Abstract:
INTRODUCTION:Cancer diagnosis in primary care is an important challenge for general practitioners (GPs) due to the relatively low frequency of any single type of cancer and the heterogeneous signs and symptoms that can be present. In addition to analytical reasoning, GPs may become aware of gut feelings (GFs) as they suspect that a patient may have cancer or another serious disease. We aimed to investigate the prevalence and the predictive value of GFs for the diagnosis of cancer and serious diseases. METHODS AND ANALYSIS:Prospective observational study of diagnostic validity. Participation will be offered to GPs from Majorca and Zaragoza (Spain). They will recruit all patients with a new reason for encounter during one or two workdays. GPs will complete the Gut Feelings Questionnaire (GFQ). Variables regarding patient, GP and consultation will be collected. Two and 6 months after the first visit, incident diagnoses of cancer or other serious diseases, diagnostic tests performed, referrals and new visits will be recorded. Analysis will include a descriptive analysis of the variables and prevalence of GFs, and the sensitivity, specificity, predictive values and likelihood ratios of the GFs (sense of alarm and sense of reassurance) for diagnosing cancer and other serious diseases, as measured with the GFQ. ETHICS AND DISSEMINATION:The study has obtained approval from the Majorcan Primary Care Research Committee and from the Balearic Islands Ethical Committee, with reference number IB 3210/16 PI. The results may help GPs to make more accurate decisions about which patients need further examinations to rule out or to confirm a diagnosis of cancer or a serious disease, and which ones do not. The results will be published as part of the PhD project of the first author and in open access journals, and will be presented at medical conferences.
journal_name
BMJ Openjournal_title
BMJ openauthors
Oliva-Fanlo B,March S,Medina D,Martín-Rabadán M,Tamborero G,Stolper E,Esteva Mdoi
10.1136/bmjopen-2019-032404subject
Has Abstractpub_date
2019-10-28 00:00:00pages
e032404issue
10issn
2044-6055pii
bmjopen-2019-032404journal_volume
9pub_type
杂志文章相关文献
BMJ Open文献大全abstract:PURPOSE:Occupational and environmental exposures remain important modifiable risk factors of public health. Existing cohort studies are often limited by the level of detail of data collected on these factors and health. It is also often assumed that the more healthy group is over-represented in cohort studies, which is...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005858
更新日期:2014-11-26 00:00:00
abstract:OBJECTIVE:To complete a systematic review of the literature describing associations between all environmental exposures and asthma symptoms and exacerbations in children up to mean age of 9 years. DESIGN:Systematic review. SETTING:Reference lists of identified studies and reviews were searched for all articles publis...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2013-003827
更新日期:2014-02-12 00:00:00
abstract:OBJECTIVES:Rapid initiation of antiretroviral therapy (ART) engenders faster viral suppression but with suboptimal rates of durable viral suppression and engagement in care, as reported by clinical trials in resource-limited settings. Real-world experience with rapid ART initiation remains limited in resource-rich sett...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033246
更新日期:2019-09-20 00:00:00
abstract:OBJECTIVES:The number of women entering medicine has increased significantly, yet women are still under-represented at senior levels in academic medicine. To support the gender equality action plan at one School of Medicine, this study sought to (1) identify the range of viewpoints held by staff on how to address gende...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-015973
更新日期:2017-08-22 00:00:00
abstract:INTRODUCTION:The Afghanistan war (2003-2014) was a unique period in military medicine. Many service personnel survived injuries of a severity that would have been fatal at any other time in history; the long-term health outcomes of such injuries are unknown. The ArmeD SerVices TrAuma and RehabilitatioN OutComE (ADVANCE...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037850
更新日期:2020-10-30 00:00:00
abstract:PURPOSE:Efforts to promote the health and well-being of military veterans have been criticised for being inadequately informed of veterans' most pressing needs as they separate from military service, as well as the programmes that are most likely to meet these needs. The current article summarises limitations of the cu...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-020734
更新日期:2018-06-11 00:00:00
abstract:OBJECTIVES:The rate of falling among older citizens appears to vary across different countries, but the underlying aspects causing this variation are unexplained. We aim to describe between-country variation in falling and explore whether intrinsic fall risk factors can explain possible variation. DESIGN:Prospective s...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-015827
