Abstract:
BACKGROUND:Despite evidence that psychological stress is an important risk factor for age-related cognitive loss, little research has directly evaluated psychological and physiological mediators of the relationship between stressful experiences and cognitive function. A key objective of the ESCAPE (Effects of Stress on Cognitive Aging, Physiology, and Emotion) project is to evaluate whether engaging in stress-related unconstructive repetitive thought (URT) is a pathway through which stressful experiences negatively affect cognitive health over the short- and long-term. Over the short-term, we hypothesize that engaging in URT will deplete attentional resources and result in worse cognitive performance in daily life. Over the long-term, we expect that the effects of chronic stress, from repeated exposure to stressors and regular engagement in URT, will be apparent in dysregulated hypothalamic-pituitary-adrenal (HPA) axis function and inflammation. Over time, stress-related physiological dysregulation will result in accelerated cognitive decline. METHODS/DESIGN:This study utilizes a prospective longitudinal measurement-burst design. A systematic probability sample of participants aged 25 to 65 is recruited from residents of the Bronx, NY. Consenting participants complete a baseline assessment and follow-up waves at 9, 18, and 27 months post-baseline. At each wave, participants complete a 14 day measurement burst of brief surveys and cognitive assessments delivered via study smartphones during daily life. Participants provide saliva samples four times each day for five days during the measurement burst and fasting blood samples at the end of each burst from which cortisol and dehydroepiandrosterone sulfate (DHEAS), circulating inflammatory markers, and stimulated inflammatory responses to lipopolysaccharide in whole blood are determined. DISCUSSION:This study takes a multi-pronged approach to assessing stress (i.e., early adversity, chronic strains, major events, daily hassles), psychological mediators (e.g., URT), biological mechanisms (i.e., HPA function, inflammation) and outcomes across different time-scales (i.e., momentary cognitive performance, cognitive decline across years). The systematic probability sample is locally representative and can be compared with national norms on key markers of health and well-being. The findings will improve our understanding of how environmental, psychological, and physiological stress-related influences accumulate to affect cognitive health and identify potential targets (e.g., URT, inflammation) for prevention and intervention promoting cognitive health.
journal_name
BMC Psychiatryjournal_title
BMC psychiatryauthors
Scott SB,Graham-Engeland JE,Engeland CG,Smyth JM,Almeida DM,Katz MJ,Lipton RB,Mogle JA,Munoz E,Ram N,Sliwinski MJdoi
10.1186/s12888-015-0497-7subject
Has Abstractpub_date
2015-07-03 00:00:00pages
146issn
1471-244Xpii
10.1186/s12888-015-0497-7journal_volume
15pub_type
杂志文章相关文献
BMC Psychiatry文献大全abstract:BACKGROUND:In 1963, Nicolaas Tinbergen published an article on "the aims and methods of ethology" in which he identified a fundamental framework for the scientific inquiry into the understanding of biological phenomena. In particular, he emphasized to not only study what he called the "proximate" causes, that is, mecha...
journal_title:BMC psychiatry
pub_type: 杂志文章
doi:10.1186/s12888-014-0364-y
更新日期:2014-12-21 00:00:00
abstract:BACKGROUND:Depression is a highly prevalent and disabling mental disorder with an incidence rate which appears to be increasing in the developed world. This fact seems to be at least partially related to lifestyle factors. Some hygienic-dietary measures have shown their efficacy as a coadjuvant of standard treatment. H...
journal_title:BMC psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-244X-12-201
更新日期:2012-11-16 00:00:00
abstract:BACKGROUND:Auditory verbal hallucinations (AVHs) represent one of the most intriguing phenomena in schizophrenia, however, brain abnormalities underlying AVHs remain unclear. The present study examined the association between cortical thickness and AVHs in first-episode schizophrenia. METHOD:High-resolution MR images ...
journal_title:BMC psychiatry
pub_type: 杂志文章
doi:10.1186/s12888-015-0546-2
更新日期:2015-07-07 00:00:00
abstract:BACKGROUND:Suicidal ideation is common in patients suffering from panic disorder. The present study investigated rates of suicidal ideation and risk factors for suicidal ideation in a sample of primary care patients suffering from panic disorder with or without agoraphobia. METHODS:A total of N = 296 patients [n = 215...
journal_title:BMC psychiatry
pub_type: 杂志文章
doi:10.1186/s12888-018-1894-5
更新日期:2018-09-24 00:00:00
abstract:BACKGROUND:Depression is the most prevalent psychiatric disorder among people living with HIV (PLWHIV) and is associated with poor quality of life, additional comorbidities, disability, unemployment, poorer therapeutic outcomes and risky behaviors. The present systematic review and meta-analysis aims to systematically ...
journal_title:BMC psychiatry
pub_type: 杂志文章,meta分析
doi:10.1186/s12888-018-1835-3
更新日期:2018-08-15 00:00:00
abstract:BACKGROUND:Studies suggest that immigrants have higher rates of anxiety-depression than compatriots in low-middle income countries and lower rates than populations in host high income countries. Elucidating the factors that underlie these stepwise variations in prevalence may throw new light on the pathogenesis of anxi...
