate treatment choices in patients with new manometrically diagnosed achalasia and their outcomes. Patients referred to the esophageal function laboratory were enrolled after a new manometric diagnosis of achalasia. Patients completed an initial achalasia sym...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/dote.12348

    authors: Yeung JC,Finley C,Hanna WC,Miller L,Ferri L,Urbach DR,Darling GE

    更新日期:2016-07-01 00:00:00

  • Gastric fundus tension before and after division of the short gastric vessels in a cadaveric model of fundoplication.

    abstract::Short gastric vessels (SGV) division is a controversial topic in antireflux surgery. Some surgeons do not divide the SGV routinely to perform a fundoplication; however, excessive tension of the gastric fundus (GF) forces this procedure necessary in some cases. This study aims to evaluate in a cadaveric model of Nissen...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/j.1442-2050.2009.00945.x

    authors: Szor DJ,Herbella FA,Bonini AL,Moreno DG,Del Grande JC

    更新日期:2009-01-01 00:00:00

  • Geometrical differences in target volumes based on 18F-fluorodeoxyglucose positron emission tomography/computed tomography and four-dimensional computed tomography maximum intensity projection images of primary thoracic esophageal cancer.

    abstract::The objective of the study was to compare geometrical differences of target volumes based on four-dimensional computed tomography (4DCT) maximum intensity projection (MIP) and 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) images of primary thoracic esophageal cancer for radia...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/dote.12247

    authors: Guo Y,Li J,Wang W,Zhang Y,Wang J,Duan Y,Shang D,Fu Z

    更新日期:2014-11-01 00:00:00

  • Management of eosinophilic esophagitis is often discordant with guidelines and not patient-centered: results of a survey of gastroenterologists.

    abstract::Published guidelines for the management of eosinophilic esophagitis (EoE) recommend an initial trial of proton pump inhibitors (PPI), histologic assessment for response to therapy, and tailoring treatments to patient needs and provider resources. Effectiveness studies directly comparing therapies are lacking, leaving ...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/doy133

    authors: Chang JW,Saini SD,Mellinger JL,Chen JW,Zikmund-Fisher BJ,Rubenstein JH

    更新日期:2019-06-01 00:00:00