Targeting AGTR1/NF-κB/CXCR4 axis by miR-155 attenuates oncogenesis in glioblastoma.

abstract：:Although Chk1 kinase inhibitors are currently under clinical investigation as effective cancer cell sensitizers to the cytotoxic effects of numerous chemotherapeutics, there is still a considerable uncertainty regarding their role in modulation of anticancer potential of platinum-based drugs. Here we newly demonstrate...

journal_title：Neoplasia (New York, N.Y.)

authors： Herůdková J,Paruch K,Khirsariya P,Souček K,Krkoška M,Vondálová Blanářová O,Sova P,Kozubík A,Hyršlová Vaculová A

更新日期：2017-10-01 00:00:00

abstract：:Soluble CD44 proteins generated by proteolytic cleavage or aberrant intron retention have been shown to antagonize the ligand binding activity of the corresponding cell surface receptor, inducing apoptosis and inhibiting tumor growth. Interestingly, such findings appear to contradict recent studies demonstrating a cor...

journal_title：Neoplasia (New York, N.Y.)

authors： Chiu RK,Carpenito C,Dougherty ST,Hayes GM,Dougherty GJ

更新日期：1999-11-01 00:00:00

abstract：:The ZNF198- FGFR1 fusion gene arises as a result of the t(8;13)(p11;q12) in the 8p11 myeloproliferative syndrome. To determine the transforming properties of this chimeric protein we transfected ZNF198-FGFR1 into the interleukin (IL)-3 dependent cell line Ba/F3. Growth factor independent subclones were obtained in whi...

journal_title：Neoplasia (New York, N.Y.)

authors： Smedley D,Demiroglu A,Abdul-Rauf M,Heath C,Cooper C,Shipley J,Cross NC

更新日期：1999-10-01 00:00:00

abstract：:Endothelin (ET) 1 is important in the growth of prostate cancer cells through the activation of the endothelin A (ET(A)) receptor. ET receptor blockade is a new therapeutic target in treating advanced prostate cancer. This study investigates the impact of the combination of the ET(A) antagonist atrasentan (ABT-627) an...

journal_title：Neoplasia (New York, N.Y.)

authors： Akhavan A,McHugh KH,Guruli G,Bies RR,Zamboni WC,Strychor SA,Nelson JB,Pflug BR

更新日期：2006-09-01 00:00:00

abstract：:The term mucositis is coined to describe the adverse effects of radiation and chemotherapy treatments. Mucositis is one of the most common adverse reactions encountered in radiation therapy for head and neck cancers, as well as in chemotherapy, in particular with drugs affecting DNA synthesis (S-phase-specific agents ...

journal_title：Neoplasia (New York, N.Y.)

authors： Naidu MU,Ramana GV,Rani PU,Mohan IK,Suman A,Roy P

更新日期：2004-09-01 00:00:00

abstract：:The purposes of this study were 1) to investigate the feasibility of using optical tomography in the near-infrared (NIR) spectrum combined with ultrasound (US) localization (NIR/US) in monitoring tumor vascular changes and assessing tumor pathological response during chemotherapy and 2) to compare the accuracy of NIR/...

journal_title：Neoplasia (New York, N.Y.)

authors： Zhu Q,Tannenbaum S,Hegde P,Kane M,Xu C,Kurtzman SH

更新日期：2008-10-01 00:00:00

abstract：:Adenomatous polyposis coli (APC) is a multifunctional protein having diverse cellular functions including cell migration, cell-cell adhesion, cell cycle control, chromosomal segregation, and apoptosis. Recently, we found a new role of APC in base excision repair (BER) and showed that it interacts with DNA polymerase β...

journal_title：Neoplasia (New York, N.Y.)

authors： Jaiswal AS,Panda H,Pampo CA,Siemann DW,Gairola CG,Hromas R,Narayan S

更新日期：2013-04-01 00:00:00

abstract：:Several studies have linked vascular density, identified in histologic sections, to "metastatic risk." Functional information of the vasculature, not readily available from histologic sections, can be obtained with contrast-enhanced MRI to exploit for therapy or metastasis prevention. Our aims were to determine if hum...

