Metabonomic analysis of liver tissue from BALB/c mice with D-galactosamine/lipopolysaccharide-induced acute hepatic failure.

Abstract:

BACKGROUND:Compared with biofluids, target tissues and organs more directly reflect the pathophysiological state of a disease process. In this study, a D-galactosamine (GalN) / lipopolysaccharide (LPS)-induced mouse model was constructed to investigate metabonomics of liver tissue and directly characterize metabolic changes in acute liver failure (ALF). METHODS:After pretreatment of liver tissue, gas chromatography coupled to time-of-flight mass spectrometry (GC/TOFMS) was used to separate and identify the liver metabolites. Partial least squares--discriminant analysis models were constructed to separate the ALF and control groups and to find those compounds whose liver levels differed significantly between the two groups. RESULTS:Distinct clustering was observed between the ALF and control mice. Fifty-eight endogenous metabolites were identified. Compared with the control mice, many metabolites, including sugars, amino acids, fatty acids, and organic acids, underwent significant changes in the ALF group, some of which differed from changes observed in plasma. Significant reduction of some important intermediate metabolites indicates that production of ketone bodies, the tricarboxylic acid and urea cycles, gluconeogenesis, glycolysis and pentose phosphate pathways are inhibited after GalN/LPS administration. CONCLUSIONS:GC/TOFMS can be a powerful technique to perform metabonomic studies of liver tissue. GalN/LPS treatment can severely disturb substance metabolism in the liver, with different effects on metabolites compared with those observed in the plasma.

journal_name

BMC Gastroenterol

journal_title

BMC gastroenterology

authors

Feng B,Wu S,Liu F,Gao Y,Dong F,Wei L

doi

10.1186/1471-230X-13-73

subject

Has Abstract

pub_date

2013-04-29 00:00:00

pages

73

issn

1471-230X

pii

1471-230X-13-73

journal_volume

13

pub_type

杂志文章
  • Lymphatic marker podoplanin/D2-40 in human advanced cirrhotic liver--re-evaluations of microlymphatic abnormalities.

    abstract:BACKGROUND:From the morphological appearance, it was impossible to distinguish terminal portal venules from small lymphatic vessels in the portal tract even using histochemical microscopic techniques. Recently, D2-40 was found to be expressed at a high level in lymphatic endothelial cells (LECs). This study was underta...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-230X-10-131

    authors: Yokomori H,Oda M,Kaneko F,Kawachi S,Tanabe M,Yoshimura K,Kitagawa Y,Hibi T

    更新日期:2010-11-08 00:00:00

  • Histological improvement in chronic hepatitis B patients treated with bicyclol: real world experience.

    abstract:BACKGROUND:Bicyclol, the most commonly-used liver hepatoprotective drug in China, is often selected to control disease progression in CHB patients who refuse anti-viral treatment. However, data on histological changes after bicyclol treatment in these patients are scarce. Therefore, this study has been conducted to fin...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-019-1005-1

    authors: Chi X,Xiao H,Shi M,Cai G,Xie Y,Jiang J,Tian G,Wu S,Zhang C,Zhao P,Chen J

    更新日期:2019-06-13 00:00:00

  • Mesenchymal stem cell transplantation improves chronic colitis-associated complications through inhibiting the activity of toll-like receptor-4 in mice.

    abstract:BACKGROUND:A variety of extra-intestinal manifestations (EIMs), including hepatobiliary complications, are associated with inflammatory bowel disease (IBD). Mesenchymal stem cells (MSCs) have been shown to play a potential role in the therapy of IBD. This study was designed to investigate the effect and mechanism of MS...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0850-7

    authors: Niu GC,Liu L,Zheng L,Zhang H,Shih DQ,Zhang X

    更新日期:2018-08-13 00:00:00

  • Alcoholic cirrhosis in Denmark - population-based incidence, prevalence, and hospitalization rates between 1988 and 2005: a descriptive cohort study.

