Prospective evaluation of improving fluoroquinolone exposure using centralised therapeutic drug monitoring (TDM) in patients with tuberculosis (PERFECT): a study protocol of a prospective multicentre cohort study.

abstract：OBJECTIVES:To compare user experiences of 8 regional urgent and emergency care systems in the Republic of Ireland, and explore potential avenues for improvement. DESIGN:A cross-sectional survey. SETTING:Several distinct models of urgent and emergency care operate in Ireland, as system reconfiguration has been impleme...

journal_title：BMJ open

authors： Foley C,Droog E,Boyce M,Healy O,Browne J

更新日期：2017-03-20 00:00:00

abstract：INTRODUCTION:Ovarian cancer is the leading cause of death from gynaecological cancer, with more than 7000 new cases registered in the UK in 2014. In patients suitable for surgery, the National Institute of Health and Care Excellence guidance for treatment recommends surgical resection of all macroscopic tumour, followe...

journal_title：BMJ open

authors： Galaal K,Lopes A,Pritchard C,Barton A,Wingham J,Marques EMR,Faulds J,Palmer J,Vickery PJ,Ralph C,Ferreira N,Ewings P

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Specialist Lifestyle Management (SLiM) is a structured patient education and self-management group weight management programme. Each session is run monthly over a 6-month period providing a less intensive long-term approach. The groups are patient-centred incorporating educational, motivational, behavioural ...

journal_title：BMJ open

authors： Brown A,Gouldstone A,Fox E,Field A,Todd W,Shakher J,Bellary S,Teh MM,Azam M,John R,Jagielski A,Arora T,Thomas GN,Taheri S

更新日期：2015-04-08 00:00:00

abstract：OBJECTIVES:To characterise the pattern of colonisation and serotypes of Streptococcus pneumoniae among patients with chronic obstructive pulmonary disease (COPD) who currently receive the 23-valent pneumococcal polysaccharide vaccine (PPV-23) according to vaccination status, use of antibiotics and steroids. To investig...

journal_title：BMJ open

authors： McCarthy H,Jackson M,Corcoran M,McElligott M,MacHale E,Sulaiman I,Cushen B,Costello RW,Humpreys H

更新日期：2017-07-09 00:00:00

abstract：INTRODUCTION:Young people with drug and alcohol problems are likely to have poorer health and other psychosocial outcomes than other young people. Residential treatment programmes have been shown to lead to improved health and related outcomes for young people in the short term. There is very little robust research sho...

journal_title：BMJ open

authors： Nathan S,Rawstorne P,Hayen A,Bryant J,Baldry E,Ferry M,Williams M,Shanahan M,Jayasinha R

更新日期：2016-05-25 00:00:00

abstract：OBJECTIVE:To develop a novel sex independent anthropometric index, termed as angle index, related to type 2 diabetes. DESIGN:Case-control. PARTICIPANTS:The study comprised 121 participants and were divided into two groups. One group had no form of diabetes and served as controls (n=50). The other group had the condit...

journal_title：BMJ open

authors： Ramnanansingh TG,Nayak SB

更新日期：2019-02-19 00:00:00

abstract：OBJECTIVE:Our cross-sectional study aimed at evaluating the diagnostic performance of Focused Assessment with Sonography for HIV-associated tuberculosis (FASH) to detect extrapulmonary tuberculosis in extremely resource-limited settings, with visceral leishmaniasis as a differential diagnosis with overlapping sonograph...

journal_title：BMJ open

authors： Bobbio F,Di Gennaro F,Marotta C,Kok J,Akec G,Norbis L,Monno L,Saracino A,Mazzucco W,Lunardi M

更新日期：2019-04-02 00:00:00

abstract：OBJECTIVE:Black women continue to have rates of mental health conditions that can be negative for their well-being. This study examined the contribution of social and contextual factors and severe physical intimate partner violence on the mental health of US Black women (African-American and Caribbean Black). SETTING:...

journal_title：BMJ open

authors： Lacey KK,Parnell R,Mouzon DM,Matusko N,Head D,Abelson JM,Jackson JS

更新日期：2015-10-19 00:00:00

abstract：OBJECTIVES:Assessing the cost-effectiveness credentials of this intervention in patients with concomitant atrial fibrillation (AF) and heart failure (HF) compared with usual medical therapy. DESIGN:A Markov model comprising two health states (ie, alive or dead) was constructed. The transition probabilities were direct...

journal_title：BMJ open

authors： Gao L,Moodie M

更新日期：2019-09-05 00:00:00

abstract：OBJECTIVES:To evaluate the prevalence of depressive symptoms and its influencing factors in late pregnancy. DESIGN:Cross-sectional study. SETTING:Fourteen community in urban areas of Hengyang City. PARTICIPANTS:The study conducted from July to October 2019, and surveyed 813 women in late pregnancy who lived in urban...

