Abstract:
BACKGROUND:Presently, for patients presenting with suspected Normal Pressure Hydrocephalus (NPH) who undergo temporary drainage of cerebrospinal fluid (CSF) there is no defined model to differentiate chance improvement form clinical significance change at the individual patient level. To address this lack of information we computed standard regression based clinical change models for the 10 Meter Walk Test, Timed Up & Go, Dual Timed Up & Go, 6-Minute Walk Test, Mini-Balance Evaluation Systems Test, Montreal Cognitive Assessment, and Symbol Digit Modalities using data from patients with suspected NPH that underwent temporary drainage of CSF. These clinically significant change modes can classify clinically significant improvement following temporary drainage of CSF at the individual patient level. This allows for physicians to differentiate a clinically significant improvement in symptoms from chance improvement. METHODS:Data was collected from 323 patients, over the age of 60, with suspected NPH that underwent temporary drainage of CSF with corresponding gait and cognitive testing. McSweeney Standardized Regression Based Clinical Change Models were computed for standard gait and cognitive measures: Timed Up & Go, Dual Timed Up & Go, 10 Meter Walk Test, MiniBESTest, 6-Minute Walk Test, Montreal Cognitive Assessment, and Symbol Digit Modalities Test. To assess the discriminate validity of the measures we used correlations, Chi2, and regression analyses. RESULTS:The clinical change models explained 69-91.8% of the variability in post-drain performance (p < 0.001). As patient scores became more impaired, the percent change required for improvement to be clinically significant increased for all measures. We found that the measures were not discriminate, the Timed Up & Go was highly related to the 10 Meter Walk Test (r = 0.85, R2 = 0.769-0.738, p < 0.001), MiniBESTest (r = - 0.67, R2 = 0.589-0.734, p < 0.001), and 6 Minute Walk Test (r = - 0.77, R2 = 0.71-0.734, p < 0.001). CONCLUSION:Standardized Regression Based Clinically Significant Change Models allow for physicians to use an evidence-based approach to differentiate clinically significant change from chance improvement at the individual patient level. The Timed Up & Go was shown to be predictive of detailed measures of gait velocity, balance, and endurance.
journal_name
BMC Neuroljournal_title
BMC neurologyauthors
Davis A,Yasar S,Emerman I,Gulyani S,Khingelova K,Rao A,Manthripragada L,Luciano M,Moghekar Adoi
10.1186/s12883-020-01719-ysubject
Has Abstractpub_date
2020-04-16 00:00:00pages
140issue
1issn
1471-2377pii
10.1186/s12883-020-01719-yjournal_volume
20pub_type
杂志文章相关文献
BMC Neurology文献大全abstract:BACKGROUND:Spinal cord infarction (SCI) is rarely caused by vertebral artery dissection (VAD), which is an important cause of posterior circulation stroke in young and middle-aged patients. We report the case of a middle-aged patient without obvious risk factors for atherosclerosis who had SCI from right VAD. CASE PRE...
journal_title:BMC neurology
pub_type: 杂志文章,评审
doi:10.1186/s12883-019-1559-0
更新日期:2019-12-12 00:00:00
abstract:BACKGROUND:Non-ataxic symptoms of spinocerebellar ataxias (SCAs) vary widely and often overlap with various types of SCAs. Duration and severity of the disease and genetic background may play a role in such phenotypic diversity. We conducted the study in order to study clinical characteristics of common SCAs in Thailan...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-14-75
更新日期:2014-04-05 00:00:00
abstract:BACKGROUND:In the pathogenesis of limbic encephalitis other promoting factors besides the pure existence of autoantibodies are increasingly discussed to play a significant role. This is to our knowledge the first described patient in whom the presence of autoantibodies precedes the manifestation of limbic encephalitis ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-015-0435-9
更新日期:2015-09-30 00:00:00
abstract:BACKGROUND:Autism spectrum disorders (ASD) are associated with widespread alterations in white matter (WM) integrity. However, while a growing body of studies is shedding light on microstructural WM alterations in high-functioning adolescents and adults with ASD, literature is still lacking in information about whole b...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-12-148
更新日期:2012-11-29 00:00:00
abstract:BACKGROUND:Cardioembolic stroke (CES) due to atrial fibrillation (AF) is associated with high stroke mortality. Oral anticoagulation (OAC) reduces stroke mortality, however, the impact of OAC-administration during hospital stay post ischemic stroke on mortality is unclear. We determined whether the timing of OAC initia...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-014-0199-7
更新日期:2014-10-08 00:00:00
