The gene encoding interleukin-13: a susceptibility locus for asthma and related traits.


:Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on chromosome 5q as a susceptibility locus for asthma. Recently, the Th2 cytokine interleukin-13 has been shown to be a critical mediator of the asthma phenotype in murine models. In this commentary we discuss several recent studies that have identified polymorphisms in the gene encoding interleukin-13. The consistent genetic associations of interleukin-13 with asthma and related traits across diverse ethnic populations in these studies provides strong support for the candidacy of this cytokine as a susceptibility locus for asthma and atopy on chromosome 5q31.


Respir Res


Respiratory research


Wills-Karp M





Has Abstract


2000-01-01 00:00:00












  • The anti-proliferative and anti-inflammatory response of COPD airway smooth muscle cells to hydrogen sulfide.

    abstract:BACKBROUND:COPD is a common, highly debilitating disease of the airways, primarily caused by smoking. Chronic inflammation and structural remodelling are key pathological features of this disease caused, in part, by the aberrant function of airway smooth muscle (ASM). We have previously demonstrated that hydrogen sulfi...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Perry MM,Tildy B,Papi A,Casolari P,Caramori G,Rempel KL,Halayko AJ,Adcock I,Chung KF

    更新日期:2018-05-09 00:00:00

  • Marketing data: has the rise of impact factor led to the fall of objective language in the scientific article?

    abstract::The language of science should be objective and detached and should place data in the appropriate context. The aim of this commentary was to explore the notion that recent trends in the use of language have led to a loss of objectivity in the presentation of scientific data. The relationship between the value-laden vo...

    journal_title:Respiratory research

    pub_type: 社论


    authors: Fraser VJ,Martin JG

    更新日期:2009-05-11 00:00:00

  • Primary data, claims data, and linked data in observational research: the case of COPD in Germany.

    abstract:BACKGROUND:Real-world evidence (RWE) can inform patient management decisions, but RWE studies are associated with limitations. Linkage of different RWE data types could address such limitations by enriching data and improving scientific quality. Using the example of chronic obstructive pulmonary disease (COPD) in Germa...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Mueller S,Gottschalk F,Groth A,Meeraus W,Driessen M,Kohlmann T,Wilke T

    更新日期:2018-08-30 00:00:00

  • Genome-wide DNA methylation analysis in lung fibroblasts co-cultured with silica-exposed alveolar macrophages.

    abstract:BACKGROUND:Exposure to crystalline silica is considered to increase the risk of lung fibrosis. The primary effector cell, the myofibroblast, plays an important role in the deposition of extracellular matrix (ECM). DNA methylation change is considered to have a potential effect on myofibroblast differentiation. Therefor...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Li J,Yao W,Zhang L,Bao L,Chen H,Wang D,Yue Z,Li Y,Zhang M,Hao C

    更新日期:2017-05-12 00:00:00

  • Profibrotic potential of prominin-1+ epithelial progenitor cells in pulmonary fibrosis.

    abstract:BACKGROUND:In idiopathic pulmonary fibrosis loss of alveolar epithelium induces inflammation of the pulmonary tissue followed by accumulation of pathogenic myofibroblasts leading eventually to respiratory failures. In animal models inflammatory and resident cells have been demonstrated to contribute to pulmonary fibros...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Blyszczuk P,Germano D,Stein S,Moch H,Matter CM,Beck-Schimmer B,Lüscher TF,Eriksson U,Kania G

    更新日期:2011-09-26 00:00:00

  • Macrophage derived chemokine (CCL22), thymus and activation-regulated chemokine (CCL17), and CCR4 in idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a chronically progressive interstitial lung disease of unknown etiology. Previously, we have demonstrated the selective upregulation of the macrophage-derived chemokine CCL22 and the thymus activation-regulated chemokine CCL17 among chemokines, in a rat model of radiati...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Yogo Y,Fujishima S,Inoue T,Saito F,Shiomi T,Yamaguchi K,Ishizaka A

    更新日期:2009-08-29 00:00:00

  • Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma.

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    pub_type: 杂志文章


    authors: Maarsingh H,Leusink J,Bos IS,Zaagsma J,Meurs H

    更新日期:2006-01-12 00:00:00

  • Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis.

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    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Atanasova KR,Reznikov LR

    更新日期:2018-08-06 00:00:00

  • DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease.

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    pub_type: 临床试验,杂志文章,多中心研究


    authors: Lee JH,McDonald ML,Cho MH,Wan ES,Castaldi PJ,Hunninghake GM,Marchetti N,Lynch DA,Crapo JD,Lomas DA,Coxson HO,Bakke PS,Silverman EK,Hersh CP,COPDGene and ECLIPSE Investigators.