journal_title：Neoplasia (New York, N.Y.)

authors： Bhujwalla ZM,Artemov D,Natarajan K,Ackerstaff E,Solaiyappan M

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Well-differentiated gastroenteropancreatic neuroendocrine neoplasms are rare tumors with a slow proliferation. They are virtually resistant to many DNA-damaging therapeutic approaches, such as chemo- and external beam therapy, which might be overcome by DNA damage inhibition induced by proteasome inhibitors ...

journal_title：Neoplasia (New York, N.Y.)

authors： Briest F,Koziolek EJ,Albrecht J,Schmidt F,Bernsen MR,Haeck J,Kühl AA,Sedding D,Hartung T,Exner S,Welzel M,Fischer C,Grötzinger C,Brenner W,Baum RP,Grabowski P

更新日期：2021-01-01 00:00:00

abstract：:PX-478 is a new agent known to inhibit the hypoxia-responsive transcription factor, HIF-1alpha, in experimental tumors. The current study was undertaken in preparation for clinical trials to determine which noninvasive imaging endpoint(s) is sensitive to this drug's actions. Dynamic contrast-enhanced (DCE) and diffusi...

journal_title：Neoplasia (New York, N.Y.)

authors： Jordan BF,Runquist M,Raghunand N,Baker A,Williams R,Kirkpatrick L,Powis G,Gillies RJ

更新日期：2005-05-01 00:00:00

abstract：:The benefits of inhibiting vascular endothelial growth factor (VEGF) signaling in cancer patients are predominantly attributed to effects on tumor endothelial cells. Targeting non-endothelial stromal cells to further impact tumor cell growth and survival is being pursued through the inhibition of additional growth fac...

journal_title：Neoplasia (New York, N.Y.)

authors： Duignan IJ,Corcoran E,Pennello A,Plym MJ,Amatulli M,Claros N,Iacolina M,Youssoufian H,Witte L,Samakoglu S,Schwartz J,Surguladze D,Tonra JR

更新日期：2011-01-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a neoplasia characterized by proliferation of a myeloid cell lineage and chromosome translocation t(9;22) (q34;q11.2). As in the case of most cancers, the average telomere length in CML cells is shorter than that in normal blood cells. However, there are currently no data available co...

journal_title：Neoplasia (New York, N.Y.)

authors： Samassekou O,Ntwari A,Hébert J,Yan J

更新日期：2009-11-01 00:00:00

abstract：:Modulation of the antitumor immune response through the engagement of NKG2D receptors with their ligands (L) on targets represents a promising therapeutic approach against cancer. In this study, we tested the effect of valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, on the expression of NKG2D ligands in m...

journal_title：Neoplasia (New York, N.Y.)

authors： Wu X,Tao Y,Hou J,Meng X,Shi J

更新日期：2012-12-01 00:00:00

abstract：:We investigated the epigenetic silencing and genetic changes of the RAS-associated domain family 1A (RASSF1A) gene and the O6-methylguanine-DNA methyltransferase (MGMT) gene in retinoblastoma. We extracted DNA from microdissected tumor and normal retina tissues of the same patient in 68 retinoblastoma cases. Promoter ...

journal_title：Neoplasia (New York, N.Y.)

authors： Choy KW,Lee TC,Cheung KF,Fan DS,Lo KW,Beaverson KL,Abramson DH,Lam DS,Yu CB,Pang CP

更新日期：2005-03-01 00:00:00

abstract：:The cyclic adenosine monophosphate (AMP) response element-binding protein, CREB, often modulates stress responses. Here, we report that CREB suppresses the glioblastoma proliferative effect of the stress-induced acetylcholinesterase variant, AChE-R. In human U87MG glioblastoma cells, AChE-R formed a triple complex wit...

journal_title：Neoplasia (New York, N.Y.)

