Abstract:
BACKGROUND:Vascular dementia (VaD) is the second most common form of dementia. However, there were mixed evidences about the association between blood pressure (BP) and risk of VaD in midlife and late life and limited evidence on the association between pulse pressure and VaD. METHODS:This is a population-based observational study. 265,897 individuals with at least one BP measurement between the ages of 60 to 65 years and 211,116 individuals with at least one BP measurement between the ages of 70 to 75 years were extracted from The Health Improvement Network in United Kingdom. Blood pressures were categorized into four groups: normal, prehypertension, stage 1 hypertension, and stage 2 hypertension. Cases of VaD were identified from the recorded clinical diagnoses. Multivariable survival analysis was used to adjust other confounders and competing risk of death. All the analysis were stratified based on antihypertensive drug use status. Multiple imputation was used to fill in missing values. RESULTS:After accounting for the competing risk of death and adjustment for potential confounders, there was an association between higher BP levels in the age 60-65 cohort with the risk of developing VaD (hazard ratio [HR] 1.53 (95% confidence interval: 1.04, 2.25) for prehypertension, 1.90 (1.30, 2.78) for stage 1 hypertension, and 2.19 (1.48, 3.26) for stage 2 hypertension) in the untreated group. There was no statistically significant association between BP levels and VaD in the treated group in the age 60-65 cohort and age 70-75 cohort. Analysis on Pulse Pressure (PP) stratified by blood pressure level showed that PP was not independently associated with VaD. CONCLUSION:High BP between the ages of 60 to 65 years is a significant risk for VaD in late midlife. Greater efforts should be placed on early diagnosis of hypertension and tight control of BP for hypertensive patients for the prevention of VaD.
journal_name
BMC Geriatrjournal_title
BMC geriatricsauthors
Peng M,Chen G,Tang KL,Quan H,Smith EE,Faris P,Hachinski V,Campbell NRCdoi
10.1186/s12877-017-0649-3subject
Has Abstractpub_date
2017-10-27 00:00:00pages
252issue
1issn
1471-2318pii
10.1186/s12877-017-0649-3journal_volume
17pub_type
杂志文章相关文献
BMC Geriatrics文献大全abstract:BACKGROUND:Despite their strong increase, the population of the very old, including near-centenarians and centenarians, represent an unstudied and underserved population. Available studies mostly concentrate on predictors of exceptional longevity, but rarely extend their focus to other areas of functioning. Also, littl...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-015-0167-0
更新日期:2016-01-05 00:00:00
abstract:BACKGROUND:Venous thromboembolic events (VTE), including deep venous thrombosis and pulmonary embolism, are common in older age. It has been suggested that statins might reduce the risk of VTE however positive results from studies of middle aged subjects may not be generalisable to elderly people. We aimed to determine...
journal_title:BMC geriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2318-11-8
更新日期:2011-02-22 00:00:00
abstract:BACKGROUND:Sarcopenia often accompanies osteoarthritis (OA), which is managed by total knee arthroplasty (TKA) in the late stage. Recent studies have suggested a higher risk of post-operative complications after TKA in sarcopenic OA subjects, but whether TKA can benefit them similar to non-sarcopenic subjects remains u...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-020-01929-6
更新日期:2021-01-04 00:00:00
abstract:BACKGROUND:Research has shown that engaging in leisure-time physical activity (LTPA) and consuming dairy foods can lead to better sleep. Combining these two non-invasive prescriptions may be more effective for helping people fall asleep. This study investigates whether participating in LTPA in conjunction with consumin...
journal_title:BMC geriatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2318-14-118
更新日期:2014-11-18 00:00:00
abstract:BACKGROUND:The incidence of community-acquired pneumonia (CAP) almost triples for older adults aged 65 years or older. In Canada, CAP is a leading cause of hospital admissions and mortality. Although CAP is very prevalent, complications due to CAP may be reduced with the pneumococcal polysaccharide vaccine (PPV). The p...