    更新日期:2014-08-20 00:00:00

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    journal_title:Respiratory research

    pub_type: 杂志文章,评审


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    更新日期:2001-01-01 00:00:00

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    journal_title:Respiratory research

    pub_type: 杂志文章


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    更新日期:2014-11-29 00:00:00

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    abstract:BACKGROUND:Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated by these drugs. We hypothesized that small molecule drugs could function either alone or as an adju...

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    pub_type: 杂志文章


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    更新日期:2019-12-21 00:00:00

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    pub_type: 杂志文章


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    更新日期:2010-03-16 00:00:00

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    pub_type: 杂志文章


    authors: Hodge G,Jersmann H,Tran HB,Holmes M,Reynolds PN,Hodge S

    更新日期:2015-01-09 00:00:00

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    pub_type: 杂志文章


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    更新日期:2019-10-16 00:00:00

  • TLR4 signaling is essential for survival in acute lung injury induced by virulent Pseudomonas aeruginosa secreting type III secretory toxins.

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    pub_type: 杂志文章


    authors: Faure K,Sawa T,Ajayi T,Fujimoto J,Moriyama K,Shime N,Wiener-Kronish JP

    更新日期:2004-02-12 00:00:00

  • Serum surfactant protein D as a predictive biomarker for the efficacy of pirfenidone in patients with idiopathic pulmonary fibrosis: a post-hoc analysis of the phase 3 trial in Japan.

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    pub_type: 杂志文章


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    更新日期:2020-11-30 00:00:00

  • Different effects of deep inspirations on central and peripheral airways in healthy and allergen-challenged mice.

    abstract:BACKGROUND:Deep inspirations (DI) have bronchodilatory and bronchoprotective effects in healthy human subjects, but these effects appear to be absent in asthmatic lungs. We have characterized the effects of DI on lung mechanics during mechanical ventilation in healthy mice and in a murine model of acute and chronic air...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Jonasson S,Swedin L,Lundqvist M,Hedenstierna G,Dahlén SE,Hjoberg J

    更新日期:2008-02-28 00:00:00

  • Marked alveolar apoptosis/proliferation imbalance in end-stage emphysema.

    abstract:BACKGROUND:Apoptosis has recently been proposed to contribute to the pathogenesis of emphysema. METHODS:In order to establish if cell fate plays a role even in end-stage disease we studied 16 lungs (9 smoking-associated and 7 alpha1antitrypsin (AAT)-deficiency emphysema) from patients who had undergone lung transplant...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Calabrese F,Giacometti C,Beghe B,Rea F,Loy M,Zuin R,Marulli G,Baraldo S,Saetta M,Valente M

    更新日期:2005-02-10 00:00:00

  • Effects of cigarette smoke on barrier function and tight junction proteins in the bronchial epithelium: protective role of cathelicidin LL-37.

    abstract:BACKGROUND:Airway epithelial barrier function is maintained by the formation of tight junctions (TJs) and adherens junctions (AJs). Inhalation of cigarette smoke causes airway epithelial barrier dysfunction and may contribute to the pathogenesis of chronic lung diseases such as asthma and chronic obstructive pulmonary ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Tatsuta M,Kan-O K,Ishii Y,Yamamoto N,Ogawa T,Fukuyama S,Ogawa A,Fujita A,Nakanishi Y,Matsumoto K

    更新日期:2019-11-09 00:00:00

  • Macrophage CD74 contributes to MIF-induced pulmonary inflammation.

    abstract:BACKGROUND:MIF is a critical mediator of the host defense, and is involved in both acute and chronic responses in the lung. Neutralization of MIF reduces neutrophil accumulation into the lung in animal models. We hypothesized that MIF, in the alveolar space, promotes neutrophil accumulation via activation of the CD74 r...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Takahashi K,Koga K,Linge HM,Zhang Y,Lin X,Metz CN,Al-Abed Y,Ojamaa K,Miller EJ

    更新日期:2009-05-04 00:00:00

  • Pathophysiological classification of chronic rhinosinusitis.

    abstract:BACKGROUND:Recent consensus statements demonstrate the breadth of the chronic rhinosinusitis (CRS) differential diagnosis. However, the classification and mechanisms of different CRS phenotypes remains problematic. METHOD:Statistical patterns of subjective and objective findings were assessed by retrospective chart re...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Baraniuk JN,Maibach H

