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Disease-specific and general health-related quality of life in newly diagnosed prostate cancer patients: the Pros-IT CNR study.

Abstract：

BACKGROUND:The National Research Council (CNR) prostate cancer monitoring project in Italy (Pros-IT CNR) is an observational, prospective, ongoing, multicentre study aiming to monitor a sample of Italian males diagnosed as new cases of prostate cancer. The present study aims to present data on the quality of life at time prostate cancer is diagnosed. METHODS:One thousand seven hundred five patients were enrolled. Quality of life is evaluated at the time cancer was diagnosed and at subsequent assessments via the Italian version of the University of California Los Angeles-Prostate Cancer Index (UCLA-PCI) and the Short Form Health Survey (SF-12). RESULTS:At diagnosis, lower scores on the physical component of the SF-12 were associated to older ages, obesity and the presence of 3+ moderate/severe comorbidities. Lower scores on the mental component were associated to younger ages, the presence of 3+ moderate/severe comorbidities and a T-score higher than one. Urinary and bowel functions according to UCLA-PCI were generally good. Almost 5% of the sample reported using at least one safety pad daily to control urinary loss; less than 3% reported moderate/severe problems attributable to bowel functions, and sexual function was a moderate/severe problem for 26.7%. Diabetes, 3+ moderate/severe comorbidities, T2 or T3-T4 categories and a Gleason score of eight or more were significantly associated with lower sexual function scores at diagnosis. CONCLUSIONS:Data collected by the Pros-IT CNR study have clarified the baseline status of newly diagnosed prostate cancer patients. A comprehensive assessment of quality of life will allow to objectively evaluate outcomes of different profile of care.

journal_name

Health Qual Life Outcomes

journal_title

Health and quality of life outcomes

authors

Porreca A,Noale M,Artibani W,Bassi PF,Bertoni F,Bracarda S,Conti GN,Corvò R,Gacci M,Graziotti P,Magrini SM,Mirone V,Montironi R,Muto G,Pecoraro S,Ricardi U,Russi E,Tubaro A,Zagonel V,Crepaldi G,Maggi S,Pros-IT C

doi

10.1186/s12955-018-0952-5

subject

Has Abstract

pub_date

2018-06-13 00:00:00

pages

122

issue

issn

1477-7525

pii

10.1186/s12955-018-0952-5

journal_volume

pub_type

杂志文章,多中心研究

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Disease-specific and general health-related quality of life in newly diagnosed prostate cancer patients: the Pros-IT CNR study.