Effects of kidney function, serum albumin and hemoglobin on dementia severity in the oldest old people with newly diagnosed Alzheimer's disease in a residential aged care facility: a cross-sectional study.

Abstract:

BACKGROUND:Chronic kidney disease (CKD), low serum albumin, and anemia are known risk factors for cognitive decline in older people. We investigated the association between kidney function and cognitive impairment severity in oldest-old people with a diagnosis of Alzheimer's disease (AD). METHODS:A cross-sectional study of patients aged 80 years and older was conducted at a veterans' home in Taiwan between 2012 and 2016. Their estimated glomerular filtration rate (eGFR) was determined using the Modification of Diet in Renal Diseases (MDRD) equation. Cognitive function was evaluated with the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR). RESULTS:A total of 84 patients (age mean ± SD, 86.6 ± 3.9 years) had MMSE scores of 10.1 ± 6.7, and CDR scores of 1.6 ± 0.7. The average eGFR was 61.7 ± 21.5 mL/min/1.73m2. The mean hemoglobin concentration was 12.7 ± 1.7 g/dl, and the mean albumin concentration was 4.5 ± 4.8 g/dl. Multivariate regression analyses showed that scores of CDR were significantly correlated with eGFR after adjustment for potential confounders. The scores of MMSE were significantly correlated with serum albumin and hemoglobin after adjustment for potential confounders. CONCLUSIONS:We found dementia severity was significantly associated with kidney function, serum albumin, and hemoglobin in the oldest-old with AD. We recommend that oldest-old people with a diagnosis of AD be evaluated to determine kidney function, as well as nutritional and hematological status. Further study is needed to establish whether prevention of CKD deterioration, and correction of malnutrition and anemia may help to slow cognitive decline in oldest-old people with dementia.

journal_name

BMC Geriatr

journal_title

BMC geriatrics

authors

Wu JJ,Weng SC,Liang CK,Lin CS,Lan TH,Lin SY,Lin YT

doi

10.1186/s12877-020-01789-0

subject

Has Abstract

pub_date

2020-10-07 00:00:00

pages

391

issue

1

issn

1471-2318

pii

10.1186/s12877-020-01789-0

journal_volume

20

pub_type

杂志文章
  • Neuropsychiatric symptoms in patients with dementia in primary care: a study protocol.

    abstract:BACKGROUND:Neuropsychiatric symptoms (NPS) frequently occur in patients with dementia. To date, prospective studies on the course of NPS have been conducted in patients with dementia in clinical centers or psychiatric services. The primary goal of this study is to investigate the course of NPS in patients with dementia...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2318-14-32

    authors: Borsje P,Wetzels RB,Lucassen PL,Pot AM,Koopmans RT

    更新日期:2014-03-17 00:00:00

  • Is the Nintendo Wii Fit really acceptable to older people? A discrete choice experiment.

    abstract:BACKGROUND:Interactive video games such as the Nintendo Wii Fit are increasingly used as a therapeutic tool in health and aged care settings however, their acceptability to older people is unclear. The aim of this study was to determine the acceptability of the Nintendo Wii Fit as a therapy tool for hospitalised older ...

    journal_title:BMC geriatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2318-11-64

    authors: Laver K,Ratcliffe J,George S,Burgess L,Crotty M

    更新日期:2011-10-20 00:00:00

  • Lower body functioning and correlates among older American Indians: The Cerebrovascular Disease and Its Consequences in American Indians Study.

    abstract:BACKGROUND:More than six million American Indians live in the United States, and an estimated 1.6 million will be aged ≥65 years old by 2050 tripling in numbers since 2012. Physical functioning and related factors in this population are poorly understood. Our study aimed to assess lower body functioning and identify th...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/s12877-017-0697-8

    authors: Goins RT,Schure M,Jensen PN,Suchy-Dicey A,Nelson L,Verney SP,Howard BV,Buchwald D

