abstract：:Damage to the vestibular sense organs evokes static and dynamic deficits in the eye movements, posture and vegetative functions. After a shorter or longer period of time, the vestibular function is partially or completely restored via a series of processes such as modification in the efficacy of synaptic inputs. As th...

authors： Magyar A,Racz E,Matesz C,Wolf E,Kiss P,Gaal B

更新日期：2022-03-01 00:00:00

abstract：Background:Chuna Manual Therapy (CMT) has been widely used in Korea, and coverage in Korean National Health Insurance (NHI) was finally implemented in 2019. The objectives of this study were to analyze the process of NHI coverage for CMT qualitatively, and to summarize important roles, streams, and implications regardi...

authors： Yu J,Shin BC,Kim H,Hyun E,Lee JH,Kim MR,Lim B

更新日期：2022-03-01 00:00:00

abstract：:Store-operated Ca2+ entry is a central component of intracellular Ca2+ signaling pathways. The Ca2+ release-activated channel (CRAC) mediates store-operated Ca2+ entry in many different cell types. The CRAC channel is composed of the plasma membrane (PM)-localized Orai1 channel and endoplasmic reticulum (ER)-localized...

authors： West SJ,Kodakandla G,Wang Q,Tewari R,Zhu MX,Boehning D,Akimzhanov AM

更新日期：2022-03-01 00:00:00

abstract：:The regulation of adult neural stem cells (NSCs) is critical for lifelong neurogenesis. MicroRNAs (miRNAs) are a type of small, endogenous RNAs that regulate gene expression post-transcriptionally and influence signaling networks responsible for several cellular processes. In this study, miR-103-3p was transfected int...

authors： Li W,Wang SS,Shan BQ,Qin JB,Zhao HY,Tian ML,He H,Cheng X,Zhang XH,Jin GH

更新日期：2022-02-01 00:00:00

abstract：:Amyotrophic lateral sclerosis is the most common adult-onset neurodegenerative disease affecting motor neurons. Its defining feature is progressive loss of motor neuron function in the cortex, brainstem, and spinal cord, leading to paralysis and death. Despite major advances in identifying genes that can cause disease...

authors： Marques RF,Duncan KE

更新日期：2022-02-01 00:00:00

abstract：:22q11.2 Deletion Syndrome (22q11DS) is a neurodevelopmental disorder associated with cranial nerve anomalies and disordered oropharyngeal function, including pediatric dysphagia. Using the LgDel 22q11DS mouse model, we investigated whether sensory neuron differentiation in the trigeminal ganglion (CNgV), which is esse...

authors： Karpinski BA,Maynard TM,Bryan CA,Yitsege G,Horvath A,Lee NH,Moody SA,LaMantia AS

更新日期：2022-02-01 00:00:00

abstract：:The critical role microRNAs play in modulating global functions is emerging, both in the maintenance of homeostatic mechanisms and in the adaptation to diverse environmental stresses. When stressed, cells must divert metabolic requirements toward immediate survival and eventual recovery and the unique features of miRN...

authors： Hadj-Moussa H,Hawkins LJ,Storey KB

更新日期：2022-01-01 00:00:00

abstract：:During the past decade, Chromosome Conformation Capture (3C/Hi-C)-based methods have been used to probe the 3D structure and organization of bacterial genomes, revealing fundamental aspects of chromosome dynamics. However, the current protocols are expensive, inefficient, and limited in their resolution. Here we prese...

authors： Thierry A,Cockram C

更新日期：2022-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding elements that play essential roles in the posttranscriptional regulation of biochemical processes. miRNAs recognize and target multiple mRNAs; therefore, investigating miRNA dysregulation is an indispensable strategy to understand pathological conditions and to design innovative ...

authors： Ghanbarian H,Yıldız MT,Tutar Y

更新日期：2022-01-01 00:00:00

abstract：:The number of ABO-incompatible solid organ transplantations (ABOi SOTs) has markedly increased worldwide since the early 2000s. We investigated the choice of ABO group for blood component transfusion in ABOi SOT. We conducted a survey by e-mailing a questionnaire to blood bank specialists at 77 major hospitals in Kore...

