Altered expression of the CSMD1 gene in the peripheral blood of schizophrenia patients.

Abstract:

BACKGROUND:Schizophrenia (SCZ) is a heritable, refractory, and devastating psychiatric disorder. Previous studies have shown that the variants of CUB and sushi multiple domains 1 (CSMD1) demonstrate significant genome-wide association with SCZ. However, few studies have been conducted on the effect of antipsychotics on the expression levels of CSMD1. This study explored whether a change occurs in the expression of the CSMD1 gene before and after antipsychotic treatment in SCZ patients. METHODS:The study population comprised Han Chinese patients from eastern China, including 32 SCZ patients and 48 healthy controls. The expression of CSMD1 before and after treatment in the SCZ group and between the two groups was analyzed using real-time quantitative polymerase chain reaction (RT-qPCR). RESULTS:The expression levels of the CSMD1 gene in the peripheral blood mononuclear cells (PBMCs) of SCZ patients were lower than those in the healthy controls. The expression levels of the CSMD1 gene in the PBMCs of the SCZ patients after antipsychotic treatment were higher than those in the baseline SCZ patients (all P <  0.05). CONCLUSIONS:Our results showed that the expression levels of CSMD1 are correlated with the development and treatment of SCZ, providing further evidence for the involvement of CSMD1 in SCZ.

journal_name

BMC Psychiatry

journal_title

BMC psychiatry

authors

Liu Y,Fu X,Tang Z,Li C,Xu Y,Zhang F,Zhou D,Zhu C

doi

10.1186/s12888-019-2089-4

subject

Has Abstract

pub_date

2019-04-15 00:00:00

pages

113

issue

1

issn

1471-244X

pii

10.1186/s12888-019-2089-4

journal_volume

19

pub_type

杂志文章
  • Clinical utility of the Montgomery-Åsberg Depression Rating Scale for the detection of depression among bariatric surgery candidates.

    abstract:BACKGROUND:Clinical assessment of depression is an important part of pre-surgical assessment among individuals with morbid obesity. However, there is no agreed-upon instrument to identify mood psychopathology in this population. We examined the reliability and criterion validity of the clinician-administered Montgomery...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-016-0823-8

    authors: Duarte-Guerra LS,Gorenstein C,Paiva-Medeiros PF,Santo MA,Lotufo Neto F,Wang YP

    更新日期:2016-04-30 00:00:00

  • Positive and Negative Affect Schedule (PANAS): psychometric properties of the online Spanish version in a clinical sample with emotional disorders.

    abstract:BACKGROUND:The Positive and Negative Affect Schedule (PANAS) is the most widely and frequently used scale to assess positive and negative affect. The PANAS has been validated in several languages, and it has shown excellent psychometric properties in the general population and some clinical samples, such as forensic sa...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-020-2472-1

    authors: Díaz-García A,González-Robles A,Mor S,Mira A,Quero S,García-Palacios A,Baños RM,Botella C

    更新日期:2020-02-10 00:00:00

  • A case of malignant catatonia with idiopathic pulmonary arterial hypertension treated by electroconvulsive therapy.

    abstract:BACKGROUND:Idiopathic pulmonary arterial hypertension (IPAH) is a progressive and fatal cardiovascular disease if left untreated. In patients with IPAH with psychiatric illness or other complications, careful attention is required when administering medical therapies that may affect their hemodynamics. Patients sufferi...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-016-0835-4

    authors: Hobo M,Uezato A,Nishiyama M,Suzuki M,Kurata J,Makita K,Yamamoto N,Nishikawa T

    更新日期:2016-05-06 00:00:00

  • Selective acquired long QT syndrome (saLQTS) upon risperidone treatment.