    更新日期:2018-01-05 00:00:00

  • Self-reported hearing difficulties and changes in life-space mobility among community-dwelling older adults: a Two-year follow-Up study.

    abstract:BACKGROUND:Life-space mobility reflects individuals' actual mobility and engagement with society. Difficulty in hearing is common among older adults and can complicate participation in everyday activities, thus restricting life-space mobility. The aim of this study was to examine whether self-reported hearing predicts ...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/s12877-015-0119-8

    authors: Polku H,Mikkola TM,Rantakokko M,Portegijs E,Törmäkangas T,Rantanen T,Viljanen A

    更新日期:2015-10-12 00:00:00

  • Unplanned Readmission prevention by Geriatric Emergency Network for Transitional care (URGENT): protocol of a prospective single centre quasi-experimental study.

    abstract:BACKGROUND:International guidelines recommend adapting the classic emergency department (ED) management model to the needs of older adults in order to ameliorate post-ED outcomes among this vulnerable group. To improve the care for older ED patients and especially prevent unplanned ED readmissions, the URGENT care mode...

    journal_title:BMC geriatrics

    pub_type: 临床试验,杂志文章

    doi:10.1186/s12877-018-0933-x

    authors: Devriendt E,Heeren P,Fieuws S,Wellens NIH,Deschodt M,Flamaing J,Sabbe M,Milisen K

    更新日期:2018-10-16 00:00:00

  • The impact of frailty on healthcare utilisation in Ireland: evidence from the Irish longitudinal study on ageing.

    abstract:INTRODUCTION:To examine the impact of frailty on medical and social care utilisation among the Irish community-dwelling older population to inform strategies of integrated care for older people with complex needs. METHODS:Participants aged ≥65 years from the Irish Longitudinal Study on Ageing (TILDA) representative of...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/s12877-017-0579-0

    authors: Roe L,Normand C,Wren MA,Browne J,O'Halloran AM

    更新日期:2017-09-05 00:00:00

  • Smoking, dementia and cognitive decline in the elderly, a systematic review.

    abstract:BACKGROUND:Nicotine may aid reaction time, learning and memory, but smoking increases cardiovascular risk. Cardiovascular risk factors have been linked to increased risk of dementia. A previous meta-analysis found that current smokers were at higher risk of subsequent dementia, Alzheimer's disease, vascular dementia an...

    journal_title:BMC geriatrics

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2318-8-36

    authors: Peters R,Poulter R,Warner J,Beckett N,Burch L,Bulpitt C

    更新日期:2008-12-23 00:00:00

  • Mothers and daughters-in-law: a prospective study of informal care-giving arrangements and survival in Japan.

    abstract:BACKGROUND:Daughters-in-law have played an important role in informal care-giving arrangements within East Asian traditional norms. The aim of this study was to measure the impact of daughter-in-law care-giving on the survival of care recipients. We prospectively examined the associations between different types of kin...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2318-10-61

    authors: Nishi A,Tamiya N,Kashiwagi M,Takahashi H,Sato M,Kawachi I

    更新日期:2010-08-29 00:00:00

  • The prevalence and determinants of polypharmacy at age 69: a British birth cohort study.

    abstract:BACKGROUND:To describe the development of polypharmacy and its components in a British birth cohort in its seventh decade and to investigate socioeconomic and gender differences independent of disease burden. METHODS:Data from the MRC National Survey for Health and Development were analysed to determine the prevalence...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/s12877-018-0795-2

    authors: Rawle MJ,Richards M,Davis D,Kuh D

    更新日期:2018-05-16 00:00:00

  • 10-year follow-up of the Super-Seniors Study: compression of morbidity and genetic factors.