journal_title：BMJ open

authors： Yu Y,Zhu X,Xu H,Hu Z,Zhou W,Zheng B,Yin S

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:The Upper Gastrointestinal Cancer Registry (UGICR) was developed to monitor and improve the quality of care provided to patients with upper gastrointestinal cancers in Australia. PARTICIPANTS:It supports four cancer modules: pancreatic, oesophagogastric, biliary and primary liver cancer. The pancreatic cancer ...

journal_title：BMJ open

authors： Maharaj AD,Holland JF,Scarborough RO,Evans SM,Ioannou LJ,Brown W,Croagh DG,Pilgrim CHC,Kench JG,Lipton LR,Leong T,McNeil JJ,Nikfarjam M,Aly A,Burton PR,Cashin PA,Chu J,Duong CP,Evans P,Goldstein D,Haydon A,Hii M

更新日期：2019-09-30 00:00:00

abstract：:Aims To study long-term sick-listed patients' self-estimated ability to return to work after experiences of healthcare encounters that made them feel either respected or wronged. Methods A cross-sectional and questionnaire-based survey was used to study a sample of long-term sick-listed patients (n=5802 respondents)....

journal_title：BMJ open

authors： Lynöe N,Wessel M,Olsson D,Alexanderson K,Helgesson G

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Primary sclerosing cholangitis (PSC) is a progressive inflammatory liver disease characterised by relentless liver fibrosis and a high unmet need for new therapies. Preventing fibrosis represents an important area of interest in the development of vital new drugs. Vascular adhesion protein-1 (VAP-1) drives...

journal_title：BMJ open

authors： Arndtz K,Corrigan M,Rowe A,Kirkham A,Barton D,Fox RP,Llewellyn L,Athwal A,Wilkhu M,Chen YY,Weston C,Desai A,Adams DH,Hirschfield GM,BUTEO trial team.

更新日期：2017-07-03 00:00:00

abstract：INTRODUCTION:Corticosteroid injections (CSI) are a recommended and often-used first-line intervention for shoulder impingement syndrome (SIS) in primary care and orthopaedic settings. Manual physical therapy (MPT) offers a non-invasive approach with negligible risk for managing SIS. There is limited evidence to suggest...

journal_title：BMJ open

authors： Rhon DI,Boyles RE,Cleland JA,Brown DL

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To explore the barriers faced by healthcare professionals (HCPs) in managing falls among older people (aged above 60 years) who have a high risk of falling. RESEARCH DESIGN:The study used a qualitative methodology, comprising 10 in-depth interviews and two focus group discussions. A semistructured topic guid...

journal_title：BMJ open

authors： Loganathan A,Ng CJ,Tan MP,Low WY

更新日期：2015-11-05 00:00:00

abstract：OBJECTIVES:Limited data exist assessing the relationship between ambulance versus self-presentation and outcomes in patients with acute heart failure (AHF). SETTING:Clinical trial sites in North America. PARTICIPANTS:1068 patients enrolled in the Acute Studies of Nesiritide in Decompensated Heart Failure (ASCEND-HF) ...

journal_title：BMJ open

authors： Ezekowitz JA,Podder M,Hernandez AF,Armstrong PW,Starling RC,O'Connor CM,Califf RM

更新日期：2016-03-17 00:00:00

abstract：OBJECTIVES:Physically demanding work increases the risk of developing musculoskeletal disorders during working life, with low back pain (LBP) as the most prevalent and debilitating musculoskeletal disorder worldwide. However, a lack of knowledge exists about the role of early working years on musculoskeletal health lat...

journal_title：BMJ open

authors： Bláfoss R,Skovlund SV,López-Bueno R,Calatayud J,Sundstrup E,Andersen LL

更新日期：2020-12-07 00:00:00

abstract：OBJECTIVES:In 2012, Australia was the first country in the world to introduce plain or standardised tobacco packaging, coupled with larger graphic health warnings. This policy was fiercely opposed by industry. Media coverage can be an influential contributor to public debate, and both public health advocates and indust...

journal_title：BMJ open

authors： Miller CL,Brownbill AL,Dono J,Ettridge K

更新日期：2018-09-17 00:00:00

abstract：INTRODUCTION:Bicycling is promoted as a transportation and population health strategy globally. Yet bicycling has low uptake in North America (1%-2% of trips) compared with European bicycling cities (15%-40% of trips) and shows marked sex and age trends. Safety concerns due to collisions with motor vehicles are primary...

journal_title：BMJ open

authors： Winters M,Branion-Calles M,Therrien S,Fuller D,Gauvin L,Whitehurst DGT,Nelson T

更新日期：2018-01-21 00:00:00

abstract：OBJECTIVE:To establish a baseline of national practice for follow-up after treatment for gynaecological cancer. DESIGN:Questionnaire survey. SETTING:Gynaecological cancer centres and units. GEOGRAPHICAL LOCATION UK PARTICIPANTS:Members of the British Gynaecological Cancer Society and the National Forum of Gynaecolog...

journal_title：BMJ open

authors： Leeson S,Stuart N,Sylvestre Y,Hall L,Whitaker R

更新日期：2013-07-24 00:00:00

abstract：INTRODUCTION:A substantial minority of children who sustain a concussion suffer prolonged postconcussive symptoms. These symptoms can persist for more than 1 month postinjury and include physical, cognitive, behavioural and emotional changes. Those affected can develop significant disability, diminishing their quality ...