authors： Chung Y,Ko DH,Lim J,Kim KH,Kim H

更新日期：2022-01-01 00:00:00

abstract：Background:Laboratory parameter abnormalities are commonly observed in COVID-19 patients; however, their clinical significance remains controversial. We assessed the prevalence, characteristics, and clinical impact of laboratory parameters in COVID-19 patients hospitalized in Daegu, Korea. Methods:We investigated the ...

authors： Yoo EH,Chang SH,Song DY,Lee CH,Cheong GY,Park S,Lee JH,Lee S,Kwak SG,Jeon CH,Song KE

更新日期：2022-01-01 00:00:00

abstract：:In view of the ongoing COVID-19 pandemic and its effects on global health, understanding and accurately modelling the propagation of human biological aerosols has become crucial. Worldwide, health professionals have been one of the most affected demographics, representing approximately 20% of all cases in Spain, 10% i...

authors： Calmet H,Bertomeu PF,McIntyre C,Rennie C,Gouder K,Houzeaux G,Fletcher C,Still R,Doorly D

更新日期：2022-01-01 00:00:00

abstract：:Homophily, or the tendency for social contact to occur among those who are similar, plays a crucial role in structuring our social networks. Most previous work considers whether homophily shapes the patterns of all social ties, regardless of their frequency of interaction or level of intimacy. As complex network data ...

authors： McMillan C

更新日期：2022-01-01 00:00:00

abstract：:Mesenchymal stem cell (MSC) transplantation is a promising treatment strategy for spinal cord injury, but immunological rejection and possible tumor formation limit its application. The therapeutic effects of MSCs mainly depend on their release of soluble paracrine factors. Exosomes are essential for the secretion of ...

authors： Zhou Y,Wen LL,Li YF,Wu KM,Duan RR,Yao YB,Jing LJ,Gong Z,Teng JF,Jia YJ

更新日期：2022-01-01 00:00:00

abstract：:Exposure to explosive shockwave often leads to blast-induced traumatic brain injury in military and civilian populations. Unprotected ears are most often damaged following exposure to blasts. Although there is an association between tympanic membrane perforation and TBI in blast exposure victims, little is known about...

authors： Ou Y,Clifton BA,Li J,Sandlin D,Li N,Wu L,Zhang C,Chen T,Huang J,Yu Y,Allison J,Fan F,Roman RJ,Shaffery J,Zhou W,Pang Y,Zhu H

更新日期：2022-01-01 00:00:00

abstract：:Knowledge of the mechanisms that trigger infection-related encephalopathies is still very limited and cell therapies are one of the most promising alternatives for neurodegenerative diseases, and its application in infectious diseases can be of great relevance. Mesenchymal stromal cells are cells with great immunomodu...

authors： Lima MN,Barbosa-Silva MC,Maron-Gutierrez T

更新日期：2022-01-01 00:00:00

abstract：CONTEXT:Restriction in ankle dorsiflexion range of motion (ROM) has been previously associated with excessive dynamic knee valgus. This, in turn, has been correlated with knee pain in women with patellofemoral pain. OBJECTIVES:To investigate the immediate effect of 3 ankle mobilization techniques on dorsiflexion ROM, ...

authors： Coelho BAL,Rodrigues HLDN,Almeida GPL,João SMA

更新日期：2021-12-29 00:00:00

abstract：:This paper proposes a wavelet and artificial intelligence-enabled rapid and efficient testing procedure for patients with Severe Acute Respiratory Coronavirus Syndrome (SARS-nCoV) through a deep learning approach from thoracic X-ray images. Presently, the virus infection is diagnosed primarily by a process called the ...

authors： Verma AK,Vamsi I,Saurabh P,Sudha R,G R S,S R

更新日期：2021-12-15 00:00:00

abstract：:To determine the effects of Follicle Stimulating Hormone (FSH) treatment and subsequent withdrawal on uterine proliferation and estrogen receptor (ESR), Brahman crossbred heifers (n = 12) were twice daily injected with FSH (4, 3, and 2 mg/injection) on Days 17-19 of the estrous cycle (FSH 3 days) and (4 and 3 mg/injec...

authors： Bunma T,Kanjanaruch C,Kogram N,Uriyapongson S,Khanthusaeng V,Navanukraw C

更新日期：2021-12-01 00:00:00

abstract：:This article deals with drivers for and barriers to patient involvement in Greenland hospital-care, from the patients' perspective.Data were generated in 2019, via semi-structured research interviews and field observations. At the National Hospital in Nuuk, participants were purposively included to ensure variation re...