    abstract:BACKGROUND:Super-Seniors are healthy, long-lived individuals who were recruited at age 85 years or older with no history of cancer, cardiovascular disease, diabetes, dementia, or major pulmonary disease. In a 10-year follow-up, we aimed to determine whether surviving Super-Seniors showed compression of morbidity, and t...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/s12877-019-1080-8

    authors: Tindale LC,Salema D,Brooks-Wilson AR

    更新日期:2019-02-28 00:00:00

  • Pre-arrest predictors of survival after resuscitation from out-of-hospital cardiac arrest in the elderly a systematic review.

    abstract:BACKGROUND:To enable older people to make decisions about the appropriateness of cardiopulmonary resuscitation (CPR), information is needed about the predictive value of pre-arrest factors such as comorbidity, functional and cognitive status on survival and quality of life of survivors. We systematically reviewed the l...

    journal_title:BMC geriatrics

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2318-13-68

    authors: van de Glind EM,van Munster BC,van de Wetering FT,van Delden JJ,Scholten RJ,Hooft L

    更新日期:2013-07-03 00:00:00

  • Initiating Aha moments when implementing person-centered care in nursing homes: a multi-arm, pre-post intervention.

    abstract:BACKGROUND:Comprehensive adoption of culture change via person-centered care (PCC) practices in nursing homes has been slow. Change such as this, requires transformation of organizational culture, frequently generating resistance and slow moving change. This study examined how nursing homes perceive their adoption of P...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/s12877-019-1121-3

    authors: Cornelison LJ,Hermer L,Syme ML,Doll G

    更新日期:2019-04-23 00:00:00

  • Translation and adaption of the interRAI Suite to local requirements in Belgian hospitals.

    abstract:BACKGROUND:The interRAI Suite contains comprehensive geriatric assessment tools designed for various healthcare settings. Although each instrument is developed for a particular population, together they form an integrated health evaluation system. The interRAI Acute Care Minimum Data Set (interRAI AC) is tailored for h...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2318-12-53

    authors: Wellens NI,Flamaing J,Moons P,Deschodt M,Boonen S,Milisen K

    更新日期:2012-09-07 00:00:00

  • Validation of a one year fracture prediction tool for absolute hip fracture risk in long term care residents.

    abstract:BACKGROUND:Frail older adults living in long term care (LTC) homes have a high fracture risk, which can result in reduced quality of life, pain and death. The Fracture Risk Scale (FRS) was designed for fracture risk assessment in LTC, to optimize targeting of services in those at highest risk. This study aims to examin...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/s12877-018-1010-1

    authors: Negm AM,Ioannidis G,Jantzi M,Bucek J,Giangregorio L,Pickard L,Hirdes JP,Adachi JD,Richardson J,Thabane L,Papaioannou A

    更新日期:2018-12-27 00:00:00

  • Sensor-based characterization of daily walking: a new paradigm in pre-frailty/frailty assessment.

    abstract:BACKGROUND:Frailty is a highly recognized geriatric syndrome resulting in decline in reserve across multiple physiological systems. Impaired physical function is one of the major indicators of frailty. The goal of this study was to evaluate an algorithm that discriminates between frailty groups (non-frail and pre-frail...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/s12877-020-01572-1

    authors: Pradeep Kumar D,Toosizadeh N,Mohler J,Ehsani H,Mannier C,Laksari K

    更新日期:2020-05-06 00:00:00

  • Balancing the struggle to live with dementia: a systematic meta-synthesis of coping.

    abstract:BACKGROUND:People with dementia describe experiences of loss that threaten their autonomy and ability to contribute to society. They often have difficulties with orientation, loss of roll function, and fear about the future, and need help from others. An increasing body of literature also focuses on how people with dem...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/s12877-019-1306-9

    authors: Bjørkløf GH,Helvik AS,Ibsen TL,Telenius EW,Grov EK,Eriksen S

    更新日期:2019-10-30 00:00:00

  • Exposure to general anesthesia and risk of Alzheimer's disease: a systematic review and meta-analysis.

    abstract:BACKGROUND:Alzheimer's disease (AD) is common among older adults and leads to significant disability. Volatile anesthetic gases administered during general anesthesia (GA) have been hypothesized to be a risk factor for the development of AD. The objective of this study is to systematically review the association betwee...