journal_title:BMC geriatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2318-10-44
更新日期:2010-06-30 00:00:00
abstract:BACKGROUND:China and India are the world's two most populous countries. Although their populations are growing in number and life expectancies are extending they have different trajectories of economic growth, epidemiological transition and social change. Cross-country comparisons can allow national and global insights...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-017-0589-y
更新日期:2017-08-31 00:00:00
abstract:BACKGROUND:Caring for a family member with dementia is extremely stressful, and contributes to psychiatric and physical illness among caregivers. Therefore, a comprehensive programme called Resources for Enhancing Alzheimer's Caregiver Health II (REACH II) was developed in the United States to enhance the health of Alz...
journal_title:BMC geriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2318-14-21
更新日期:2014-02-12 00:00:00
abstract:BACKGROUND:Delayed diagnosis of bloodstream infection (BSI) occurs in > 20% of older patients, with misdiagnosis in 35%. Our objective was to develop and validate a clinically useful screening tool to identify older patients with a high probability of having a BSI. METHODS:Hospitalized patients > 80 years old with BSI...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-019-1402-x
更新日期:2020-01-03 00:00:00
abstract:BACKGROUND:Interactive video games such as the Nintendo Wii Fit are increasingly used as a therapeutic tool in health and aged care settings however, their acceptability to older people is unclear. The aim of this study was to determine the acceptability of the Nintendo Wii Fit as a therapy tool for hospitalised older ...
journal_title:BMC geriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2318-11-64
更新日期:2011-10-20 00:00:00
abstract:BACKGROUND:Falls are the leading cause of fatal and non-fatal injuries among older adults. Exercise programs appear to reduce fall risk, but the optimal type, frequency, and duration of exercise is unknown. External perturbations such as tripping and slipping are a major contributor to falls, and task-specific perturba...
journal_title:BMC geriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2318-13-49
更新日期:2013-05-16 00:00:00
abstract:BACKGROUND:Frailty and hemoglobin concentration, above what would be considered clinical anemia, are two common findings in older patients that lead to an increased risk of negative health outcomes. The objective of this study is to evaluate whether hemoglobin concentration is an independent predictor of frailty and in...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-020-01597-6
更新日期:2020-06-11 00:00:00
abstract:BACKGROUND:For patients with advanced dementia, pain diagnosis and assessment requires observations of pain-indicative behavior by others. One type of behavior that has been shown to be a promising candidate is the facial response to pain. To further test how pain-indicative facial responses are, we investigated the pr...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-018-0773-8
更新日期:2018-04-11 00:00:00
abstract:BACKGROUND:Collaborative medication review (CMR) practices for older adults are evolving in many countries. Development has been under way in Finland for over a decade, but no inventory of evolved practices has been conducted. The aim of this study was to identify and describe CMR practices in Finland after 10 years of...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-019-1317-6
更新日期:2019-11-21 00:00:00
abstract:BACKGROUND:Caregiver interventions may help improve the quality of informal care. Yet the lack of a systematic framework specifying the targets and outcomes of caregiver interventions hampers our ability to understand what has been studied, to evaluate existing programs, and to inform the design of future programs. Our...
journal_title:BMC geriatrics
pub_type: 杂志文章,评审
doi:10.1186/1471-2318-11-77
更新日期:2011-11-22 00:00:00
abstract:BACKGROUND:A dearth of differential research exists regarding the determinants of mild cognitive impairment (MCI) and moderate cognitive impairment or dementia among nursing home residents. This study aimed to identify and examine the association between medical factors (number of comorbidities, hospitalization, disabi...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-020-01875-3
更新日期:2020-11-18 00:00:00
abstract:BACKGROUND:People with dementia describe experiences of loss that threaten their autonomy and ability to contribute to society. They often have difficulties with orientation, loss of roll function, and fear about the future, and need help from others. An increasing body of literature also focuses on how people with dem...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-019-1306-9
更新日期:2019-10-30 00:00:00
abstract:BACKGROUND:Improved usual gait speed predicts substantial reduction in mortality. A better understanding of the modifiable factors that are independently associated with improved gait speed would ensure that intervention strategies are developed based on a valid theoretical framework. Thus, we examined the independent ...
journal_title:BMC geriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2318-10-25
更新日期:2010-05-19 00:00:00
abstract:BACKGROUND:The early screening of frail individuals and of patients with complex care needs are challenges that countries witnessing population aging face. Homecare nurses are actors of choice in meeting these challenges, yet they need means of identifying frail and complex patients in their routine practice. The fraXi...
