Effects of the pattern of glucocorticoid replacement on neural processing, emotional reactivity and well-being in healthy male individuals: study protocol for a randomised controlled trial.

abstract：BACKGROUND:Chronic subdural haematoma (CSDH) is a common neurosurgical condition, typically treated with surgical drainage of the haematoma. However, surgery is associated with mortality and morbidity, including up to 20% recurrence of the CSDH. Steroids, such as dexamethasone, have been identified as a potential thera...

journal_title：Trials

authors： Kolias AG,Edlmann E,Thelin EP,Bulters D,Holton P,Suttner N,Owusu-Agyemang K,Al-Tamimi YZ,Gatt D,Thomson S,Anderson IA,Richards O,Whitfield P,Gherle M,Caldwell K,Davis-Wilkie C,Tarantino S,Barton G,Marcus HJ,Chari A

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Inconsistent outcome reporting is one significant hurdle to combining results from trials into systematic reviews. Core outcome sets (COS) can reduce this barrier. The aim of this review was to map outcomes reported in caries prevention and management randomised controlled trials (RCT) as a first step to COS...

journal_title：Trials

authors： Levey C,Innes N,Schwendicke F,Lamont T,Göstemeyer G

更新日期：2017-11-02 00:00:00

abstract：BACKGROUND:Diabetic kidney disease (DKD) is one of the most common microvascular complications of diabetes mellitus and the main cause of end-stage renal disease. Present medications for DKD are not entirely satisfactory. Preliminary studies indicate that the Chinese herbal formula Tangshen Formula (TSF) appears to dec...

journal_title：Trials

authors： Yan M,Wen Y,Yang L,Wu X,Lu X,Zhang B,Huang W,Li P

更新日期：2016-05-23 00:00:00

abstract：BACKGROUND:Untreated advanced hepatocellular carcinoma (HCC) is linked to poor prognosis. While sorafenib is the current recommended treatment for advanced HCC, radioembolisation (RE; also called selective internal radiation therapy or SIRT) with yttrium-90 microspheres has shown efficacy in cohort studies. However, th...

journal_title：Trials

authors： Vilgrain V,Abdel-Rehim M,Sibert A,Ronot M,Lebtahi R,Castéra L,Chatellier G,SARAH Trial Group.

更新日期：2014-12-03 00:00:00

abstract：BACKGROUND:The burden of acute gastroenteritis on children and their families continues to be enormous. Probiotics, defined as viable microbial preparations that have a beneficial effect on the health of the host, represent a rapidly expanding field. Although clinical trials in children with gastroenteritis have been p...

journal_title：Trials

authors： Freedman SB,Williamson-Urquhart S,Schuh S,Sherman PM,Farion KJ,Gouin S,Willan AR,Goeree R,Johnson DW,Black K,Schnadower D,Gorelick MH,Pediatric Emergency Research Canada (PERC) Gastroenteritis Study Group.

更新日期：2014-05-14 00:00:00

abstract：BACKGROUND:Surgical microvascular decompression (MVD) is the curative treatment for hemifacial spasm (HFS). Monitoring MVD by recording the lateral spread response (LSR) intraoperatively can predict a successful clinical outcome. However, the rate of the LSR varies between trials, and the reason for this variation is u...

journal_title：Trials

authors： Fang Y,Zhang H,Liu W,Li Y

更新日期：2012-09-08 00:00:00

abstract：BACKGROUND:College is an exciting but also challenging time with an increased risk for mental health issues. Only a minority of the college students concerned get professional help, a problem that might be improvable by internet- and mobile-based interventions (IMIs). However, adherence of IMIs is a concern. While guid...

journal_title：Trials

authors： Küchler AM,Schultchen D,Pollatos O,Moshagen M,Ebert DD,Baumeister H

更新日期：2020-11-26 00:00:00

abstract：BACKGROUND:Although conventional laparoscopic and hand-assisted laparoscopic surgery for colorectal cancer is widely used today, there remain many technical challenges especially for right colon cancer in obese patients. Herein, we develop a novel hand-assisted laparoscopic surgery (HALS) with complete mesocolic excisi...

journal_title：Trials

authors： Yang X,Wu Q,Jin C,He W,Wang M,Yang T,Wei M,Deng X,Meng W,Wang Z

更新日期：2017-07-26 00:00:00

abstract：BACKGROUND:Clavicle fractures account for around 4% of all fractures and up to 44% of fractures of the shoulder girdle. Fractures of the middle third (or mid-shaft) account for approximately 80% of all clavicle fractures. Management of this group of fractures is often challenging and the outcome can be unsatisfactory. ...

journal_title：Trials

authors： Longo UG,Banerjee S,Barber J,Chambler A,Cobiella C,Corbett S,Crowther M,Drew S,Francis A,Lee M,Garlick N,Packham I,Pearse Y,Richards A,Roberts C,Tennent D,Tims E,Ahrens PM

更新日期：2011-02-28 00:00:00

abstract：BACKGROUND:The purpose of clinical trials of acupuncture is to help clinicians and patients make decisions about treatment. Yet this is not straightforward: some trials report acupuncture to be superior to sham (placebo) acupuncture while others show evidence that acupuncture is superior to usual care but not sham, and...

journal_title：Trials

authors： Vickers AJ,Cronin AM,Maschino AC,Lewith G,Macpherson H,Victor N,Sherman KJ,Witt C,Linde K,Acupuncture Trialists' Collaboration.