    abstract:BACKGROUND:Numerous structurally unrelated drugs, including antipsychotics, can prolong QT interval and trigger the acquired long QT syndrome (aLQTS). All of them are thought to act at the level of KCNH2, a subunit of the potassium channel. Although the QT-prolonging drugs are proscribed in the subjects with aLQTS, the...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/1471-244X-12-220

    authors: Lazarczyk MJ,Bhuiyan ZA,Perrin N,Giannakopoulos P

    更新日期:2012-12-05 00:00:00

  • Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders.

    abstract:BACKGROUND:Anxiety and related disorders are among the most common mental disorders, with lifetime prevalence reportedly as high as 31%. Unfortunately, anxiety disorders are under-diagnosed and under-treated. METHODS:These guidelines were developed by Canadian experts in anxiety and related disorders through a consens...

    journal_title:BMC psychiatry

    pub_type: 杂志文章,评审

    doi:10.1186/1471-244X-14-S1-S1

    authors: Katzman MA,Bleau P,Blier P,Chokka P,Kjernisted K,Van Ameringen M,Canadian Anxiety Guidelines Initiative Group on behalf of the Anxiety Disorders Association of Canada\/Association Canadienne des troubles anxieux and McGill University.,Anto

    更新日期:2014-01-01 00:00:00

  • Prevalence of obesity and overweight among Chinese children with attention deficit hyperactivity disorder: a survey in Zhejiang Province, China.

    abstract:BACKGROUND:Attention Deficit Hyperactivity Disorder (ADHD) is often comorbid with psychiatric and developmental disorders. This study aimed to investigate the prevalence of obesity and overweight among Chinese children with ADHD, and to explore which subtypes of the disorder may specifically be associated with obesity/...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/1471-244X-13-133

    authors: Yang R,Mao S,Zhang S,Li R,Zhao Z

    更新日期:2013-05-10 00:00:00

  • Internal structure and reliability of the Attachment Insecurity Screening Inventory (AISI) for children age 6 to 12.

    abstract:BACKGROUND:The aim of the present study was to examine the internal structure and reliability of the Attachment Insecurity Screening Inventory (AISI) 6-12. The AISI 6-12 years is a parent-report questionnaire for assessing the parents' perspective on the quality of the attachment relationship with their child aged betw...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-018-1608-z

    authors: Spruit A,Wissink I,Noom MJ,Colonnesi C,Polderman N,Willems L,Barning C,Stams GJJM

    更新日期:2018-02-05 00:00:00

  • Screening value of the Center for epidemiologic studies - depression scale among people living with HIV/AIDS in Ho Chi Minh City, Vietnam: a validation study.

    abstract:BACKGROUND:Depression is believed to be under-diagnosed and under-treated in people living with HIV/AIDS (PLHIV). Early screening and referral to mental health services for treatment has been shown to enhance HIV patients' health during the course of HIV treatment. A lack of psychiatric specialist services for PLHIV at...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-016-0860-3

    authors: Thai TT,Jones MK,Harris LM,Heard RC

    更新日期:2016-05-13 00:00:00

  • Executive attention impairment in first-episode schizophrenia.

    abstract:BACKGROUND:We compared the attention abilities of a group of first-episode schizophrenia (FES) patients and a group of healthy participants using the Attention Network Test (ANT), a standard procedure that estimates the functional state of three neural networks controlling the efficiency of three different attentional ...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/1471-244X-12-154

    authors: Orellana G,Slachevsky A,Peña M

    更新日期:2012-09-22 00:00:00

  • Correction to: Dialectical behaviour therapy for treating adults and adolescents with emotional and behavioural dysregulation: study protocol of a coordinated implementation in a publicly funded health service.

    abstract::Upon publication of the original article (1) it was highlighted by the authors that there was just one error in the manuscript in the 'Sample size' subsection of the Methods/Design. ...

    journal_title:BMC psychiatry

    pub_type: 杂志文章,已发布勘误

    doi:10.1186/s12888-018-1694-y

    authors: Flynn D,Kells M,Joyce M,Suarez C,Gillespie C

    更新日期:2018-05-07 00:00:00

  • Suicidal ideation in primary care patients suffering from panic disorder with or without agoraphobia.

    abstract:BACKGROUND:Suicidal ideation is common in patients suffering from panic disorder. The present study investigated rates of suicidal ideation and risk factors for suicidal ideation in a sample of primary care patients suffering from panic disorder with or without agoraphobia. METHODS:A total of N = 296 patients [n = 215...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-018-1894-5

    authors: Teismann T,Lukaschek K,Hiller TS,Breitbart J,Brettschneider C,Schumacher U,Margraf J,Gensichen J,Jena Paradies Study Group.

