Abstract:
:The aim of this study was to assess if women with a low first trimester maternal pregnancy-associated plasma protein-A (PAPP-A) level are at increased risk of emergency cesarean (EmCS) for intrapartum fetal compromise (IFC) and/or adverse neonatal outcomes. This was a retrospective cohort study performed at Mater Mother's Hospital, Brisbane, Australia, between 2016 and 2018. All women with a singleton, euploid, non-anomalous fetus with a documented PAPP-A level measured between 10 +0 and 13 +6 weeks gestation during the study period were included. Data were extracted from the institution's perinatal database and dichotomized according to PAPP-A level (≤0.4 Multiples of Medium (MoM) vs. >0.4 MoM). The primary outcomes were EmCS-IFC and a composite of severe adverse neonatal outcomes (SCNO). Nine thousand sixty-one pregnancies were included, 3.3% with a PAPP-A ≤ 0.4 MoM. Low maternal PAPP-A was not associated with an increased risk of EmCS-IFC (adjusted odds ratio (aOR) 0.77, 95% confidence interval (CI) 0.24-2.46, p = 0.66) or SCNO (aOR 0.65, 95% CI 0.39-1.07, p = 0.09). Low PAPP-A was associated with increased odds of pre-eclampsia, preterm birth and birthweight < 10th centile. In conclusion, low maternal PAPP-A level is not associated with an increased risk of EmCS IFC or adverse neonatal outcomes despite greater odds of low-birthweight infants and preterm birth.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Turner JM,Kumar Sdoi
10.3390/jcm9041108subject
Has Abstractpub_date
2020-04-13 00:00:00issue
4issn
2077-0383pii
jcm9041108journal_volume
9pub_type
杂志文章abstract::Mitochondrial respiratory chain (MRC) disorders have a multifaceted clinical presentation and genetic origin[...]. ...
journal_title:Journal of clinical medicine
pub_type: 社论
doi:10.3390/jcm7040066
更新日期:2018-03-29 00:00:00
abstract:INTRODUCTION:The inherent immunosuppression of uremia increases the susceptibility of hemodialysis patients to infection. There is still limited evidence on hemodialysis patients and COVID-19. The clinical and analytical spectrum and treatment responses and mortality are poorly characterized. MATERIAL AND METHODS:Clin...
journal_title:Journal of clinical medicine
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更新日期:2020-07-16 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
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更新日期:2017-11-03 00:00:00
abstract::Pancreatic cancer is the fourth leading cause of cancer death. Soluble receptor for glycation end products (sRAGE), which is modulated by anti-hypertensive (HT) medications, has been inversely associated with pancreatic cancer. However, the association between commonly used anti-HT medications and risk of pancreatic c...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7080197
更新日期:2018-08-02 00:00:00
abstract::It is now widely established that management of lung cancer is much more complex and cannot be centered on the binary classification of small-cell versus non-small cell lung cancer (NSCLC). Lung cancer is now recognized as a highly heterogeneous disease that develops from genetic mutations and gene expression patterns...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7060153
更新日期:2018-06-15 00:00:00
abstract::Neovascular age related macular degeneration (nAMD) leads to severe vision loss worldwide and is characterized by the formation of choroidal neovascularization (CNV) and fibrosis. In the current study, we aimed to investigate the effect of blockade for platelet derived growth factor receptor-β (PDGFR-β) on the formati...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2020-07-15 00:00:00
abstract::Minimal residual disease evaluation refers to a series of molecular and immunophenotypical techniques aimed at detecting submicroscopic disease after therapy. As such, its application in acute myeloid leukemia has greatly increased our ability to quantify treatment response, and to determine the chemosensitivity of th...