更新日期:2017-06-30 00:00:00
abstract:OBJECTIVE:To determine levels of public registration for a cohort of clinical trials reviewed and given a favourable opinion by research ethics committees in the United Kingdom. STUDY DESIGN:Audit of records. SETTING:Clinical trials receiving a favourable ethics opinion between 1 January 2016 and 30 June 2016. MAIN ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-026840
更新日期:2019-02-21 00:00:00
abstract:INTRODUCTION:Acute hypoxaemic respiratory failure (AHRF) in children is the most frequent reason for non-elective hospital admission. During the initial phase, AHRF is a clinical syndrome defined for the purpose of this study by an oxygen requirement and caused by pneumonia, lower respiratory tract infections, asthma o...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030516
更新日期:2019-12-18 00:00:00
abstract:OBJECTIVES:Injection drug use is the most important risk factor for the spread of HIV in China over the past two decades. People who use drugs (PWUD) who were diagnosed at an early stage with HIV have gradually developed AIDS. This study investigated the factors associated with disease progression following HIV diagnos...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-023841
更新日期:2019-07-03 00:00:00
abstract:INTRODUCTION:Increasing prevalence of both thinness and excess weight during childhood and adolescence is a significant public health issue because of short-term health consequences and long-term tracking of weight status. Monitoring weight status in Europe may serve to identify countries and regions where rates of the...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2017-018241
更新日期:2017-12-21 00:00:00
abstract:INTRODUCTION:Children with acute respiratory tract infections (ARTIs) are prescribed up to 11.4 million unnecessary antibiotic prescriptions annually. Inadequate parent-provider communication is a chief contributor, yet efforts to reduce overprescribing have only indirectly targeted communication or been impractical. T...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2017-020981
更新日期:2018-05-09 00:00:00
abstract:OBJECTIVE:To review a sample of cluster randomised controlled trials and explore the quality of reporting of (1) enabling or support activities provided to the staff during the trial, (2) strategies used to monitor fidelity throughout the trial and (3) the extent to which the intervention being tested was delivered as ...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2015-008251
更新日期:2015-10-09 00:00:00
abstract:OBJECTIVE:The objective of this study is to assess the determinants of BCG vaccination in Ethiopia from 2016 Ethiopia Demographic and Health Survey (EDHS). SETTING:Since Ethiopia has nine regional states and two administrative cities, sample was taken from all the divisions. The population-based sample was intended to...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-023634
更新日期:2019-02-21 00:00:00
abstract:INTRODUCTION:Low back pain (LBP) is a leading cause of disability associated with high healthcare utilisation and costs. Mental health symptoms are negative prognostic factors for LBP recovery; however, no population-based studies have assessed the joint effects of LBP and mental health symptoms on healthcare utilisati...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-031749
更新日期:2019-09-27 00:00:00
abstract:OBJECTIVE:To evaluate the impact of a model of rural community health service (CHS) on the use and acceptability of primary healthcare services. DESIGN:Quasi-experimental. SETTING:Two adjacent rural counties in China. PARTICIPANTS:5842 residents in 2009 and 3807 in 2010 from 980 households in 7 intervention township...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-004148
更新日期:2014-02-28 00:00:00
abstract:OBJECTIVE:Elevated levels of intercellular adhesion molecule-1 (ICAM-1) are demonstrated in diabetes complications. The current study aims to understand association of K469E (rs5498) in ICAM-1 gene, in type 2 diabetic (T2D) subjects with retinopathy. DESIGN:Case-control study. SETTING:Sankara Nethralaya Diabetic Reti...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001036
更新日期:2012-08-17 00:00:00
abstract:INTRODUCTION:Whether acupuncture is efficacious for patients with functional dyspepsia is still controversial. So we designed a randomised controlled trial to settle the problem. METHODS AND ANALYSIS:We designed a multicentre, two-arm, sham-controlled clinical trial. 200 participants with functional dyspepsia will be ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003377
更新日期:2013-07-30 00:00:00