更新日期：2010-09-28 00:00:00

abstract：BACKGROUND:Immune function may influence the ability of older adults to maintain or improve muscle mass, strength, and function during aging. Thus, nutritional supplementation that supports the immune system could complement resistance exercise as an intervention for age-associated muscle loss. The current study will d...

journal_title：Trials

authors： Dennis RA,Ponnappan U,Kodell RL,Garner KK,Parkes CM,Bopp MM,Padala KP,Peterson CA,Padala PR,Sullivan DH

更新日期：2015-03-27 00:00:00

abstract：BACKGROUND:The high co-morbidity of mental disorders, particularly depression, with non-communicable diseases (NCDs) such as cardiovascular disease (CVD), is concerning given the rising burden of NCDs globally, and the role depression plays in confounding prevention and treatment of NCDs. The objective of this randomis...

journal_title：Trials

authors： Petersen I,Bhana A,Folb N,Thornicroft G,Zani B,Selohilwe O,Petrus R,Mntambo N,Georgeu-Pepper D,Kathree T,Lund C,Lombard C,Bachmann M,Gaziano T,Levitt N,Fairall L,PRIME-SA research team.

更新日期：2018-03-22 00:00:00

abstract：BACKGROUND:Endovenous thermal techniques, such as endovenous laser ablation (EVLA), are the recommended treatment for truncal varicose veins. However, a disadvantage of thermal techniques is that it requires the administration of tumescent anaesthesia, which can be uncomfortable. Non-thermal, non-tumescent techniques, ...

journal_title：Trials

authors： Leung CC,Carradice D,Wallace T,Chetter IC

更新日期：2016-08-24 00:00:00

abstract：BACKGROUND:Randomised controlled trials are being increasingly used to evaluate new surgical interventions. There are a number of problematic methodological issues specific to surgical trials, the most important being identifying whether patients are eligible for recruitment into the trial. This is in part due to the d...

journal_title：Trials

authors： Parsons NR,Kulikov Y,Girling A,Griffin D

更新日期：2011-12-13 00:00:00

abstract：BACKGROUND:Approximately 2 million children are hospitalized each year in the United States, with more than three-quarters of non-elective hospitalizations admitted through emergency departments (EDs). Direct admission, defined as admission to hospital without first receiving care in the hospital's ED, may offer benefi...

journal_title：Trials

authors： Leyenaar JK,McDaniel CE,Acquilano SC,Schaefer AP,Bruce ML,O'Malley AJ

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:There is a strong evidence base for the benefits of parenting interventions for parents without severe mental illness (SMI). As the impact of maternal SMI can be significant on child development, mothers need support to maximise outcomes for themselves and their children. Some mothers with SMI require admiss...

journal_title：Trials

authors： Wittkowski A,Cartwright K,Emsley R,Bee P,Calam R,Cross C,Abel KM,Reid H

更新日期：2018-09-10 00:00:00

abstract：OBJECTIVES:Entertainment-education (E-E) media can improve behavioral intent toward health-related practices. In the era of COVID-19, millions of people can be reached by E-E media without requiring any physical contact. We have designed a short, wordless, animated video about COVID-19 hygiene practices-such as social ...

journal_title：Trials

authors： Vandormael A,Adam M,Greuel M,Bärnighausen T

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Surgical interventions are complex, which complicates their rigorous assessment through randomised clinical trials. An important component of complexity relates to surgeon experience and the rate at which the required level of skill is achieved, known as the learning curve. There is considerable evidence tha...

journal_title：Trials

authors： Papachristofi O,Jenkins D,Sharples LD

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Non-inferiority trials are increasingly used to evaluate new treatments that are expected to have secondary advantages over standard of care, but similar efficacy on the primary outcome. When designing a non-inferiority trial with a binary primary outcome, the choice of effect measure for the non-inferiority...

journal_title：Trials

authors： Quartagno M,Walker AS,Babiker AG,Turner RM,Parmar MKB,Copas A,White IR

更新日期：2020-02-06 00:00:00

abstract：:After publication of our article [1] we have been notified on a mistake in the sample size. ...

