Abstract:
OBJECTIVES:To assess the impact of both the Committee on Safety of Medicines (CSM) warning (December 2003) and the National Institute for Health and Care Excellence (NICE) guidance (September 2005) on antidepressant prescription rates in children and adolescents within the UK primary care service. SETTING:Population based study of primary care antidepressant prescribing using the Clinical Practice Research Datalink (CPRD). PARTICIPANTS:Under-18s presenting to primary care with a depressive disorder or related diagnostic code recorded in the CPRD. PRIMARY OUTCOME MEASURE:Antidepressant prescription rates per month per 100 000 depressed 4-17 year olds. RESULTS:Following the CSM warning, the prior trend towards increased prescribing rates for selective serotonin reuptake inhibitors (SSRIs) in children was significantly reversed (β for change in trend -12.34 (95% CI -18.67 to -6.00, p<0.001)). However, after the publication of the NICE guidelines the prior trend towards increased prescribing resumed for those SSRIs mentioned as potential treatments in the guidance (fluoxetine, citalopram and sertraline) (β for change in trend 11.52 (95% CI 5.32 to 17.73, p<0.001)). Prescribing of other SSRIs and tricyclics remained low. CONCLUSIONS:Despite a strong emphasis on psychosocial interventions for child and adolescent depression, it may be that the NICE guidelines inadvertently encouraged further antidepressant prescribing, at least for those SSRIs cited. Although the guidelines gave cautions and caveats for the use of antidepressants, practitioners may have interpreted these recommendations as endorsing their use in young people with depression and related conditions. However, more accurate prevalence trend estimates for depression in this age group, and information on the use of psychosocial interventions would be needed to rule out other reasons underlying this increase in prescribing.
journal_name
BMJ Openjournal_title
BMJ openauthors
Tiffin PA,Mediavilla JL,Close H,Kasim AS,Welsh P,Paton LW,Mason JMdoi
10.1136/bmjopen-2018-028201subject
Has Abstractpub_date
2019-08-07 00:00:00pages
e028201issue
8issn
2044-6055pii
bmjopen-2018-028201journal_volume
9pub_type
杂志文章相关文献
BMJ Open文献大全abstract:OBJECTIVE:To evaluate the effectiveness of injection-based therapy in base of thumb osteoarthritis. DESIGN:Systematic review and meta-analysis. DATA SOURCES:MEDLINE and EMBASE via OVID, CINAHL and SPORTDiscus via EBSCO were searched from inception to 22 May 2018. STUDY SELECTION:Randomised controlled trials (RCTs) a...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2018-027507
更新日期:2019-09-11 00:00:00
abstract:OBJECTIVES:To investigate the role of socioeconomic status and psychological stress to potential associations between confidence in the future and a wide range of health-related behaviours. DESIGN:Web-based cross-sectional study including an 'Electronic Health Check' at the Finnish Happiness-Flourishing Study website ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-002397
更新日期:2013-06-20 00:00:00
abstract:INTRODUCTION:Asthma-related morbidity and mortality in the UK is higher than elsewhere in Europe. Although the reasons for this are largely unclear, one explanation could be a higher prevalence of poorly controlled asthma in the UK. Findings from our earlier study found that, in a sample of 766 children with asthma, 45...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-025867
更新日期:2019-04-23 00:00:00
abstract:OBJECTIVE:This study assessed the incidence of tuberculosis (TB) and its predictors among adults living with HIV/AIDS in government health facilities in north-east Ethiopia. SETTING:A 5-year retrospective cohort study was conducted from May to June 2015 on 451 adult HIV/AIDS-infected individuals who enrolled in the HI...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2017-016961
更新日期:2018-02-06 00:00:00
abstract:OBJECTIVE:Although chronic non-bacterial osteitis (CNO) is an ever-increasingly recognised illness in the paediatric community and the adult healthcare community, a study to assess diagnosing, treatment and the psychosocial aspect of CNO from a large population pool was not available. We aimed to investigate CNO from t...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-017599
更新日期:2017-12-26 00:00:00
abstract:PURPOSE:The Dutch IBD Biobank aims to facilitate the discovery of predictors for individual disease course and treatment response in patients with inflammatory bowel disease (IBD). In this paper, we aim to describe the establishment of the Dutch IBD Biobank, including the facilitators and barriers to establishment. Mor...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2017-016695
更新日期:2017-11-08 00:00:00
abstract:OBJECTIVE:The COVID-19 pandemic has set unprecedented demand on the healthcare workforce around the world. The UK has been one of the most affected countries in Europe. The aim of this study was to explore the perceptions and experiences of healthcare workers (HCWs) in relation to COVID-19 and care delivery models impl...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-040503
