Sputum and blood transcriptomics characterisation of the inhaled PDE4 inhibitor CHF6001 on top of triple therapy in patients with chronic bronchitis.

abstract：BACKGROUND:Using guinea pig tracheal preparations, we have recently shown that endogenous arginase activity attenuates inhibitory nonadrenergic noncholinergic (iNANC) nerve-mediated airway smooth muscle relaxation by reducing nitric oxide (NO) production--due to competition with neuronal NO-synthase (nNOS) for the comm...

journal_title：Respiratory research

authors： Maarsingh H,Leusink J,Bos IS,Zaagsma J,Meurs H

更新日期：2006-01-12 00:00:00

abstract：BACKGROUND:Preserved Ratio Impaired Spirometry (PRISm), defined as a reduced FEV1 in the setting of a preserved FEV1/FVC ratio, is highly prevalent and is associated with increased respiratory symptoms, systemic inflammation, and mortality. Studies investigating quantitative chest tomographic features, genetic associat...

journal_title：Respiratory research

authors： Wan ES,Castaldi PJ,Cho MH,Hokanson JE,Regan EA,Make BJ,Beaty TH,Han MK,Curtis JL,Curran-Everett D,Lynch DA,DeMeo DL,Crapo JD,Silverman EK,COPDGene Investigators.

更新日期：2014-08-06 00:00:00

abstract：BACKGROUND:Mutations in the eukaryotic translation initiation factor 2α kinase 4 (EIF2AK4) gene have recently been identified in recessively inherited veno-occlusive disease. In this study we assessed if EIF2AK4 mutations occur also in a family with autosomal dominantly inherited pulmonary arterial hypertension (HPAH) ...

journal_title：Respiratory research

authors： Eichstaedt CA,Song J,Benjamin N,Harutyunova S,Fischer C,Grünig E,Hinderhofer K

更新日期：2016-11-04 00:00:00

abstract：:Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on chromosome 5q as a susceptibility locus for asthma. Recently, the Th2 cytokine interleukin-13 has been shown to be a critical m...

journal_title：Respiratory research

authors： Wills-Karp M

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Hypoxia-induced mitogenic factor (HIMF) is developmentally regulated and plays an important role in lung pathogenesis. We initially found that HIMF promotes vascular tubule formation in a matrigel plug model. In this study, we investigated the mechanisms which HIMF enhances expression of vascular endothelial...

journal_title：Respiratory research

authors： Tong Q,Zheng L,Lin L,Li B,Wang D,Huang C,Li D

更新日期：2006-03-02 00:00:00

abstract：BACKGROUND:Studies have shown that epinephrine release is impaired in patients with asthma. The pregnancy of female rats (dams) with asthma promotes in their pups the differentiation of adrenal medulla chromaffin cells (AMCCs) into sympathetic neurons, mediated by nerve growth factor, which leads to a reduction in epin...

journal_title：Respiratory research

authors： Feng JT,Wu XM,Li XZ,Zou YQ,Qin L,Hu CP

更新日期：2012-11-08 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is a protein with anti-inflammatory properties and the archetypal member of the dual-specificity phosphatases (DUSPs) family that have emerged over the past decade as playing an instrumental role in the regulation of airway inflammation. Not only does MKP-1...

journal_title：Respiratory research

authors： Moosavi SM,Prabhala P,Ammit AJ

更新日期：2017-08-10 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is chronic fibrosing pneumonia with an unpredictable natural disease history. Functional respiratory imaging (FRI) has potential to better characterize this disease. The aim of this study was to identify FRI parameters, which predict FVC decline in patients with IPF. METH...

journal_title：Respiratory research

authors： Clukers J,Lanclus M,Mignot B,Van Holsbeke C,Roseman J,Porter S,Gorina E,Kouchakji E,Lipson KE,De Backer W,De Backer J

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Myofibroblasts play a major role in the synthesis of extracellular matrix (ECM) and the stimulation of these cells is thought to play an important role in the development of silicosis. The present study was undertaken to investigate the anti-fibrotic effects of dibutyryl-cAMP (db-cAMP) on rats induced by sil...

journal_title：Respiratory research

authors： Liu Y,Xu H,Geng Y,Xu D,Zhang L,Yang Y,Wei Z,Zhang B,Li S,Gao X,Wang R,Zhang X,Brann D,Yang F

更新日期：2017-02-21 00:00:00

abstract：RESEARCH QUESTION:There is no widely accepted grading system for IPF disease severity, although physiologic impairment based on pulmonary function testing is frequently employed. We sought to describe clinical and functional characteristics as well as outcomes of patients with severe physiologic impairment. PATIENTS A...

journal_title：Respiratory research

authors： Pastre J,Barnett S,Ksovreli I,Taylor J,Brown AW,Shlobin OA,Ahmad K,Khangoora V,Aryal S,King CS,Nathan SD