authors： Seibæk L

更新日期：2021-12-01 00:00:00

abstract：:Purpose: Many countries around the world are facing an ageing society in which older persons share the fate of carrying a burden in their families, especially in skipped-generation families. This increasing trend has noted over the past several years in Thailand. This is an interpretive phenomenological study that see...

authors： Hongthai K,Jongudomkarn D

更新日期：2021-12-01 00:00:00

abstract：:Circular RNA is an innovative kind of endogenous non-coding RNA, which could take part in tumorigenesis. Nonetheless, the potential molecular mechanisms of circVRK1 in the progression of osteosarcoma remain unresolved. In the current study, we initially investigated circVRK1 levels in osteosarcoma clinical samples and...

authors： Cheng C,Zhang H,Dai Z,Zheng J

更新日期：2021-12-01 00:00:00

abstract：:Widespread infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has led to a global pandemic. Currently, various approaches are being taken up to develop vaccines and therapeutics to treat SARS-CoV2 infection. Consequently, the S protein has become an important target protein for developing vac...

authors： Das A,Dutta S,Sharma D,Pal A,Ganguli N,Majumdar SS

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Telemedicine, once defined merely as the treatment of certain conditions remotely, has now often been supplanted in use by broader terms such as 'virtual care', in recognition of its increasing capability to deliver a diverse range of healthcare services from afar. With the unexpected onset of COVID-19, virt...

authors： Neves AL,Li E,Gupta PP,Fontana G,Darzi A

更新日期：2021-12-01 00:00:00

abstract：:Medical students experience rising rates of burnout throughout their training. Efforts have been made to not only mitigate its negative effects, but also prevent its development. Medical improv takes the basic ideas of improvisational theatre and applies them to clinical situations. Given improv's focus on self-awaren...

authors： Neel N,Maury JM,Heskett KM,Iglewicz A,Lander L

更新日期：2021-12-01 00:00:00

abstract：:Brucella endocarditis is a fatal complication and the most frequent cause of death for human brucellosis. This study aimed to systematically review the literature on the follow-up outcomes of Brucella endocarditis and analyze the determinants affecting the follow-up outcomes. The databases PubMed, Web of Science, Emba...

authors： Li X,Wang T,Wang Y,Xie S,Tan W,Li P

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Among myeloproliferative neoplasms, it is often difficult to distinguish essential thrombocythaemia (ET) from prefibrotic-stage primary myelofibrosis (PMF) with thrombocytosis given their overlapping clinicopathological phenotypes. CASE PRESENTATION:We encountered a 45-year-old male who was initially diagno...

authors： Sasaki K,Nannya Y,Nakamura Y,Ichikawa M,Ogawa S,Mitani K

更新日期：2021-12-01 00:00:00

abstract：:3D printing technology has brought light in the fight against the COVID-19 global pandemic event through the decentralized and on-demand manufacture of different personal protective equipment and medical devices. Nonetheless, since this technology is still in an early stage, the use of 3D-printed electronic devices fo...

authors： Muñoz J,Pumera M

更新日期：2021-12-01 00:00:00

abstract：:Bladder cancer (BLCA), originating from the epithelium of the urinary bladder, was the second most common malignancy in the urinary system with a high metastasis rate and poor post-metastasis prognosis. Alternative splicing events (ASEs) were regarded as important markers of tumor progression and prognosis, however, t...

authors： Huang R,Zheng Z,Xian S,Zhang J,Jia J,Song D,Yan P,Yin H,Hu P,Zhu X,Huang Z,Meng T,Zhang J

更新日期：2021-12-01 00:00:00

abstract：:Luteolin (Lut) is a natural flavonoid polyphenolic compound with multiple pharmacological activities, such as anti-oxidant, anti-inflammatory, and anti-tumor effects. However, the poor aqueous solubility and low bioactivity of Lut restrict its clinical translation. Herein, we developed a reactive oxygen species (ROS)-...

authors： Wang Y,Wang Q,Feng W,Yuan Q,Qi X,Chen S,Yao P,Dai Q,Xia P,Zhang D,Sun F

更新日期：2021-12-01 00:00:00

abstract：:The aim of this study is to identify how managers of micro-sized enterprises experience the impact of the Covid-19 pandemic on their business operations, work-life balance and well-being. Further, the study aims to make comparisons between managers of micro-sized businesses and managers of small-sized businesses. This...

