Abstract:
BACKGROUND:Denmark has one of the highest alcohol consumption rates in Northern Europe. The overall per capita alcohol consumption has been stable in recent decades, but surveys have indicated that consumption has decreased in the young and increased in the old. However, there is no recent information on the epidemiology of alcoholic cirrhosis. We examined time trends in incidence, prevalence, and hospitalization rates of alcoholic cirrhosis in Denmark between 1988 and 2005. METHODS:We used data from a nationwide population-based hospital registry to identify all Danish citizens with a hospital diagnosis of alcoholic cirrhosis. We computed standardized incidence rates, prevalence and hospitalization rates of alcoholic cirrhosis within the Danish population. We also computed the number of hospitalizations per alcoholic cirrhosis patient per year. RESULTS:From 1988 to 1993, incidence rates for men and women of any age showed no clear trend, and after a 32 percent increase in 1994, rates were stable throughout 2005. In 2001-2005, the incidence rates were 265 and 118 per 1,000,000 per year for men and women, respectively, and the prevalence rates were 1,326 and 701 per 1,000,000. From 1994, incidence, prevalence, and hospitalization rates decreased for men and women younger than 45 years and increased in the older population, although the latter finding might be partly explained by changes in coding practice. Men and women born around 1960 or later had progressively lower age-specific alcoholic cirrhosis incidence rates than the generations before them. From 1996 to 2005, the number of hospitalizations per alcoholic cirrhosis patient per year increased from 1.3 to 1.5 for men and from 1.1 to 1.2 for women. CONCLUSION:From 1988 to 2005, alcoholic cirrhosis put an increasing burden on the Danish healthcare system. However, the decreasing incidence rate in the population younger than 45 years from 1994 indicated that men and women born around 1960 or later had progressively lower incidence rates than the generations before them. Therefore, we expect the overall incidence and prevalence rates of alcoholic cirrhosis to decrease in the future.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Jepsen P,Vilstrup H,Sørensen HTdoi
10.1186/1471-230X-8-3subject
Has Abstractpub_date
2008-02-09 00:00:00pages
3issn
1471-230Xpii
1471-230X-8-3journal_volume
8pub_type
杂志文章abstract:BACKGROUND:Colorectal liver metastases (CLM) occur frequently and postoperative intestinal infection is a common complication. Our previous study showed that probiotics could decrease the rate of infectious complications after colectomy for colorectal cancer. To determine the effects of the perioperative administration...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12876-015-0260-z
更新日期:2015-03-20 00:00:00
abstract:BACKGROUND:Stress is a common contributing factor for irritable bowel syndrome (IBS). This study was to evaluate the efficacy of the centralized health education program in improving the quality of life (QOL) of middle school students with IBS who experienced the Wenchuan earthquake on May 12, 2008. METHODS:A multi-ce...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12876-018-0845-4
更新日期:2018-07-27 00:00:00
abstract:BACKGROUND:Enteric glia cells (EGC) play an important role in the maintenance of intestinal mucosa integrity. During the course of acute Crohn's disease (CD), mucosal EGC progressively undergo apoptosis, though the mechanisms are largely unknown. We investigated the role of Glial-derived neurotrophic factor (GDNF) in t...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-6
更新日期:2012-01-17 00:00:00
abstract:BACKGROUND:Irritable bowel syndrome (IBS) is defined as a multifactorial disorder associated with visceral hypersensitivity, altered gut motility and dysfunction of the brain-gut axis. Gut microbiota and its metabolites are proposed as possible etiological factors of IBS. Short chain fatty acids (SCFAs) induce both inh...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-021-01613-y
更新日期:2021-01-26 00:00:00
abstract:BACKGROUND:Hepatic artery dissection after liver transplantation is an uncommon morbidity. The onset mechanism and management for this disorder remain unclear. The present report describes the cases of two patients with hepatic artery dissection after living-donor liver transplantation (LDLT) with simultaneous splenect...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01528-0
更新日期:2020-11-12 00:00:00
abstract:BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastrointestinal tract. We assessed the relevance of Slug in measuring the invasive potential of ESCC cells in vitro and in vivo in immunodeficient mice. METHODS:We utilized RNA interference to knockdown Slug gene expr...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-60
更新日期:2011-05-20 00:00:00
abstract:BACKGROUND:There is insufficient evidence on the effectiveness of acupuncture for irritable bowel syndrome (IBS) for conclusions to be drawn. Given the current interest in acupuncture by patients, it is in the public interest to establish more rigorous evidence. Building on the positive findings from a pilot study, in ...
