当前位置： SCI文献检索 > BMC Medical Research Methodology期刊下所有文献 > Impact of preconception enrollment on birth enrollment and timing of exposure assessment in the initial vanguard cohort of the U.S. National Children's Study.

Impact of preconception enrollment on birth enrollment and timing of exposure assessment in the initial vanguard cohort of the U.S. National Children's Study.

Abstract：

BACKGROUND:The initial vanguard cohort of the U.S. National Children's Study was a pregnancy and birth cohort study that sought to enroll some women prior to pregnancy, and to assess exposures early in pregnancy. METHODS:During the recruitment phase (2009-2010), geographically based sampling was used to recruit women early in pregnancy and women not currently pregnant, not using contraception and heterosexually active. We assessed the following outcomes for women enrolled preconception and early in pregnancy: yield of births; demographic characteristics of births for different enrollment groups; time to pregnancy for preconception women; and the timing of study visits for exposure assessment. RESULTS:1399 women were recruited into the initial vanguard cohort: 429 preconception (198 trying for pregnancy, and 231 not trying) and 970 already pregnant. There were 1135 pregnancies (81% of women) and 922 newborns enrolled (81% of pregnancies) through September 2012. Preconception women represented 30.6% of women enrolled, and contributed 14.5% of births. Among women who gave birth, and who had enrolled preconception trying for pregnancy, 67.3% were white non-Hispanic, compared to 50.0% of preconception women not trying for pregnancy, and 61.5% of pregnant women. Women enrolled preconception who were trying for pregnancy had higher cumulative probability of pregnancy at one year compared to women not trying (adjusted 86% versus 56%). Of 165 women enrolled preconception who became pregnant, 19% had a study visit within 30 days of conception. By 10.5 weeks after conception, 75% of women enrolled preconception had completed a pregnancy study visit; for women enrolled pregnant, the 75% threshold was reached at 28.4 weeks. CONCLUSIONS:There were demographic differences in births from women enrolled preconception trying for pregnancy, preconception not trying for pregnancy, or during pregnancy. Time to pregnancy was shorter for women actively trying for pregnancy. Most women enrolled preconception did not have exposure assessment within 30 days of conception, but they did have exposure assessment much earlier during pregnancy than women who enrolled during pregnancy.

journal_name

BMC Med Res Methodol

journal_title

BMC medical research methodology

authors

Stanford JB,Brenner R,Fetterer D,Palmer L,Schoendorf KC,U.S. National Children’s Study.

doi

10.1186/s12874-015-0067-1

subject

Has Abstract

pub_date

2015-09-24 00:00:00

pages

issn

1471-2288

pii

10.1186/s12874-015-0067-1

journal_volume

pub_type

杂志文章

在线工具

Impact of preconception enrollment on birth enrollment and timing of exposure assessment in the initial vanguard cohort of the U.S. National Children's Study.