Abstract:
:The consensus Immunoscore is a routine assay quantifying the adaptive immune response within the tumor microenvironment. It has a prognostic value that has been confirmed in a phase 3 clinical trial (NCCTG N0147) in stage III colon cancers. Moreover, results from another phase 3 randomized trial revealed the predictive value of Immunoscore for response to adjuvant chemotherapy duration. These results highlight the clinical utility of Immunoscore. In its latest edition, the World Health Organization classification of Digestive System Tumors introduced for the first time the immune response as an essential and desirable diagnostic criterion for colorectal cancer. Within the tumor microenvironment, the immune response provides an important estimate of the risk of recurrence and death in colon cancer. The international validation of the prognostic value of the consensus Immunoscore together with its prognostic value in the N0147 trial and its predictive utility for response to chemotherapy in stage III patients provide valuable information for patient management.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Lanzi A,Sinicrope FA,Benson AB,Galon Jdoi
10.1080/2162402X.2020.1796003subject
Has Abstractpub_date
2020-07-20 00:00:00pages
1796003issue
1eissn
2162-4011issn
2162-402Xpii
1796003journal_volume
9pub_type
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