journal_title：BMJ open

authors： Bressan S,Takagi M,Anderson V,Davis GA,Oakley E,Dunne K,Clarke C,Doyle M,Hearps S,Ignjatovic V,Seal M,Babl FE

更新日期：2016-01-12 00:00:00

abstract：INTRODUCTION:Making change towards child and family-based and coordinated services is critical to improve quality, outcomes and value. The Let's Talk about Children (LTC) approach, which consists of brief psychoeducational discussions with parents of kindergarten-aged and school-aged children, has been launched as a mu...

journal_title：BMJ open

authors： Kujala V,Jokinen J,Ebeling H,Pohjola A

更新日期：2017-07-13 00:00:00

abstract：BACKGROUND:Dual antiplatelet therapy (DAPT) is frequently discontinued after drug-eluting stent (DES) implantation, which could increase the risk of major adverse cardiovascular events (MACEs). Few studies have attempted to improve DAPT adherence through web-based social media. OBJECTIVE:To explore the effect of socia...

journal_title：BMJ open

authors： Sun GL,Lei L,Liu L,Liu J,He Y,Guo Z,Dai X,He L,Chen SQ,Liang Y,Ye J,Hu Y,Chen G,Chen JY,Liu Y

更新日期：2020-01-07 00:00:00

abstract：OBJECTIVES:To identify rates of potentially preventable complications for dementia patients compared with non-dementia patients. DESIGN:Retrospective cohort design using hospital discharge data for dementia patients, case matched on sex, age, comorbidity and surgical status on a 1 : 4 ratio to non-dementia patients. ...

journal_title：BMJ open

authors： Bail K,Berry H,Grealish L,Draper B,Karmel R,Gibson D,Peut A

更新日期：2013-06-20 00:00:00

abstract：OBJECTIVES:To assess the association between prenatal exposure to monotherapy with the antiepileptic drugs (AEDs) most commonly used during pregnancy and the risk of various neurodevelopmental outcomes compared with lamotrigine. DESIGN:Nationwide population-based cohort study. SETTING:French national healthcare datab...

journal_title：BMJ open

authors： Blotière PO,Miranda S,Weill A,Mikaeloff Y,Peyre H,Ramus F,Mahmoud Z,Coste J,Dray-Spira R

更新日期：2020-06-07 00:00:00

abstract：INTRODUCTION:Commonly used clinical tests for posterior cruciate ligament (PCL) rupture detection exhibit several limitations, thus requiring more precise clinical PCL tests. The lateral-anterior drawer (LAD) test has been proposed as a manually applied testing alternative but not yet been evaluated in vivo. METHODS A...

journal_title：BMJ open

authors： Seeber GH,Thalhamer C,Hahne J,Matthijs O

更新日期：2018-05-29 00:00:00

abstract：INTRODUCTION:This study aims to assess the feasibility of acupuncture and a Pericardium 6 (PC6) wristband as an add-on intervention of antiemetic medication for the prevention of postoperative nausea and vomiting (PONV) in patients undergoing elective laparoscopic colorectal cancer resection. METHODS AND ANALYSIS:A to...

journal_title：BMJ open

authors： Kim KH,Kim DH,Bae JM,Son GM,Kim KH,Hong SP,Yang GY,Kim HY

更新日期：2017-01-04 00:00:00

abstract：INTRODUCTION:Diabetic macular oedema (DMO) and proliferative diabetic retinopathy (PDR) are the major causes of sight loss in people with diabetes. Due to the increased prevalence of diabetes, the workload related to these complications is increasing making it difficult for Hospital Eye Services (HSE) to meet demands. ...

journal_title：BMJ open

authors： Lois N,Cook J,Aldington S,Waugh N,Mistry H,Sones W,McAuley D,Aslam T,Bailey C,Chong V,Ghanchi F,Scanlon P,Sivaprasad S,Steel D,Styles C,McNally C,Rice R,Prior L,Azuara-Blanco A,EMERALD Study Group.

更新日期：2019-06-28 00:00:00

abstract：OBJECTIVES:To analyse free-text responses from the first Scottish Cancer Patient Experience Survey (SCPES) to understand patients' experiences of care, identify valued aspects and areas for improvement. DESIGN:Inductive thematic analysis of seven free-text comment boxes covering all stages of the cancer experience, fr...

journal_title：BMJ open

authors： Cunningham M,Wells M

更新日期：2017-06-15 00:00:00

abstract：INTRODUCTION:Lumbar discectomy is a widely used surgical procedure internationally with the majority of patients experiencing significant benefit. However, approximately 20% of patients report suboptimal functional recovery and quality of life. The impact and meaning of the surgical experience from the patients' perspe...

journal_title：BMJ open

authors： White L,Heneghan NR,Furtado N,Masson A,Rushton AB

更新日期：2019-08-15 00:00:00