    abstract:BACKGROUND:Denmark has one of the highest alcohol consumption rates in Northern Europe. The overall per capita alcohol consumption has been stable in recent decades, but surveys have indicated that consumption has decreased in the young and increased in the old. However, there is no recent information on the epidemiolo...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-8-3

    authors: Jepsen P,Vilstrup H,Sørensen HT

    更新日期:2008-02-09 00:00:00

  • Adenosine preconditioning attenuates hepatic reperfusion injury in the rat by preventing the down-regulation of endothelial nitric oxide synthase.

    abstract:BACKGROUND:Previous work has suggested that in the liver, adenosine preconditioning is mediated by nitric oxide. Whether the endothelial isoform of nitric oxide synthase plays a part in this mechanism has however not yet been investigated. METHODS:Wistar rats were used (6 in each group)--Groups: (1) sham, (2) ischemia...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230x-2-22

    authors: Serracino-Inglott F,Virlos IT,Habib NA,Williamson RC,Mathie RT

    更新日期:2002-09-20 00:00:00

  • Is discard better than return gastric residual aspirates: a systematic review and meta-analysis.

    abstract:BACKGROUND:The assessment of residual gastric volume is common practice in critical care units. However, the effects and safety of discarding or returning gastric aspirates remain uncertain. Therefore, we aimed to evaluate the role of discarding or returning gastric aspirates on the gastric residual volumes in critical...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12876-019-1028-7

    authors: Wen Z,Xie A,Peng M,Bian L,Wei L,Li M

    更新日期:2019-06-28 00:00:00

  • Unusual manifestation of Erdheim-Chester disease.

    abstract:BACKGROUND:Erdheim-Chester disease (ECD) is a rare multisystem non-Langerhans cell histiocytosis that is characterized histologically by xanthogranulomatous infiltrates and radiologically by symmetrical sclerosis of long bones. The xanthomatous process is characterized by prominent foamy histiocytes staining positive f...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-11-77

    authors: Pan A,Doyle T,Schlup M,Lubcke R,Schultz M

    更新日期:2011-06-22 00:00:00

  • "Fast track" rehabilitation after gastric cancer resection: experience with 80 consecutive cases.

    abstract:BACKGROUND:To evaluate the safety, efficacy and outcomes of fast-track rehabilitation applied to gastric cancer proximal, distal and total gastrectomy. METHODS:Eighty consecutive patients undergoing gastric cancer resection performed by a single surgeon, received perioperative multimodal rehabilitation. Demographic an...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-14-147

    authors: Song JX,Tu XH,Wang B,Lin C,Zhang ZZ,Lin LY,Wang L

    更新日期:2014-08-18 00:00:00

  • Endoscopic ultrasound criteria to predict the need for intervention in pancreatic necrosis.

    abstract:BACKGROUND:The natural course and treatment strategies for asymptomatic or oligosymptomatic pancreatic necrosis are still poorly defined. The aim of this retrospective study was to establish criteria for the need of intervention in patients with pancreatic necrosis. METHODS:A total of 31 consecutive patients (18 male,...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-48

    authors: Jürgensen C,Arlt A,Neser F,Fritscher-Ravens A,Stölzel U,Hampe J

    更新日期:2012-05-14 00:00:00

  • Acute cholestasis as uncommon onset of Kawasaki disease: a case report.

    abstract:BACKGROUND:Kawasaki disease (KD) or mucocutaneous lymph node syndrome is a vasculitis that mostly occurs in young children. Adult-onset KD (AKD) is rare and often misdiagnosed. Here we report a rare case of KD with cholestasis as principal symptom. CASE PRESENTATION:A 43-year-old caucasian man was admitted to our hosp...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01495-6

    authors: Gallerani M,Pala M,Fabbian F,De Giorgi A

    更新日期:2020-10-28 00:00:00

  • A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data.