更新日期:2020-11-05 00:00:00
abstract:INTRODUCTION:Despite advances in infection prevention and control, catheter-associated urinary tract infections (CAUTIs) are common and remain problematic. A number of measures can be taken to reduce the risk of CAUTI in hospitals. Appropriate urinary catheter insertion procedures are one such method. Reducing bacteria...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2017-018871
更新日期:2017-11-28 00:00:00
abstract:OBJECTIVE:This study examined the risk factors associated with failure of enhanced recovery protocol after major hepatobiliary and pancreatic (HBP) surgery. SETTING AND PARTICIPANTS:A retrospective cohort of 194 adult patients undergoing major HBP surgery at a university hospital in Hong Kong was followed up for 30 da...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005330
更新日期:2014-07-10 00:00:00
abstract:INTRODUCTION:Understanding what enhances the motivation and performance of community health workers (CHWs) in humanitarian emergencies represents a key research gap within the field of human resources for health. This paper presents the research protocol for the Performance ImprovEment of CHWs in Emergency Settings (PI...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011753
更新日期:2016-08-16 00:00:00
abstract:OBJECTIVES:To better model underlying trends in cervical cancer incidence so as to model past trends, to estimate the impact of cervical screening on cervical cancer rates at different ages and to obtain a counterfactual baseline under a no-screening scenario. DESIGN:Trend analysis of cancer registry data recorded bet...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-026292
更新日期:2019-01-24 00:00:00
abstract:OBJECTIVES:To study whether self-reported health problems predict sickness absence (SA) from work in employees from different industries. METHODS:The results of a health risk appraisal (HRA) were combined with archival data of SA of 21 608 employees (59% female, 56% clerical). Exposure variables were self-reported hea...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-025967
更新日期:2019-10-31 00:00:00
abstract:OBJECTIVES:Interventions to prevent postpartum common mental disorders (PCMD) among unselected populations of women have had limited success. The aim was to determine whether What Were We Thinking (WWWT) a gender-informed, psychoeducational programme for couples and babies can prevent PCMD among primiparous women 6 mon...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2015-009396
更新日期:2016-03-07 00:00:00
abstract:OBJECTIVES:The number of women entering medicine has increased significantly, yet women are still under-represented at senior levels in academic medicine. To support the gender equality action plan at one School of Medicine, this study sought to (1) identify the range of viewpoints held by staff on how to address gende...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-015973
更新日期:2017-08-22 00:00:00
abstract:OBJECTIVE:To compare maternal and neonatal birth outcomes and morbidities associated with the intention to give birth in two freestanding midwifery units and two tertiary-level maternity units in New South Wales, Australia. DESIGN:Prospective cohort study. PARTICIPANTS:494 women who intended to give birth at freestan...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-006252
更新日期:2014-10-31 00:00:00
abstract:OBJECTIVE:To identify the main areas of uncertainty and subsequent research priorities to inform the ongoing debate around assisted dying. DESIGN:Two-round electronic modified Delphi consultation with experts and interested bodies. SETTING AND PARTICIPANTS:110 groups and individuals interested in the subject of end-o...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-012213
更新日期:2016-06-07 00:00:00
abstract:INTRODUCTION:Commonly used clinical tests for posterior cruciate ligament (PCL) rupture detection exhibit several limitations, thus requiring more precise clinical PCL tests. The lateral-anterior drawer (LAD) test has been proposed as a manually applied testing alternative but not yet been evaluated in vivo. METHODS A...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-020999
更新日期:2018-05-29 00:00:00
abstract:INTRODUCTION:The incidence of head and neck cancer (HNC) in the UK is rising, with an average of 31 people diagnosed daily. Patients affected by HNC suffer significant short-term and long-term post-treatment morbidity as a result of dysphagia, which affects daily functioning and quality of life (QOL). Pretreatment swal...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2016-014167
更新日期:2017-03-27 00:00:00
abstract:OBJECTIVE:To explore how patients who are wait-listed for or who have received a kidney transplant understand the current UK kidney allocation system, and their views on ways to allocate kidneys in the future. DESIGN:Qualitative study using semistructured interviews and thematic analysis based on a pragmatic approach....