journal_title：Trials

authors： Zhu L,Shi X,Yin S,Yin J,Zhu Z,Gao X,Jiao Y,Yu W,Yang L

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Spin in the reporting of randomized controlled trials, where authors report research in a way that potentially misrepresents results and mislead readers, has been demonstrated in the broader medical literature. We investigated spin in wound care trials with (a) no statistically significant result for the pri...

journal_title：Trials

authors： Lockyer S,Hodgson R,Dumville JC,Cullum N

更新日期：2013-11-06 00:00:00

abstract：BACKGROUND:Intrathecally administered morphine is effective as part of a postoperative analgesia regimen following major hepatopancreaticobiliary surgery. However, the potential for postoperative respiratory depression at the doses required for effective analgesia currently limits its clinical use. The use of a low-dos...

journal_title：Trials

authors： Cosgrave D,Galligan M,Soukhin E,McMullan V,McGuinness S,Puttappa A,Conlon N,Boylan J,Hussain R,Doran P,Nichol A

更新日期：2017-12-29 00:00:00

abstract：BACKGROUND:Individuals with spinal cord injuries (SCI) are prone to pressure ulcers (PUs) because of the loss of sensorimotor function involved as well as increased skin moisture. Treatment of PU after SCI is complicated, involving different specialties and with need for long-lasting follow-up. This study should identi...

journal_title：Trials

authors： Irgens I,Hoff JM,Sørli H,Haugland H,Stanghelle JK,Rekand T

更新日期：2019-01-24 00:00:00

abstract：BACKGROUND:This study is a part of a series of two clinical trials. We consider diabetic polyneuropathy (DPN), a common chronic and progressive complication of diabetes mellitus that has several impacts on individuals' foot health and quality of life. Based on the current trends of self-monitoring and self-care, provid...

journal_title：Trials

authors： Silva EQ,Suda EY,Santos DP,Veríssimo JL,Ferreira JSSP,Cruvinel Júnior RH,Monteiro RL,Sartor CD,Sacco ICN

更新日期：2020-02-13 00:00:00

abstract：BACKGROUND:Classroom-based stuttering intervention addressing negative peer attitudes, perceptions, teasing and bullying of children who stutter (CWS) is required as part of holistic stuttering management because of its occurrence in primary school. This study was conducted in 2017, in 10 primary schools in the Western...

journal_title：Trials

authors： Mallick R,Kathard H,Borhan ASM,Pillay M,Thabane L

更新日期：2018-11-29 00:00:00

abstract：BACKGROUND:Age-related muscle wasting has been strongly implicated with falls and fractures in the elderly, but it has also been associated with cognitive decline and dementia. Progressive resistance training (PRT) and adequate dietary protein are recognised as important contributors to the maintenance of muscle health...

journal_title：Trials

authors： Daly RM,Gianoudis J,Prosser M,Kidgell D,Ellis KA,O'Connell S,Nowson CA

更新日期：2015-08-08 00:00:00

abstract：BACKGROUND:Chronic back pain is a major public health problem and the primary reason patients seek massage treatment. Despite the growing use of massage for chronic low back pain, there have been few studies of its effectiveness. This trial will be the first evaluation of the effectiveness of relaxation massage for chr...

journal_title：Trials

authors： Cherkin DC,Sherman KJ,Kahn J,Erro JH,Deyo RA,Haneuse SJ,Cook AJ

更新日期：2009-10-20 00:00:00

abstract：BACKGROUND:Plaque psoriasis is a refractory inflammatory skin disease. The common therapies used to treat plaque psoriasis in traditional Chinese medicine (TCM) and western medicine (WM) have distinct characteristics and advantages. Although a combination of TCM and WM therapies, adjusted to the clinical situation, is ...

journal_title：Trials

authors： Sun X,Zhou X,Wei Y,Yang W,Huang N,Ding Y,Hu R,Guo S,Yang C,Weng H,Zhang Y,Chen X,Ding X,Liu L,Yin Q,Wang R,Li X,Li B

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Suicide risk among individuals with schizophrenia (SZ) is intractably high, with over 40% of individuals attempting to take their own lives during their lifetime and an estimated 5-10% completing suicide. At present, available pharmacological and psychotherapeutic treatments offer limited risk reduction bene...

journal_title：Trials

authors： Beck-Felts K,Goodman M,Ospina LH,Wall M,McEvoy J,Jarskog LF,Ballon JS,Bartels MN,Buchsbaum R,Sloan RP,Stroup TS,Kimhy D

更新日期：2020-10-21 00:00:00

abstract：BACKGROUND:Cognitive behavioural therapy is an effective treatment for depression. However, one third of the patients do not respond satisfactorily, and relapse rates of around 30 % within the first post-treatment year were reported in a recent meta-analysis. In total, 30-50 % of remitted patients present with residual...

journal_title：Trials

authors： Hvenegaard M,Watkins ER,Poulsen S,Rosenberg NK,Gondan M,Grafton B,Austin SF,Howard H,Moeller SB

更新日期：2015-08-11 00:00:00