Abstract:
BACKGROUND:The evolution of technology in healthcare has increased the health care's costs and, the universal healthcare systems, in developed countries, need to ensure proper allocation of resources. Thus, the major issue is assessing the effectiveness of new medical technologies. The evaluation of quality of life in response to new treatments has become a key indicator in chronic conditions for which medical interventions are evaluated not only in terms of increasing the number of expected life years but also in terms of increasing quality of life. The aim of this observational study was to verify whether a simple instrument (EQ-5D-5 L) can capture variations in health-related quality of life (HRQoL) and allow us to evaluate the impact of different drug treatment protocols in patients with hepatitis C virus (HCV) on daily activities. METHODS:Sixty six patients with HCV were consecutively enrolled in the Hepatology Unit at the University Hospital of Catania "G. Rodolico". Sixteen patients received new direct-acting-antiviral agents (DAAs) plus pegylated alpha interferon (Peg-α-IFN) protocol (Group A) and 50 DAAs IFN free protocol (Group B). The EQ-5D-5 L® questionnaire and visual analog scale (VAS) were given to both groups to calculate coefficient's utility. We used the EQ-5D-5 L Crosswalk Index Value Calculator to obtain the utility EQIndex and both parametric and non parametric tests for the statistical analysis. RESULTS:The biopsy taken at the beginning of treatment showed comparable cell damage in both groups. The difference in the VAS results was negative for patients who received protocols containing IFN (indicating decreased quality of life),whereas it was positive in patients treated with IFN-free protocols. The baseline EQIndex did not reveal any differences between the two treatment groups. The post-treatment EQIndex was statistically better in the groups that received IFN-free therapy. CONCLUSIONS:When innovative treatments are introduced into clinical practice, assessing quality of life is mandatory to determine their benefits. The instruments used in the present study are effective in detecting the areas in which improvement has occurred. These instruments can be easily managed by general practitioners for follow up of progression of the disease and referred to the specialist.
journal_name
Health Qual Life Outcomesjournal_title
Health and quality of life outcomesauthors
Ragusa R,Bertino G,Bruno A,Frazzetto E,Cicciu F,Giorgianni G,Lupo Ldoi
10.1186/s12955-018-0842-xsubject
Has Abstractpub_date
2018-01-17 00:00:00pages
17issue
1issn
1477-7525pii
10.1186/s12955-018-0842-xjournal_volume
16pub_type
杂志文章abstract:BACKGROUND:To assess QOL of patients with stroke in comparison to other groups (caregivers and CHF patients), to identify which items of QOL are more affected on each group and what is the functional profile of patients with stroke. METHODS:Consecutive stroke or congestive heart failure (CHF) patients were evaluated a...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-9-65
更新日期:2011-08-10 00:00:00
abstract:BACKGROUND:Cold climates traditionally have conferred long sleep duration in the residents in northeast China; however, modern lifestyle reduces sleep duration. In this study, we investigated social-biological factors influencing sleep duration in the adult residents in northeast China. METHODS:This study was performe...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-019-1111-3
更新日期:2019-03-15 00:00:00
abstract:BACKGROUND:To date, reliable and comprehensive health-related quality of life data for patients with relapsed or refractory B-precursor acute lymphoblastic leukemia (ALL) have not been collected in clinical trials of the disease, and no utility studies have been published. The purpose of this study was to define and va...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-015-0377-3
更新日期:2015-11-16 00:00:00
abstract:BACKGROUND:The Hip disability and Osteoarthritis Outcome Score (HOOS) is a frequently used patient-reported outcome measure (PROM) for assessment of hip disorders and treatment effects following hip surgery. The objective of the study was to translate and adapt the Hip disability and Osteoarthritis Outcome Score (HOOS)...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-020-01390-4
更新日期:2020-05-12 00:00:00
abstract:BACKGROUND:Amblyopia is a visual condition that occurs in childhood. Screening programmes exist within the United Kingdom (UK) to detect amblyopia, and once detected treatment is given.Existing patient reported outcome (PRO) measures for amblyopia do not meet current recommendations for the methods adopted during their...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-11-174
更新日期:2013-10-22 00:00:00
abstract:BACKGROUND:The majority of individuals with dementia live in the community; thus, regional dementia care networks are becoming increasingly more important for the provision of care. To date, four different types of dementia care networks have been identified in Germany (stakeholder, organisation, hybrid, mission); howe...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章,多中心研究
doi:10.1186/s12955-018-0990-z
更新日期:2018-09-14 00:00:00
abstract:BACKGROUND:The last decade has evidenced a dramatic increase in the development and utilization of pediatric health-related quality of life (HRQOL) measures in an effort to improve pediatric patient health and well-being and determine the value of healthcare services. The emerging paradigm shift toward patient-reported...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-5-1