    更新日期:2005-12-19 00:00:00

  • The unsynchronized changes of CT image and nucleic acid detection in COVID-19: reports the two cases from Gansu, China.

    abstract::The novel coronavirus disease (COVID-19) outbreak started in December 2019 in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The CT image is used to assess the disease progress, whereas the continued two times of negative results from SARS-CoV-2 nucleic acid detection had been co...

    journal_title:Respiratory research

    pub_type: 信件


    authors: Gao J,Liu JQ,Wen HJ,Liu H,Hu WD,Han X,Li CX,Wang XJ

    更新日期:2020-04-22 00:00:00

  • Childhood infections and asthma: at the crossroads of the hygiene and Barker hypotheses.

    abstract::The hygiene hypothesis states that childhood asthma develops as a result of decreased exposure to infectious agents during infancy and early childhood. This results in the persistence of the neonatal T helper lymphocyte 2 immunophenotype, thereby predisposing the child to atopic disease. While multiple studies support...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Tantisira KG,Weiss ST

    更新日期:2001-01-01 00:00:00

  • Exogenous interleukin-6, interleukin-13, and interferon-γ provoke pulmonary abnormality with mild edema in enterovirus 71-infected mice.

    abstract:BACKGROUND:Neonatal mice developed neurological disease and pulmonary dysfunction after an infection with a mouse-adapted human Enterovirus 71 (EV71) strain MP4. However, the hallmark of severe human EV71 infection, pulmonary edema (PE), was not evident. METHODS:To test whether EV71-induced PE required a proinflammato...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Huang SW,Lee YP,Hung YT,Lin CH,Chuang JI,Lei HY,Su IJ,Yu CK

    更新日期:2011-11-06 00:00:00

  • Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells.

    abstract:BACKGROUND:The elastolytic enzyme matrix metalloproteinase (MMP)-12 has been implicated in the development of airway inflammation and remodeling. We investigated whether human airway smooth muscle cells could express and secrete MMP-12, thereby participating in the pathogenesis of airway inflammatory diseases. METHODS...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Xie S,Issa R,Sukkar MB,Oltmanns U,Bhavsar PK,Papi A,Caramori G,Adcock I,Chung KF

    更新日期:2005-12-16 00:00:00

  • Role of epidermal growth factor receptor activation in regulating mucin synthesis.

    abstract::Healthy individuals have few goblet cells in their airways, but in patients with hypersecretory diseases goblet-cell upregulation results in mucus hypersecretion, airway plugging, and death. Multiple stimuli produce hypersecretion via epidermal growth factor receptor (EGFR) expression and activation, causing goblet-ce...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Nadel JA

    更新日期:2001-01-01 00:00:00

  • Network analysis of quantitative proteomics on asthmatic bronchi: effects of inhaled glucocorticoid treatment.

    abstract:BACKGROUND:Proteomic studies of respiratory disorders have the potential to identify protein biomarkers for diagnosis and disease monitoring. Utilisation of sensitive quantitative proteomic methods creates opportunities to determine individual patient proteomes. The aim of the current study was to determine if quantita...

    journal_title:Respiratory research

    pub_type: 杂志文章,随机对照试验


    authors: O'Neil SE,Sitkauskiene B,Babusyte A,Krisiukeniene A,Stravinskaite-Bieksiene K,Sakalauskas R,Sihlbom C,Ekerljung L,Carlsohn E,Lötvall J

    更新日期:2011-09-22 00:00:00

  • The revised ATS/ERS/JRS/ALAT diagnostic criteria for idiopathic pulmonary fibrosis (IPF)--practical implications.

    abstract::Idiopathic pulmonary fibrosis (IPF), the most prevalent idiopathic interstitial pneumonia, is associated with a poor prognosis. An accurate diagnosis of IPF is essential for optimal management. The recent ATS/ERS/JRS/ALAT recommendations on the diagnosis and management of IPF were developed from a systematic review of...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Wells AU

    更新日期:2013-01-01 00:00:00

  • Apoptosis and the activity of ceramide, Bax and Bcl-2 in the lungs of neonatal rats exposed to limited and prolonged hyperoxia.

    abstract:BACKGROUND:The aim of the study is to examine the effect of limited and prolonged hyperoxia on neonatal rat lung. This is done by examining the morphologic changes of apoptosis, the expression of ceramide, an important mediator of apoptosis, the expression of inflammatory mediators represented by IL-1beta and the expre...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Husari AW,Dbaibo GS,Bitar H,Khayat A,Panjarian S,Nasser M,Bitar FF,El-Sabban M,Zaatari G,Mroueh SM

    更新日期:2006-07-26 00:00:00