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:MIF is a critical mediator of the host defense, and is involved in both acute and chronic responses in the lung. Neutralization of MIF reduces neutrophil accumulation into the lung in animal models. We hypothesized that MIF, in the alveolar space, promotes neutrophil accumulation via activation of the CD74 r...

journal_title：Respiratory research

authors： Takahashi K,Koga K,Linge HM,Zhang Y,Lin X,Metz CN,Al-Abed Y,Ojamaa K,Miller EJ

更新日期：2009-05-04 00:00:00

abstract：BACKGROUND:Long-term lung allograft survival is limited by bronchiolitis obliterans syndrome (BOS). Mannose binding lectin (MBL) belongs to the innate immune system, participates in complement activation, and may predispose to graft rejection. We investigated mannose binding (MBL) during cold ischemia and in tissue sam...

journal_title：Respiratory research

authors： Budd SJ,Aris RM,Medaiyese AA,Tilley SL,Neuringer IP

更新日期：2012-07-04 00:00:00

abstract：:The role of the ATP binding cassette transporter A1 (ABCA1) in maintaining cellular lipid homeostasis in cardiovascular disease is well established. More recently, the important beneficial role played by ABCA1 in modulating pathogenic disease mechanisms, such as inflammation, in a broad range of chronic conditions has...

journal_title：Respiratory research

authors： He P,Gelissen IC,Ammit AJ

更新日期：2020-09-25 00:00:00

abstract：BACKGROUND:Airway smooth muscle contraction is critical for maintenance of appropriate airway tone, and has been implicated in asthma pathogenesis. Smooth muscle contraction requires an "engine" (myosin activation) and a "transmission system" (actin cytoskeletal remodeling). However, the mechanisms that control actin r...

journal_title：Respiratory research

authors： Wang Y,Rezey AC,Wang R,Tang DD

更新日期：2018-01-05 00:00:00

abstract：BACKGROUND:Heightened inflammation, including expression of COX-2, is associated with COPD pathogenesis. RelB is an NF-κB family member that attenuates COX-2 in response to cigarette smoke by a mechanism that may involve the miRNA miR-146a. There is no information on the expression of RelB in COPD or if RelB prevents C...

journal_title：Respiratory research

authors： Sheridan JA,Zago M,Nair P,Li PZ,Bourbeau J,Tan WC,Hamid Q,Eidelman DH,Benedetti AL,Baglole CJ

更新日期：2015-05-06 00:00:00

abstract：:Many patients with persistent asthma can be controlled with inhaled corticosteroids (ICS). However, a considerable proportion of patients remain symptomatic, despite the use of ICS. We present systematically evidence that supports the different treatment options. A literature search was made of Medline/PubMed to ident...

journal_title：Respiratory research

authors： Kankaanranta H,Lahdensuo A,Moilanen E,Barnes PJ

更新日期：2004-10-27 00:00:00

abstract：BACKGROUND:Family history of asthma and other allergic diseases have been linked to the risk of childhood asthma previously, but little is known about their effect on the age-of-onset and persistency of asthma until young adulthood. METHODS:We assessed the effect of the family history of asthma and allergic diseases o...

journal_title：Respiratory research

authors： Paaso EM,Jaakkola MS,Rantala AK,Hugg TT,Jaakkola JJ

更新日期：2014-11-27 00:00:00

abstract：BACKGROUND:Alveolar macrophages are professional phagocytes that remove microbial pathogens inhaled into the lung. The phagocytic ability is compromised in chronic obstructive pulmonary disease (COPD). However, the molecular mechanisms underlying this defect in phagocytosis are not clearly defined. MATERIALS AND METHO...

journal_title：Respiratory research

authors： Tanno A,Fujino N,Yamada M,Sugiura H,Hirano T,Tanaka R,Sano H,Suzuki S,Okada Y,Ichinose M

更新日期：2020-01-28 00:00:00

abstract：BACKGROUND:Allergic asthma is characterized by airway inflammation in response to antigen exposure, leading to airway remodeling and lung dysfunction. Epithelial-mesenchymal transition (EMT) may play a role in airway remodeling through the acquisition of a mesenchymal phenotype in airway epithelial cells. TGF-β1 is kno...

journal_title：Respiratory research

authors： Johnson JR,Nishioka M,Chakir J,Risse PA,Almaghlouth I,Bazarbashi AN,Plante S,Martin JG,Eidelman D,Hamid Q

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:In order to find novel noninvasive biomarkers with high accuracy for the screening of early-stage non-small cell lung cancer (NSCLC), we investigate the predictive power of 5 microRNAs (miR-20a, miR-145, miR-21, miR223 and miR-221) as potential biomarkers in early-stage NSCLC. METHODS:In training set, 25 ea...

journal_title：Respiratory research

authors： Geng Q,Fan T,Zhang B,Wang W,Xu Y,Hu H

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:We have recently reported that protein phosphate 2A (PP2A) inactivation resulted in increased phosphorylation of the mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase 1 (JNK1) and glucocorticoid receptors (GR) at Ser(226), thereby reducing GR nuclear translocation and causing corticosteroid ins...

