Abstract：
BACKGROUND:TGF-β has been described as a mediator of fibrosis and scarring. Several studies achieved reduction in experimental scarring through the inhibition of TGF-β. Fibroblasts have been defined as the cell population originating fibrosis, blocking fibroblast invasion may impair epidural fibrosis appearance. For this purpose, biocompatible materials used as mechanical barriers and a TGF-β inhibitor peptide were evaluated in the reduction of epidural fibrosis. METHODS:A L6 laminectomy was performed in 40 New Zealand white rabbits. Divided into four groups, each rabbit was assigned to receive either collagen sponge scaffold (CS group), gelatin-based gel (GCP group), P144® (iTGFβ group), or left untreated (control group). Four weeks after surgery, cell density, collagen content, and new bone formation of the scar area were determined by histomorphometry. Two experienced pathologists scored dura mater adhesion, scar density, and inflammatory infiltrate in a blinded manner. RESULTS:In all groups, laminectomy site was filled with fibrous tissue and the dura mater presented adhesions. Only GCP group presented a significant reduction in collagen content and scar density. CONCLUSION:GCP treatment reduces epidural fibrosis although did not prevent dura mater adhesion completely.
journal_name
J Orthop Surg Resjournal_title
Journal of orthopaedic surgery and researchauthors
Albiñana-Cunningham JN,Ripalda-Cemboráin P,Labiano T,Echeveste JI,Granero-Moltó F,Alfonso-Olmos Mdoi
10.1186/s13018-018-0781-6subject
Has Abstractpub_date
2018-04-05 00:00:00pages
72issue
1issn
1749-799Xpii
10.1186/s13018-018-0781-6journal_volume
13pub_type
杂志文章abstract：BACKGROUND:One potential complication of retrograde femoral nailing in the treatment of femur fractures is the risk of septic knee. This risk theoretically increases in open fractures as a contaminated fracture site has the potential to seed the instrumentation being passed in and out of the sterile intraarticular star...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/1749-799X-7-7
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abstract：BACKGROUND:In cases of poor bone quality, intraoperative torque measurement might be an alternative to preoperative dual-energy X-ray absorptiometry (DXA) to assess bone quality in total hip arthroplasty (THA). METHODS:Trabecular peak torque measurement was applied in 14 paired fresh frozen human femurs. Here, a 6.5 ×...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-014-0109-0
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journal_title：Journal of orthopaedic surgery and research
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doi：10.1186/s13018-020-02062-1
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-017-0608-x
更新日期：2017-07-17 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-019-1472-7
更新日期：2019-12-09 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/1749-799X-3-12
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journal_title：Journal of orthopaedic surgery and research
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更新日期：2019-07-17 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-020-02034-5
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
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journal_title：Journal of orthopaedic surgery and research
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-020-01937-7
更新日期：2020-09-11 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-015-0240-6
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-017-0557-4
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-019-1212-z
更新日期：2019-06-10 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章,meta分析
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更新日期：2019-07-18 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-019-1487-0
更新日期：2019-12-05 00:00:00
abstract：:Ankle sprains are very common injuries seen in the athletic and young population. Majority of patients will improve with a course of rest and physical therapy. However, with conservative management about twenty percent of all patients will go on to develop chronic lateral ankle instability. This manuscript describes o...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/1749-799X-4-41
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journal_title：Journal of orthopaedic surgery and research
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journal_title：Journal of orthopaedic surgery and research
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/1749-799X-6-11
更新日期：2011-02-21 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-015-0170-3
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/1749-799X-6-23
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journal_title：Journal of orthopaedic surgery and research
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-020-01771-x
更新日期：2020-07-09 00:00:00
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