Abstract：
:As proton therapy becomes increasingly popular, so does the need for Monte Carlo simulation studies involving accurate beam line modeling of proton treatment units. In this study, the 24 beam configurations of the Mevion S250 proton therapy system installed recently at our institution were modeled using the TOolkit for PArticle Simulation (TOPAS) code. Pristine Bragg peak, spread out Bragg peak (SOBP), and lateral beam profile dose distributions were simulated and matched to the measurements taken during commissioning of the unit. Differences in the range for all Percent Depth Dose (PDD) curves between measured and simulated data agreed to within 0.1 cm. For SOBP scans, the SOBP widths all agreed to within 0.3 cm. With regards to lateral beam profile comparisons between the measured and simulated data, the penumbras differed by less than 1 mm and the flatness differed by less than 1% in nearly all cases. This study shows that Monte Carlo simulation studies involving the Mevion S250 proton therapy unit can be a viable tool in commissioning and verification of the proton treatment planning system.
journal_name
J Appl Clin Med Physjournal_title
Journal of applied clinical medical physicsauthors
Prusator M,Ahmad S,Chen Ydoi
10.1002/acm2.12077subject
Has Abstractpub_date
2017-05-01 00:00:00pages
88-95issue
3issn
1526-9914journal_volume
18pub_type
杂志文章abstract：:The purpose of this study is to simulate random and systematic RapidArc delivery errors for external beam prostate radiotherapy plans in order to determine the dose sensitivity for each error type. Ten prostate plans were created with a single 360° arc. The DICOM files for these treatment plans were then imported into...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v12i3.3409
更新日期：2011-05-20 00:00:00
abstract：:Many head-and-neck cancer (HNC) patients treated with radiotherapy suffer significant anatomical changes due to tumor shrinkage or weight loss. The purpose of this study was to assess dose changes over target volumes and organs at risk during intensity-modulated radiotherapy for HNC patients. Sixteen HNC IMRT patients...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v13i6.3723
更新日期：2012-11-08 00:00:00
abstract：:Chest wall radiation therapy treatment delivery was monitored using a 5 mm thick radiochromic poly(vinyl alcohol) cryogel that also provided buildup material. The cryogels were used to detect positioning errors and measure the impact of shifts for a chest wall treatment that was delivered to a RANDO phantom. The phant...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v17i5.6148
更新日期：2016-09-08 00:00:00
abstract：:The American Association of Physicists in Medicine Task Group 36 (AAPM TG-36) data can be used to estimate peripheral dose (PD) distributions outside the primary radiation field. However, the report data does not apply to linear accelerators equipped with a multileaf collimator (MLC) and universal wedge (UW). Tertiary...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v3i4.2554
更新日期：2002-10-01 00:00:00
abstract：:The design concept and dosimetric characteristics of a new applicator system for intraoperative radiation therapy (IORT) are presented in this work. A new hard-docking commercial system includes polymethylmethacrylate (PMMA) applicators with different diameters and applicator end angles and a set of secondary lead col...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v11i4.3244
更新日期：2010-07-19 00:00:00
abstract：:Two patients with multiple lung metastases (≥ 5) were treated using frameless stereotactic body radiation therapy (SBRT) on an Elekta Axesse linear accelerator equipped with an interdigitation-capable multileaf collimator and four-dimensional cone-beam CT (4D CBCT). The technique and the early clinical outcomes were e...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v15i4.4737
更新日期：2014-07-08 00:00:00
abstract：:A wide variety of existing combinations of target and filter materials (target/filter combinations) are used in mammography equipment. The patient dose depends on the X-ray quality that is derived from the target/filter combination, and a calibration of the dosimeter that is used in the measurement that corresponds to...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v16i6.5604
更新日期：2015-11-08 00:00:00
abstract：:The aim of this study was to compare image noise properties of GE Discovery HD 750 and Toshiba Aquilion ONE. The uniformity section of a Catphan 600 image quality assurance phantom was scanned with both scanners, at different dose levels and with extension rings simulating patients of different sizes. 36 datasets were...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v17i3.5900