journal_title：Respiratory research

authors： Kobayashi Y,Ito K,Kanda A,Tomoda K,Miller-Larsson A,Barnes PJ,Mercado N

更新日期：2016-03-24 00:00:00

abstract：BACKGROUND:Myofibroblasts, proposed as being derived from circulating fibrocytes, are considered to be important cells in thickening of the basement membrane in patients with asthma. We have studied the correlation of tissue fibrocyte levels to basement membrane thickness and the presence of fibrocytes in bronchoalveol...

journal_title：Respiratory research

authors： Nihlberg K,Larsen K,Hultgårdh-Nilsson A,Malmström A,Bjermer L,Westergren-Thorsson G

更新日期：2006-03-29 00:00:00

abstract：:The molecular mechanisms of Idiopathic Pulmonary Fibrosis (IPF) remain elusive. Transforming Growth Factor beta 1(TGF-beta1) is a key effector cytokine in the development of lung fibrosis. We used microarray and computational biology strategies to identify genes whose expression is significantly altered in alveolar ep...

journal_title：Respiratory research

authors： Keating DT,Sadlier DM,Patricelli A,Smith SM,Walls D,Egan JJ,Doran PP

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:While glucocorticoids are currently the most effective therapy for asthma, associated side effects limit enthusiasm for their use. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activators include the synthetic thiazolidinediones (TZDs) which exhibit anti-inflammatory effects that suggest usef...

journal_title：Respiratory research

authors： Narala VR,Ranga R,Smith MR,Berlin AA,Standiford TJ,Lukacs NW,Reddy RC

更新日期：2007-12-04 00:00:00

abstract：BACKBROUND:COPD is a common, highly debilitating disease of the airways, primarily caused by smoking. Chronic inflammation and structural remodelling are key pathological features of this disease caused, in part, by the aberrant function of airway smooth muscle (ASM). We have previously demonstrated that hydrogen sulfi...

journal_title：Respiratory research

authors： Perry MM,Tildy B,Papi A,Casolari P,Caramori G,Rempel KL,Halayko AJ,Adcock I,Chung KF

更新日期：2018-05-09 00:00:00

abstract：BACKGROUND:Alpha-1-Antitrypsin (AAT) deficiency (AATD) is a hereditary disorder that manifests primarily as pulmonary emphysema and liver cirrhosis. The clinically most relevant mutation causing AATD is a single nucleotide polymorphism Glu342Lys (Z-mutation). Despite the recommendation to test every COPD patient, the c...

journal_title：Respiratory research

authors： Greulich T,Rodríguez-Frias F,Belmonte I,Klemmer A,Vogelmeier CF,Miravitlles M

更新日期：2018-08-13 00:00:00

abstract：BACKGROUND:Surfactant protein D (SP-D) can regulate both innate and adaptive immunity. Recently, SP-D has been shown to contribute to the pathogenesis of airway allergic inflammation and bleomycin-induced pulmonary fibrosis. However, in allergic airways disease, the role of SP-D in airway remodeling remains unknown. Th...

journal_title：Respiratory research

authors： Ogawa H,Ledford JG,Mukherjee S,Aono Y,Nishioka Y,Lee JJ,Izumi K,Hollingsworth JW

更新日期：2014-11-29 00:00:00

abstract：BACKGROUND:Apoptosis has recently been proposed to contribute to the pathogenesis of emphysema. METHODS:In order to establish if cell fate plays a role even in end-stage disease we studied 16 lungs (9 smoking-associated and 7 alpha1antitrypsin (AAT)-deficiency emphysema) from patients who had undergone lung transplant...

journal_title：Respiratory research

authors： Calabrese F,Giacometti C,Beghe B,Rea F,Loy M,Zuin R,Marulli G,Baraldo S,Saetta M,Valente M

更新日期：2005-02-10 00:00:00

abstract：BACKGROUND:In utero exposure to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) has been linked to child lung function. Overlapping evidence suggests that child sex and exposure timing may modify effects and associations may be mediated through glutathione S-transferase P1 (GSTP1) methylatio...

journal_title：Respiratory research

authors： Lee AG,Le Grand B,Hsu HL,Chiu YM,Brennan KJ,Bose S,Rosa MJ,Brunst KJ,Kloog I,Wilson A,Schwartz J,Morgan W,Coull BA,Wright RO,Baccarelli AA,Wright RJ

更新日期：2018-04-27 00:00:00

abstract：BACKGROUND:The aim of the study was to assess the chronic effects of combined phosphodiesterase 3/4 inhibitor tolafentrine, administered by inhalation, during monocrotaline-induced pulmonary arterial hypertension (PAH) in rats. METHODS:CD rats were given a single subcutaneous injection of monocrotaline to induce PAH. ...

journal_title：Respiratory research

authors： Pullamsetti S,Krick S,Yilmaz H,Ghofrani HA,Schudt C,Weissmann N,Fuchs B,Seeger W,Grimminger F,Schermuly RT

更新日期：2005-11-01 00:00:00