    journal_title:BMC geriatrics

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/1471-2318-11-83

    authors: Seitz DP,Shah PS,Herrmann N,Beyene J,Siddiqui N

    更新日期:2011-12-14 00:00:00

  • Association between estimated glomerular filtration rate (eGFR) and asymmetric dimethylarginine (ADMA) concentrations among the elderly in a rural community: a cross-sectional study.

    abstract:BACKGROUND:Reduced glomerular filtration rate and increased asymmetric dimethylarginine (ADMA) are prevalent in elderly people. However, most of the studies that have examined the association between the two conditions were performed in patients with renal dysfunction, but not in the general elderly population. Thus, w...

    journal_title:BMC geriatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12877-019-1388-4

    authors: Choi HR,Lee SW,Jeon DH,Hur NW,Youm Y,Kim HC

    更新日期:2019-12-23 00:00:00

  • Physical inactivity and self-reported depression among middle- and older-aged population in South Asia: World health survey.

    abstract:BACKGROUND:With the increase in the understanding of the influence of various lifestyle factors such as sedentary behaviour and level of physical activity (PA) on physical and mental health, there has been a growing research interest on how physical inactivity correlates with depressive outcomes across countries. The p...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/s12877-017-0489-1

    authors: Bishwajit G,O'Leary DP,Ghosh S,Yaya S,Shangfeng T,Feng Z

    更新日期:2017-04-28 00:00:00

  • End-of-life care communications and shared decision-making in Norwegian nursing homes--experiences and perspectives of patients and relatives.

    abstract:BACKGROUND:Involving nursing home patients and their relatives in end-of-life care conversations and treatment decisions has recently gained increased importance in several Western countries. However, there is little knowledge about how the patients themselves and their next-of-kin look upon involvement in end-of-life ...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/s12877-015-0096-y

    authors: Gjerberg E,Lillemoen L,Førde R,Pedersen R

    更新日期:2015-08-19 00:00:00

  • Does owning a pet protect older people against loneliness?

    abstract:BACKGROUND:Pet ownership is thought to make a positive contribution to health, health behaviours and the general well-being of older people. More specifically pet ownership is often proposed as a solution to the problem of loneliness in later life and specific 'pet based' interventions have been developed to combat lon...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2318-14-106

    authors: Pikhartova J,Bowling A,Victor C

    更新日期:2014-09-20 00:00:00

  • Lower dietary variety is a relevant factor for malnutrition in older Japanese home-care recipients: a cross-sectional study.

    abstract:BACKGROUND:Nutritional status of the older people is affected by various life-style factors. Although dietary habit is one of the life-style factors, it is unknown which of older home-care recipients' dietary habits are associated with malnutrition. The purpose of this study was to examine the association of dietary va...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/s12877-019-1206-z

    authors: Tsuji T,Yamamoto K,Yamasaki K,Hayashi F,Momoki C,Yasui Y,Ohfuji S,Fukushima W,Habu D

    更新日期:2019-07-26 00:00:00

  • Effectiveness of oral nutritional supplementation for older women after a fracture: rationale, design and study of the feasibility of a randomized controlled study.

    abstract:BACKGROUND:Malnutrition is a problem for many older people recovering from a hip and other major fractures. Oral supplementation with high calorie high protein nutrients is a simple intervention that may help older people with fractures to improve their recovery in terms of rehabilitation time, length of hospital stay ...

    journal_title:BMC geriatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2318-11-32

    authors: Cameron ID,Kurrle SE,Uy C,Lockwood KA,Au L,Schaafsma FG

    更新日期:2011-06-10 00:00:00

  • The use of PDSA methodology to evaluate and optimise an inner city memory clinic: a quality improvement project.