    abstract:BACKGROUND:Intussusception (IS) is a form of acute intestinal obstruction that occurs mainly in infants and is usually of unknown cause. An association between IS and the first licensed rotavirus vaccine, a reassortant-tetravalent, rhesus-based rotavirus vaccine (RRV-TV), led to the withdrawal of the vaccine. New rotav...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-13-95

    authors: Sáez-Llorens X,Velázquez FR,Lopez P,Espinoza F,Linhares AC,Abate H,Nuñez E,Venegas G,Vergara R,Jimenez AL,Rivera M,Aranza C,Richardson V,Macias-Parra M,Palacios GR,Rivera L,Ortega-Barria E,Cervantes Y,Rüttimann R,Ru

    更新日期:2013-05-27 00:00:00

  • HPV positive, wild type TP53, and p16 overexpression correlate with the absence of residual tumors after chemoradiotherapy in anal squamous cell carcinoma.

    abstract:BACKGROUND:Anal residual tumors are consensually identified within six months of chemoradiotherapy and represent a persistent lesion that may have prognostic value for overall survival. The aim of this study was to evaluate the association of HPV and HIV status, p16 expression level and TP53 mutations with the absence ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0758-2

    authors: Soares PC,Abdelhay ES,Thuler LCS,Soares BM,Demachki S,Ferro GVR,Assumpção PP,Lamarão LM,Ribeiro Pinto LF,Burbano RMR

    更新日期:2018-02-21 00:00:00

  • GERD assessment including pH metry predicts a high response rate to PPI standard therapy.

    abstract:BACKGROUND:Inadequate response to proton pump inhibitor (PPI) therapy in patients with gastroesophageal reflux disease (GERD) is reported in up to 40%. Patients with non erosive reflux disease (NERD) have lower response rates compared to patients with erosive reflux disease (ERD); pH metry contributes to GERD diagnosis...

    journal_title:BMC gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-230X-13-12

    authors: Kandulski A,Peitz U,Mönkemüller K,Neumann H,Weigt J,Malfertheiner P

    更新日期:2013-01-16 00:00:00

  • Pancreatic hamartoma: a case report and literature review.

    abstract:BACKGROUND:Pancreatic hamartoma is an extremely rare benign disease of the pancreas. Only 30 cases have been reported to date. CASE PRESENTATION:A 68-year-old man presented with an asymptomatic solid and multi-cystic lesion in the uncus of the pancreas, incidentally detected on abdominal enhanced computed tomography. ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1186/s12876-016-0419-2

    authors: Matsushita D,Kurahara H,Mataki Y,Maemura K,Higashi M,Iino S,Sakoda M,Shinchi H,Ueno S,Natsugoe S

    更新日期:2016-01-14 00:00:00

  • The addition of a pH-sensitive gel improves microemulsion stability for the targeted removal of colonic ammonia.

    abstract:BACKGROUND:We prepared an oral W/O microemulsion for the removal of colonic ammonia (ME-RCA). The effect of this microemulsion was influenced by the digestion process in the gastrointestinal tract. In this paper, we aim to show that stability was improved by using a microemulsion-based gel for the removal of colonic am...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-11-50

    authors: Wang AH,Duan ZJ,Tian G,Lu D,Zhang WJ,He GH,Fang GH

    更新日期:2011-05-10 00:00:00

  • Endoscopic stent placement above the sphincter of Oddi for biliary strictures after living donor liver transplantation.

    abstract:BACKGROUND:Endoscopic balloon dilation and/or plastic stent placement has been a standard method for treating biliary strictures complicated post living donor liver transplantation (LDLT). The strictures may be refractory to endoscopic treatment and require long-term stent placement. However, consensus on the optimal p...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01226-x

    authors: Koizumi M,Kumagi T,Kuroda T,Imamura Y,Kanemitsu K,Ogawa K,Takada Y,Hiasa Y

    更新日期:2020-04-06 00:00:00

  • Reactive lymphoid hyperplasia of the liver in a patient with colon cancer: report of two cases.

    abstract:BACKGROUND:Reactive lymphoid hyperplasia (RLH) of the liver is very rarely reported, and we encountered two cases of RLH of the liver in a patient with colon cancer. CASE PRESENTATION:In the first case, a 77-year-old woman was admitted for the surgical removal of a ascending colon cancer. A hepatic tumor in the left l...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-6-25

    authors: Takahashi H,Sawai H,Matsuo Y,Funahashi H,Satoh M,Okada Y,Inagaki H,Takeyama H,Manabe T