更新日期:2007-01-03 00:00:00
abstract:BACKGROUND:To establish the validity and reliability of the Short Warwick Edinburgh Mental Well-being Scale (SWEMWBS) in service users with schizophrenia, depression and anxiety spectrum disorders in Singapore and estimate SWEMWBS scores across socio-demographic and the three psychiatric diagnostic groups in the sample...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-017-0728-3
更新日期:2017-08-01 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-018-1077-6
更新日期:2019-01-22 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-10-127
更新日期:2012-10-18 00:00:00
abstract:BACKGROUND:Poststroke fatigue is a persistent and distressing symptom among stroke survivors. In this study, we investigated the reliability and validity of a vertical numerical rating scale supplemented with a faces rating scale (NRS-FRS) in measuring poststroke fatigue. METHODS:The fatigue intensity of 106 individua...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-015-0290-9
更新日期:2015-06-30 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-12-27
更新日期:2014-02-28 00:00:00
abstract:BACKGROUND:While there are many published studies on HIV and functional limitations, there are few in the context of early abuse and its impact on functionality and Quality of Life (QoL) in HIV. METHODS:The present study focused on HIV in the context of childhood trauma and its impact on functionality and Quality of L...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-9-84
更新日期:2011-09-30 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-015-0292-7
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) patients are confronted with reduced daily activities (DA) and reduced health-related quality of life (HRQoL) caused by dyspnea and systemic effects such as skeletal muscle dysfunction and co-morbidities. To understand the complexity of living with COPD, it is imp...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-11-190
更新日期:2013-11-05 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-6-15
更新日期:2008-02-15 00:00:00
abstract:BACKGROUND:Post-traumatic stress disorder (PTSD) occurs in 1-7% of women following childbirth. While having a caesarean section (C-section) is known to be a significant risk factor for postpartum PTSD, it is currently unknown whether coexisting anaesthesia-related factors are also associated to the disorder. The aim of...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-017-0692-y
更新日期:2017-06-02 00:00:00
abstract:BACKGROUND:We investigated the relationship between Body Mass Index (BMI) and health-related quality of life (HRQOL) indicated by baseline health status in elementary school children. METHODS:Data were obtained via parents whose children enrolled in an elementary school, kindergarten to fourth grade, in southern Missi...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-6-77
更新日期:2008-10-09 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章,随机对照试验
doi:10.1186/1477-7525-9-77
更新日期:2011-09-22 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-2-16
更新日期:2004-03-23 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-10-58
更新日期:2012-05-31 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-017-0707-8
更新日期:2017-07-04 00:00:00
abstract:BACKGROUND:A Task Force from the International Society of Pharmacoeconomics and Outcomes Research (ISPOR) provides recommendations on how to systematically identify and appraise health state utility (HSU) weights for cost-effectiveness analyses. We applied these recommendations to conduct a systematic review (SR) to id...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-020-01559-x
更新日期:2020-09-21 00:00:00
abstract:BACKGROUND:Many studies have demonstrated that health related quality of life (HRQoL) improves, on average, after coronary artery bypass graft surgery (CABGS). However, this average improvement may not be realized for all patients, and it is possible that there are two or more distinctive groups with different, possibl...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-4-49
更新日期:2006-08-13 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-6-36
更新日期:2008-05-27 00:00:00
abstract:PURPOSE:To develop an algorithm for mapping the Functional Assessment of Cancer Therapy-Breast (FACT-B) to the 5-level EuroQoL Group's 5-dimension questionnaire (EQ-5D-5L) utility index. METHODS:A survey of 238 breast cancer patients in Singapore was conducted. Models using various regression methods with or without r...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-014-0180-6
更新日期:2014-12-12 00:00:00
abstract:BACKGROUND:To investigate the impact of the gap between subjective and objective social status on health-related quality of life. METHODS:We analyzed data from 12,350 participants aged ≥ 18 years in the Korean Health Panel Survey. Health-related quality of life was measured by EuroQol-Visual analogue scale. Objective ...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-015-0319-0
更新日期:2015-08-08 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章,多中心研究
doi:10.1186/s12955-020-01542-6
更新日期:2020-09-04 00:00:00
abstract:BACKGROUND:Participating in regular physical activity contributes to significant improvements of quality of life (QOL) in adults. Understanding psychosocial factors that influence physical activity and QOL in working adults may have important implications for future interventions aimed at improving their health. The ma...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-019-1145-6
更新日期:2019-04-25 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-015-0304-7
更新日期:2015-08-22 00:00:00