    更新日期:2018-09-24 00:00:00

  • A new clinical rating scale for work absence and productivity: validation in patients with major depressive disorder.

    abstract:BACKGROUND:The prevalence of major depressive disorder (MDD) is highest in working age people and depression causes significant impairment in occupational functioning. Work productivity and work absence should be incorporated into clinical assessments but currently available scales may not be optimized for clinical use...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/1471-244X-9-78

    authors: Lam RW,Michalak EE,Yatham LN

    更新日期:2009-12-03 00:00:00

  • Web-based cognitive behavioural therapy (W-CBT) for diabetes patients with co-morbid depression: design of a randomised controlled trial.

    abstract:BACKGROUND:Depression is common among people with diabetes, negatively affecting quality of life, treatment adherence and diabetes outcomes. In routine clinical care, diabetes patients have limited access to mental health services and depression therefore often remains untreated. Web-based therapy could potentially be ...

    journal_title:BMC psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-244X-8-9

    authors: van Bastelaar KM,Pouwer F,Cuijpers P,Twisk JW,Snoek FJ

    更新日期:2008-02-19 00:00:00

  • Study protocol: cluster randomised controlled trial to assess the clinical and cost effectiveness of a staff training intervention in inpatient mental health rehabilitation units in increasing service users' engagement in activities.

    abstract:BACKGROUND:This study focuses on people with complex and severe mental health problems who require inpatient rehabilitation. The majority have a diagnosis of schizophrenia whose recovery has been delayed due to non-response to first-line treatments, cognitive impairment, negative symptoms and co-existing problems such ...

    journal_title:BMC psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-244X-13-216

    authors: Killaspy H,Cook S,Mundy T,Craig T,Holloway F,Leavey G,Marston L,McCrone P,Koeser L,Arbuthnott M,Omar RZ,King M

    更新日期:2013-08-28 00:00:00

  • The importance of the concepts of disaster, catastrophe, violence, trauma and barbarism in defining posttraumatic stress disorder in clinical practice.

    abstract:BACKGROUND:Several terms in the scientific literature about posttraumatic stress disorder are used with different meanings in studies conducted by different authors. Words such as trauma, violence, catastrophe, disaster and barbarism are often used vaguely or confusingly, and their meanings change in different articles...

    journal_title:BMC psychiatry

    pub_type: 杂志文章,评审

    doi:10.1186/1471-244X-8-68

    authors: Braga LL,Fiks JP,Mari JJ,Mello MF

    更新日期:2008-08-12 00:00:00

  • A case study of suicidality presenting as a restricted interest in autism Spectrum disorder.

    abstract:BACKGROUND:Suicidality has been under-researched in autism spectrum disorders (ASD). Most studies have linked increased suicidality in ASD to psychiatric comorbidities such as depression. Here we investigated, from a neuropsychological and clinical standpoint, the relationship between core ASD symptoms, i.e., restricte...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-019-2122-7

    authors: Weiner L,Flin A,Causin JB,Weibel S,Bertschy G

    更新日期:2019-04-27 00:00:00

  • Crucial factors preceding compulsory psychiatric admission: a qualitative patient-record study.

    abstract:BACKGROUND:Compulsory admissions have a strong effect on psychiatric patients and represent a deprivation of personal liberty. Although the rate of such admissions is tending to rise in several Western countries, there is little qualitative research on the mental health-care process preceding compulsory admission. The ...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-017-1512-y

    authors: de Jong MH,Oorschot M,Kamperman AM,Brussaard PE,Knijff EM,van de Sande R,Van Gool AR,Mulder CL