    更新日期:2006-09-12 00:00:00

  • Validation of the BARD scoring system in Polish patients with nonalcoholic fatty liver disease (NAFLD).

    abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of liver diseases, ranging from pure steatosis to nonalcoholic steatohepatitis (NASH), and eventually to liver cirrhosis with its complications. Identifying advanced fibrosis in patients is crucial to evaluating prognosis and possible therapeu...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-10-67

    authors: Raszeja-Wyszomirska J,Szymanik B,Ławniczak M,Kajor M,Chwist A,Milkiewicz P,Hartleb M

    更新日期:2010-06-28 00:00:00

  • Ultrasonic assessment of liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis.

    abstract:BACKGROUND:This study investigated the relationship between liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis. We used an acoustic radiation force impulse (ARFI) technique to measure stiffness, and a radio frequency (RF) vascular quantitative ultrasound technique to measure changes ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0910-z

    authors: Li JH,Zhu N,Min YB,Shi XZ,Duan YY,Yang YL

    更新日期:2018-12-05 00:00:00

  • Factors associated with consultation behaviour for primary symptoms potentially indicating colorectal cancer: a cross-sectional study on response to symptoms.

    abstract:BACKGROUND:Little data exists on the factors associated with health care seeking behaviour for primary symptoms of colorectal cancer (CRC). This study aimed to identify individual, provider and psychosocial factors associated with (i) ever seeking medical advice and (ii) seeking early medical advice for primary symptom...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-100

    authors: Courtney RJ,Paul CL,Sanson-Fisher RW,Macrae FA,Attia J,McEvoy M

    更新日期:2012-08-03 00:00:00

  • Clinical and molecular characterization of a patient with mitochondrial Neurogastrointestinal Encephalomyopathy.

    abstract:BACKGROUND:Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disorder caused by mutations in TYMP gene, encoding nuclear thymidine phosphorylase (TP). MNGIE mainly presents with gastrointestinal symptoms and is mostly misdiagnosed in many patients as malabsorption syndrome, inf...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01280-5

    authors: Habibzadeh P,Silawi M,Dastsooz H,Bahramjahan S,Ezzatzadegan Jahromi S,Ostovan VR,Yavarian M,Mofatteh M,Faghihi MA

    更新日期:2020-05-08 00:00:00

  • A retrospective case-control study of hepatitis C virus infection and oral lichen planus in Japan: association study with mutations in the core and NS5A region of hepatitis C virus.

    abstract:BACKGROUND:The aims of this study were to assess the prevalence of hepatitis C virus (HCV) infection in Japanese patients with oral lichen planus and identify the impact of amino acid (aa) substitutions in the HCV core region and IFN-sensitivity-determining region (ISDR) of nonstructural protein 5A (NS5A) associated wi...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-31

    authors: Nagao Y,Sata M

    更新日期:2012-04-10 00:00:00

  • Chronic active EBV infection in refractory enteritis with longitudinal ulcers with a cobblestone appearance: an autopsied case report.

    abstract:BACKGROUND:Chronic active Epstein-Barr virus infection (CAEBV) is defined as Epstein-Barr virus (EBV)-positive T/NK cell-related neoplasia, and its major clinical symptom is systemic inflammation presenting as infectious mononucleocytosis, whereas enteritis and diarrhea are minor clinical symptoms. The complex mixture ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01589-1

    authors: Aihara Y,Moriya K,Shimozato N,Nagamatsu S,Kobayashi S,Uejima M,Matsuo H,Ishida E,Yagi H,Nakatani T,Yoshiji H,Kikuchi E

    更新日期:2021-01-06 00:00:00

  • Gastric bacterial Flora in patients Harbouring Helicobacter pylori with or without chronic dyspepsia: analysis with matrix-assisted laser desorption ionization time-of-flight mass spectroscopy.