journal_title:BMC geriatrics
pub_type: 临床试验,杂志文章
doi:10.1186/s12877-019-1230-z
更新日期:2019-08-05 00:00:00
abstract:BACKGROUND:An attenuation of the insulin-like growth factor 1 (IGF-1) signaling has been associated with elongation of the lifespan in simple metazoan organisms and in rodents. In humans, IGF-1 level has an age-related modulation with a lower concentration in the elderly, depending on hormonal and genetic factors affec...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/1471-2318-9-19
更新日期:2009-05-21 00:00:00
abstract:BACKGROUND:Increasingly, older Chinese adults from rural areas are moving to urban areas to live with their children who have already migrated to these areas. However, few studies have examined this pattern of migration and its effects on cognitive function. We aimed to investigate the association between domestic rura...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-020-01772-9
更新日期:2020-09-21 00:00:00
abstract:BACKGROUND:Frailty is seen across various health and social care settings. However, little is known about how healthcare professionals, particularly those who provide care for older adults living in the community view frailty. There is also a dearth of information about the extent to which a shared understanding of fra...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-019-1069-3
更新日期:2019-02-19 00:00:00
abstract:BACKGROUND:Many balance and strength tests exist that have been designed for older seniors, often aged ≥70 years. To guide strategies for preventing functional decline, valid and reliable tests are needed to detect early signs of functional decline in young seniors. Currently, little is known about which tests are bein...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-018-1011-0
更新日期:2019-01-09 00:00:00
abstract:BACKGROUND:Medication safety is an important health issue for nursing home residents (NHR). They usually experience polypharmacy and often take potentially inappropriate medications (PIM) and antipsychotics. This, coupled with a frail health state, makes NHR particularly vulnerable to adverse drug events (ADE). The val...
journal_title:BMC geriatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12877-019-1027-0
更新日期:2019-01-25 00:00:00
abstract:BACKGROUND:Dementia is characterized by a progressive decline and deterioration of brain regions such as memory, spatial navigation and language, along with disturbances in daily functioning. Non-pharmacological interventions that offer a holistic approach by targeting cognitive functioning, prognosis and the psycholog...
journal_title:BMC geriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12877-015-0123-z
更新日期:2015-10-19 00:00:00
abstract:BACKGROUND:With the increase in the understanding of the influence of various lifestyle factors such as sedentary behaviour and level of physical activity (PA) on physical and mental health, there has been a growing research interest on how physical inactivity correlates with depressive outcomes across countries. The p...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-017-0489-1
更新日期:2017-04-28 00:00:00
abstract:BACKGROUND:Current model of medication supply to Residential Aged Care Facilities (RACFs) in Australia is dependent on paper-based prescriptions. This study is aimed at assessing the use of a centralized medication chart as a prescription-less model for supplying medications to RACFs. METHODS:Two separate focus groups...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/1471-2318-12-25
更新日期:2012-07-11 00:00:00
abstract:BACKGROUND:The European population is rapidly ageing. There is an urgent need for innovative solutions to reduce fall risk in older adults. Perturbation-based gait training is a promising new method to improve reactive balance responses. Whereas positive effects on task-specific dynamic balance recovery during gait hav...
journal_title:BMC geriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12877-020-01566-z
更新日期:2020-05-07 00:00:00
abstract:BACKGROUND:Previous literature has reported that loneliness is a strong predictor of frailty risk. However, less is known about the role of loneliness in frailty transition types. This study aimed to examine whether and how loneliness are related to frailty transition among older Chinese people. METHODS:Our study used...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-020-01714-5
更新日期:2020-08-24 00:00:00
abstract:BACKGROUND:Geriatric Patients Living with HIV/AIDS (GEPPO) is a new prospective observational multicentre cohort consisting of all the HIV-positive geriatric patients being treated at 10 clinics in Italy, and HIV-negative controls attending a single geriatric clinic. The aim of this analysis of the GEPPO cohort was to ...
journal_title:BMC geriatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/s12877-018-0789-0
更新日期:2018-04-20 00:00:00
abstract:BACKGROUND:Continued aging of the population is expected to be accompanied by substantial increases in the number of people with dementia and in the number of health care staff required to care for them. Adequate knowledge about dementia among health care staff is important to the quality of care delivered to this vuln...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/1471-2318-13-2
更新日期:2013-01-02 00:00:00