更新日期：2016-05-08 00:00:00
abstract：:The purpose of this study was to develop and validate cardiac computed tomog-raphy (CT) quantitative analysis software with a patient-specific, 17-segment myocardial model that uses electrocardiogram (ECG)-gated cardiac CT images to differentiate between normal controls and severe aortic stenosis (AS) patients. ECG-ga...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v17i5.6237
更新日期：2016-09-08 00:00:00
abstract：:Reducing the treatment time for IMRT patients is highly desirable. The objective of this work was to evaluate the new clinical Siemens KonRad inverse treatment planning system (TPS) and compare it to the CMS XiO TPS with special emphasis on the segmentation efficiency. For head and neck, liver and prostate cancer pati...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v9i3.2770
更新日期：2008-07-14 00:00:00
abstract：:We retrospectively generated IMRT plans for 14 NSCLC patients who had experienced grade 2 or 3 esophagitis (CTCAE version 3.0). We generated 11-beam and reduced esophagus dose plan types to compare changes in the volume and length of esophagus receiving doses of 50, 55, 60, 65, and 70 Gy. Changes in planning target vo...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v14i4.4248
更新日期：2013-07-08 00:00:00
abstract：INTRODUCTION:Designing a radiation plan that optimally delivers both target coverage and normal tissue sparing is challenging. There are limited tools to determine what is dosimetrically achievable and frequently the experience of the planner/physician is relied upon to make these determinations. PlanIQ software provid...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1002/acm2.12165
更新日期：2017-09-01 00:00:00
abstract：:This study utilizes process control techniques to identify action limits for TomoTherapy couch positioning quality assurance tests. A test was introduced to monitor accuracy of the applied couch offset detection in the TomoTherapy Hi-Art treatment system using the TQA "Step-Wedge Helical" module and MVCT detector. Ind...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1002/acm2.12136
更新日期：2017-09-01 00:00:00
abstract：:The objective of this work is the investigation of intense pulsed light (IPL) photoepilation using Monte Carlo simulation to model the effect of the output dosimetry with millisecond exposure used by typical commercial IPL systems. The temporal pulse shape is an important parameter, which may affect the biological tis...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v13i5.3702
更新日期：2012-09-06 00:00:00
abstract：PURPOSE:Targeting and tracking of central lung tumors may be feasible on the Elekta MRI-linac (MRL) due to the soft-tissue visualization capabilities of MRI. The purpose of this work is to develop a novel treatment planning methodology to simulate tracking of central lung tumors with the MRL and to quantify the benefit...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1002/acm2.12233
更新日期：2018-01-01 00:00:00
abstract：:Prostate cancer radiotherapy workflows, solely based on magnetic resonance imaging (MRI), are now in clinical use. In these workflows, intraprostatic gold fiducial markers (GFM) show similar signal behavior as calcifications and bleeding in T2-weighted MRI-images. Accurate GFM identification in MRI-only radiotherapy w...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1002/acm2.12478
更新日期：2018-11-01 00:00:00
abstract：:Studies have shown that source dwells within Varian's HDR CT/MR compatible ring applicators can deviate from intended positions by several millimeters. Quantifying this offset is an important part of commissioning. The aims of this study were to: 1) determine the reproducibility of the offset, 2) study the interobserv...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v12i4.3447
更新日期：2011-11-15 00:00:00
abstract：:Performing a procedure on the wrong patient or site is one of the greatest errors that can occur in medicine. The addition of automation has been shown to reduce errors in many processes. In this work we explore the use of an automated patient identification process using optical surface imaging for radiotherapy treat...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v17i2.6066
更新日期：2016-03-08 00:00:00
abstract：:In this study, we compared the amount of lung tissue irradiated when respiratory gating was imposed during expiration with the amount of lung tissue irradiated when gating was imposed during inspiration. Our hypothesis was that the amount of lung tissue spared increased as inspiration increased. Computed tomography (C...