abstract:BACKGROUND:Stroke increases the risk of cognitive impairment even several years after the stroke event. The exact mechanisms of post-stroke cognitive decline are unclear, but the immunological response to stroke might play a role. The aims of the StrokeCog study are to examine the associations between immunological res...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01897-9
更新日期:2020-08-26 00:00:00
abstract:BACKGROUND:A description of the complexity of the process of self-management and the way stroke survivors give meaning to their process of self-management post-stroke is lacking. This study explores how stroke survivors managed their lives, gave meaning to their self-management post-stroke and how this evolved over tim...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-016-0739-4
更新日期:2016-11-15 00:00:00
abstract:BACKGROUND:Evidence indicates that the continuation of therapy among community-dwelling stroke survivors improves physical function. Community rehabilitation programmes often face limitations in terms of resources. It is imperative to include new motivational interventions to encourage some level of non-clinician manag...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-13-199
更新日期:2013-12-13 00:00:00
abstract:BACKGROUND:Prevalence of degenerative dementias and dementias associated with cerebrovascular disease is increasing. Dementia is one of the most significant public health problem. In recent years, the role of vascular risk factors (hypertension, diabetes mellitus and hypercholesterolemia) and depression has been evalua...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-8-39
更新日期:2008-10-15 00:00:00
abstract:BACKGROUND:There is need for a cognitive test battery that can be easily used in clinical practice to detect or monitor cognitive performance in patients with multiple sclerosis (MS). In order to conduct, in this patient group, a preliminary investigation of the validity and utility of a brief computerized battery, the...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-11-68
更新日期:2011-06-07 00:00:00
abstract:BACKGROUND:Cerebral amyloid angiopathy (CAA) is characterized by the deposition of ß-amyloid peptides (Aß) in and surrounding the wall of microvasculature in the central nervous system, together with parenchymal amyloid plaques collectively referred to as cerebral amyloidosis, which occurs in the brain commonly among t...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-017-0942-y
更新日期:2017-08-25 00:00:00
abstract:BACKGROUND:Complaints of unrefreshing sleep are a prominent component of chronic fatigue syndrome (CFS); yet, polysomnographic studies have not consistently documented sleep abnormalities in CFS patients. We conducted this study to determine whether alterations in objective sleep characteristics are associated with sub...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-7-40
更新日期:2007-12-05 00:00:00
abstract:BACKGROUND:Active Rehabilitation (AR) is a community peer-based concept for people with spinal cord injury (SCI) that is primarily delivered through brief residential training programmes. Despite a plethora of positive anecdotal evidence of AR programmes as life-changing experiences, the effects of AR-programmes have n...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-019-1546-5
更新日期:2020-01-11 00:00:00
abstract:BACKGROUND:The study of muscle metabolism by near-infrared spectroscopy (NIRS) has been poorly implemented in multiple sclerosis (MS). Aims of the study were to compare resting muscle oxygen consumption (rmVO2) at gastrocnemius in MS patients and in age-matched healthy controls (HC) measured using NIRS, and to evaluate...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-13-52
更新日期:2013-05-29 00:00:00
abstract:BACKGROUND:Cubital tunnel syndrome is common nerve compression syndrome among peripheral nerve compression diseases. However, the syndrome caused by intraneural ganglion cysts has been rarely reported. Medical approaches, like ultrasound-guided aspiration and open surgical treatment remain to be discussed. CASE PRESEN...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-018-1229-7
更新日期:2018-12-22 00:00:00
abstract:BACKGROUND:Migraine is a highly prevalent disorder. The disability provoked by its attacks results in suffering as well as considerable economic and social losses. The objective of migraine acute treatment is to restore the patient to normal function as quickly and consistently as possible. There are numerous drugs ava...
journal_title:BMC neurology
pub_type: 杂志文章,评审
doi:10.1186/1471-2377-4-4
更新日期:2004-01-28 00:00:00
abstract:BACKGROUND:The partial form of the complex regional pain syndrome of the hand type 1 (CRPS 1), involving only 1 to 3 fingers, is a rare condition first described in 1972. The aim of the study is to define more precisely the diagnosis workup and the prognosis of this clinical entity. METHODS:Retrospective study of CRPS...