authors： Vinberg S,Danielsson P

更新日期：2021-12-01 00:00:00

abstract：:The current study investigated the ability of resveratrol to protect RGC-5 retinal ganglion cells in culture against H2O2-induced apoptosis and the underlying mechanism of protection. RGC-5 cells were pre-exposed to resveratrol (5, 10, or 20 μM), followed by 200 μM H2O2. Cell viability and apoptosis were detected to a...

authors： Ye MJ,Meng N

更新日期：2021-12-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most important causes of morbidity and mortality in the developed world and is gradually more frequent in the developing world including Saudi Arabia. According to the Saudi Cancer Registry report 2015, CRC is the most common cancer in men (14.9%) and the second most prevalent can...

authors： Rasool M,Carracedo A,Sibiany A,Al-Sayes F,Karim S,Haque A,Natesan Pushparaj P,Asif M,Achakzai NM

更新日期：2021-12-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) signalling and the interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) are aberrantly activated in ovarian cancer. However, inhibition of EGFR signalling in ovarian cancer patients resulted in a disappointing clinical benefit. In this study, we found ...

authors： Yan M,Han M,Yang X,Shen R,Wang H,Zhang L,Xia S,Yang P,Zhai G,Shao Q

更新日期：2021-12-01 00:00:00

abstract：:Some of the biochemical abnormalities underlying schizophrenia, involve differences in methylation and methylating enzymes, as well as other related target genes. We present results of a study of differences in mRNA expression in peripheral blood lymphocytes (PBLs) and post-mortem brains of chronic schizophrenics (CSZ...

authors： Sershen H,Guidotti A,Auta J,Drnevich J,Grayson DR,Veldic M,Meyers J,Youseff M,Zhubi A,Faurot K,Wu R,Zhao J,Jin H,Lajtha A,Davis JM,Smith RC

更新日期：2021-12-01 00:00:00

abstract：:Identifying isoform-specific inhibitors for closely related kinase family members remains a substantial challenge. The necessity for achieving this specificity is exemplified by the RSK family, downstream effectors of ERK1/2, which have divergent physiological effects. The natural product, SL0101, a flavonoid glycosid...

authors： Wright EB,Fukuda S,Li M,Li Y,O'Doherty GA,Lannigan DA

更新日期：2021-12-01 00:00:00

abstract：:Objectives: Chronic myeloid leukemia (CML) is a malignant tumor of the blood system. Gö6976, as a type of indolocarbazole and shows strong antitumor effects, but there have been no reports on the effect of Gö6976 on CML. The objectives of this research were: (1) to explore the impact of Gö6976 on CML in vitro and in v...

authors： Cao ZR,Chen XP,Feng M,Hou YL,Li Y,Hu XL,Huang ZL,Hu J

更新日期：2021-12-01 00:00:00

abstract：:To probe into the efffects of miR-101-3p via regulating CUL4B within PI3K/AKT/mTOR signaling pathway on progression of prostate cancer (PCA). Western blot and qRT-PCR were adopted to detect CUL4B and miR-101-3p expressions in 75 cases with PCA . The cellular strains of PCA (LNCaP and PC3) were chose as the objects to ...

authors： Gu Z,You Z,Yang Y,Ding R,Wang M,Pu J,Chen J

更新日期：2021-12-01 00:00:00

abstract：:Endometrial cancer (EC) is the most common gynecological malignancy. Recent studies have uncovered miRNA acted a striking role in predicting the prognosis of multiple tumors. Over 500 EC samples were selected from the Cancer Genome Atlas (TCGA) database. Univariate, LASSO and multivariate Cox regression analysis were ...

authors： Lu J,Liang J,Xu M,Wu Z,Cheng W,Wu J

更新日期：2021-12-01 00:00:00

abstract：:Hypervirulent Klebsiella pneumoniae (HvKP), which causes highly fatal infections, is a new threat to human health. In an attempt to investigate the underlying mechanisms of resistance to neutrophil-mediated killing and hence expression of high-level virulence by HvKP, we tested the binding affinity of HvKP strains to ...

authors： Xu Q,Yang X,Chan EWC,Chen S

更新日期：2021-12-01 00:00:00