abstract:OBJECTIVE:High-performance marine craft personnel (HPMCP) are regularly exposed to vibration and repeated shock (VRS) levels exceeding maximum limitations stated by international legislation. Whereas such exposure reportedly is detrimental to health and performance, the epidemiological data necessary to link these adve...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-016006
更新日期:2017-07-20 00:00:00
abstract:OBJECTIVE:Obtaining informed consent is a cornerstone requirement of conducting ethical research. Traditional paper-based consent is often excessively lengthy and may fail to achieve the desired participant understanding of study requirements. Multimedia tools including video and audio may be a useful alternative. This...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-036977
更新日期:2020-07-26 00:00:00
abstract:INTRODUCTION:Telemedical lifestyle programmes for people with type 2 diabetes mellitus (T2DM) provide an opportunity to develop a healthier lifestyle and consequently to improve health outcomes. When implementing new programmes into standard care, considering patients' preferences may increase the success of the partic...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-036995
更新日期:2020-09-09 00:00:00
abstract:OBJECTIVES:We aimed to examine longitudinally whether workplace bullying was associated with subsequent psychotropic medication among women and men. DESIGN:A cohort study. SETTING:Helsinki, Finland. PARTICIPANTS:Employees of the City of Helsinki, Finland (n=6606, 80% women), 40-60 years at baseline in 2000-2002, and...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001660
更新日期:2012-12-12 00:00:00
abstract:INTRODUCTION:HIV-associated neurocognitive disorder (HAND) may affect 30%-50% of people ageing with HIV. HAND may increase stress and anxiety, and impede coping. Psychosocial group therapy may ameliorate HAND's symptoms, yet the ideal intervention is unclear. This protocol outlines a pilot randomised controlled trial (...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033183
更新日期:2019-10-31 00:00:00
abstract:OBJECTIVES:To elucidate the views of intermittent catheter (IC) users regarding urinary tract infection (UTI) symptom presentation, terminology for describing signs and symptoms, the cause of UTI and management strategies. DESIGN:Qualitative study with semi-structured interviews. The transcribed text was analysed them...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-016453
更新日期:2017-09-03 00:00:00
abstract:INTRODUCTION:Major depression is a highly prevalent pathology that is currently the second most common cause of disease-induced disability in our society. The onset and continuation of depression may be related to a wide variety of biological and psychosocial factors, many of which are linked to different lifestyle asp...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-038457
更新日期:2020-12-28 00:00:00
abstract:INTRODUCTION:Institutional care has been strongly promoted in China to meet seniors' long-term care needs. Empty-nest elderly, in comparison with their counterparts, have less social support and fewer caring networks. This study aimed to compare the utilisation willingness for institutional care and its predictors betw...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-022324
更新日期:2018-08-17 00:00:00
abstract:INTRODUCTION:Complex population health interventions that are effective in one context may not be effective elsewhere, and may even be harmful. As such, an intervention may require adaptation to ensure it fits with a new context. To date, there is no overarching guidance to help researchers to adapt and evaluate interv...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-038965
更新日期:2020-07-20 00:00:00
abstract:INTRODUCTION:Cigarette smoking is one of the leading causes of early death in the UK and worldwide. Public health guidance recommends the use of varenicline, bupropion and nicotine replacement therapy (NRT) as smoking cessation aids in the UK. Additionally, the first electronic cigarette has been licensed for use as a ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-015414
更新日期:2017-06-17 00:00:00
abstract:INTRODUCTION:Idiopathic Parkinson's disease (PD) is a progressive neurodegenerative disorder related to α-synuclein misfolding and aggregation. For this reason, it belongs to the family of 'synucleinopathies', which also includes some other neurological diseases. Although imaging and ancillary investigations may be hel...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2017-018177
更新日期:2017-11-22 00:00:00
abstract:BACKGROUND:COVID-19 has posed several medical, psychosocial and economic impacts among the majority of the society. The ambiguity of its transmission, the intense desire of self-protection, family, and friends, the unknown impact of catching the disease itself, unstoppable spread, the panic and outright misinformation ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-043185
更新日期:2021-01-06 00:00:00