authors： Perry C,Sklan EH,Soreq H

更新日期：2004-05-01 00:00:00

abstract：:Our recent studies have shown that annexin II, expressed on the cell surface of osteoblasts, plays an important role in the adhesion of hematopoietic stem cells (HSCs) to the endosteal niche. Similarly, prostate cancer (PCa) cells express the annexin II receptor and seem to use the stem cell niche for homing to the bo...

journal_title：Neoplasia (New York, N.Y.)

authors： Shiozawa Y,Pedersen EA,Patel LR,Ziegler AM,Havens AM,Jung Y,Wang J,Zalucha S,Loberg RD,Pienta KJ,Taichman RS

更新日期：2010-02-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the major gastrointestinal mesenchymal tumors with a variable malignancy ranging from a curable disorder to highly malignant sarcomas. Metastasis and recurrence are the main causes of death in GIST patients. To further explore the mechanism of metastasis and to more accurate...

journal_title：Neoplasia (New York, N.Y.)

authors： Ma MZ,Zhuang C,Yang XM,Zhang ZZ,Ma H,Zhang WM,You H,Qin W,Gu J,Yang S,Cao H,Zhang ZG

更新日期：2014-03-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common malignant primary tumor of the central nervous system. With no effective therapy, the prognosis for patients is terrible poor. It is highly heterogeneous and EGFR amplification is its most frequent molecular alteration. In this light, we aimed to examine the genetic heterogeneity ...

journal_title：Neoplasia (New York, N.Y.)

authors： Muñoz-Hidalgo L,San-Miguel T,Megías J,Monleón D,Navarro L,Roldán P,Cerdá-Nicolás M,López-Ginés C

更新日期：2020-01-01 00:00:00

abstract：:Head and neck squamous cell carcinomas (HNSCC) are frequently characterized by chemotherapy and radiation resistance, and by overexpression of Bcl-XL, an antiapoptotic member of the Bcl-2 protein family. In this report we examined whether cell-permeable peptides derived from the BH3 domains of proapoptotic Bax, Bad, o...

journal_title：Neoplasia (New York, N.Y.)

authors： Li R,Boehm AL,Miranda MB,Shangary S,Grandis JR,Johnson DE

更新日期：2007-10-01 00:00:00

abstract：:Signaling events leading to Schwann cell tumor initiation have been extensively characterized in the context of neurofibromatosis (NF). Similar tumors are also observed in patients with the endocrine neoplasia syndrome Carney complex, which results from inactivating mutations in PRKAR1A. Loss of PRKAR1A causes enhance...

journal_title：Neoplasia (New York, N.Y.)

authors： Jones GN,Tep C,Towns WH 2nd,Mihai G,Tonks ID,Kay GF,Schmalbrock PM,Stemmer-Rachamimov AO,Yoon SO,Kirschner LS

更新日期：2008-11-01 00:00:00

abstract：:A mathematical model is presented for the cellular uptake and cytotoxicity of the anticancer drug doxorubicin. The model assumes sigmoidal, Hill-type dependence of cell survival on drug-induced damage. Experimental evidence indicates distinct intracellular and extracellular mechanisms of doxorubicin cytotoxicity. Drug...

journal_title：Neoplasia (New York, N.Y.)

authors： El-Kareh AW,Secomb TW

更新日期：2005-07-01 00:00:00

abstract：:Two genetically engineered, conditional mouse models of lung tumor formation, K-ras(LSL-G12D) and K-ras(LSL-G12D)/p53(LSL-R270H), are commonly used to model human lung cancer. Developed by Tyler Jacks and colleagues, these models have been invaluable to study in vivo lung cancer initiation and progression in a genetic...

journal_title：Neoplasia (New York, N.Y.)

authors： Haines BB,Bettano KA,Chenard M,Sevilla RS,Ware C,Angagaw MH,Winkelmann CT,Tong C,Reilly JF,Sur C,Zhang W

更新日期：2009-01-01 00:00:00

abstract：:SAG (Sensitive to Apoptosis Gene), also known as RBX2 or ROC2, is a RING component of CRL (Cullin-RING ligase), required for its activity. Our previous studies showed that Sag/Rbx2 co-operated with Kras or Pten loss to promote tumorigenesis in the lung and prostate, respectively, but antagonized Kras to inhibit skin t...