    abstract::The Memory Services National Accreditation Programme states that memory services should provide "timely access to assessment and diagnosis" of dementia. We undertook a quality improvement project using Plan-Do-Study-Act methodology to improve patient access to an inner city memory service. This report focuses on the t...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2318-14-4

    authors: Perry J,Bell F,Shaw T,Fitzpatrick B,Sampson EL

    更新日期:2014-01-15 00:00:00

  • Effects of two exercise protocols on postural balance of elderly women: a randomized controlled trial.

    abstract:BACKGROUND:The aging process reduces both sensory capabilities and the capabilities of the motor systems responsible for postural control, resulting in a high number of falls among the elderly. Some therapeutic interventions can directly interrupt this process, including physical exercise. This study compares and exami...

    journal_title:BMC geriatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12877-015-0059-3

    authors: Mesquita LS,de Carvalho FT,Freire LS,Neto OP,Zângaro RA

    更新日期:2015-06-02 00:00:00

  • Health economic evaluations of non-pharmacological interventions for persons with dementia and their informal caregivers: a systematic review.

    abstract:BACKGROUND:This systematic review aims to review the literature on trial-based economic evaluations of non-pharmacological interventions directly targeted at persons with dementia as well as persons with mild cognitive impairment and their respective caregivers. METHODS:A systematic literature research was conducted f...

    journal_title:BMC geriatrics

    pub_type: 杂志文章,评审

    doi:10.1186/s12877-018-0751-1

    authors: Nickel F,Barth J,Kolominsky-Rabas PL

    更新日期:2018-03-09 00:00:00

  • Hand-grip strength among older adults in Singapore: a comparison with international norms and associative factors.

    abstract:BACKGROUND:Hand-grip strength (HGS) serves as a proxy measure for muscle function and physical health. Studies have shown that low HGS is associated with common age-related disorders including frailty and sarcopenia. The aim of the present study was to establish the normative values of HGS among older adults in Singapo...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/s12877-017-0565-6

    authors: Ong HL,Abdin E,Chua BY,Zhang Y,Seow E,Vaingankar JA,Chong SA,Subramaniam M

    更新日期:2017-08-04 00:00:00

  • Pain treatment for nursing home residents differs according to cognitive state - a cross-sectional study.

    abstract:BACKGROUND:Communication skills are known to decrease with advancing cognitive impairment. Analgesic treatment in long-term care may be deficient due to the residents' impaired ability to communicate their pain and needs. Undertreated pain frequently leads to rising BPSD in residents with cognitive impairment, resultin...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/s12877-016-0295-1

    authors: Bauer U,Pitzer S,Schreier MM,Osterbrink J,Alzner R,Iglseder B

    更新日期:2016-06-17 00:00:00

  • Service users' involvement in the development of individual Cognitive Stimulation Therapy (iCST) for dementia: a qualitative study.

    abstract:BACKGROUND:Individual Cognitive Stimulation Therapy (iCST) is a one to one, carer led psychosocial intervention for people with dementia, adapted from group Cognitive Stimulation Therapy (CST). It is increasingly recognised that involving service users in research is key to developing interventions and treatments that ...

    journal_title:BMC geriatrics

    pub_type: 杂志文章

    doi:10.1186/s12877-015-0004-5

    authors: Yates LA,Orrell M,Spector A,Orgeta V

    更新日期:2015-02-06 00:00:00

  • Does the timed up and go test predict future falls among British community-dwelling older people? Prospective cohort study nested within a randomised controlled trial.

    abstract:BACKGROUND:Falling is common among older people. The Timed-Up-and-Go Test (TUG) is recommended as a screening tool for falls but its predictive value has been challenged. The objectives of this study were to examine the ability of TUG to predict future falls and to estimate the optimal cut-off point to identify those w...

    journal_title:BMC geriatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12877-015-0039-7

    authors: Kojima G,Masud T,Kendrick D,Morris R,Gawler S,Treml J,Iliffe S

    更新日期:2015-04-03 00:00:00