Abstract:
BACKGROUND:Sarcopenia often accompanies osteoarthritis (OA), which is managed by total knee arthroplasty (TKA) in the late stage. Recent studies have suggested a higher risk of post-operative complications after TKA in sarcopenic OA subjects, but whether TKA can benefit them similar to non-sarcopenic subjects remains unexplored. This study aimed to examine the dynamic, mutual impact of sarcopenia and TKA in a one-year post-operative period. METHODS:This prospective cohort study was conducted between 2015 to 2018 at our hospital. Patients with end-stage OA of the knee waiting for TKA were recruited into the study. Primary outcome measures were change in muscle strength, mass and function. Secondary outcome measures were quality of life (QOL) measurements for pain, psychological and physical health. RESULTS:Fifty-eight patients were recruited, of which 79.3% were female and 32.8% already had sarcopenia at baseline. The average age of sarcopenic subjects and non-sarcopenic subjects was comparable (67.89 ± 7.07 vs. 67.92 ± 6.85; p = 0.99), but sarcopenic subjects had a lower body mass index (BMI) (25.64 ± 2.64 vs. 28.57 ± 4.04; p = 0.01). There was a statistically significant improvement in walking speed (10.24 ± 5.35 vs. 7.69 ± 2.68, p < 0.01) and muscle strength in both sarcopenic and non-sarcopenic patients after TKA. This was accompanied by an improvement trend in muscle mass in all subjects. There was no change in handgrip power before and after TKA and subsequent follow-up (19.31 ± 5.92 vs. 18.98 ± 6.37 vs. 19.36 ± 7.66; p = 0.97). QOL measured before, after and at follow-up with WOMAC (total: 42.27 ± 15.98 vs. 20.65 ± 15.24 vs. 16.65 ± 18.13) and SF12v2 (PCS: 33.06 ± 8.55 vs. 38.96 ± 8.01 vs. 40.67 ± 7.93) revealed progressive significant improvement (both comparisons p ≤ 0.01). Further analysis with the IPAQ also found increased engagement of high-intensity activities. CONCLUSIONS:This study showed that sarcopenia among patients with end-stage OA of the knee is not uncommon, but both sarcopenic and non-sarcopenic OA patients achieved significant clinical and functional improvement after TKA. Further studies with a larger sample size and different ethnicities could help ascertain a beneficial role of TKA in sarcopenic OA subjects. TRIAL REGISTRATION:Registry: ClinicalTrials.gov , Registration number: NCT03579329 . Date of registration: 6 July 2018. Retrospectively registered.
journal_name
BMC Geriatrjournal_title
BMC geriatricsauthors
Ho KK,Lau LC,Chau WW,Poon Q,Chung KY,Wong RMdoi
10.1186/s12877-020-01929-6subject
Has Abstractpub_date
2021-01-04 00:00:00pages
2issue
1issn
1471-2318pii
10.1186/s12877-020-01929-6journal_volume
21pub_type
杂志文章相关文献
BMC Geriatrics文献大全abstract:BACKGROUND:Physical activity is of vital importance to older peoples' health. Physical activity intervention studies with older people often have low recruitment, yet little is known about non-participants. METHODS:Patients aged 60-74 years from three UK general practices were invited to participate in a nurse-support...
journal_title:BMC geriatrics
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2318-14-46
更新日期:2014-04-12 00:00:00
abstract:BACKGROUND:With the increase in the understanding of the influence of various lifestyle factors such as sedentary behaviour and level of physical activity (PA) on physical and mental health, there has been a growing research interest on how physical inactivity correlates with depressive outcomes across countries. The p...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-017-0489-1
更新日期:2017-04-28 00:00:00
abstract:BACKGROUND:Currently, primary care for frail older people is reactive, time consuming and does not meet patients' needs. A transition is needed towards proactive and integrated care, so that daily functioning and a good quality of life can be preserved. To work towards these goals, two interventions were developed to e...
journal_title:BMC geriatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2318-12-16
更新日期:2012-04-25 00:00:00
abstract:BACKGROUND:Hand-grip strength (HGS) serves as a proxy measure for muscle function and physical health. Studies have shown that low HGS is associated with common age-related disorders including frailty and sarcopenia. The aim of the present study was to establish the normative values of HGS among older adults in Singapo...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-017-0565-6
更新日期:2017-08-04 00:00:00
abstract:BACKGROUND:Risk prediction after myocardial infarction is often complex in older patients. The Global Registry of Acute Coronary Events (GRACE) model includes clinical parameters and age, but not frailty. We hypothesised that frailty would enhance the prognostic properties of GRACE. METHODS:We performed a prospective ...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-020-1500-9
更新日期:2020-03-13 00:00:00
abstract:BACKGROUND:With the ageing population, the number of older trauma patients has increased. The aim of this study was to assess non-surgical health care costs of older trauma patients and to identify which characteristics of older trauma patients were associated with high health care costs. METHODS:Trauma patients aged ...