journal_title:BMC gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-230X-10-63
更新日期:2010-06-17 00:00:00
abstract:BACKGROUND:A validated histopathological tool to precisely evaluate bowel fibrosis in patients with Crohn's disease is lacking. We attempted to establish a new index to quantify the severity of bowel fibrosis in patients with Crohn's disease-associated fibrostenosis. METHODS:We analyzed the histopathological data of 3...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1100-3
更新日期:2019-11-11 00:00:00
abstract:BACKGROUND:Ulcerative colitis (UC) patients failing medical management require colectomy. This study compares risk estimates for predictors of postoperative complication derived from administrative data against that of chart review and evaluates the accuracy of administrative coding for this population. METHODS:Hospit...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-39
更新日期:2012-04-27 00:00:00
abstract:BACKGROUND:Benign biliary strictures may be a consequence of surgical procedures, chronic pancreatitis or iatrogenic injuries to the ampulla. Stents are increasingly being used for this indication, however it is not completely clear which stent type should be preferred. METHODS:A systematic review on stent placement f...
journal_title:BMC gastroenterology
pub_type: 杂志文章,评审
doi:10.1186/1471-230X-9-96
更新日期:2009-12-17 00:00:00
abstract:BACKGROUND:Gastroparesis (Gp) is a poorly understood chronic gastrointestinal medical condition for which patient reported outcomes (PRO) are lacking. Previously developed symptoms scoring has been used for several decades. Using symptoms scores as a basis for documentation, 12 years of support/focus group patient feed...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-016-0523-3
更新日期:2016-08-31 00:00:00
abstract:BACKGROUND:Increasing evidence elucidating the pathogenic mechanisms of ulcerative colitis (UC) has accumulated and the disease is widely assumed to be the consequence of genetic susceptibility and an abnormal immune response to commensal bacteria. However evidence regarding an infectious etiology in UC remains elusive...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-5-3
更新日期:2005-01-24 00:00:00
abstract:BACKGROUND:The Korean National Cancer Screening Program has been providing annual fecal immunochemical test for colorectal cancer (CRC) to adults aged 50 years and older since 2004. The Korean Colonoscopy Screening Pilot Study was developed to evaluate the effectiveness of colonoscopy screening for CRC incidence and mo...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-021-01610-1
更新日期:2021-01-26 00:00:00
abstract:BACKGROUND:The nuclear protein high-mobility group box 1 (HMGB1) is a key trigger for the inflammatory reaction during liver ischemia reperfusion injury (IRI). Hydrogen treatment was recently associated with down-regulation of the expression of HMGB1 and pro-inflammatory cytokines during sepsis and myocardial IRI, but ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-12
更新日期:2014-01-12 00:00:00
abstract:BACKGROUND:The emergence of multidrug-resistant (MDR) Escherichia coli (E. coli), particularly E. coli sequence type ST131, is becoming a global concern. Commensal bacteria, an important reservoir of antibiotic resistance genes, facilitate the spread of such genes to pathogenic bacterial strains. The objective of the s...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0807-x
更新日期:2018-06-15 00:00:00
abstract:BACKGROUND:Children with cyclic vomiting syndrome (CVS) have a high degree of maternal inheritance of functional gastrointestinal and neurological disorders. CVS in children is also associated with an increased prevalence of mitochondrial DNA single-nucleotide polymorphisms (mtDNA SNPs) 16519 T and 3010A. Preliminary d...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-181
更新日期:2014-10-21 00:00:00
abstract:BACKGROUND:The occurrence of non-alcoholic fatty liver disease (NAFLD) is found to be higher in patients with obstructive sleep apnea (OSA), which is characterized by intermittent hypoxia. Activation of hypoxia-inducible factors has been shown in the development and progression of NAFLD, implying a cause and effects re...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01515-5
更新日期:2020-11-03 00:00:00
abstract:BACKGROUND:The value of abdominal echography in primary care is great because it is innocuous, inexpensive, easy to perform and provides a great deal of information making this the first examination to be requested in cases of probable abdominal disease. However, too many abdominal echographies are probably requested o...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-230X-10-101
更新日期:2010-09-06 00:00:00