journal_title:BMC neurology
pub_type: 杂志文章,评审
doi:10.1186/1471-2377-13-28
更新日期:2013-03-18 00:00:00
abstract:BACKGROUND:This study aimed to determine the risk of thromboembolic events in patients with junctional bradycardia(JB). METHODS:We retrospectively reviewed electrocardiograms(ECGs) for 380,682 patients. Those with JB on an ECG at least twice over a ≥3-month interval were included for analysis. We additionally included...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-016-0645-9
更新日期:2016-07-25 00:00:00
abstract:BACKGROUND:Gait ability and cognitive function are interrelated during both normal walking (NW) and dual-task walking (DTW), and gait ability is thus adversely affected by cognitive impairment in both situations. However, this association is insufficiently understood in people with mild cognitive impairment (MCI). Here...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-14-67
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Recovery patterns of upper extremity motor function have been described in several longitudinal studies, but most of these studies have had selected samples, short follow up times or insufficient outcomes on motor function. The general understanding is that improvements in upper extremity occur mainly during...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-11-56
更新日期:2011-05-25 00:00:00
abstract:BACKGROUND:Anticoagulation using vitamin K antagonists (VKAs) significantly reduces the risk of recurrent stroke in stroke patients with atrial fibrillation (AF) and is recommended by guidelines. METHODS:The German Competence NETwork on Atrial Fibrillation established a nationwide prospective registry including 9,574 ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-015-0371-8
更新日期:2015-08-05 00:00:00
abstract:BACKGROUND:Cerebral venous sinus thrombosis or stenosis (here collectively referred to as cerebral venous sinus occlusion, CVSO) can cause chronically-elevated intracranial pressure (ICP). Patients may have no neurological symptoms other than visual impairment, secondary to bilateral papilledema. Correctly recognizing ...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-018-1156-7
更新日期:2018-09-29 00:00:00
abstract:BACKGROUND:Balanced Steady State Free Precession (b-SSFP) sequences and the newly developed Fast-Spin-Echo (FSE)-sequences enable an optimized visualization of neurovascular compression (NVC) in patients with trigeminal neuralgia (TN). Arterial conflicts are mostly associated with a favorable outcome of microvascular d...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01860-8
更新日期:2020-07-14 00:00:00
abstract:ASBTRACT:BACKGROUND: There are limited neuroprotective treatment options for patients with aneurysmal subarachnoid hemorrhage (SAH). Cerebrolysin, a brain-specific proposed pleiotropic neuroprotective agent, has been suggested to improve global functional outcomes in ischemic stroke. We investigated the efficacy, safet...
journal_title:BMC neurology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12883-020-01908-9
更新日期:2020-11-03 00:00:00
abstract:BACKGROUND:Acute seizures are a common cause of paediatric admissions to hospitals in Africa, and malaria is an important cause of seizures in endemic areas. Malaria has declined in the past decade whilst neonatal admissions have increased, both which may affect the incidence and phenotypes of acute seizures in African...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-015-0444-8
更新日期:2015-10-06 00:00:00
abstract:BACKGROUND:Central sensitization is thought to be an important contributing factor in many chronic pain disorders. The Central Sensitization Inventory (CSI) is a patient-reported measure frequently used to assess symptoms related to central sensitization. The aims of the study were to translate and cross-culturally ada...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01867-1
更新日期:2020-07-27 00:00:00
abstract:BACKGROUND:While both hypercapnia and hypocapnia are harmful in patients with subarachnoid hemorrhage (SAH), it is unknown whether high-normal PaCO2 values are better than low-normal values. We hypothesized that high-normal PaCO2 values have more detrimental than beneficial effects on outcome. METHODS:Consecutive pati...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-1603-0
更新日期:2020-01-20 00:00:00
abstract:BACKGROUND:Cholinesterase inhibitors remain the first line therapy for people with mild to moderate Alzheimer's disease (AD). Response is modest and difficult to predict from pre-treatment characteristics. We hypothesise that skin vascular response to iontophoresis of acetylcholine, which is partly determined by the le...
journal_title:BMC neurology
pub_type: 临床试验,杂志文章
doi:10.1186/s12883-019-1316-4
更新日期:2019-05-03 00:00:00
abstract:BACKGROUND:Neuroprotective strategies after cardiopulmonary resuscitation are currently the focus of experimental and clinical research. Levosimendan has been proposed as a promising drug candidate because of its cardioprotective properties, improved haemodynamic effects in vivo and reduced traumatic brain injury in vi...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/1471-2377-12-81
更新日期:2012-08-24 00:00:00
abstract:BACKGROUND:A number of emerging studies have evaluated clot composition in acute ischemic stroke. Studies of clot composition of embolic strokes of undetermined strokes are lacking. OBJECTIVES:We sought to analyze the RBC to platelet ratios in clots and correlated our findings with stroke etiology. METHODS:This was a...
journal_title:BMC neurology
pub_type: 杂志文章
doi:10.1186/s12883-020-01969-w
更新日期:2020-10-21 00:00:00