journal_title：Journal of applied clinical medical physics
pub_type： 临床试验,杂志文章
doi：10.1120/jacmp.26.146
更新日期：2004-01-01 00:00:00
abstract：:This study investigates the dosimetry and radiobiological model variation when a second photon arc was added to prostate volumetric-modulated arc therapy (VMAT) using the single-arc technique. Dosimetry and radiobiological model comparison between the single-arc and double-arc prostate VMAT plans were performed on fiv...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v14i3.4053
更新日期：2013-05-06 00:00:00
abstract：:The purpose of this investigation is to measure, characterize and report stray photon leakage and scatter radiation measurements from the Mobetron, an intraoperative electron linear accelerator designed for use in an operating room environment. The study is needed due to recent changes to the shielding design of the M...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v11i4.3151
更新日期：2010-09-07 00:00:00
abstract：:Radiochromic film has become an important tool to verify dose distributions in highly conformal radiation therapy such as IMRT. Recently, a new generation of these films, EBT3, has become available. EBT3 has the same composition and thickness of the sensitive layer of the previous EBT2 films, but its symmetric layer c...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v14i2.4111
更新日期：2013-03-04 00:00:00
abstract：:Endorectal balloons (ERBs) are routinely used in prostate proton radiation therapy to immobilize the prostate and spare the rectal wall. Rectal gas can distend the rectum and displace the prostate even in the presence of ERBs. The purpose of this work was to quantify the effects an ERB with a passive gas release condu...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v13i5.3945
更新日期：2012-09-06 00:00:00
abstract：:Intraoperative electron radiation therapy (IOERT) cannot usually benefit, as conventional external radiotherapy, from software systems of treatment planning based on computed tomography and from common dose verify procedures. For this reason, in vivo film dosimetry (IVFD) proves to be an effective methodology to evalu...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v16i1.5065
更新日期：2014-01-08 00:00:00
abstract：:The goal of this study was to investigate small field output factors (OFs) for flat-tening filter-free (FFF) beams on a dedicated stereotactic linear accelerator-based system. From this data, the collimator exchange effect was quantified, and detector-specific correction factors were generated. Output factors for 16 j...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v17i6.6433
更新日期：2016-11-08 00:00:00
abstract：INTRODUCTION:A previous pilot study has demonstrated the feasibility of a novel image-based approach for remote dosimetric auditing of clinical trials. The approach uses a model to convert in-air acquired intensity modulated radiotherapy (IMRT) images to delivered dose inside a virtual phantom. The model was developed ...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1002/acm2.12521
更新日期：2019-01-01 00:00:00
abstract：:We investigate the role of adaptive radiation therapy in pediatric patients with diffuse pontine glioma and the impact of steroid-related weight gain on treatment parameters utilizing cone-beam CT. Fifteen patients with diffuse pontine glioma were treated with three-dimensional conformal radiation therapy and enrolled...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：
更新日期：2011-01-30 00:00:00
abstract：:The dosimetry of very small electron fields can be challenging due to relative shifts in percent depth-dose curves, including the location of dmax, and lack of lateral electronic equilibrium in an ion chamber when placed in the beam. Conventionally a small parallel plate chamber or film is utilized to perform small fi...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v12i1.3267
更新日期：2010-10-04 00:00:00
abstract：:Hypofractionated treatments generally increase the complexity of a treatment plan due to the more stringent constraints of normal tissues and target coverage. As a result, treatment plans contain more modulated MLC motions that may require extra efforts for accurate dose calculation. This study explores methods to min...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v17i2.4989
更新日期：2016-03-08 00:00:00
abstract：:The purpose was to assess the variability in automated translational head/neck setup corrections computed from several different imaging modalities and rigid registration methods using patient anatomy. Shifts were calculated using three commercial and one in-house automated rigid registration methods for nine head/nec...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v12i1.3337
更新日期：2010-10-13 00:00:00