journal_title：Neoplasia (New York, N.Y.)

authors： Zhang Q,Wei D,Tan M,Li H,Morgan MA,Sun Y

更新日期：2020-04-24 00:00:00

abstract：:Although it is well known that nasopharyngeal carcinoma (NPC) is closely related with Epstein-Barr virus (EBV), few data are available about which and how EBV-expressed gene is involved in the carcinogenesis of human nasopharyngeal epithelial cells. EBV-encoded BARF1 (BamH I-A right frame 1) gene has been shown to be ...

journal_title：Neoplasia (New York, N.Y.)

authors： Jiang R,Cabras G,Sheng W,Zeng Y,Ooka T

更新日期：2009-09-01 00:00:00

abstract：:Several observations suggest a potential role of T-cell-mediated immunity in the control of neuroblastoma (NB). However, the generation of NB-specific cytotoxic T lymphocytes (CTL) on T-cell priming with tumor mRNA-transfected dendritic cells (DC) has never been investigated before. In the present study, the feasibili...

journal_title：Neoplasia (New York, N.Y.)

authors： Morandi F,Chiesa S,Bocca P,Millo E,Salis A,Solari M,Pistoia V,Prigione I

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:Upregulation of Bcl-2 family members is a well-established mechanism in the development of androgen-independent prostate cancer. Inhibition of the antiapoptotic proteins Bcl-2 and Mcl-1 may delay the transition to androgen-independent growth. EXPERIMENTAL DESIGN:We have established a prostate cancer model with...

journal_title：Neoplasia (New York, N.Y.)

authors： Loberg RD,McGregor N,Ying C,Sargent E,Pienta KJ

更新日期：2007-12-01 00:00:00

abstract：:Recent studies suggest that tumor-infiltrating immune cells can benefit the tumor by producing factors that promote angiogenesis and suppress immunity. Because the tumor microenvironment is characterized by high adenosine levels, we hypothesized that the low-affinity A(2B) adenosine receptor located on host immune cel...

journal_title：Neoplasia (New York, N.Y.)

authors： Ryzhov S,Novitskiy SV,Zaynagetdinov R,Goldstein AE,Carbone DP,Biaggioni I,Dikov MM,Feoktistov I

更新日期：2008-09-01 00:00:00

abstract：:Even with increasing evidence for roles of glycolytic enzymes in controlling cancerous characteristics, the best target of candidate metabolic enzymes for lessening malignancy remains under debate. Pyruvate is a main glycolytic metabolite that could be mainly converted into either lactate by Lactate Dehydrogenase A (L...

journal_title：Neoplasia (New York, N.Y.)

authors： Chen TY,Hsieh YT,Huang JM,Liu CJ,Chuang LT,Huang PC,Kuo TY,Chia HY,Chou CY,Chang CW,Chen YF,Chen HM,Lo JF,Li WC

更新日期：2019-07-01 00:00:00

abstract：:We examined correlations between TGF-beta1, TbetaR-I and TbetaR-II, p12(CDK2-AP1), p21(WAF1), p27(KIP1), Smad2, and p-Smad2 in 125 cases of human oral squamous cell carcinoma (OSCC) to test the hypothesis that resistance to TGF-beta1-induced growth suppression is due to the disruption of its signaling pathway as a con...

journal_title：Neoplasia (New York, N.Y.)

authors： Peng H,Shintani S,Kim Y,Wong DT

更新日期：2006-12-01 00:00:00

abstract：:Salmonella infection is a major public health concern, and colonization in humans can be chronic and increases the risk of cancers. Wnt signaling is a key pathway for intestinal renewal and development, inflammation, and tumorigenesis. In the current study, we report a novel role of Wnt1 in infection and colon cancer ...

journal_title：Neoplasia (New York, N.Y.)

authors： Wang J,Lu R,Fu X,Dan Z,Zhang YG,Chang X,Liu Q,Xia Y,Liu X,Sun J

更新日期：2018-05-01 00:00:00