Abstract:
BACKGROUND:Anal residual tumors are consensually identified within six months of chemoradiotherapy and represent a persistent lesion that may have prognostic value for overall survival. The aim of this study was to evaluate the association of HPV and HIV status, p16 expression level and TP53 mutations with the absence of residual tumors (local response) in Squamous Cell Carcinoma (SCC) of the anal canal after chemoradiotherapy. METHODS:We performed a study on 78 patients with SCC of the anal canal who submitted to chemoradiotherapy and were followed for a six-month period to identify the absence or presence of residual tumors. HPV DNA was identified by polymerase chain reaction and direct sequencing, HIV RNA was detected by TaqMan amplification, p16 expression was detected by western blotting, and the mutational analysis of TP53 was performed by direct sequencing; additionally, samples carrying mutations underwent fluorescent in sit hybridization. The evaluation of the tumor response to treatment was conducted six months after the conclusion of chemoradiotherapy. The following classifications were used to evaluate the outcomes: a) no response (presence of residual tumor) and b) complete response (absence of residual tumor). RESULTS:The significant variables associated with the absence of residual tumors were HPV positive, p16 overexpressed, wild-type TP53, female gender, and stages I and II. Only the presence of HPV was independently correlated with the clinical response; this variable increased the chances of a response within six months by 31-fold. CONCLUSIONS:The presence of HPV in tumor cells was correlated with the absence of a residual tumor. This correlation is valuable and can direct future therapeutic approaches in the anal canal.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Soares PC,Abdelhay ES,Thuler LCS,Soares BM,Demachki S,Ferro GVR,Assumpção PP,Lamarão LM,Ribeiro Pinto LF,Burbano RMRdoi
10.1186/s12876-018-0758-2subject
Has Abstractpub_date
2018-02-21 00:00:00pages
30issue
1issn
1471-230Xpii
10.1186/s12876-018-0758-2journal_volume
18pub_type
杂志文章abstract:BACKGROUND:Bicyclol, the most commonly-used liver hepatoprotective drug in China, is often selected to control disease progression in CHB patients who refuse anti-viral treatment. However, data on histological changes after bicyclol treatment in these patients are scarce. Therefore, this study has been conducted to fin...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1005-1
更新日期:2019-06-13 00:00:00
abstract:BACKGROUND:Compared with biofluids, target tissues and organs more directly reflect the pathophysiological state of a disease process. In this study, a D-galactosamine (GalN) / lipopolysaccharide (LPS)-induced mouse model was constructed to investigate metabonomics of liver tissue and directly characterize metabolic ch...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-13-73
更新日期:2013-04-29 00:00:00
abstract:BACKGROUND:The nuclear protein high-mobility group box 1 (HMGB1) is a key trigger for the inflammatory reaction during liver ischemia reperfusion injury (IRI). Hydrogen treatment was recently associated with down-regulation of the expression of HMGB1 and pro-inflammatory cytokines during sepsis and myocardial IRI, but ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-12
更新日期:2014-01-12 00:00:00
abstract:BACKGROUND:To observe and compare the short term results and functional recovery of laparoscopic subtotal colectomy with antiperistaltic cecorectal anastomosis (LSCACRA) in the treatment of Adult slow transit constipation (STC) with two different reservoir length: short colonic reservoir and long colonic reservoir. ME...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-015-0257-7
更新日期:2015-03-18 00:00:00
abstract:BACKGROUND:Ulcerative colitis (UC) patients failing medical management require colectomy. This study compares risk estimates for predictors of postoperative complication derived from administrative data against that of chart review and evaluates the accuracy of administrative coding for this population. METHODS:Hospit...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-39
更新日期:2012-04-27 00:00:00
abstract:BACKGROUND:The impact of viral subtype on the rate of sustained virological response (SVR) to antiviral therapy in patients chronically infected with hepatitis C genotype 1 subtype 1a and 1b has not been extensively investigated. The aim of this study is to determine whether the HCV genotype 1 subtypes 1a and 1b respon...
journal_title:BMC gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1186/1471-230X-12-162
更新日期:2012-11-16 00:00:00
abstract:BACKGROUND:Chronic diarrhea in adults is a common symptom with a wide range of underlying etiologies. Although various strategies have been proposed for evaluation, there are still cases with undetermined origins even after extensive workup. Amyloidosis with gastrointestinal (GI) involvement is one of the causes that s...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-13-71
更新日期:2013-04-24 00:00:00
abstract:BACKGROUND:From the morphological appearance, it was impossible to distinguish terminal portal venules from small lymphatic vessels in the portal tract even using histochemical microscopic techniques. Recently, D2-40 was found to be expressed at a high level in lymphatic endothelial cells (LECs). This study was underta...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-230X-10-131
更新日期:2010-11-08 00:00:00
abstract:BACKGROUND:Wireless capsule pH-metry (WC) is better tolerated than standard nasal pH catheter (SC), but endoscopic placement is expensive. AIMS:to confirm that non-endoscopic peroral manometric placement of WC is as effective and better tolerated than SC and to perform a cost analysis of the available esophageal pH-me...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-230X-12-58
更新日期:2012-05-31 00:00:00
abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of liver diseases, ranging from pure steatosis to nonalcoholic steatohepatitis (NASH), and eventually to liver cirrhosis with its complications. Identifying advanced fibrosis in patients is crucial to evaluating prognosis and possible therapeu...
journal_title:BMC gastroenterology
pub_type: 杂志文章
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更新日期:2010-06-28 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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更新日期:2014-08-20 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-4-30
更新日期:2004-12-03 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0883-y
更新日期:2018-10-29 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0852-5
更新日期:2018-08-02 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-0951-y
更新日期:2019-02-11 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230x-1-5
更新日期:2001-01-01 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0850-7
更新日期:2018-08-13 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-8-3
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
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更新日期:2017-04-04 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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更新日期:2015-07-24 00:00:00
abstract:BACKGROUND:Irritable Bowel Syndrome (IBS) is a common chronic gastrointestinal disorder and the evidence for efficacy of most drug therapies in the treatment of IBS is weak. A popular alternative is probiotics, which have been used in several conditions. including IBS. Probiotics are live microbial food supplements.The...
journal_title:BMC gastroenterology
pub_type: 杂志文章,meta分析,评审
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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更新日期:2017-01-13 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12876-015-0278-2
更新日期:2015-05-02 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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更新日期:2018-07-06 00:00:00
abstract:BACKGROUND:Many studies suggest that in chronic hepatitis B virus (HBV) infection regulate T (Treg) cells and interlukin-17-producing T help cells (Th17) are mutually antagonistic in the immune response. This study is aimed to reveal the cell differentiation environment and the significance of Treg and Th17 balance in ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-43
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Helicobacter pylori (H. pylori) infection and excessive salt intake are known as important risk factors for stomach cancer in humans. However, interactions of these two factors with gene expression profiles during gastric carcinogenesis remain unclear. In the present study, we investigated the global gene ex...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-13-122
更新日期:2013-07-30 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00