Abstract:
BACKGROUND:Post transplantation diabetes mellitus (PTDM) is a common and serious complication after renal transplantation with significant morbidity and mortality. Metformin has proven benefits in the general population and might be advantageous in the prevention and management of PTDM. METHODS:Transplantation and Diabetes (Transdiab) is a single-centre, unblinded, pilot randomised controlled trial assessing the feasibility, tolerability and efficacy of metformin after renal transplantation in patients with impaired glucose tolerance (IGT). Participants had an oral glucose tolerance test (OGTT) in the 4-12 weeks post-transplantation; those with IGT were randomised to standard care or standard care and metformin 500 mg twice daily and followed up for 12 months. RESULTS:Seventy eight patients had an OGTT over 24 months, 25 of them had IGT, of those, 19 patients were randomised, giving a feasibility of recruitment of 24.4%. Ten patients were randomised to metformin and 9 patients to standard care. Tolerability and efficacy was similar between the 2 groups with no serious adverse events. There was no difference in secondary outcomes relating to the metabolic profile. CONCLUSIONS:The use of metformin post renal transplantation appeared feasible and safe. Larger randomised controlled trials (RCTs) are needed to establish and confirm the efficacy and safety of metformin post renal transplantation. TRIAL REGISTRATION:Australian New Zealand Clinical Trials Registry ACTRN12614001171606 . Date of registration 7/11/2014.
journal_name
BMC Nephroljournal_title
BMC nephrologyauthors
Alnasrallah B,Goh TL,Chan LW,Manley P,Pilmore Hdoi
10.1186/s12882-019-1321-2subject
Has Abstractpub_date
2019-04-29 00:00:00pages
147issue
1issn
1471-2369pii
10.1186/s12882-019-1321-2journal_volume
20pub_type
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