    更新日期:2017-10-24 00:00:00

  • Subjective and objective evaluation of alertness and sleep quality in depressed patients.

    abstract:BACKGROUND:The reliability of the subjective statements reports on disturbed night sleep and alertness in the daytime was assessed by their correlation to the objective indicators in patients with mild depression. METHOD:Among patients with depression, altogether 28 patients with insomnia were examined. Their answers ...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/1471-244X-4-14

    authors: Matousek M,Cervena K,Zavesicka L,Brunovsky M

    更新日期:2004-05-26 00:00:00

  • Training in dual diagnosis interventions (the COMO Study): randomised controlled trial.

    abstract:BACKGROUND:Despite the high prevalence of co-morbid substance use among mental health service users (dual diagnosis), very few mental health workers in the UK have had training and/or clinical experience to equip them to deliver targeted interventions to this client group. METHOD:In a randomised controlled trial of tr...

    journal_title:BMC psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-244X-8-12

    authors: Hughes E,Wanigaratne S,Gournay K,Johnson S,Thornicroft G,Finch E,Marshall J,Smith N

    更新日期:2008-02-27 00:00:00

  • Mindfulness-based cognitive therapy versus psychoeducational intervention in bipolar outpatients with sub-threshold depressive symptoms: a randomized controlled trial.

    abstract:BACKGROUND:The presence of depressive subsyndromal symptoms (SS) in bipolar disorder (BD) increases the risk of affective relapse and worsens social, cognitive functioning, and quality of life. Nonetheless, there are limited data on how to optimize the treatment of subthreshold depressive symptoms in BD. Mindfulness-Ba...

    journal_title:BMC psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s12888-014-0215-x

    authors: Lahera G,Bayón C,Fe Bravo-Ortiz M,Rodríguez-Vega B,Barbeito S,Sáenz M,Avedillo C,Villanueva R,Ugarte A,González-Pinto A,de Dios C

    更新日期:2014-08-15 00:00:00

  • Perceived Stress Scale (PSS-10) psychometric properties in migrants and native Germans.

    abstract:BACKGROUND:With the increasing diversity of the German population, it is important to test the psychometric validity and reliability of the German version Perceived Stress Scale (PSS-10) specifically between German natives and residents with a migration background. METHODS:Using nationally representative data (N = 252...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-020-02851-2

    authors: Bastianon CD,Klein EM,Tibubos AN,Brähler E,Beutel ME,Petrowski K

    更新日期:2020-09-11 00:00:00

  • The characteristics and health needs of pregnant women with schizophrenia compared with bipolar disorder and affective psychoses.

    abstract:BACKGROUND:Most women with psychotic disorders and bipolar disorders have children but their pregnancies are at risk of adverse psychiatric and fetal outcome. The extent of modifiable risk factors - both clinical and socio-demographic - is unclear as most studies have used administrative data or recruited from speciali...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-015-0451-8

    authors: Taylor CL,Stewart R,Ogden J,Broadbent M,Pasupathy D,Howard LM

    更新日期:2015-04-17 00:00:00

  • Brief gatekeeper training for suicide prevention in an ethnic minority population: a controlled intervention.

    abstract:BACKGROUND:Suicide is a critical public health problem around the globe. Asian populations are characterized by elevated suicide rates and a tendency to seek social support from family and friends over mental health professionals. Gatekeeper training programs have been developed to train frontline individuals in behavi...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-016-0924-4

    authors: Teo AR,Andrea SB,Sakakibara R,Motohara S,Matthieu MM,Fetters MD

    更新日期:2016-07-07 00:00:00

  • A stepped wedge cluster randomised trial of a cognitive remediation intervention in alcohol and other drug (AOD) residential treatment services.