journal_title:BMC psychiatry
pub_type: 杂志文章
doi:10.1186/1471-244X-13-329
更新日期:2013-12-02 00:00:00
abstract:BACKGROUND:Mood and anxiety disorders are leading causes of disability and mortality, due largely to their onset during adolescence and young adulthood and broader impact on functioning. Key factors that are associated with disability and these disorders in young people are social and economic participation (e.g. educa...
journal_title:BMC psychiatry
pub_type: 杂志文章,评审
doi:10.1186/s12888-016-0852-3
更新日期:2016-05-23 00:00:00
abstract:BACKGROUND:Hypercortisolism as a sign of hypothamamus-pituitary-adrenocortical (HPA) axis overactivity and sleep EEG changes are frequently observed in depression. Closely related to the HPA axis is the renin-angiotensin-aldosterone system (RAAS) as 1. adrenocorticotropic hormone (ACTH) is a common stimulus for cortiso...
journal_title:BMC psychiatry
pub_type: 杂志文章
doi:10.1186/1471-244X-3-15
更新日期:2003-10-29 00:00:00
abstract:BACKGROUND:Bitopertin, a glycine reuptake inhibitor, was investigated as a novel treatment for schizophrenia. We report all the results of a double-blind randomized study assessing safety and efficacy following 52-week adjunctive treatment with bitopertin in Japanese patients with schizophrenia. METHODS:This study enr...
journal_title:BMC psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12888-016-0778-9
更新日期:2016-03-15 00:00:00
abstract:BACKGROUND:Adolescents treated for self-poisoning with medication have a high prevalence of mental health problems and constitute a high-risk population for self-harm repetition. However, little is known about whether this population is also prone to injuries of other forms. METHODS:Data were extracted from the Norweg...
journal_title:BMC psychiatry
pub_type: 杂志文章
doi:10.1186/s12888-018-1778-8
更新日期:2018-06-18 00:00:00
abstract:BACKGROUND:Depression is common among people with diabetes, negatively affecting quality of life, treatment adherence and diabetes outcomes. In routine clinical care, diabetes patients have limited access to mental health services and depression therefore often remains untreated. Web-based therapy could potentially be ...
journal_title:BMC psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-244X-8-9
更新日期:2008-02-19 00:00:00
abstract:BACKGROUND:Studies have reported that up to 60% of individuals with schizophrenia are overweight or obese. This study explored the relationship between obesity and cognitive performance in Chinese patients with schizophrenia. METHODS:Outpatients with schizophrenia aged 18-50 years were recruited from 10 study sites ac...
journal_title:BMC psychiatry
pub_type: 杂志文章
doi:10.1186/1471-244X-13-109
更新日期:2013-04-09 00:00:00
abstract:BACKGROUND:Roughly one third of disability pensions in Norway are issued for mental and behavioral disorders, and vocational rehabilitation offered to this group has traditionally been dominated by train-and-place approaches with assisted or sheltered employment. Based on a more innovative place-and-train approach, Ind...
journal_title:BMC psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12888-014-0307-7
更新日期:2014-11-18 00:00:00
abstract:BACKGROUND:This randomized controlled trial (RCT) investigated the effectiveness of a combined treatment for co-morbid Posttraumatic Stress Disorder (PTSD) and severe Substance Use Disorder (SUD). METHODS:Structured Writing Therapy for PTSD (SWT), an evidence-based traumafocused intervention, was added on to Treatment...
journal_title:BMC psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-244X-13-172
更新日期:2013-06-19 00:00:00
abstract:BACKGROUND:Suicidality has been under-researched in autism spectrum disorders (ASD). Most studies have linked increased suicidality in ASD to psychiatric comorbidities such as depression. Here we investigated, from a neuropsychological and clinical standpoint, the relationship between core ASD symptoms, i.e., restricte...
journal_title:BMC psychiatry
pub_type: 杂志文章
doi:10.1186/s12888-019-2122-7
更新日期:2019-04-27 00:00:00
abstract:BACKGROUND:Good sibling relationships in adulthood are known to be a protective factor for mental health. The present study examined and compared the relationships of siblings with either a healthy brother or sister or one experiencing schizophrenia. METHODS:In the first phase, we ran a statistical comparison of the t...
journal_title:BMC psychiatry
pub_type: 杂志文章
doi:10.1186/s12888-020-02510-6
更新日期:2020-03-13 00:00:00
abstract:BACKGROUND:The rise of the internet and related technologies has significant implications for the treatment of complex health problems, including the combination of depression and alcohol/other drug (AOD) misuse. To date, no research exists to test the real world uptake of internet and computer-delivered treatment prog...
journal_title:BMC psychiatry
pub_type: 临床试验,杂志文章
doi:10.1186/1471-244X-12-77
更新日期:2012-07-07 00:00:00
abstract:BACKGROUND:There are no standard diagnostic criteria or interventions for internet gaming addiction (IGA) even though IGA is one of the most pervasive public health issues among youth worldwide. Internet gaming reasons or motivations have been studied as a potential predictor of IGA, but the results have been inconsist...