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-013896
更新日期:2017-01-27 00:00:00
abstract:BACKGROUND:WHO Disability Assessment Schedule 2.0 (WHODAS 2.0) is a feasible tool for assessing functional disability and analysing the risk of institutionalisation among elderly patients with dementia. However, the data for the effect of education on disability status in patients with dementia is lacking. The aim of t...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-013841
更新日期:2017-05-04 00:00:00
abstract:INTRODUCTION:Community health workers (CHWs)-shown to improve access to care and reduce maternal, newborn, and child morbidity and mortality-are re-emerging as a key strategy to achieve health-related Sustainable Development Goals (SDGs). However, recent evaluations of national programmes for CHW-led integrated communi...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2018-027487
更新日期:2019-08-26 00:00:00
abstract:OBJECTIVES:The COVID-19 pandemic has required drastic safety measures to control virus spread, including an extended self-isolation period. Stressful situations increase alcohol craving and consumption in alcohol use disorder (AUD) and non-AUD drinkers. Thus, we assessed how COVID-19 related stress may have affected dr...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2020-044276
更新日期:2020-11-26 00:00:00
abstract:OBJECTIVES:The Acne Priority Setting Partnership (PSP) was set up to identify and rank treatment uncertainties by bringing together people with acne, and professionals providing care within and beyond the National Health Service (NHS). SETTING:The UK with international participation. PARTICIPANTS:Teenagers and adults...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-008085
更新日期:2015-07-17 00:00:00
abstract:OBJECTIVES:'Horizontal inequity' in healthcare finance occurs when people with equal income contribute unequally to healthcare payments. Prior research is lacking on horizontal inequity in China. Accordingly, this study set out to examine horizontal inequity in the Chinese healthcare financing system in 2002 and 2007 t...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-025184
更新日期:2019-01-09 00:00:00
abstract:OBJECTIVES:To explore the prevalence, discomfort, and self-relief behaviours of painful diabetic neuropathy (PDN) among rural community residents with type 2 diabetes. DESIGN:A community-based, cross-sectional study. SETTING:This study was part of a longitudinal cohort study of a nurse-led health promotion programme ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011897
更新日期:2016-10-03 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The Kumamoto earthquakes struck Kumamoto prefecture, in the southwest part of Japan in April 2016. Physical and mental disorders presenting to hospital increased after the 2016 Kumamoto earthquakes. Impaired access to primary care due to the earthquakes may have contributed to this increase. H...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-021294
更新日期:2018-07-12 00:00:00
abstract:INTRODUCTION:Arthroscopic surgery is a very common orthopaedic procedure. While several trials have investigated the effect of knee arthroscopy for middle-aged and older patients with meniscal tears, there is a paucity of trials comparing meniscal surgery with non-surgical treatment for younger adults. The aim of this ...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2017-017436
更新日期:2017-08-21 00:00:00
abstract:OBJECTIVES:To compare cardiovascular risk factors as well as rates of cardiovascular diseases in middle-aged women from urban areas in Scotland and Sweden. DESIGN:Comparative cross-sectional study. SETTING:Data from the general population in urban areas of Scotland and the general population in two major Swedish citi...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-016527
更新日期:2017-08-07 00:00:00
abstract:OBJECTIVE:Perioperative shivering (POS) is a common complication in patients undergoing spinal anaesthesia. The present study investigated the efficacy of 5-HT3 receptor antagonists in preventing POS following spinal anaesthesia. DESIGN:Systematic review and meta-analysis. DATA SOURCES:Pubmed, Embase, the Web of Scie...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-038293
更新日期:2020-10-05 00:00:00
abstract:OBJECTIVE:In ST elevation myocardial infarction women received less evidence-based medicine and had worse outcome during the fibrinolytic era. With the shift to primary percutaneous coronary intervention (pPCI) as preferred reperfusion strategy, the authors aimed to investigate whether these gender differences has dimi...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000726
更新日期:2012-03-27 00:00:00