journal_title:BMC geriatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/s12877-020-01825-z
更新日期:2020-10-21 00:00:00
abstract:BACKGROUND:Our research sought to understand how falls risk, cognitive function, and daily function are associated with health related quality of life (using the EuroQol-5D) and quality of life (using the ICECAP-O) among older adults with mobility impairments. METHODS:The EQ-5D and ICECAP-O were administered at 12 mon...
journal_title:BMC geriatrics
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2318-12-65
更新日期:2012-10-24 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD), low serum albumin, and anemia are known risk factors for cognitive decline in older people. We investigated the association between kidney function and cognitive impairment severity in oldest-old people with a diagnosis of Alzheimer's disease (AD). METHODS:A cross-sectional stu...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-020-01789-0
更新日期:2020-10-07 00:00:00
abstract:INTRODUCTION:This paper details a subset of the findings from a participatory action research project exploring a palliative intervention in long-term care sites across Canada. The findings presented in this paper relate to understanding compassion within the context of a palliative approach to long-term care. METHODS...
journal_title:BMC geriatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/s12877-019-1135-x
更新日期:2019-05-06 00:00:00
abstract:BACKGROUND:Self-rated health predicts health outcomes independently of levels of disability or mood. Little is known about what influences the subjective health experience of stroke survivors. Our aim was to investigate stroke survivors' perceptions of self-rated health, with the intention of informing the design of in...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-018-0765-8
更新日期:2018-04-02 00:00:00
abstract:BACKGROUND:Social wellbeing factors such as loneliness and social support have a major impact on the health of older adults and can contribute to physical and mental wellbeing. However, with increasing age, social contacts and social support typically decrease and levels of loneliness increase. Group social engagement ...
journal_title:BMC geriatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/s12877-018-0913-1
更新日期:2018-09-24 00:00:00
abstract:BACKGROUND:Little is known about met and unmet needs of individuals in residential care, many of whom suffer from dementia. Unmet needs are associated with a decreased quality of life, worse mental health, dissatisfaction with services, and increased costs of care. The aim of this study was to compare the number and ty...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/1471-2318-13-51
更新日期:2013-05-24 00:00:00
abstract:BACKGROUND:An increasingly high number of patients admitted to hospital have dementia. Hospital environments can be particularly confusing and challenging for people living with dementia (Plwd) impacting their wellbeing and the ability to optimize their care. Improving the experience of care in hospital has been recogn...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-020-01534-7
更新日期:2020-04-10 00:00:00
abstract:BACKGROUND:Cross-sectional relationships between physical activity and health have been explored extensively, but less is known about how physical activity changes with time in older people. The aim of this study was to assess baseline predictors of how objectively measured physical activity changes with time in older ...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-017-0578-1
更新日期:2017-08-14 00:00:00
abstract:BACKGROUND:As populations are aging, a growing number of home care clients are frail and use multiple, complex medications. Combined with the lack of coordination of care this may pose uncontrolled polypharmacy and potential patient safety risks. The aim of this study was to assess the impact of a care coordination int...
journal_title:BMC geriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12877-019-1353-2
更新日期:2019-11-27 00:00:00
abstract:BACKGROUND:Sarcopenia is a condition that is characterized by loss of muscle mass, muscle strength and muscle functional impairment with ageing. It is associated with poor health outcomes, premature death and a significant burden on the global health economy. The prevalence of sarcopenia in China is unknown since most ...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-020-1468-5
更新日期:2020-02-17 00:00:00
abstract:BACKGROUND:Previous studies suggest that psychotropic drug changes may signal an acute period of time whereby a person is highly vulnerable to fall. It is unknown whether certain classes of psychotropic agents are less safe with respect to the acute risk of falls. Our purpose was to compare fall rates in the 7 days fol...