    abstract:BACKGROUND:Executive functioning impairment is common in substance use disorder and is a major risk factor for poor treatment outcomes, including treatment drop-out and relapse. Cognitive remediation interventions seek to improve executive functioning and offer a promising approach to increase the efficacy of alcohol a...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-019-2044-4

    authors: Berry J,Jacomb I,Lunn J,Sedwell A,Shakeshaft A,Kelly PJ,Sarrami P,James M,Russell S,Nardo T,Barker D,Holmes J

    更新日期:2019-02-13 00:00:00

  • Self-reported contacts for mental health problems by rural residents: predicted service needs, facilitators and barriers.

    abstract:BACKGROUND:Rural and remote Australians face a range of barriers to mental health care, potentially limiting the extent to which current services and support networks may provide assistance. This paper examines self-reported mental health problems and contacts during the last 12 months, and explores cross-sectional ass...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-014-0249-0

    authors: Handley TE,Kay-Lambkin FJ,Inder KJ,Lewin TJ,Attia JR,Fuller J,Perkins D,Coleman C,Weaver N,Kelly BJ

    更新日期:2014-09-06 00:00:00

  • Somatic comorbidity among migrants with posttraumatic stress disorder and depression - a prospective cohort study.

    abstract:BACKGROUND:In a cohort of migrants in Denmark, we compared somatic disease incidence among migrants diagnosed with posttraumatic stress disorder (PTSD) and depression with migrants without a diagnosed psychiatric disorder. METHODS:The study builds on a unique cohort of migrants who obtained residence permit in Denmark...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-016-1149-2

    authors: Lolk M,Byberg S,Carlsson J,Norredam M

    更新日期:2016-12-13 00:00:00

  • Universality of interpersonal psychotherapy (IPT) problem areas in Thai depressed patients.

    abstract:BACKGROUND:Many studies have shown the efficacy of interpersonal psychotherapy (IPT) on depression; however, there are limited studies concerning the universality of the IPT problem areas in different countries. This study identifies whether the interpersonal problem areas defined in the IPT manual are endorsed by Thai...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/1471-244X-10-87

    authors: Lueboonthavatchai P,Thavichachart N

    更新日期:2010-10-21 00:00:00

  • Evaluating the national multisite implementation of dialectical behaviour therapy in a community setting: a mixed methods approach.

    abstract:BACKGROUND:The implementation of evidence-based interventions for borderline personality disorder in community settings is important given that individuals with this diagnosis are often extensive users of both inpatient and outpatient mental health services. Although work in this area is limited, previous studies have ...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-020-02610-3

    authors: Flynn D,Joyce M,Gillespie C,Kells M,Swales M,Spillane A,Hurley J,Hayes A,Gallagher E,Arensman E,Weihrauch M

    更新日期:2020-05-14 00:00:00

  • Maintenance treatment of adolescent bipolar disorder: open study of the effectiveness and tolerability of quetiapine.

    abstract:BACKGROUND:The purpose of the study was to determine the effectiveness and tolerability of quetiapine as a maintenance treatment preventing against relapse or recurrence of acute mood episodes in adolescent patients diagnosed with bipolar disorder. METHODS:Consenting patients meeting DSM-IV lifetime criteria for a bip...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/1471-244X-9-4

    authors: Duffy A,Milin R,Grof P

    更新日期:2009-02-06 00:00:00

  • Collaborative Care for patients with severe borderline and NOS personality disorders: a comparative multiple case study on processes and outcomes.

    abstract:BACKGROUND:Structured psychotherapy is recommended as the preferred treatment of personality disorders. A substantial group of patients, however, has no access to these therapies or does not benefit. For those patients who have no (longer) access to psychotherapy a Collaborative Care Program (CCP) is developed. Collabo...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/1471-244X-11-102

    authors: Stringer B,van Meijel B,Koekkoek B,Kerkhof A,Beekman A

    更新日期:2011-06-24 00:00:00