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pub_type: 杂志文章,评审
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更新日期:2017-06-03 00:00:00
abstract::A recent study suggested mortality benefits using vitamin C, hydrocortisone, and thiamine combination therapy (triple therapy) in addition to standard care in patients with severe sepsis and septic shock. In order to further evaluate the effects of triple therapy in real-world clinical practice, we conducted a retrosp...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040478
更新日期:2019-04-09 00:00:00
abstract::Significant others are often crucial for suicidal persons or suicide attempters' access to care, yet little is known about their efforts to seek help. This article presents the findings of a qualitative pilot study carried out in Switzerland on the help-seeking process of 18 significant others, their perception of the...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm6020017
更新日期:2017-02-13 00:00:00
abstract::Small-intestinal neuroendocrine tumors (SI-NETs) are the most prevalent small bowel neoplasms with an increasing frequency. In the multimodal management of SI-NETs, surgery plays a key role, either in curative intent, even if R0 resection is feasible in only 20% of patients due to advanced stage at diagnosis, or palli...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
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更新日期:2020-07-21 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061780
更新日期:2020-06-08 00:00:00
abstract::Diabetes in pregnancy, both preexisting type 1 or type 2 and gestational diabetes, is a highly prevalent condition, which has a great impact on maternal and fetal health, with short and long-term implications. Gestational Diabetes Mellitus (GDM) is a condition triggered by metabolic adaptation, which occurs during the...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7020011
更新日期:2018-01-25 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111906
更新日期:2019-11-07 00:00:00
abstract::Acute cardiovascular disease after community-acquired pneumonia is a well-accepted complication for which definitive treatment strategies are lacking. These complications share some common features but have distinct diagnostic and treatment approaches. We therefore undertook an updated systematic review and meta-analy...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9020414
更新日期:2020-02-03 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061625
更新日期:2020-05-27 00:00:00
abstract:BACKGROUND:Heart failure with preserved ejection fraction (HFpEF) remains an ongoing therapeutic and diagnostic challenge to date. In this study we aimed for an analysis of the diagnostic potential of four novel cardiovascular biomarkers, GDF-15, H-FABP, sST2, and suPAR in HFpEF patients compared to controls as well as...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041130
更新日期:2020-04-15 00:00:00
abstract::Endometriosis concerns more than 10% of women of reproductive age, frequently leading to chronic pelvic pain. Repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) induces an analgesic effect. This effect on chronic pelvic pain is yet to be evaluated. The objective of this study was to...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040508
更新日期:2019-04-13 00:00:00
abstract::The main objective was to assess the efficacy of botulinum toxin-based treatment for sialorrhea in adult patients with Parkinson's disease. The search was performed by using the Medline-PubMed, EMBASE and Cochrane Library databases from January 2000⁻December 2017, in English/Spanish in patients with Parkinson's diseas...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8030317
更新日期:2019-03-06 00:00:00
abstract::The investigation of the potential association between ischemic stroke and subclinical atrial fibrillation (SCAF) is important for secondary prevention. We aimed to determine whether SCAF can be predicted by atrial substrate measurement with P wave signal-averaged electrocardiography (SAECG). We recruited 125 consecut...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041134
更新日期:2020-04-15 00:00:00
abstract::Elevated blood pressure (BP) is a major cause of death, yet hypertension commonly goes undetected. Owing to its nature, it is typically asymptomatic until later in its progression when the vessel or organ structure has already been compromised. Therefore, noninvasive and continuous BP measurement methods are needed to...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9041203
更新日期:2020-04-22 00:00:00
abstract::There is a large body of research showing that psychological treatment can be effectively delivered via the internet, and Digital Mental Health Services (DMHS) are now delivering those interventions in routine care. However, not all attempts to translate these research outcomes into routine care have been successful. ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8081239
更新日期:2019-08-17 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8122179
更新日期:2019-12-11 00:00:00
abstract::The vasodilator-associated stimulated phosphoprotein (VASP) phosphorylation level is a highly specific method to assess P2Y12 receptor inhibition. Traditionally, VASP phosphorylation is analyzed by flow cytometry, which is laborious and restricted to specialized laboratories. Recently, a simple ELISA kit has been comm...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9020332
更新日期:2020-01-24 00:00:00
abstract::Although the introduction of bortezomib as a therapeutic strategy has improved the overall survival of multiple myeloma (MM) patients, 15-20% of high-risk patients do not respond to bortezomib over time or become resistant to treatment. Therefore, the development of new therapeutic strategies, such as combination ther...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9020552
更新日期:2020-02-18 00:00:00
abstract:BACKGROUND:Postoperative Acute Kidney Injury (AKI) is a common and serious complication associated with significant morbidity and mortality. While several pre- and intra-operative risk factors for AKI have been recognized in cardiac surgery patients, relatively few data are available regarding the incidence and risk fa...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7110431
更新日期:2018-11-09 00:00:00
abstract:INTRODUCTION:Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated disease characterised pathologically by the infiltration of IgG4-bearing plasma cells into the involved organs. Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis with a heavy lymphocytic infiltration and two distinct hi...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9020409
更新日期:2020-02-03 00:00:00
abstract::Recently, proton pump inhibitor (PPI) intake has been linked to acute kidney injury and chronic kidney disease. The objective of this study was to assess the effect of PPIs on renal function and rejection rate in kidney transplant patients. We performed a single center, retrospective analysis of 455 patients who recei...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010258
更新日期:2020-01-18 00:00:00
abstract::Suprascapular neuropathy is an uncommon but increasingly recognized cause of shoulder pain and dysfunction due to nerve entrapment. The aim of this review is to summarize some important aspects of this shoulder pathology. An extensive research was performed on PubMed and Clinical Key. The goal was to collect all the a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9082331
更新日期:2020-07-22 00:00:00
abstract::We sought to clarify the correlation between non-protein respiratory quotient (npRQ) in indirect calorimetry and serum zinc (Zn) level in chronic liver diseases (CLDs, n = 586, 309 liver cirrhosis (LC) patients, median age = 63 years). Clinical parameters potentially linked to npRQ <0.85 (best cutoff point for the pro...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010255
更新日期:2020-01-17 00:00:00
abstract:BACKGROUND:Cefazolin is in vitro active against wild isolates of Escherichia coli, Klebsiella species, and Proteus mirabilis (EKP), but clinical evidence supporting the contemporary susceptibility breakpoint issued by the Clinical and Laboratory Standards Institute (CLSI) are limited. METHODS:Between 2010 and 2015, ad...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010157
更新日期:2020-01-07 00:00:00