journal_title:BMC geriatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2318-13-19
更新日期:2013-02-22 00:00:00
abstract:BACKGROUND:The aim of the present paper is to assess the gait pattern of patients with Peripheral Artery Disease (PAD). A more specific aim is to compare the gait pattern of PAD patients before and after the appearance of intermittent claudication symptoms. METHODS:The study involved 34 PAD patients with a claudicatio...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-018-0727-1
更新日期:2018-02-20 00:00:00
abstract:BACKGROUND:Vascular dementia (VaD) is the second most common form of dementia. However, there were mixed evidences about the association between blood pressure (BP) and risk of VaD in midlife and late life and limited evidence on the association between pulse pressure and VaD. METHODS:This is a population-based observ...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-017-0649-3
更新日期:2017-10-27 00:00:00
abstract:BACKGROUND:Medication related harm (MRH) is a common cause of morbidity and hospital admission in the elderly, and has significant cost implications for both primary and secondary healthcare resources. The development of risk prediction models has become an increasingly common phenomenon in medicine and can be useful t...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-016-0191-8
更新日期:2016-01-19 00:00:00
abstract:BACKGROUND:International guidelines recommend adapting the classic emergency department (ED) management model to the needs of older adults in order to ameliorate post-ED outcomes among this vulnerable group. To improve the care for older ED patients and especially prevent unplanned ED readmissions, the URGENT care mode...
journal_title:BMC geriatrics
pub_type: 临床试验,杂志文章
doi:10.1186/s12877-018-0933-x
更新日期:2018-10-16 00:00:00
abstract:BACKGROUND:Delayed diagnosis of bloodstream infection (BSI) occurs in > 20% of older patients, with misdiagnosis in 35%. Our objective was to develop and validate a clinically useful screening tool to identify older patients with a high probability of having a BSI. METHODS:Hospitalized patients > 80 years old with BSI...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-019-1402-x
更新日期:2020-01-03 00:00:00
abstract:BACKGROUND:The number of people with dementia is increasing alongside the aging population, and most of these patients manifest with neuropsychiatric symptoms (NPS). The objective of this study was to investigate anti-dementia drug use and its associations with NPS. METHODS:Questionnaires on demographic information, c...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-015-0102-4
更新日期:2015-08-13 00:00:00
abstract:BACKGROUND:Current guidelines recommend considering life expectancy before aortic valve replacement (AVR). We compared the performance of a general mortality index, the Lee index, to a frailty index. METHODS:We conducted a prospective cohort study of 246 older adults undergoing surgical (SAVR) or transcatheter aortic ...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-020-1440-4
更新日期:2020-02-03 00:00:00
abstract:BACKGROUND:Falls are a major problem for older adults. Many falls occur when a person's attention is divided between two tasks, such as a dual task (DT) involving walking. Most recently, the role of personality in walking performance was addressed; however, its association with DT performance remains to be determined. ...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-017-0691-1
更新日期:2018-01-02 00:00:00
abstract:BACKGROUND:Primary care physicians need a brief and accurate screening test of dementia. The objective of this study was to determine whether a short form of Mini-Mental State Examination (SMMSE) was as accurate as the Mini-Mental State Examination (MMSE) in screening dementia. METHODS:Based on case control design stu...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/1471-2318-11-59
更新日期:2011-10-04 00:00:00
abstract:BACKGROUND:Individualized decision making has been recommended for cancer screening decisions in older adults. Because older adults' preferences are central to individualized decisions, we assessed older adults' perspectives about continuing cancer screening later in life. METHODS:Face to face interviews with 116 resi...
journal_title:BMC geriatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2318-6-10
更新日期:2006-08-03 00:00:00
abstract:BACKGROUND:Anticholinergic medication use is linked with increased cognitive decline, dementia, falls and mortality, and their use should be limited in older people. Here we estimate the prevalence of anticholinergic use in England's older population in 1991 and 2011, and describe changes in use by participant's age, s...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-020-01657-x
更新日期:2020-07-31 00:00:00
abstract:BACKGROUND:Using Singapore as a case study, this paper aims to understand the effects of the current long-term care policy and various alternative policy options on the labor market participation of primary informal family caregivers of elderly with disability. METHODS:A model of the long-term care system in Singapore...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-016-0243-0
更新日期:2016-03-23 00:00:00
abstract:BACKGROUND:Collaborative medication review (CMR) practices for older adults are evolving in many countries. Development has been under way in Finland for over a decade, but no inventory of evolved practices has been conducted. The aim of this study was to identify and describe CMR practices in Finland after 10 years of...
journal_title:BMC geriatrics
pub_type: 杂志文章
doi:10.1186/s12877-019-1317-6
更新日期:2019-11-21 00:00:00