abstract:BACKGROUND:Tuberous Sclerosis Complex (TSC) is a complex and heterogeneous genetic disease that has well-established clinical diagnostic criteria. These criteria do not include gastrointestinal tumors. CASE PRESENTATION:We report a 45-year-old patient with a clinical and molecular diagnosis of TSC and a family history...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01481-y
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:Wireless capsule pH-metry (WC) is better tolerated than standard nasal pH catheter (SC), but endoscopic placement is expensive. AIMS:to confirm that non-endoscopic peroral manometric placement of WC is as effective and better tolerated than SC and to perform a cost analysis of the available esophageal pH-me...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-230X-12-58
更新日期:2012-05-31 00:00:00
abstract:BACKGROUND:Recent studies have shown that bile acids (BAs) are closely related to metabolic and inflammatory diseases. Our study aimed to investigate whether circulating total bile acid (TBA) levels were associated with the severity of acute pancreatitis (AP). METHODS:We retrospectively collected data on patients diag...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01243-w
更新日期:2020-07-13 00:00:00
abstract:BACKGROUND:Biliary atresia (BA) is a progressive inflammatory disorder of the extrahepatic bile ducts leading to the obliteration of bile flow. The purpose of this study was to determine serum adiponectin in BA patients and to investigate the relationship of adiponectin with clinical parameters and liver stiffness scor...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-16
更新日期:2011-02-28 00:00:00
abstract:BACKGROUND:Currently there is no disease-specific outcome measure to assess the health-related quality of life (HRQOL) of pediatric patients with Eosinophilic Esophagitis (EoE). Therefore, the objective of this qualitative study was to further develop and finalize the items and support the content validity for the new ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-135
更新日期:2012-09-25 00:00:00
abstract:BACKGROUND:Capsule endoscopy (CE) is the preferred diagnostic test of choice in the investigation of obscure gastrointestinal bleeding (OGIB). Although, a conservative strategy is recommended in the short-term, for cases with a negative result from CE, the impact of CE on long-term re-bleeding still remains unclear. He...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1137-3
更新日期:2019-12-16 00:00:00
abstract:BACKGROUND:Endoscopic balloon dilation and/or plastic stent placement has been a standard method for treating biliary strictures complicated post living donor liver transplantation (LDLT). The strictures may be refractory to endoscopic treatment and require long-term stent placement. However, consensus on the optimal p...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01226-x
更新日期:2020-04-06 00:00:00
abstract:BACKGROUND:Dysphagia and feeding intolerance are common in neurologically handicapped children. The aim is to determine the etiologies of feeding intolerance in neurologically handicapped children who are intolerant of tube feedings. METHODS:Eighteen neurologically handicapped children, followed in the Tube Feeding Cl...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-4-19
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Glycoprotein 2 (GP2) was discovered as the major autoantigen of Crohn's disease (CD)-specific pancreatic autoantibodies (PAB). We investigated anti-GP2 IgA and IgG antibodies as novel serological parameters in CD and assessed their association with distinct disease phenotypes. METHODS:Anti-GP2 and anti-Sacc...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-102
更新日期:2012-08-06 00:00:00
abstract:BACKGROUND:Apoptosis inhibitor of macrophage (AIM) and adipocytokines are involved in the metabolic syndrome, which has been putatively associated with the progression of chronic hepatitis C (CHC). However, the association between these cytokines and CHC is not fully elucidated. The aim of this study is to test whether...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-27
更新日期:2014-02-13 00:00:00
abstract:BACKGROUND:A tenth of patients with involuntary weight loss (IWL) have gastrointestinal cancer. Ferritin is the first parameter to be modified during the process leading to iron deficiency anaemia, therefore it should be the most sensitive. The aim of this study was to assess the ability of ferritin to rule out gastroi...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-86
更新日期:2012-07-09 00:00:00
abstract:BACKGROUND:Bicyclol, the most commonly-used liver hepatoprotective drug in China, is often selected to control disease progression in CHB patients who refuse anti-viral treatment. However, data on histological changes after bicyclol treatment in these patients are scarce. Therefore, this study has been conducted to fin...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1005-1
更新日期:2019-06-13 00:00:00