    abstract:BACKGROUND:The gastric microbiota has recently been implicated in the causation of organic/structural gastroduodenal diseases (gastric and duodenal ulcers, gastric cancer) in patients with Helicobacter pylori (H. pylori) infection. We aimed to ascertain, in patients harbouring H. pylori, the role of the gastric microbi...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0744-8

    authors: Pereira V,Abraham P,Nallapeta S,Shetty A

    更新日期:2018-01-26 00:00:00

  • Folate levels in hepatocellular carcinoma patients with portal vein thrombosis.

    abstract:BACKGROUND:Portal vein thrombosis (PVT) occurs frequently in hepatocellular carcinoma (HCC) and is often diagnosed in the course of a routine patient evaluation and surveillance for liver cancer. The purpose of this study is to investigate the relationship between folate status and portal vein thrombosis. METHODS:HCC ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01525-3

    authors: Malaguarnera G,Catania VE,Latteri S,Borzì AM,Bertino G,Madeddu R,Drago F,Malaguarnera M

    更新日期:2020-11-10 00:00:00

  • Gastric tuberculosis mimicking submucosal tumor: a case series.

    abstract:BACKGROUND:Gastric tuberculosis mimicking submucosal tumors is extremely rare and often misdiagnosed. CASE PRESENTATION:Three cases of gastric tuberculosis mimicking submucosal tumors were identified among patients admitted to local county hospitals because of upper abdominal discomfort and pain, with gastroscopy show...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-1175-x

    authors: Zhu R,Zhou Y,Wang H,Di L,Zhao K,Tuo B,Wu H

    更新日期:2020-01-30 00:00:00

  • Comparison of oesophageal function tests between Chinese non-erosive reflux disease and reflux hypersensitivity patients.

    abstract:BACKGROUND:By means of 24 h multi-channel intraluminal impedance and pH recording (MII/pH), patients with heartburn and normal upper gastrointestinal endoscopy findings can be classified into those with non-erosive reflux disease (NERD) and those with reflux hypersensitivity (RH). Therefore, in this study, we investiga...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-017-0624-7

    authors: Gao F,Gao Y,Chen X,Qian J,Zhang J

    更新日期:2017-05-23 00:00:00

  • Metabolic syndrome and biochemical changes among non-alcoholic fatty liver disease patients attending a tertiary care hospital of Nepal.

    abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is mutually and bidirectionally linked with metabolic syndrome (MetS) of which it is both the cause and the consequences. Worldwide, 6.3 to 33% of the general populations are estimated to suffer from the disease with even higher prevalence in the group sharing metabo...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0843-6

    authors: Pardhe BD,Shakya S,Bhetwal A,Mathias J,Khanal PR,Pandit R,Shakya J,Joshi HO,Marahatta SB

    更新日期:2018-07-06 00:00:00

  • Absence of Helicobacter pylori high tetracycline resistant 16S rDNA AGA926-928TTC genotype in gastric biopsy specimens from dyspeptic patients of a city in the interior of São Paulo, Brazil.

    abstract:BACKGROUND:Treatment effectiveness of Helicobacter pylori varies regionally and is decreasing worldwide, principally as a result of antibiotic resistant bacterium. Tetracycline is generally included in second line H. pylori eradication regimens. In Brazil, a high level of tetracycline resistance (TetR) is mainly associ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-49

    authors: Suzuki RB,Almeida CM,Sperança MA

    更新日期:2012-05-17 00:00:00

  • Clinical predictors of incident gallstone disease in a Chinese population in Taipei, Taiwan.

    abstract:BACKGROUND:Gallstone disease (GSD) is a common gastrointestinal disorder throughout the world. The authors explored the incidence of GSD in Taiwan and its condition-associated predictive factors. METHODS:The initial study cohort comprised 2386 healthy adult participants, who were voluntarily admitted to a teaching hos...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-14-83

    authors: Chen JY,Hsu CT,Liu JH,Tung TH

    更新日期:2014-04-28 00:00:00