journal_title:BMC psychiatry
pub_type: 杂志文章
doi:10.1186/s12888-020-02714-w
更新日期:2020-06-30 00:00:00
abstract:BACKGROUND:The reliability of the subjective statements reports on disturbed night sleep and alertness in the daytime was assessed by their correlation to the objective indicators in patients with mild depression. METHOD:Among patients with depression, altogether 28 patients with insomnia were examined. Their answers ...
journal_title:BMC psychiatry
pub_type: 杂志文章
doi:10.1186/1471-244X-4-14
更新日期:2004-05-26 00:00:00
abstract:BACKGROUND:Although massive studies have explored the risk factors of suicidal ideation (SI), the prevalence of SI and its associated factors in the hypertensive individuals are largely unknown. This study aims to investigate the factors associated with SI in the hypertensive individuals. METHODS:Three thousand nine h...
journal_title:BMC psychiatry
pub_type: 杂志文章
doi:10.1186/s12888-019-2256-7
更新日期:2019-09-02 00:00:00
abstract:BACKGROUND:Biomarkers are now widely used in many fields of medicine, and the identification of biomarkers that predict antipsychotic efficacy and adverse reactions is a growing area of psychiatric research. Monoamine molecules of the peripheral bloodstream are possible prospective biomarkers based on a growing body of...
journal_title:BMC psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12888-017-1562-1
更新日期:2017-12-08 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated that individual measures of fitness - such as reduced pulmonary function, slow walking speed and weak handgrip - are associated with an increased risk of dementia. Only a minority of participants included in these studies were aged over 80. The aim of this study was therefo...
journal_title:BMC psychiatry
pub_type: 杂志文章
doi:10.1186/s12888-018-1851-3
更新日期:2018-09-04 00:00:00
abstract:BACKGROUND:Little is known about the public stigma on mental illness and mental health knowledge (MHK) in China, public stigma and low MHK can negatively affect patients' health and increase the burden of mental disorders on society. This study aimed at investigating the rates of stigma and MHK, the correlates of stigm...
journal_title:BMC psychiatry
pub_type: 杂志文章
doi:10.1186/s12888-020-02705-x
更新日期:2020-06-22 00:00:00
abstract:BACKGROUND:The symptom profile and neuropsychological functioning of individuals with Attention Deficit/Hyperactivity Disorder (ADHD), change as they enter adolescence. It is unclear whether variation in brain structure and function parallels these changes, and also whether deviations from typical brain development tra...
journal_title:BMC psychiatry
pub_type: 杂志文章
doi:10.1186/s12888-016-0770-4
更新日期:2016-03-11 00:00:00
abstract:BACKGROUND:Schizophrenia is a chronic mental health disorder associated with increased hospital admissions and excessive utilization of outpatient services and long-term care. This analysis examined health care resource utilization from a 24-month observational study of patients with schizophrenia initiated on risperid...
journal_title:BMC psychiatry
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/1471-244X-11-168
更新日期:2011-10-14 00:00:00
abstract:BACKGROUND:Individuals affected by severe Borderline Personality Disorder (BPD) are often heavy users of Mental Health Services (MHS). Short-term treatments currently used in BPD therapy are useful to target disruptive behaviors but they are less effective in reducing heavy MHS use. Therefore, alternative short-term tr...
journal_title:BMC psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-244X-11-181
更新日期:2011-11-21 00:00:00
abstract:BACKGROUND:For around a third of people with a diagnosis of schizophrenia, the condition proves to respond poorly to treatment with many typical and atypical antipsychotics. This is commonly referred to as treatment-resistant schizophrenia. Clozapine is the only antipsychotic with convincing efficacy for people whose s...
journal_title:BMC psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12888-016-0983-6
更新日期:2016-08-05 00:00:00
abstract:BACKGROUND:There are currently no systematic reviews or meta-analyses of Chinese calligraphy therapy (CCT) to reduce neuropsychiatric symptoms. The aim of this systematic review and meta-analysis was to explore the efficacy of CCT for people with neuropsychiatric symptoms. METHODS:We searched Chinese and English datab...
journal_title:BMC psychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12888-018-1611-4
更新日期:2018-03-07 00:00:00
abstract:BACKGROUND:Individuals with schizophrenia may have a higher risk of encounters with the criminal justice system than the general population, but there are limited data on such encounters and their attendant costs. This study assessed the prevalence of encounters with the criminal justice system, encounter types, and th...
journal_title:BMC psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-244X-10-11
更新日期:2010-01-28 00:00:00
abstract:BACKGROUND:Research indicates schizophrenia is a cause of burden for patients and caregivers. This study examined health-related quality of life (HRQoL) and comorbidities experienced by informal schizophrenia caregivers compared with non-caregivers and caregivers of adults with other conditions (e.g., Alzheimer's disea...
journal_title:BMC psychiatry
pub_type: 杂志文章
doi:10.1186/s12888-015-0547-1
更新日期:2015-07-21 00:00:00